Michael K Leuchter, Cole Citrenbaum, Andrew C Wilson, Tristan D Tibbe, Nicholas J Jackson, David E Krantz, Scott A Wilke, Juliana Corlier, Thomas B Strouse, Gil D Hoftman, Reza Tadayonnejad, Ralph J Koek, Aaron R Slan, Nathaniel D Ginder, Margaret G Distler, Hewa Artin, John H Lee, Adesewa E Adelekun, Evan H Einstein, Hanadi A Oughli, Andrew F Leuchter
{"title":"The effect of older age on outcomes of rTMS treatment for treatment-resistant depression.","authors":"Michael K Leuchter, Cole Citrenbaum, Andrew C Wilson, Tristan D Tibbe, Nicholas J Jackson, David E Krantz, Scott A Wilke, Juliana Corlier, Thomas B Strouse, Gil D Hoftman, Reza Tadayonnejad, Ralph J Koek, Aaron R Slan, Nathaniel D Ginder, Margaret G Distler, Hewa Artin, John H Lee, Adesewa E Adelekun, Evan H Einstein, Hanadi A Oughli, Andrew F Leuchter","doi":"10.1017/S1041610224000462","DOIUrl":"https://doi.org/10.1017/S1041610224000462","url":null,"abstract":"<p><p>Clinical outcomes of repetitive transcranial magnetic stimulation (rTMS) for treatment of treatment-resistant depression (TRD) vary widely and there is no mood rating scale that is standard for assessing rTMS outcome. It remains unclear whether TMS is as efficacious in older adults with late-life depression (LLD) compared to younger adults with major depressive disorder (MDD). This study examined the effect of age on outcomes of rTMS treatment of adults with TRD. Self-report and observer mood ratings were measured weekly in 687 subjects ages 16-100 years undergoing rTMS treatment using the Inventory of Depressive Symptomatology 30-item Self-Report (IDS-SR), Patient Health Questionnaire 9-item (PHQ), Profile of Mood States 30-item, and Hamilton Depression Rating Scale 17-item (HDRS). All rating scales detected significant improvement with treatment; response and remission rates varied by scale but not by age (response/remission ≥ 60: 38%-57%/25%-33%; <60: 32%-49%/18%-25%). Proportional hazards models showed early improvement predicted later improvement across ages, though early improvements in PHQ and HDRS were more predictive of remission in those < 60 years (relative to those ≥ 60) and greater baseline IDS burden was more predictive of non-remission in those ≥ 60 years (relative to those < 60). These results indicate there is no significant effect of age on treatment outcomes in rTMS for TRD, though rating instruments may differ in assessment of symptom burden between younger and older adults during treatment.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"36 11","pages":"1070-1075"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brianna M Hoffmann, Nutta-On P Blair, Timothy L McAuliffe, Gyujoon Hwang, Eric Larson, Stacy A Claesges, Abigail Webber, Charles F Reynolds, Joseph S Goveas
{"title":"Neuropsychological correlates of early grief in bereaved older adults.","authors":"Brianna M Hoffmann, Nutta-On P Blair, Timothy L McAuliffe, Gyujoon Hwang, Eric Larson, Stacy A Claesges, Abigail Webber, Charles F Reynolds, Joseph S Goveas","doi":"10.1017/S1041610224000048","DOIUrl":"10.1017/S1041610224000048","url":null,"abstract":"<p><p>Prolonged grief disorder (PGD) is associated with impairments in cognitive functioning, but the neuropsychological correlates of early grief in older adults are poorly understood. This preliminary study cross-sectionally examined neuropsychological functioning in bereaved adults with high and low grief symptoms and a non-bereaved comparison sample and further explored the relationship between multidomain cognitive measures and grief severity. A total of ninety-three nondemented older adults (high grief: <i>n</i> = 44; low grief: <i>n</i> = 49) within 12 months post-bereavement and non-bereaved comparison participants (<i>n</i> = 43) completed neuropsychological battery including global and multiple domain-specific cognitive functioning. Linear regression models were used to analyze differences in multidomain cognitive measures between the groups and specifically examine the associations between cognitive performance and grief severity in the bereaved, after covariate adjustment, including depressive symptoms. Bereaved older adults with higher grief symptoms performed worse than those with lower symptoms and non-bereaved participants on executive functioning and attention and processing speed measures. In the bereaved, poorer executive functioning, attention and processing speed correlated with higher grief severity. Attention/processing speed-grief severity correlation was seen in those with time since loss ≤ 6 months, but not > 6 months. Intense early grief is characterised by poorer executive functioning, attention, and processing speed, resembling findings in PGD. The putative role of poorer cognitive functioning during early grief on the transition to integrated grief or the development of PGD remains to be elucidated.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"1064-1069"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Atee, Claire V Burley, Victor Adekola Ojo, Agboola Jamiu Adigun, Hayoung Lee, Daniel Jake Hoyle, Olufisayo Elugbadebo, Tomas Leon
