International psychogeriatrics最新文献

{"title":"Global crisis and mental health and well-being of older adults.","authors":"Helen Lavretsky, Anne Margriet Pot","doi":"10.1017/S1041610223000960","DOIUrl":"10.1017/S1041610223000960","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1007-1008"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growing trends in conceptualizing geriatric mental health within a neural context.","authors":"Nathan Hantke, Shanna Cooper","doi":"10.1017/S1041610224000413","DOIUrl":"10.1017/S1041610224000413","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"991-994"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of older age on outcomes of rTMS treatment for treatment-resistant depression.","authors":"Michael K Leuchter, Cole Citrenbaum, Andrew C Wilson, Tristan D Tibbe, Nicholas J Jackson, David E Krantz, Scott A Wilke, Juliana Corlier, Thomas B Strouse, Gil D Hoftman, Reza Tadayonnejad, Ralph J Koek, Aaron R Slan, Nathaniel D Ginder, Margaret G Distler, Hewa Artin, John H Lee, Adesewa E Adelekun, Evan H Einstein, Hanadi A Oughli, Andrew F Leuchter","doi":"10.1017/S1041610224000462","DOIUrl":"10.1017/S1041610224000462","url":null,"abstract":"<p><p>Clinical outcomes of repetitive transcranial magnetic stimulation (rTMS) for treatment of treatment-resistant depression (TRD) vary widely and there is no mood rating scale that is standard for assessing rTMS outcome. It remains unclear whether TMS is as efficacious in older adults with late-life depression (LLD) compared to younger adults with major depressive disorder (MDD). This study examined the effect of age on outcomes of rTMS treatment of adults with TRD. Self-report and observer mood ratings were measured weekly in 687 subjects ages 16-100 years undergoing rTMS treatment using the Inventory of Depressive Symptomatology 30-item Self-Report (IDS-SR), Patient Health Questionnaire 9-item (PHQ), Profile of Mood States 30-item, and Hamilton Depression Rating Scale 17-item (HDRS). All rating scales detected significant improvement with treatment; response and remission rates varied by scale but not by age (response/remission ≥ 60: 38%-57%/25%-33%; <60: 32%-49%/18%-25%). Proportional hazards models showed early improvement predicted later improvement across ages, though early improvements in PHQ and HDRS were more predictive of remission in those < 60 years (relative to those ≥ 60) and greater baseline IDS burden was more predictive of non-remission in those ≥ 60 years (relative to those < 60). These results indicate there is no significant effect of age on treatment outcomes in rTMS for TRD, though rating instruments may differ in assessment of symptom burden between younger and older adults during treatment.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1070-1075"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11422516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the first COVID-19 lockdown on presentations with depressive symptoms in older people - an electronic health records study.","authors":"Latha Velayudhan, Wai Yan Cheung, Gayan Perera, Robert Stewart, Christoph Mueller","doi":"10.1017/S104161022200062X","DOIUrl":"10.1017/S104161022200062X","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1076-1078"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10213286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression.","authors":"D C Steffens, M E Garrett, K L Soldano, D R McQuoid, A E Ashley-Koch, G G Potter","doi":"10.1017/S1041610220001143","DOIUrl":"10.1017/S1041610220001143","url":null,"abstract":"<p><strong>Objective: </strong>This study sought to conduct a comprehensive search for genetic risk of cognitive decline in the context of geriatric depression.</p><p><strong>Design: </strong>A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elderly (NCODE) study.</p><p><strong>Setting: </strong>Longitudinal, naturalistic follow-up study.</p><p><strong>Participants: </strong>Older depressed adults, both outpatients and inpatients, receiving care at an academic medical center.</p><p><strong>Measurements: </strong>The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery was administered to the study participants at baseline and a minimum of twice within a subsequent 3-year period in order to measure cognitive decline. A GWAS analysis was conducted to identify genetic variation that is associated with baseline and change in the CERAD Total Score (CERAD-TS) in NCODE.