International Ophthalmology Clinics最新文献_第2页

Ocular Adnexal Natural Killer- and T-cell Lymphomas: A Review. 眼附件自然杀伤细胞淋巴瘤和t细胞淋巴瘤：综述。

International Ophthalmology Clinics Pub Date : 2025-10-01 Epub Date: 2025-09-25 DOI: 10.1097/IIO.0000000000000583

Stine Dahl Vest, Mikkel Straarup Thagaard, Peter de Nully Brown, Jens Folke Kiilgaard, Steffen Heegaard

{"title":"Ocular Adnexal Natural Killer- and T-cell Lymphomas: A Review.","authors":"Stine Dahl Vest, Mikkel Straarup Thagaard, Peter de Nully Brown, Jens Folke Kiilgaard, Steffen Heegaard","doi":"10.1097/IIO.0000000000000583","DOIUrl":"https://doi.org/10.1097/IIO.0000000000000583","url":null,"abstract":"Natural Killer- (NK) and T-cell lymphomas presenting in the ocular adnexa are rare. They account for ~3% of all ocular adnexal lymphomas and 17% of eyelid lymphomas. This article presents the epidemiology, clinics, treatment, and prognosis of ocular adnexal NK- and T-cell lymphomas. Orbital involvement is the most common in systemic NK- and T-cell lymphomas, including extranodal NK/T-cell lymphoma (ENKTL), systemic anaplastic large cell lymphoma (sALCL), and peripheral T-cell lymphoma (not otherwise specified) (PTCL-NOS). Primary cutaneous T-cell lymphomas, including mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma (C-ALCL), may present in the eyelids or periorbital skin. Several of the NK- and T-cell lymphomas, including ENKTL, sALCL, C-ALCL, PTCL-NOS, and MF, show a male predilection and present in adults. However, some subtypes including T-lymphoblastic leukemia/lymphoma are frequent in adolescents and young adults. Systemic ocular adnexal NK- and T-cell lymphomas often mimic inflammatory orbital conditions. Early biopsies, even in younger patients are therefore important to not miss these rare malignancies, which often have advanced stage disease and a poor prognosis. Primary cutaneous lymphomas can present with erythematous patches or as ulcerated eyelid tumors. In general, cutaneous lymphomas have a better prognosis, although recurrences may occur, leading to increased patient morbidity. The treatment for systemic NK- and T-cell lymphomas includes chemotherapy regimens depending on the lymphoma subtype, combined with ocular adnexal radiotherapy, and in some cases hematological stem-cell transplantation. Primary cutaneous lymphomas are frequently treated with radiotherapy, skin-directed therapies, and in some advanced cases with systemic treatments.","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"65 4","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coats Disease With Macular Nodule. Coats病伴黄斑结节。

International Ophthalmology Clinics Pub Date : 2025-10-01 Epub Date: 2025-09-25 DOI: 10.1097/IIO.0000000000000592

Anasua Ganguly Kapoor, Sameera Nayak, Simranjeet Aulakh, Vijitha S Vempuluru, Swathi Kaliki

{"title":"Coats Disease With Macular Nodule.","authors":"Anasua Ganguly Kapoor, Sameera Nayak, Simranjeet Aulakh, Vijitha S Vempuluru, Swathi Kaliki","doi":"10.1097/IIO.0000000000000592","DOIUrl":"https://doi.org/10.1097/IIO.0000000000000592","url":null,"abstract":"Purpose: To describe a case series of Coats disease with macular nodule mimicking retinoblastoma.Methods: Retrospective case series.Results: Of 339 patients with Coats disease, 7 (2%) with macular nodules were included. All had a referral diagnosis of retinoblastoma. All were males (mean age-6 y). The most common presenting complaint was decreased vision (n=4, 57%). Median best corrected visual acuity at presentation was counting fingers close to face, which was maintained at last follow-up (mean, 8 months). The nodule had a mean diameter of 5x4x3 mm, was grayish white, and bilobed (n=3, 43%), or dome shaped (n=4, 57%) with surface pigmentation (n=4, 57%), involving fovea (n=5, 71%), with surrounding exudates and second- or third-order retinal vessels. OCT (n=4) showed a well-defined hyperreflective subretinal nodule with posterior shadowing, cysts, and exudates. USG (n=6) showed an echodense intraocular nodule with moderate internal reflectivity with hyperechoic foci in 2 (33%) cases. FFA showed early- and mid-phase hypo-fluorescence with focal leakage with late-phase hyperfluorescence. Focal green laser photocoagulation of the telangiectatic vessels was performed in 5, one underwent subretinal fluid drainage and scleral buckling, and one was observed.Conclusion: Macular nodule in Coats disease represents a preferential accumulation of lipid in the macula. This rare variant of Coats disease can mimic retinoblastoma process. Be aware of this entity to ensure appropriate diagnosis and treatment.","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"65 4","pages":"74-81"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug Delivery in Retinoblastoma. 视网膜母细胞瘤的药物递送。

