International journal of surgery最新文献

{"title":"Global landscape of clinical trials for endometriosis: dynamic trends and future directions.","authors":"Sijie He, Houhong Li, Li Wan, Xianya Qin","doi":"10.1097/JS9.0000000000002854","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002854","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: A commentary on \"Clinical efficacy and chemoresistance analysis of precision neoadjuvant chemotherapy for borderline resectable pancreatic cancer: a prospective, single-arm pilot study\".","authors":"Qinglong Wang, Gang Qin","doi":"10.1097/JS9.0000000000002859","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002859","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"The influence of familiarity between the surgeon and their assistant on patient outcomes: a prospective observational cohort study\".","authors":"Xiaoping Sheng, Hongsheng Zhan, Zhengyan Li, Guoqing Du","doi":"10.1097/JS9.0000000000002849","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002849","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: A commentary on \"Application of radiomics for preoperative prediction of lymph node metastasis in colorectal cancer: a systematic review and meta-analysis\".","authors":"Yue Deng","doi":"10.1097/JS9.0000000000002865","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002865","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: A commentary on \"Breast neurotization along with breast reconstruction after nipple sparing mastectomy enhances quality of life and reduces denervation symptoms in patient reported outcome: a prospective cohort study\".","authors":"Liao Li, Xiangfu Sun, Fan Wang","doi":"10.1097/JS9.0000000000002801","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002801","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-route levofloxacin delivery following revision surgery: a synergistic intravenous/intra-articular strategy for enhanced bactericidal effect against prosthetic pseudomonas aeruginosa infections.","authors":"Mengqiu Lie, Tao Zhang, Dehua Wang, Yan Liy, Xinyu Li","doi":"10.1097/JS9.0000000000002712","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002712","url":null,"abstract":"<p><strong>Purpose: </strong>Pseudomonas aeruginosa (PA)-associated periprosthetic joint infection (PJI) is notoriously difficult to treat due to biofilm formation and poor antibiotic penetration into joint tissues. This study investigates the efficacy of combined intravenous (IV) and intra-articular (IA) levofloxacin administration in targeting PA biofilms in PJI.</p><p><strong>Methods: </strong>A retrospective cohort of nine knee PJI patients received daily IV (500 mg) and IA (100 mg) levofloxacin post-revision surgery. Patients were followed for ≥2 years for their long-term clinical outcomes, with synovial and serum levofloxacin concentrations analyzed to assess minimum biofilm eradication concentration (MBEC) attainment. Physiologically based pharmacokinetic (PBPK) modeling simulated levofloxacin distribution in plasma, synovial fluid, and synovium. In vitro studies quantified biofilm biomass and metabolic activity reduction, while scanning electron microscopy (SEM) evaluated biofilm disruption on 3D-printed knee implants.</p><p><strong>Results: </strong>Over two years, no patients required reoperation, experienced mortality, or needed ongoing antibiotic suppression. Daily living activities and Knee Society Scores improved, with no major adverse events. On postoperative day 7, synovial levofloxacin concentrations reached 110.20 ± 39.20 mg/L, exceeding the MBEC for 80% of PA isolates. Serum levofloxacin concentrations were measured at 1.76 ± 0.37 mg/L, showing only a marginal increase compared to the levels specified in FDA-approved labeling. In vitro, levofloxacin reduced biofilm biomass to 28.65 ± 5.12% and metabolic activity to 39.66 ± 4.28% of baseline. SEM confirmed reduced bacterial cell counts and disrupted biofilm structure on 3D printed implants. PBPK modeling demonstrated elevated levofloxacin concentrations in synovial fluid and synovium, with minimal systemic exposure.</p><p><strong>Conclusions: </strong>Combined IV and IA levofloxacin effectively targets PA biofilms in PJI without significant safety concerns, offering a promising therapeutic strategy for PA-induced PJI.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor:\"an updated systematic review, meta-analysis, and trial sequential analysis of the efffcacy and safety of en bloc transurethral resection vs. conventional transurethral resection for nonmuscle-invasive bladder tumor\".","authors":"Chao Wu, Yanfei Yang, Zongyao LiuMD, Xiaoxi Wang","doi":"10.1097/JS9.0000000000002756","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002756","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of SPHK1 as a prognostic marker and therapeutic target in colorectal cancer: insights from bioinformatics and experimental analysis.","authors":"Yandong Miao, Jian Gan, Yan-Jing Ni, Zhao-Nan Zhang, Ling-Xia Yu, Wu-Xia Quan, Zheng-Chao Zhang, Hui-Min Wang, Shuang Han, Fan-Yong Qu, Qian-Qian Lu, Rui Ma, Jiang-Tao Wang, Wen-Yu Luan, Si-Xiang Lin, Deng-Hai Mi, Wen-Hua Huang","doi":"10.1097/JS9.0000000000002506","DOIUrl":"10.1097/JS9.0000000000002506","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) remains a major cause of cancer-related mortality globally, primarily due to its aggressive progression and poor prognosis in many patients. Despite treatment advances, new therapeutic targets are critically needed to enhance patient outcomes. Although sphingosine kinase 1 (SPHK1) has been linked to various cancers, its role in CRC progression, prognosis, and as a therapeutic target is not well understood.</p><p><strong>Objective: </strong>This study aimed to investigate the role and molecular mechanisms through which SPHK1 contributes to CRC progression, with a focus on its potential as a prognostic marker and therapeutic target by bioinformatics and experimental analysis.