International psychogeriatrics最新文献

{"title":"Walking The Talk for Dementia: A model for genuine patient involvement and advocacy.","authors":"Lynne Hagan, Charlotte L Deasy","doi":"10.1016/j.inpsyc.2026.100245","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2026.100245","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100245"},"PeriodicalIF":6.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' response to the letter.","authors":"Yuto Satake, Minna Nygren, Clare Yu, Kunihiko Katsuki, Ippei Endo, Akira Tsuboi, Daiki Ishimaru, Kazuhiro Umemura, Penny Rapaport, Nadia Bianchi-Berthouze, Manabu Ikeda, Robert Howard","doi":"10.1016/j.inpsyc.2026.100252","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2026.100252","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100252"},"PeriodicalIF":6.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of ADL and IADL independence across MMSE score ranges in Alzheimer's disease, dementia with Lewy bodies, and frontotemporal dementia: A cross-sectional analysis of a memory-clinic cohort.","authors":"Maki Hotta, Takayuki Tabira, Miki Murata, Kazuhiro Yoshiura, Tomohisa Ishikawa, Hibiki Tanaka, Yuma Nagata, Mamoru Hashimoto, Manabu Ikeda","doi":"10.1016/j.inpsyc.2026.100250","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2026.100250","url":null,"abstract":"<p><strong>Background: </strong>Domain-level ADL and IADL independence across MMSE score ranges has been less well described in Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). This study described the observed proportions of basic ADL and IADL independence across MMSE score ranges in these three neurodegenerative dementias.</p><p><strong>Methods: </strong>In a cohort of 650 patients (524 AD, 90 DLB, 36 FTD), cognitive function was assessed with the Mini-Mental State Examination (MMSE), and daily function was evaluated using the Physical Self-Maintenance Scale and the Lawton IADL scale. Patients were grouped into MMSE score ranges. For each diagnosis and MMSE score range, we calculated the observed proportion of participants rated as independent in each ADL/IADL domain and Wilson score 95% confidence intervals. Because the FTD sample was small (n = 36), with only 1-11 participants in individual five-point MMSE score ranges, and several MMSE-specific subgroup counts were sparse, the analyses were descriptive.</p><p><strong>Results: </strong>Observed independence proportions varied across ADL/IADL domains, MMSE score ranges, and diagnostic groups. In AD and DLB, shopping, food preparation, and medication management had low observed independence proportions even in higher MMSE ranges. In the MMSE 21-30 stratum, selected absolute numerical contrasts between DLB and AD ranged from 7.2 percentage points for feeding to 18.4 percentage points for bathing. Estimates for FTD, which were based on only 1-11 participants per five-point MMSE score range, and for DLB in the MMSE 0-10 stratum were based on small denominators and were therefore imprecise.</p><p><strong>Conclusions: </strong>This study provides descriptive estimates of domain-level ADL and IADL independence across MMSE score strata in AD, DLB, and FTD. The results may contribute to domain-specific assessment and support planning for people living at home with MCI or dementia. These findings should be regarded as hypothesis-generating for future studies.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100250"},"PeriodicalIF":6.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional heterogeneity across structural MRI-based atrophy subtypes in Alzheimer's disease.","authors":"Dong Xu, Huanhuan Zhang, Zhiyan Piao, Yong He, Haiyan Li, Nan Zhang","doi":"10.1016/j.inpsyc.2026.100255","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2026.100255","url":null,"abstract":"<p><strong>Objectives: </strong>This study explored whether distinct Alzheimer's disease (AD) structural atrophy subtypes exhibit divergent functional profiles.</p><p><strong>Design: </strong>A cross-sectional multimodal neuroimaging and electrophysiological study.</p><p><strong>Setting: </strong>Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.</p><p><strong>Participants: </strong>A total of 116 patients with AD and 74 cognitively unimpaired controls underwent structural MRI. Patients with AD were stratified into three MRI-derived atrophy-pattern groups corresponding to hippocampal-sparing (HpSp-MRI), typical (tAD-MRI), and limbic-predominant (LP-MRI) subtypes.