International Ophthalmology Clinics Pub Date : 2025-10-01 Epub Date: 2025-09-25 DOI: 10.1097/IIO.0000000000000590

Steven Trinh, Amit Joshi, Shyam S Chaurasia, Aparna Ramasubramanian

引用次数: 0

Role of PPV in Advanced Retinal Hemangioblastoma-A Systematic Review. PPV在晚期视网膜血管母细胞瘤中的作用——系统综述。

International Ophthalmology Clinics Pub Date : 2025-10-01 Epub Date: 2025-09-25 DOI: 10.1097/IIO.0000000000000588

Payal N Shah, P Mahesh Shanmugam, Buse Guneri Beser, Aslan Aykut

{"title":"Role of PPV in Advanced Retinal Hemangioblastoma-A Systematic Review.","authors":"Payal N Shah, P Mahesh Shanmugam, Buse Guneri Beser, Aslan Aykut","doi":"10.1097/IIO.0000000000000588","DOIUrl":"https://doi.org/10.1097/IIO.0000000000000588","url":null,"abstract":"Introduction: In eyes with retinal hemangioblastomas (RH), vision loss may occur despite treatment due to recurrent macular edema, macular pucker, vitreous hemorrhage, and exudative, tractional, or combined retinal detachment. Pars plana vitrectomy (PPV) plays a critical role in managing these complications. This review aims to evaluate the outcomes of PPV in patients with RH.Methodology: We searched PubMed/MEDLINE, Embase, Cochrane Library, Scopus, Google Scholar, and Web of Science (2000 to 2025) using the keywords \"retinal hemangioblastoma,\" \"capillary hemangioblastoma,\" \"von Hippel-Lindau retina,\" combined with \"vitrectomy,\" or \"pars plana vitrectomy.\" Given the rarity of the condition, retrospective case series were included if they had ≥4 cases. Single anecdotes and non-English articles were excluded. Two independent reviewers evaluated the studies for qualitative and quantitative synthesis.Results: Our search yielded 120 results, of which eight studies published between 2011 and 2024 met the inclusion criteria. All were retrospective case series (level IV evidence). A total of 107 eyes from 102 patients were analyzed, with sample sizes ranging from 4 to 23 eyes. Anatomic success, defined as retinal reattachment, ranged from 70% to 100% by final follow-up. However, many eyes remained in the low vision range despite anatomic success.Conclusions: New tumor development and proliferative vitreoretinopathy (PVR)-related complications remain key challenges in long-term management. While the evidence is limited due to study design and sample size, consistent trends across the literature suggest PPV is anatomically effective, though visual outcomes remain guarded.","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"65 4","pages":"82-88"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanded Field Swept-source Optical Coherence Tomography Angiography in the Assessment of Proliferative Diabetic Retinopathy and Associated Complications: A Review. 扩展视场扫描源光学相干断层血管造影评估增生性糖尿病视网膜病变及相关并发症：综述。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000577

Edward S Lu, Francesco Romano, Xinyi Ding, John B Miller

{"title":"Expanded Field Swept-source Optical Coherence Tomography Angiography in the Assessment of Proliferative Diabetic Retinopathy and Associated Complications: A Review.","authors":"Edward S Lu, Francesco Romano, Xinyi Ding, John B Miller","doi":"10.1097/IIO.0000000000000577","DOIUrl":"https://doi.org/10.1097/IIO.0000000000000577","url":null,"abstract":"Retinal imaging plays a critical role in the detection and management of proliferative diabetic retinopathy (PDR). Commonly used imaging modalities in the retina clinic include ultra-widefield fundus photography, ultra-widefield fluorescein angiography (FA), and optical coherence tomography (OCT). OCT angiography (OCTA) provides a noninvasive method to assess the retinal microvasculature and detect vascular alterations, including retinal neovascularization (NV). More recently, the emergence of expanded field swept-source OCTA (SS-OCTA) has offered faster en-face and cross-sectional imaging of the retina with a broader field of view. Prior reviews have highlighted the role of SS-OCTA in assessing associated lesions of PDR, including NV, microaneurysms, foveal avascular zone, intraretinal microvascular abnormalities, and capillary non-perfusion. In this review, we explore the clinical applications of expanded field SS-OCTA in characterizing NV morphology, comparing NV detection to FA, and offering potential imaging biomarkers associated with vision-threatening complications of PDR, including vitreous hemorrhage, neovascular glaucoma, and tractional retinal detachment.","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"65 3","pages":"12-16"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periocular Manifestations and Management of Immunoglobulin G4-Related Disease. 免疫球蛋白g4相关疾病的眼周表现和治疗。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000572