</p><p><strong>Methods: </strong>Multi-omics analysis was conducted using data from TCGA, GEPIA2, and other publicly available databases, as well as single-cell RNA sequencing data, to assess SPHK1 expression and its correlation with immune infiltration in CRC tissues. A Mendelian Randomization (MR) approach was employed to investigate the causal relationship between sphingomyelin levels and CRC risk. Multiplex Fluorescence Immunohistochemistry was used to analyze the expression levels of SPHK1, E-cadherin, and Vimentin in 90 CRC and corresponding normal tissues. Migration, invasion, and apoptosis assays were performed in CRC cell lines to examine the functional impact of SPHK1 modulation.</p><p><strong>Results: </strong>SPHK1 expression was significantly elevated in CRC tissues and correlated with poor prognosis. MR analysis confirmed a causal relationship between sphingomyelin levels and increased CRC risk. SPHK1 gene expression was significantly positively related to methylation levels at sites cg11001059 and cg26442874 and significantly negatively associated with methylation levels at cg02028751. SPHK1 expression was associated with immune cell infiltration and sphingolipid metabolism pathways. SPHK1 was found to modulate the expression of E-cadherin, promoting CRC cell migration and invasion, while inhibiting apoptosis.</p><p><strong>Conclusion: </strong>SPHK1 plays a key role in facilitating the epithelial-to-mesenchymal transition of CRC cells, enhancing their migratory and invasive abilities, and influencing the tumor microenvironment. The findings suggest that SPHK1 could be a potential biomarker and therapeutic target for CRC, with implications for the development of targeted therapies to improve patient outcomes.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of endoscopic versus microscopic transsphenoidal surgery in patients with pituitary adenomas: a propensity score matched study.","authors":"Chengkai Zhang, Shunchang Ma, Dan Xiao, Luwen Zhang, Songbai Gui, Pinan Liu, Jingyao Geng, Huizhen Yang, Xuyang Zhao, Chuanbao Zhang, Xiudong Guan, Dainan Zhang, Liwei Zhang, Deling Li, Wang Jia","doi":"10.1097/JS9.0000000000002889","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002889","url":null,"abstract":"<p><strong>Background: </strong>The comparative efficacy of endoscopic versus microscopic transsphenoidal surgery for patients with pituitary adenoma (PA) remains controversial. Previous retrospective studies have often been limited by inconsistencies in baseline characteristics of patients, which may affect the validity of the comparisons. This study aimed to evaluate the trend in the proportion of transsphenoidal endoscopic and microscopic surgeries in China and compare outcomes in comparable patients.</p><p><strong>Materials and methods: </strong>The National Brain Tumor Registry of China (NBTRC) database was queried to extract PA patients (2011-2021) for trend analysis. Stratified sampling was performed, and a 1:1 propensity score matching (PSM) was used to balance the patients' baseline characteristics. Postoperative outcomes, complications, and prognosis were compared.</p><p><strong>Results: </strong>Among the nationwide 17 012 PA patients, there was a gradual increase in the proportion of endoscopic surgeries (annual percent change, 11.89%). Among the 1863 stratified patients, those who underwent endoscopic surgery had a higher preoperative recurrence rate and higher Knosp and Hardy grades (P < 0.05). Endoscopic surgery showed a similar gross total resection (GTR) rate to microscopy (55.6% vs. 54.9%, P = 0.886) in the real-world cohort and a higher GTR rate (59.5% vs. 54.3%, P = 0.037) in the PSM cohort. After PSM, there was no significant difference in cerebrospinal fluid leak and secondary surgery (P > 0.05); endoscopic surgery showed more bleeding, longer surgical time, shorter hospital stay, and higher costs (all P < 0.001) compared to microscopic surgery. The risk of postoperative progression was similar between endoscopic and microscopic surgeries for comparable PA patients (P = 0.45).</p><p><strong>Conclusion: </strong>Endoscopic transsphenoidal surgery is increasingly adopted in China, demonstrating a higher GTR rate than microscopic transsphenoidal surgery in PA patients with similar characteristics, without increasing severe complication rates. The risk of postoperative progression was similar between the two techniques.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A national road map for improving children surgical care: an Experience From Tanzania.","authors":"Godfrey Sama Philipo, Zaitun M Bokhary, Kokila Lakhoo","doi":"10.1097/JS9.0000000000002629","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002629","url":null,"abstract":"<p><strong>Purpose: </strong>Nearly 1.75 billion children lack access to basic surgical care. The majority are in low and middle income countries (LMICs) where 50% of the population are children. Our aim was to develop a policy level action-orientated and implementable strategies to improve children surgery in Tanzania.</p><p><strong>Methods: </strong>A bottom-up Participatory Approach was used for needs assessment and priority setting. This started 2-years after the launch of Tanzania National Surgical, Obstetrics and Anesthesia Plans. Steps taken were: i) stakeholder identification and engagement ii) desk review of existing research, iii) focused research on access to children surgery, iv) site visits and geographical mapping of the reach of selected hospitals and v) presentation to the ministry of health for validation. Findings were summarized in line with the NSOAP's building blocks.</p><p><strong>Results: </strong>A bottom-up approach was feasible in identifying children surgical care challenges of policy priority. We noted that regional hospitals are the main provider of children surgery but majority lacked the necessary resources and were beyond recommended 2-hours reach. A Super Hub-Hub-Spoke model is a feasible model to pragmatically address patient, provider, facility and national challenges at all levels of healthcare system.</p><p><strong>Conclusion: </strong>Our findings propose a road-map to practically achieve access to children surgery, complementing existing NSOAPs. It highlights feasibility of the approach in developing context relevant interventions that could guide integration of surgery in existing national plans. Developing a functional surgical system in LMICs should be pragmatic to improve overall quality of children surgical care despite limited resources.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}