</p><p><strong>Measurements: </strong>Resting-state functional MRI was used to assess intra- and internetwork functional connectivity, and EEG was used to evaluate spectral power and microstate dynamics.</p><p><strong>Results: </strong>The HpSp-MRI subtype showed lower intranetwork connectivity than both the LP-MRI and tAD-MRI subtypes in the visual, somatomotor, and dorsal attention networks. The LP-MRI and tAD-MRI subtypes differed in ventral attention network connectivity. Moreover, the LP-MRI subtype exhibited stronger internetwork connectivity in specific network pairs compared with the other subtypes. EEG analysis suggested a possible difference in the microstate 3-to-1 transition between the LP-MRI and tAD-MRI groups.</p><p><strong>Conclusions: </strong>MRI-derived atrophy-pattern subtypes showed different resting-state functional connectivity profiles, providing a potential basis for personalized brain network-targeted interventions in AD.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100255"},"PeriodicalIF":6.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal order of clinical symptoms in Alzheimer's disease.","authors":"Mingqing Wei, Junlei Zhang, Jing Shi, Ting Li, Lulu Yao, Fuyao Li, Wei Xiao, Jingnian Ni, Jinzhou Tian","doi":"10.1016/j.inpsyc.2026.100253","DOIUrl":"https://doi.org/10.1016/j.inpsyc.2026.100253","url":null,"abstract":"<p><strong>Background: </strong>Understanding the temporal order of clinical symptoms is critical for improving disease progression assessment in biomarker-defined Alzheimer's disease (AD). However, the sequential emergence of cognitive, neuropsychiatric, and functional manifestations remains incompletely characterized. The purpose of this study is to characterize the population-level sequence in which Alzheimer's disease symptoms appear, to help understand how the disease is progressing.</p><p><strong>Methods: </strong>We analyzed 932 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI), including 546 amyloid-positive individuals across the AD continuum and 386 amyloid-negative individuals in the comparison group. Longitudinal cumulative incidence was analyzed to estimate the temporal emergence of major clinical symptoms. Any symptom onset was defined using a > 50% cumulative incidence threshold. Cross-sectional relationships between the sequence of clinical symptoms and Mini-Mental State Examination (MMSE) scores were analyzed using locally estimated scatterplot smoothing (LOESS). The concordance between the clinical symptom sequence and PET-derived Braak staging was assessed using weighted kappa statistics.</p><p><strong>Results: </strong>A reproducible temporal ordering of clinical symptoms was observed across longitudinal and cross-sectional analyses. Memory impairment emerged earliest, affecting 63.75% of participants at baseline, followed by behavioral and affective symptoms. At intermediate stages, executive dysfunction and instrumental activities of daily living (IADL) impairment affected 52.44% and 54.85% of participants, respectively. Language and visuospatial impairments appeared later, affecting 51.25% and 51.54% of participants, respectively, followed by psychotic symptoms and severe functional decline in basic activities of daily living (BADL), which suggests the disease has reached its late stage. The order in which different symptom groups appear-from memory to executive function and instrumental abilities, then language and visuospatial skills, and finally psychotic symptoms and basic abilities-shows moderate consistency respectively with CDR staging (κ = 0.596, 95%CI: 0.524-0.668), and the PET-derived Braak staging (κ = 0.517, 95%CI: 0.436-0.598).</p><p><strong>Conclusion: </strong>Clinical symptoms in AD tend to emerge in a temporal sequence. This finding may help to better characterize disease progression clinically, serving as a symptom-staging framework for symptomatic AD and providing interpretable turning points for clinical assessment and individualized management.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100253"},"PeriodicalIF":6.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148678702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse childhood experiences contribute to increased risk of health in middle and late life: The longitudinal mediating effect of activities of daily living and chronic diseases.","authors":"Yijun Liu, Zhe Zhao, Shiyin Tian, Shaojie Yu, Juanfang Zhu, Yuanyuan Yang, Qinqin Jiang, Jinhai Sun, Shengjun Wang, Lei Yuan","doi":"10.1016/j.inpsyc.2025.100117","DOIUrl":"10.1016/j.inpsyc.2025.100117","url":null,"abstract":"<p><strong>Background: </strong>Adverse Childhood Experiences (ACEs) have long-term effects on health, but the mechanisms remain unclear.