{"title":"Letter to the editor: Artificial Intelligence-powered copilots for precision diagnosis and surgical assessment of histological growth patterns in resectable colorectal liver metastases: a prospective study.","authors":"Junquan Shen, Dandan Weng, Ningning Chen","doi":"10.1097/JS9.0000000000003664","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003664","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Circulating exosomes in sepsis induce PD-1 expression in macrophages and promote Th17 differentiation.","authors":"Shao-Chun Wu, Yi-Chan Wu, Chia-Wei Lin, Tsu-Hsiang Lu, Ming-Yu Yang, Chia-Wen Tsai, Cheng-Shyuan Rau, Ching-Hua Hsieh","doi":"10.1097/JS9.0000000000003651","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003651","url":null,"abstract":"<p><strong>Background: </strong>Sepsis induces complex immunological responses; however, the role of circulating exosomes in regulating macrophage function and T cell responses remains unknown. This study examined the effects of sepsis-derived exosomes on macrophages and their subsequent T cell differentiation.</p><p><strong>Materials and methods: </strong>A cecal ligation and puncture (CLP) model was used to induce sepsis in C57BL/6 mice. Exosomes were isolated from the blood of septic (CLP-exo) and sham-operated (Control-exo) mice. Their effects on macrophage proliferation, polarization, and phagocytic function were assessed in vitro. T cell responses were evaluated through co-culture experiments with CLP-exo-treated or Control-exo-treated macrophages and in vivo studies.</p><p><strong>Results: </strong>CLP-exo inhibited macrophage proliferation, induced apoptosis, and suppressed M2 polarization. Phagocytic function was impaired and accompanied by increased PD-1 expression. Co-culture of T cells with CLP-exo-treated macrophages activated the KLF4 pathway and increased Th17-related cytokine expression. In vivo, PD-1 expression in CLP-exo-treated macrophages was associated with enhanced T cell differentiation toward the Th17 subtype in blood. PCR array analysis revealed the activation of multiple T cell-related genes, including Csf2, IL-2, IL-4, STAT4, and STAT6.</p><p><strong>Conclusion: </strong>Sepsis-derived exosomes induced PD-1 expression in macrophages and promoted Th17 differentiation, revealing a novel mechanism of immune dysregulation in sepsis. These findings provide new insights into immune dysregulation in sepsis pathophysiology.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A commentary on \"clinicopathological characteristics and biomarker alterations in early-onset vs. late-onset colorectal cancer: a systematic review and meta-analysis\".","authors":"Shijun Xia, Shiwei Chen, Wenjiang Wu","doi":"10.1097/JS9.0000000000003650","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003650","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kutub Uddin Ahamed, Emad Rashad Sindi, Taha Alqahtani, Humood Al Shmrany, Maria Karolaynne da Silva, Jonas Ivan Nobre Oliveira, Magdi E A Zaki
{"title":"Rising surgical site infections and antibiotic resistance: current status and potential therapeutic strategies-research letter.","authors":"Kutub Uddin Ahamed, Emad Rashad Sindi, Taha Alqahtani, Humood Al Shmrany, Maria Karolaynne da Silva, Jonas Ivan Nobre Oliveira, Magdi E A Zaki","doi":"10.1097/JS9.0000000000003674","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003674","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor: \"associations of the NPAR index with breast cancer incidence and mortality Based on the National Health and Nutrition Examination Survey (NHANES) 2001-2018 a Cross-sectional Study\".","authors":"Si Li, Meihan Guo, Dapeng Ding","doi":"10.1097/JS9.0000000000003690","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003690","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A commentary on \"Comparison of accuracy, efficiency and safety between robotic-assisted and non-robotic-assisted deep brain stimulation: systematic review and/or meta-analysis\".","authors":"Long Wei, Cui Liu, Xiaozheng Du","doi":"10.1097/JS9.0000000000003662","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003662","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A commentary on: \"Treatment-related Adverse events, immune-related adverse events and discontinuation in patients with solid tumors adding adjuvant immune checkpoint blockade: a meta-analysis of 38 randomized controlled trials\".","authors":"Lei Wang, Ji Ma","doi":"10.1097/JS9.0000000000003645","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003645","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}