</p><p><strong>Results: </strong>The GWAS of baseline CERAD-TS revealed a significant association with an intergenic single-nucleotide polymorphism (SNP) on chromosome 6, rs17662598, that surpassed adjustment for multiple testing (<i>p</i> = 3.7 × 10^-7; false discovery rate <i>q</i> = 0.0371). For each additional G allele, average baseline CERAD-TS decreased by 8.656 points. The most significant SNP that lies within a gene was rs11666579 in <i>SLC27A1</i> (<i>p</i> = 1.1 × 10^-5). Each additional copy of the G allele was associated with an average decrease of baseline CERAD-TS of 4.829 points. <i>SLC27A1</i> is involved with processing docosahexaenoic acid (DHA), an endogenous neuroprotective compound in the brain. Decreased levels of DHA have been associated with the development of Alzheimer's disease. The most significant SNP associated with CERAD-TS decline over time was rs73240021 in <i>GRXCR1</i> (<i>p</i> = 1.1 × 10^-6), a gene previously linked with deafness. However, none of the associations within genes survived adjustment for multiple testing.</p><p><strong>Conclusions: </strong>Our GWAS of cognitive function and decline among individuals with late-life depression (LLD) has identified promising candidate genes that, upon replication in other cohorts of LLD, may be potential biomarkers for cognitive decline and suggests DHA supplementation as a possible therapy of interest.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1021-1029"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794099/pdf/nihms-1601798.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38139095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression.","authors":"D C Steffens, M E Garrett, K L Soldano, D R McQuoid, A E Ashley-Koch, G G Potter","doi":"10.1017/S1041610220001143","DOIUrl":"https://doi.org/10.1017/S1041610220001143","url":null,"abstract":"<p><strong>Objective: </strong>This study sought to conduct a comprehensive search for genetic risk of cognitive decline in the context of geriatric depression.</p><p><strong>Design: </strong>A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elderly (NCODE) study.</p><p><strong>Setting: </strong>Longitudinal, naturalistic follow-up study.</p><p><strong>Participants: </strong>Older depressed adults, both outpatients and inpatients, receiving care at an academic medical center.</p><p><strong>Measurements: </strong>The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery was administered to the study participants at baseline and a minimum of twice within a subsequent 3-year period in order to measure cognitive decline. A GWAS analysis was conducted to identify genetic variation that is associated with baseline and change in the CERAD Total Score (CERAD-TS) in NCODE.</p><p><strong>Results: </strong>The GWAS of baseline CERAD-TS revealed a significant association with an intergenic single-nucleotide polymorphism (SNP) on chromosome 6, rs17662598, that surpassed adjustment for multiple testing (p = 3.7 × 10^-7; false discovery rate q = 0.0371). For each additional G allele, average baseline CERAD-TS decreased by 8.656 points. The most significant SNP that lies within a gene was rs11666579 in SLC27A1 (p = 1.1 × 10^-5). Each additional copy of the G allele was associated with an average decrease of baseline CERAD-TS of 4.829 points. SLC27A1 is involved with processing docosahexaenoic acid (DHA), an endogenous neuroprotective compound in the brain. Decreased levels of DHA have been associated with the development of Alzheimer's disease. The most significant SNP associated with CERAD-TS decline over time was rs73240021 in GRXCR1 (p = 1.1 × 10^-6), a gene previously linked with deafness. However, none of the associations within genes survived adjustment for multiple testing.</p><p><strong>Conclusions: </strong>Our GWAS of cognitive function and decline among individuals with late-life depression (LLD) has identified promising candidate genes that, upon replication in other cohorts of LLD, may be potential biomarkers for cognitive decline and suggests DHA supplementation as a possible therapy of interest.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"36 11","pages":"1021-1029"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grey matter volume predicts improvement in geriatric depression in response to Tai Chi compared to Health Education.","authors":"Beatrix Krause-Sorio, Prabha Siddarth, Michaela M Milillo, Lisa Kilpatrick, Linda Ercoli, Katherine L Narr, Helen Lavretsky","doi":"10.1017/S1041610223004386","DOIUrl":"https://doi.org/10.1017/S1041610223004386","url":null,"abstract":"<p><strong>Objectives: </strong>Geriatric depression (GD) is associated with cognitive impairment and brain atrophy. Tai-Chi-Chih (TCC) is a promising adjunct treatment to antidepressants. We previously found beneficial effects of TCC on resting state connectivity in GD. We now tested the effect of TCC on gray matter volume (GMV) change and the association between baseline GMV and clinical outcome.