</p><p><strong>Objective: </strong>To investigate the association between ACEs and health status, exploring the potential mediating roles of activities of daily living (ADL) and chronic diseases.</p><p><strong>Participants and setting: </strong>9575 middle-aged and older adults from the China Health and Retirement Longitudinal Study (CHARLS).</p><p><strong>Methods: </strong>Longitudinal analysis of 4 waves (2013-2018) data. ACEs were derived from 2014 self-report life history survey. Latent growth curve modeling assessed the mediating effect of ADL and chronic diseases on the relationship between ACEs and self-rated health (SRH).</p><p><strong>Results: </strong>Among the 9575 individuals (mean [standard deviation, SD] age, 58.12 [8.73] years; 5174 [54.04 %] were females), the average ACEs score was 2.27 (SD = 1.75). Individuals with higher ACEs reported lower baseline SRH (β = -0.156, P < .001) and greater decline over time (β = -0.075, P < .001). Mediation analysis indicated that both baseline and longitudinal changes in ADL and chronic diseases (intercept and slope) partially mediated the association between ACE and the intercept of SRH, while ADL (intercept and slope) and chronic diseases (slope) fully mediated the association between ACE and the slope of SRH.</p><p><strong>Conclusions: </strong>ACEs were associated with poorer health status and accelerated decline, partially mediated by impaired ADL and increased chronic diseases. Interventions targeting ACE reduction, enhancing ADL, and managing chronic diseases could effectively improve the health of middle-aged and older adults.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100117"},"PeriodicalIF":6.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why ethical research on aging in the context of climate change must address social susceptibilities and assets.","authors":"Liat Ayalon, Deborah Carr, Karl Pillemer, Matthew Prina, Noah Webster, Paola Zaninotto","doi":"10.1016/j.inpsyc.2025.100153","DOIUrl":"10.1016/j.inpsyc.2025.100153","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100153"},"PeriodicalIF":6.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic status, healthy lifestyle, and the risk of frailty: Evidence from two prospective cohort studies.","authors":"Ran Yan, Yawen Yin, Yizhen Hu, Juxiang Yang, Hongchu Wang, Yi Wang, Gang Song","doi":"10.1016/j.inpsyc.2025.100177","DOIUrl":"10.1016/j.inpsyc.2025.100177","url":null,"abstract":"<p><strong>Background: </strong>The intricate interplay between socioeconomic status (SES) and healthy lifestyle behaviors in the development of frailty remains incompletely understood.</p><p><strong>Methods: </strong>Using data from two nationally representative cohort studies: the Health and Retirement Study (HRS, 2008-2020; n = 23,183) and the English Longitudinal Study of Ageing (ELSA, 2004-2018; n = 11,182). SES was derived using latent class analysis (LCA) incorporating education level, total household income and wealth. A composite healthy lifestyle score included four factors: never smoking, low to moderate alcohol consumption, top tertile of physical activity, and active social contact.</p><p><strong>Results: </strong>Participants with low SES had significantly increased risks of developing frailty compared to those with high SES (HRS: HR: 2.03; 95 % CI, 1.86-2.21; ELSA: HR: 4.58; 95 % CI, 3.84-5.45). The mediating effect of a lifestyle on the SES-frailty association accounted for 5.3 % (95 % CI, 1.9-8.8) in HRS and -2.3 % (95 % CI, -3.3 to -1.3) in ELSA. Compared to individuals with both high SES and a favorable lifestyle, those with low SES and an unfavorable lifestyle exhibited a markedly elevated risk of frailty (HRS: HR: 3.70; 95 % CI, 3.20-4.27; ELSA: HR: 6.18; 95 % CI, 3.61-10.56), and persistently higher frailty index scores.</p><p><strong>Conclusions: </strong>Among older adults in the U.S. and U.K., favorable lifestyle behaviors modestly attenuated-but did not eliminate-the impact of socioeconomic disadvantage on frailty risk. Structural interventions targeting social determinants are warranted to reduce disparities in late-life health.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100177"},"PeriodicalIF":6.