International journal of surgery最新文献

{"title":"Expanding horizons: integrating multichannel deep learning predictors into patient-specific digital twins for precision lung cancer management.","authors":"Ruixin Chu, Wenrui Wang","doi":"10.1097/JS9.0000000000005064","DOIUrl":"10.1097/JS9.0000000000005064","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 6","pages":"12969-12970"},"PeriodicalIF":9.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"The value of cholinesterase inhibitors for improving neuropsychiatric and functional assessment scores in patients with Alzheimer disease: a systematic review and meta-analysis of on placebo-controlled RCTs\".","authors":"Jing Han, Meidi Wang, Zhujuan Wu","doi":"10.1097/JS9.0000000000005148","DOIUrl":"10.1097/JS9.0000000000005148","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13311-13313"},"PeriodicalIF":9.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive stratification of HER2 status in breast cancer using multiparametric DECT: a prospective cohort study.","authors":"Huifang Chen, Yao Huang, Xiangfei Zeng, Ying Cao, Xueqin Gong, Sun Tang, Lu Wang, Lan Li, Tao Yu, Yue Cheng, Xiaoxia Wang, Jiuquan Zhang","doi":"10.1097/JS9.0000000000005034","DOIUrl":"10.1097/JS9.0000000000005034","url":null,"abstract":"<p><strong>Background: </strong>HER2 heterogeneity in breast cancer requires precise stratification for treatment guidance. Differences in dual-energy computed tomography (DECT)-derived parameters among HER2-zero, HER2-low, and HER2-positive breast cancers remain unknown. We aimed to evaluate the performance of DECT-based quantitative parameters to distinguish HER2-zero, HER2-low, and HER2-positive expression status in breast cancer, and to compare the efficacy between DECT-predicted HER2 status and pathological HER2 status in predicting pathologic complete response (pCR).</p><p><strong>Methods: </strong>A total of 469 breast cancer patients who underwent chest DECT for staging (November 2020-May 2023) were prospectively recruited. DECT quantitative parameters, such as the normalized iodine concentration (NIC), the normalized effective atomic number (nZeff), the slope of the spectral Hounsfield unit curve (λHu), and polyenergetic images (PEI), were obtained from reconstructed images. Decision tree models were constructed to classify the HER2-zero, HER2-low, and HER2-positive status based on six DECT parameters. These models were tested for performance using the area under the receiver operating characteristic curve (AUC) in training (<i>n</i> = 281) and validation (<i>n</i> = 188) cohorts. Efficacy analysis was performed to compare the efficacy of the DECT-predicted HER2 status with pathological HER2 status in predicting pCR.</p><p><strong>Results: </strong>Statistical analysis revealed significant differences in arterial and venous phase NIC, ΔNIC, venous phase λHu, ΔλHu, and venous phase PEI (HU) among HER2 subtypes (all <i>P</i> < 0.001). The decision tree model achieved AUCs of 0.821 (HER2-zero), 0.848 (HER2-low), and 0.899 (HER2-positive) in training, with validation cohort AUCs of 0.825, 0.850, and 0.879, respectively. DECT-predicted HER2 combined with estrogen/progesterone receptor status demonstrated superior pCR prediction (AUC: 0.760) compared to pathological HER2-based models (AUC: 0.689; <i>P</i> = 0.010).</p><p><strong>Conclusions: </strong>DECT-based quantitative parameters enable noninvasive stratification of HER2-zero, HER2-low, and HER2-positive breast cancers. Additionally, HER2 predicted by DECT outperformed conventional pathological HER2 status in predicting pCR in patients undergoing neoadjuvant chemotherapy.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 6","pages":"12778-12788"},"PeriodicalIF":9.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical antibiotic prophylaxis duration and surgical site infection in orthopedic surgery: insights from a prospective cohort study.","authors":"Zhiyu Chen, Bin Zhou","doi":"10.1097/JS9.0000000000005134","DOIUrl":"10.1097/JS9.0000000000005134","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13305-13306"},"PeriodicalIF":9.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of enhanced recovery after surgery protocol and standard protocol for cesarean delivery: A two-center, double-blind, randomized controlled trial.","authors":"Weijia Du, Hailian Liu, Rui Liu, Chengcheng Xu, Zhendong Xu, Zhiqiang Liu","doi":"10.1097/JS9.0000000000005105","DOIUrl":"10.1097/JS9.0000000000005105","url":null,"abstract":"<p><strong>Background: </strong>Enhanced recovery after cesarean delivery (ERAC) protocols have been designed to optimize maternal recovery. Although its potential has been demonstrated, high-quality evidence supporting the efficacy of ERAC protocols remains limited. This study aimed to evaluate the effect of anesthesiologist-led bundled ERAC interventions on perioperative adverse events and recovery quality.