</p><p><strong>Participants: </strong>Forty-nine participants with GD (>=60 y) underwent antidepressant treatment (38 women).</p><p><strong>Intervention: </strong>Participants completed 3 months of TCC (N = 26) or health and wellness education control (HEW; N = 23).</p><p><strong>Measurements: </strong>Depression and anxiety symptoms and MRI scans were acquired at baseline and 3-month follow-up. General linear models (GLMs) tested group-by-time interactions on clinical scores. Freesurfer 6.0 was used to process T1-weighted images and to perform voxel-wise whole-brain GLMs of group on symmetrized percent GMV change, and on the baseline GMV and symptom change association, controlling for baseline symptom severity. Age and sex served as covariates in all models.</p><p><strong>Results: </strong>There were no group differences in baseline demographics or clinical scores, symptom change from baseline to follow-up, or treatment-related GMV change. However, whole-brain analysis revealed that lower baseline GMV in several clusters in the TCC, but not the HEW group, was associated with larger improvements in anxiety. This was similar for right precuneus GMV and depressive symptoms.</p><p><strong>Conclusions: </strong>While we observed no effect on GMV due to the interventions, baseline regional GMV predicted symptom improvements with TCC but not HEW. Longer trials are needed to investigate the long-term effects of TCC on clinical symptoms and neuroplasticity.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"36 11","pages":"1030-1038"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growing trends in conceptualizing geriatric mental health within a neural context.","authors":"Nathan Hantke, Shanna Cooper","doi":"10.1017/S1041610224000413","DOIUrl":"https://doi.org/10.1017/S1041610224000413","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"36 11","pages":"991-994"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global crisis and mental health and well-being of older adults.","authors":"Helen Lavretsky, Anne Margriet Pot","doi":"10.1017/S1041610223000960","DOIUrl":"https://doi.org/10.1017/S1041610223000960","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"36 11","pages":"1007-1008"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of older age on outcomes of rTMS treatment for treatment-resistant depression.","authors":"Michael K Leuchter, Cole Citrenbaum, Andrew C Wilson, Tristan D Tibbe, Nicholas J Jackson, David E Krantz, Scott A Wilke, Juliana Corlier, Thomas B Strouse, Gil D Hoftman, Reza Tadayonnejad, Ralph J Koek, Aaron R Slan, Nathaniel D Ginder, Margaret G Distler, Hewa Artin, John H Lee, Adesewa E Adelekun, Evan H Einstein, Hanadi A Oughli, Andrew F Leuchter","doi":"10.1017/S1041610224000462","DOIUrl":"https://doi.org/10.1017/S1041610224000462","url":null,"abstract":"<p><p>Clinical outcomes of repetitive transcranial magnetic stimulation (rTMS) for treatment of treatment-resistant depression (TRD) vary widely and there is no mood rating scale that is standard for assessing rTMS outcome. It remains unclear whether TMS is as efficacious in older adults with late-life depression (LLD) compared to younger adults with major depressive disorder (MDD). This study examined the effect of age on outcomes of rTMS treatment of adults with TRD. Self-report and observer mood ratings were measured weekly in 687 subjects ages 16-100 years undergoing rTMS treatment using the Inventory of Depressive Symptomatology 30-item Self-Report (IDS-SR), Patient Health Questionnaire 9-item (PHQ), Profile of Mood States 30-item, and Hamilton Depression Rating Scale 17-item (HDRS). All rating scales detected significant improvement with treatment; response and remission rates varied by scale but not by age (response/remission ≥ 60: 38%-57%/25%-33%; <60: 32%-49%/18%-25%). Proportional hazards models showed early improvement predicted later improvement across ages, though early improvements in PHQ and HDRS were more predictive of remission in those < 60 years (relative to those ≥ 60) and greater baseline IDS burden was more predictive of non-remission in those ≥ 60 years (relative to those < 60). These results indicate there is no significant effect of age on treatment outcomes in rTMS for TRD, though rating instruments may differ in assessment of symptom burden between younger and older adults during treatment.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"36 11","pages":"1070-1075"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}