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147432774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Bridging generations\": A scoping review of non-familial intergenerational programs and their impact on relationships between old and young.","authors":"Danhao Liu, Brigitte Fong Yeong Woo, Nan Wu, Vivien Xi Wu, Cyrus Su Hui Ho, Wilson Wai San Tam","doi":"10.1016/j.inpsyc.2025.100180","DOIUrl":"10.1016/j.inpsyc.2025.100180","url":null,"abstract":"<p><strong>Background: </strong>As populations age and families become more dispersed, opportunities for meaningful intergenerational contact are diminishing. Intergenerational programmes (IGPs) aim to bridge this divide by bringing younger and older people together through structured activities. While health and social outcomes have been examined in the literature, the impacts of IGPs on the quality of intergenerational relationships remains less clearly understood.</p><p><strong>Objectives: </strong>This scoping review aimed to map existing evidence on non-familial IGPs designed to improve intergenerational relationships and to evaluate their impacts on relationship outcomes between younger and older participants.</p><p><strong>Methods: </strong>A comprehensive search of eight electronic databases and reference lists was conducted up to 2024. Studies were eligible if they had (1) included programmes based on structured interactions between younger and older participants and (2) reported at least one relationship-focused outcome (e.g., attitudes, perceptions, or communication). Two reviewers independently screened and charted data. Given heterogeneity in study designs and outcomes, a narrative synthesis was conducted.</p><p><strong>Results: </strong>Of the 18,480 retrieved records, 69 studies were included. Seven types of IGPs were identified, though fewer than half explicitly reported theoretical underpinnings for their programme design. Most interventions were delivered in community or educational settings and used structured, small-group formats that facilitated emotional exchange and mutual learning. Reported outcomes included more positive intergenerational attitudes and improved perceptions of relationship quality.</p><p><strong>Conclusions: </strong>IGPs demonstrate a promising potential in strengthening intergenerational relationships, particularly through a structured, small-group approach. Future research should incorporate theory-informed designs, apply standardised measures of relationship quality, and report implementation processes. Embedding IGPs into routine services and evaluating long-term outcomes are essential for sustainability and scalability.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100180"},"PeriodicalIF":6.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory and cognitive contributions to everyday functioning in later life: The role of social determinants of health over time.","authors":"Deborah A Dadson, Karlene K Ball, Olivio J Clay, Tyler R Bell","doi":"10.1016/j.inpsyc.2025.100150","DOIUrl":"10.1016/j.inpsyc.2025.100150","url":null,"abstract":"<p><strong>Objectives: </strong>A reduction in an aging individual's abilities combined with environmental changes can lead to decline in everyday function. This study examined the association between visual and cognitive abilities with everyday function and assessed whether measures of Social Determinants of Health (SDoH) moderate the associations of these predictors with activities of daily living (ADLs) and instrumental activities of daily living (IADLs).</p><p><strong>Methods: </strong>Using a generalized linear mixed model, the longitudinal associations between changes in vision, cognitive function, and everyday functioning were examined.</p><p><strong>Results: </strong>Decline in reasoning abilities was associated with more ADL limitations, and the association was stronger for older adults with decreased healthcare access and lower economic stability. Furthermore, the associations between memory and speed of processing were associated with more ADL limitations, and the associations were stronger for older adults with lower educational and occupational status. Also, better memory was associated with fewer IADL limitations, and this association was weaker for older adults with higher educational and occupational status, and social and community contexts.</p><p><strong>Conclusion: </strong>Interventions to enhance cognitive abilities and modify environmental resources are essential to alleviate IADL/ADL limitations in older age.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"100150"},"PeriodicalIF":6.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}