Tatiana R Rosenblatt, Michael K Yoon

{"title":"Periocular Manifestations and Management of Immunoglobulin G4-Related Disease.","authors":"Tatiana R Rosenblatt, Michael K Yoon","doi":"10.1097/IIO.0000000000000572","DOIUrl":"https://doi.org/10.1097/IIO.0000000000000572","url":null,"abstract":"Immunoglobulin G4-related disease (IgG4-RD) comprises a spectrum of inflammatory conditions characterized by lymphoplasmacytic infiltration by IgG4+ plasma cells, resultant tumefactive lesions at various locations in the body, storiform fibrosis, and elevated serum IgG4 levels. IgG4-related ophthalmic disease (IgG4-ROD) can occur in isolation or in conjunction with systemic findings. The most common manifestations of IgG4-ROD are dacryoadenitis and eyelid edema, though patients may also have trigeminal nerve enlargement, extraocular muscle involvement, and other orbital soft tissue lesions and inflammation. Workup is multifactorial and should include full body imaging, serum IgG4 levels, and biopsy, which must include staining for IgG4+ plasma cells and may show hallmark storiform fibrosis and/or obliterative phlebitis. IgG4-ROD can be misdiagnosed due to potential clinical, radiographic, and histopathologic overlap with other orbital inflammatory conditions; however, the presence of infraorbital or supraorbital nerve enlargement on imaging, as well as biopsy with strong levels of IgG4 histochemical staining, can be helpful in distinguishing IgG4-ROD from other orbital inflammatory pathology. Steroids are typically first-line treatment, although given high rates of recurrence, patients may require concurrent or subsequent treatment with steroid-sparing agents, most commonly rituximab.","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"65 3","pages":"133-141"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune Recovery Uveitis: A Comprehensive Review. 免疫恢复性葡萄膜炎：综述。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000565

Melissa Yuan, Lucy H Young

引用次数: 0

Noninfectious Inflammatory Complications of Lamellar Refractive Corneal Surgery: A Review of Diffuse Lamellar Keratitis, Central Toxic Keratopathy, and Transient Light Sensitivity Syndrome. 板层角膜屈光手术的非感染性炎症并发症：弥漫性板层角膜炎、中枢性中毒性角膜病变和短暂光敏感综合征的综述。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000570

Enchi K Chang, Roberto Pineda

{"title":"Noninfectious Inflammatory Complications of Lamellar Refractive Corneal Surgery: A Review of Diffuse Lamellar Keratitis, Central Toxic Keratopathy, and Transient Light Sensitivity Syndrome.","authors":"Enchi K Chang, Roberto Pineda","doi":"10.1097/IIO.0000000000000570","DOIUrl":"https://doi.org/10.1097/IIO.0000000000000570","url":null,"abstract":"Laser vision correction through lamellar refractive corneal surgery, such as laser-assisted in situ keratomileusis (LASIK) and small incision lenticule extraction (SMILE), have increased in popularity given new technologies and increased patient preference for corrective lens independence. However, these surgeries are not without potential postoperative complications. Diffuse lamellar keratitis (DLK), central toxic keratopathy (CTK), and transient light sensitivity syndrome (TLSS) comprise 3 rare, noninfectious, inflammatory complications after corneal lamellar refractive surgery that differ in their clinical presentation. DLK has the most potentially severe vision-threatening outcomes and is associated with clinical findings of white, granular cells in the stromal interface. CTK is associated with the triad of central corneal opacification, central striae, and hyperopic shift. TLSS has no findings on slit lamp examination. While both DLK and TLSS are responsive to topical steroids, CTK improves without intervention. It is important to distinguish the 3 syndromes, as proper diagnosis may provide insight into the underlying cause of the patient's symptoms and thus guide treatment.","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"65 3","pages":"71-76"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence in Oculoplastic Surgery: Current Landscape. 人工智能在眼科整形手术中的应用现状。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000566

Hursuong Vongsachang, Michael K Yoon

引用次数: 0

Gene Therapy in Age-related Macular Degeneration. 老年性黄斑变性的基因治疗。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000567

Henry W Zhou, Leo A Kim

引用次数: 0