{"title":"Physical restraint in older people: an opinion from the Early Career Network of the International Psychogeriatric Association.","authors":"Mustafa Atee, Claire V Burley, Victor Adekola Ojo, Agboola Jamiu Adigun, Hayoung Lee, Daniel Jake Hoyle, Olufisayo Elugbadebo, Tomas Leon","doi":"10.1017/S1041610223000728","DOIUrl":"10.1017/S1041610223000728","url":null,"abstract":"<p><p>The International Psychogeriatric Association (IPA) has expressed significant concerns over the use of physical restraints in older people across diverse aged care settings. Following an extensive analysis of the available literature, the IPA's Early Career Network (ECN) has formulated a collection of evidence-based recommendations aimed at guiding the use of physical restraints within various care contexts and demographic groups. Physical restraints not only infringe upon human rights but also raise significant safety concerns that adversely impact the physical, psychological, social, and functional well-being of older adults. Furthermore, their effectiveness in geriatric settings remains inadequate. Given these considerations, the IPA and its ECN firmly assert that the use of physical restraints should only be considered as a final recourse in the care of older people.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"995-1006"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41101127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Latha Velayudhan, Wai Yan Cheung, Gayan Perera, Robert Stewart, Christoph Mueller
{"title":"The impact of the first COVID-19 lockdown on presentations with depressive symptoms in older people - an electronic health records study.","authors":"Latha Velayudhan, Wai Yan Cheung, Gayan Perera, Robert Stewart, Christoph Mueller","doi":"10.1017/S104161022200062X","DOIUrl":"https://doi.org/10.1017/S104161022200062X","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"36 11","pages":"1076-1078"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martin Nikolaus Dichter, Jonas Dörner, Denise Wilfling, Almuth Berg, Thomas Klatt, Ralph Möhler, Burkhard Haastert, Gabriele Meyer, Margareta Halek, Sascha Köpke
{"title":"Intervention for sleep problems in nursing home residents with dementia: a cluster-randomized study.","authors":"Martin Nikolaus Dichter, Jonas Dörner, Denise Wilfling, Almuth Berg, Thomas Klatt, Ralph Möhler, Burkhard Haastert, Gabriele Meyer, Margareta Halek, Sascha Köpke","doi":"10.1017/S1041610223004489","DOIUrl":"https://doi.org/10.1017/S1041610223004489","url":null,"abstract":"<p><strong>Objective: </strong>To reduce sleep problems in people living with dementia using a multi-component intervention.</p><p><strong>Design: </strong>Cluster-randomized controlled study with two parallel groups and a follow-up of 16 weeks.</p><p><strong>Setting: </strong>Using external concealed randomization, 24 nursing homes (NH) were allocated either to the intervention group (IG, 12 clusters, 126 participants) or the control group (12 clusters, 116 participants).</p><p><strong>Participants: </strong>Participants were eligible if they had dementia or severe cognitive impairment, at least two sleep problems, and residence of at least two weeks in a NH.</p><p><strong>Intervention: </strong>The 16-week intervention consists of six components: (1) assessment of sleep-promoting activities and environmental factors in NHs, (2) implementation of two \"sleep nurses,\" (3) basic education, (4) advanced education for staff, (5) workshops to develop sleep-promoting concepts, and (6) written information and education materials. The control group (CG) received standard care.</p><p><strong>Measurements: </strong>Primary outcome was ≥ two sleep problems after 16 weeks assessed with the Sleep Disorders Inventory (SDI).</p><p><strong>Results: </strong>Twenty-two clusters (IG = 10, CG = 12) with 191 participants completed the study. At baseline, 90% of people living with dementia in the IG and 93% in the CG had at least two sleep problems. After 16 weeks, rates were 59.3% (IG) vs 83.8% (CG), respectively, a difference of -24.5% (95% CI, -46.3% - -2.7%; cluster-adjusted odds ratio 0.281; 95% CI 0.087-0.909). Secondary outcomes showed a significant difference only for SDI scores after eight and 16 weeks.</p><p><strong>Conclusions: </strong>The MoNoPol-Sleep intervention reduced sleep problems of people living with dementia in NH compared to standard care.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"36 10","pages":"965-978"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On prospective resilience methods and precision medicine approaches.","authors":"Theodore D Cosco, John R Best, Shawna Hopper","doi":"10.1017/S1041610223000972","DOIUrl":"10.1017/S1041610223000972","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"986-987"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138295176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Are superagers super rare?","authors":"Yuta Katsumi, Alexandra Touroutoglou","doi":"10.1017/S1041610224000024","DOIUrl":"10.1017/S1041610224000024","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"853-856"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ian C Fischer, Peter J Na, David B Feldman, Alex H Krist, Harold S Kudler, Dilip V Jeste, Robert H Pietrzak