</p><p><strong>Methods: </strong>In this two-center, double-blind, randomized controlled trial, 122 women undergoing elective cesarean delivery under spinal anesthesia were allocated to receive either conventional care or a bundled ERAC protocol. The ERAC bundle included: preoperative personalized and information-based education; intraoperative prophylactic phenylephrine infusion, mandatory non-opioid analgesia (intravenous acetaminophen and ketorolac), prophylaxis for postoperative nausea and vomiting (ondansetron/dexamethasone), and active fluid warming; and postoperative scheduled ketorolac. The primary outcome was a composite of perioperative adverse events (hypotension, nausea/vomiting, shivering, pruritus, hypothermia, and moderate-to-severe pain). Secondary outcomes included opioid consumption, length of hospital stay, pain scores at rest and with movement, the ObsQoR-11 recovery score, and anxiety scores.</p><p><strong>Results: </strong>Among 116 participants who completed the study (57 conventional care, 59 ERAC), the incidence of the primary composite outcome was significantly lower in the ERAC group (45% vs. 71%; absolute risk difference -31.4%, 95% CI -48.1% to -14.7%; odds ratio 0.25, 95% CI 0.11 to 0.56; <i>P</i> = 0.001). On postoperative day 1, the ERAC group demonstrated superior recovery, with lower worst pain scores (<i>P</i><0.01), lower pain scores with movement (<i>P</i><0.01), fewer patient-controlled analgesia boluses (<i>P</i><0.01), and higher ObsQoR-11 scores (<i>P</i><0.01). No significant differences were found in pain at rest, length of stay, or anxiety scores.</p><p><strong>Conclusion: </strong>An anesthesiologist-led, bundled ERAC protocol significantly reduced perioperative adverse events and enhanced the quality of recovery after elective cesarean delivery compared to conventional care.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13124-13131"},"PeriodicalIF":9.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the snapshot: disentangling inflammation, trajectory, and functional phenotypes in preoperative nutritional assessment for AKI.","authors":"Jingxuan Peng, Xueli Shi, Sha Li","doi":"10.1097/JS9.0000000000005111","DOIUrl":"10.1097/JS9.0000000000005111","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13279-13280"},"PeriodicalIF":9.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Access matters: suprapubic-centered surgery as alternative to the transumbilical approach in laparoscopic right colectomy for colon cancer - a propensity score matched analysis.","authors":"Hannes Hoi, Robert Uzel, Hannah Hofer, Lisa Schlosser, Helmut Weiss, Christof Mittermair","doi":"10.1097/JS9.0000000000005087","DOIUrl":"10.1097/JS9.0000000000005087","url":null,"abstract":"<p><strong>Introduction: </strong>The Pfannenstiel incision has replaced the umbilicus as retrieval site in minimally invasive right colectomy. The aim of this study was to evaluate whether shifting the entire procedure towards a suprapubically centered access site provides additional advantages in terms of procedural safety, oncologic outcomes, recovery times and complication rates.</p><p><strong>Methods: </strong>A matched pair analysis was performed that compared 27 patients undergoing suprapubic laparoscopic right colectomy (study group) and 27 patients treated by transumbilical laparoscopic right colectomy (control group). Patients were matched based on age, gender and BMI. Total lymph node yield, conversion and complication rates, procedural duration, and length of stay were defined as primary outcome parameters.</p><p><strong>Results: </strong>Patients with a suprapubically centered surgery showed similar postoperative complication and conversion rates as compared to control patients. Suprapubic laparoscopic right colectomy was associated with the need for a higher number of additional working trocars (<i>P</i> < 0.05), showed a trend towards an increased total lymph node yield (<i>P</i> = 0.056), and significantly reduced the risk for postoperative incisional hernia development to 0% (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Suprapubic laparoscopic right colectomy for malignant colon cancer is safe and feasible, providing similar postoperative complication rates. This technique is favored due to a higher total lymph node harvest and a significant reduction of incisional hernia risk as compared to transumbilical laparoscopic right colectomy.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 6","pages":"12608-12614"},"PeriodicalIF":9.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Target primacy, inference robustness, and translational causality in ferroptosis-based immunotherapy combinations.","authors":"Man Sun, Jing-Mian Jiao, Jun Chen","doi":"10.1097/JS9.0000000000005114","DOIUrl":"10.1097/JS9.0000000000005114","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13283-13284"},"PeriodicalIF":9.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering strategies for cartilage endplate reconstruction: a tissue engineering perspective.","authors":"Yifan Wang, Chuyue Zhang, Zheng Wang","doi":"10.1097/JS9.0000000000005125","DOIUrl":"10.1097/JS9.0000000000005125","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13295-13296"},"PeriodicalIF":9.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor about 'Effect of remimazolam on postoperative delirium in elderly patients undergoing major abdominal surgery: a randomized controlled Trial'.","authors":"Zhihe Zeng, Yuxia Jiao, Yao Yu, Feng Zhou","doi":"10.1097/JS9.0000000000005121","DOIUrl":"10.1097/JS9.0000000000005121","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13275-13276"},"PeriodicalIF":9.0,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}