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International journal of surgery最新文献

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Letter to editor: artificial intelligence-based multi-modal multi-tasks analysis reveals tumor molecular heterogeneity, predicts preoperative lymph node metastasis and prognosis in papillary thyroid carcinoma: a retrospective study. 致编辑：基于人工智能的多模式多任务分析揭示了甲状腺乳头状癌的肿瘤分子异质性，预测了术前淋巴结转移和预后：一项回顾性研究。
IF 10.1 2区 医学
International journal of surgery Pub Date : 2025-10-14 DOI: 10.1097/JS9.0000000000003669
Liyi Zhu, Chenyu Lu, Ji Zhang
{"title":"Letter to editor: artificial intelligence-based multi-modal multi-tasks analysis reveals tumor molecular heterogeneity, predicts preoperative lymph node metastasis and prognosis in papillary thyroid carcinoma: a retrospective study.","authors":"Liyi Zhu, Chenyu Lu, Ji Zhang","doi":"10.1097/JS9.0000000000003669","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003669","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statistical and methodological considerations in adolescent PCL avulsion fracture research: a commentary on arthroscopic suspension fixation outcomes. 青少年PCL撕脱骨折研究的统计学和方法学考虑：对关节镜悬吊固定结果的评论。
IF 10.1 2区 医学
International journal of surgery Pub Date : 2025-10-14 DOI: 10.1097/JS9.0000000000003670
Peng Gao, Jiancheng Yang, Chuan Hong
{"title":"Statistical and methodological considerations in adolescent PCL avulsion fracture research: a commentary on arthroscopic suspension fixation outcomes.","authors":"Peng Gao, Jiancheng Yang, Chuan Hong","doi":"10.1097/JS9.0000000000003670","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003670","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor: Artificial Intelligence-powered copilots for precision diagnosis and surgical assessment of histological growth patterns in resectable colorectal liver metastases: a prospective study. 致编辑：一项前瞻性研究：人工智能辅助诊断和手术评估可切除的结直肠癌肝转移的组织学生长模式。
IF 10.1 2区 医学
International journal of surgery Pub Date : 2025-10-14 DOI: 10.1097/JS9.0000000000003664
Junquan Shen, Dandan Weng, Ningning Chen
{"title":"Letter to the editor: Artificial Intelligence-powered copilots for precision diagnosis and surgical assessment of histological growth patterns in resectable colorectal liver metastases: a prospective study.","authors":"Junquan Shen, Dandan Weng, Ningning Chen","doi":"10.1097/JS9.0000000000003664","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003664","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulating exosomes in sepsis induce PD-1 expression in macrophages and promote Th17 differentiation. 脓毒症循环外泌体诱导巨噬细胞PD-1表达，促进Th17分化。
IF 10.1 2区 医学
International journal of surgery Pub Date : 2025-10-14 DOI: 10.1097/JS9.0000000000003651
Shao-Chun Wu, Yi-Chan Wu, Chia-Wei Lin, Tsu-Hsiang Lu, Ming-Yu Yang, Chia-Wen Tsai, Cheng-Shyuan Rau, Ching-Hua Hsieh
{"title":"Circulating exosomes in sepsis induce PD-1 expression in macrophages and promote Th17 differentiation.","authors":"Shao-Chun Wu, Yi-Chan Wu, Chia-Wei Lin, Tsu-Hsiang Lu, Ming-Yu Yang, Chia-Wen Tsai, Cheng-Shyuan Rau, Ching-Hua Hsieh","doi":"10.1097/JS9.0000000000003651","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003651","url":null,"abstract":"<p><strong>Background: </strong>Sepsis induces complex immunological responses; however, the role of circulating exosomes in regulating macrophage function and T cell responses remains unknown. This study examined the effects of sepsis-derived exosomes on macrophages and their subsequent T cell differentiation.</p><p><strong>Materials and methods: </strong>A cecal ligation and puncture (CLP) model was used to induce sepsis in C57BL/6 mice. Exosomes were isolated from the blood of septic (CLP-exo) and sham-operated (Control-exo) mice. Their effects on macrophage proliferation, polarization, and phagocytic function were assessed in vitro. T cell responses were evaluated through co-culture experiments with CLP-exo-treated or Control-exo-treated macrophages and in vivo studies.</p><p><strong>Results: </strong>CLP-exo inhibited macrophage proliferation, induced apoptosis, and suppressed M2 polarization. Phagocytic function was impaired and accompanied by increased PD-1 expression. Co-culture of T cells with CLP-exo-treated macrophages activated the KLF4 pathway and increased Th17-related cytokine expression. In vivo, PD-1 expression in CLP-exo-treated macrophages was associated with enhanced T cell differentiation toward the Th17 subtype in blood. PCR array analysis revealed the activation of multiple T cell-related genes, including Csf2, IL-2, IL-4, STAT4, and STAT6.</p><p><strong>Conclusion: </strong>Sepsis-derived exosomes induced PD-1 expression in macrophages and promoted Th17 differentiation, revealing a novel mechanism of immune dysregulation in sepsis. These findings provide new insights into immune dysregulation in sepsis pathophysiology.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A commentary on "clinicopathological characteristics and biomarker alterations in early-onset vs. late-onset colorectal cancer: a systematic review and meta-analysis". 关于“早发性与晚发性结直肠癌的临床病理特征和生物标志物改变：系统回顾和荟萃分析”的评论。