{"title":"Well-being domains in U.S. military veterans: identifying modifiable factors to promote whole health.","authors":"Ian C Fischer, Peter J Na, David B Feldman, Alex H Krist, Harold S Kudler, Dilip V Jeste, Robert H Pietrzak","doi":"10.1017/S1041610224000589","DOIUrl":"https://doi.org/10.1017/S1041610224000589","url":null,"abstract":"<p><p>The U.S. Department of Veterans Affairs is actively transitioning away from a disease-centric model of healthcare to one that prioritizes disease prevention and the promotion of overall health and well-being. Described as Whole Health, this initiative aims to provide personalized, values-centered care that optimizes physical, behavioral, spiritual, and socioeconomic well-being. To inform this initiative, we analyzed cross-sectional data from a nationally representative sample of primarily older U.S. military veterans to estimate levels of well-being across these domains, and identify sociodemographic, military, and potentially modifiable health and psychosocial correlates of them. Results revealed that, overall, veterans reported high domain-specific well-being (average scores ranging from 6.7 to 8.3 out of 10), with the highest levels in the socioeconomic domain and lowest in the physical domain. Several modifiable factors, including purpose in life, resilience, and social support, were strongly associated with the examined well-being domains. Interventions targeting these constructs may help promote well-being among U.S. veterans.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"36 10","pages":"979-985"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predicting and promoting resilience in later life.","authors":"Lauren R Miller-Lewis","doi":"10.1017/S1041610223000820","DOIUrl":"https://doi.org/10.1017/S1041610223000820","url":null,"abstract":"","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":"36 10","pages":"849-852"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alice Powell, Ben C P Lam, David Foxe, Jacqueline C T Close, Perminder S Sachdev, Henry Brodaty
{"title":"Frequency of cognitive \"super-aging\" in three Australian samples using different diagnostic criteria.","authors":"Alice Powell, Ben C P Lam, David Foxe, Jacqueline C T Close, Perminder S Sachdev, Henry Brodaty","doi":"10.1017/S1041610223000935","DOIUrl":"10.1017/S1041610223000935","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the frequency of exceptional cognition (cognitive super-aging) in Australian older adults using different published definitions, agreement between definitions, and the relationship of super-aging status with function, brain imaging markers, and incident dementia.</p><p><strong>Design: </strong>Three longitudinal cohort studies.</p><p><strong>Setting: </strong>Participants recruited from the electoral roll, Australian Twins Registry, and community advertisements.</p><p><strong>Participants: </strong>Older adults (aged 65-106) without dementia from the Sydney Memory and Ageing Study (<i>n</i> = 1037; median age 78), Older Australian Twins Study (<i>n</i> = 361; median age 68), and Sydney Centenarian Study (<i>n</i> = 217; median age 97).</p><p><strong>Measurements: </strong>Frequency of super-aging was assessed using nine super-aging definitions based on performance on neuropsychological testing. Levels of agreement between definitions were calculated, and associations between super-aging status for each definition and functioning (Bayer ADL score), structural brain imaging measures, and incident dementia were explored.</p><p><strong>Results: </strong>Frequency of super-aging varied between 2.9 and 43.4 percent with more stringent definitions associated with lower frequency. Agreement between different criteria varied from poor (K = 0.04, AC1 = .24) to very good (K = 0.83, AC1 = .91) with better agreement between definitions using similar tests and cutoffs. Super-aging was associated with better functional performance (4.7-11%) and lower rates of incident dementia (hazard ratios 0.08-0.48) for most definitions. Super-aging status was associated with a lower burden of white matter hyperintensities (3.8-33.2%) for all definitions.</p><p><strong>Conclusions: </strong>The frequency of super-aging is strongly affected by the demographic and neuropsychological testing parameters used. Greater consistency in defining super-aging would enable better characterization of this exceptional minority.</p>","PeriodicalId":14368,"journal":{"name":"International psychogeriatrics","volume":" ","pages":"939-955"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}