IF 10.1 2区 医学
International journal of surgery Pub Date : 2025-10-14 DOI: 10.1097/JS9.0000000000003650
Shijun Xia, Shiwei Chen, Wenjiang Wu
{"title":"A commentary on \"clinicopathological characteristics and biomarker alterations in early-onset vs. late-onset colorectal cancer: a systematic review and meta-analysis\".","authors":"Shijun Xia, Shiwei Chen, Wenjiang Wu","doi":"10.1097/JS9.0000000000003650","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003650","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rising surgical site infections and antibiotic resistance: current status and potential therapeutic strategies-research letter. 不断上升的手术部位感染和抗生素耐药性：现状和潜在的治疗策略。
IF 10.1 2区 医学
International journal of surgery Pub Date : 2025-10-14 DOI: 10.1097/JS9.0000000000003674
Kutub Uddin Ahamed, Emad Rashad Sindi, Taha Alqahtani, Humood Al Shmrany, Maria Karolaynne da Silva, Jonas Ivan Nobre Oliveira, Magdi E A Zaki
{"title":"Rising surgical site infections and antibiotic resistance: current status and potential therapeutic strategies-research letter.","authors":"Kutub Uddin Ahamed, Emad Rashad Sindi, Taha Alqahtani, Humood Al Shmrany, Maria Karolaynne da Silva, Jonas Ivan Nobre Oliveira, Magdi E A Zaki","doi":"10.1097/JS9.0000000000003674","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003674","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor: "associations of the NPAR index with breast cancer incidence and mortality Based on the National Health and Nutrition Examination Survey (NHANES) 2001-2018 a Cross-sectional Study". 致编辑的信：“基于2001-2018年全国健康与营养调查（NHANES）横断面研究的NPAR指数与乳腺癌发病率和死亡率的关系”。
IF 10.1 2区 医学
International journal of surgery Pub Date : 2025-10-14 DOI: 10.1097/JS9.0000000000003690
Si Li, Meihan Guo, Dapeng Ding
{"title":"Letter to the Editor: \"associations of the NPAR index with breast cancer incidence and mortality Based on the National Health and Nutrition Examination Survey (NHANES) 2001-2018 a Cross-sectional Study\".","authors":"Si Li, Meihan Guo, Dapeng Ding","doi":"10.1097/JS9.0000000000003690","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003690","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "The mechanisms of environmental pollutant acetyl tributyl citrate-induced oral squamous cell carcinoma using network toxicology, molecular docking and molecular dynamics simulation". 对“环境污染物乙酰柠檬酸三丁酯诱发口腔鳞状细胞癌的网络毒理学、分子对接和分子动力学模拟机制”的评论。
IF 10.1 2区 医学
International journal of surgery Pub Date : 2025-10-14 DOI: 10.1097/JS9.0000000000003658
Chenzi Zhao, Rong Shi, Jing Wang
{"title":"Comment on \"The mechanisms of environmental pollutant acetyl tributyl citrate-induced oral squamous cell carcinoma using network toxicology, molecular docking and molecular dynamics simulation\".","authors":"Chenzi Zhao, Rong Shi, Jing Wang","doi":"10.1097/JS9.0000000000003658","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003658","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A commentary on "Comparison of accuracy, efficiency and safety between robotic-assisted and non-robotic-assisted deep brain stimulation: systematic review and/or meta-analysis". 对“机器人辅助和非机器人辅助脑深部刺激的准确性、效率和安全性的比较：系统回顾和/或荟萃分析”的评论。
IF 10.1 2区 医学
International journal of surgery Pub Date : 2025-10-14 DOI: 10.1097/JS9.0000000000003662
Long Wei, Cui Liu, Xiaozheng Du
{"title":"A commentary on \"Comparison of accuracy, efficiency and safety between robotic-assisted and non-robotic-assisted deep brain stimulation: systematic review and/or meta-analysis\".","authors":"Long Wei, Cui Liu, Xiaozheng Du","doi":"10.1097/JS9.0000000000003662","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003662","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A commentary on: "Treatment-related Adverse events, immune-related adverse events and discontinuation in patients with solid tumors adding adjuvant immune checkpoint blockade: a meta-analysis of 38 randomized controlled trials". 评论：“使用辅助免疫检查点阻断治疗的实体瘤患者的治疗相关不良事件、免疫相关不良事件和停药：38项随机对照试验的荟萃分析”。
IF 10.1 2区 医学
International journal of surgery Pub Date : 2025-10-14 DOI: 10.1097/JS9.0000000000003645
Lei Wang, Ji Ma
{"title":"A commentary on: \"Treatment-related Adverse events, immune-related adverse events and discontinuation in patients with solid tumors adding adjuvant immune checkpoint blockade: a meta-analysis of 38 randomized controlled trials\".","authors":"Lei Wang, Ji Ma","doi":"10.1097/JS9.0000000000003645","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003645","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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