The Immunopathogenesis of Adamantiades-Behçet Uveitis: Advances in Understanding of Genetics and Molecular Mechanisms.

Q3 Medicine
International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI:10.1097/IIO.0000000000000576
Lindsay Klofas Kozek, Demetrios G Vavvas
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引用次数: 0

Abstract

Adamantiades-Behçet disease (ABD) is a chronic inflammatory disorder manifesting as systemic vasculitis, characterized by recurrent oral and genital ulcers, skin lesions, and uveitis. Much has been elucidated regarding immunopathogenesis since the initial identification of a strong genetic susceptibility related to a HLA-B51 variant. Current understanding of the disease involves a complex interplay between defective antigen processing, environmental triggers, and an altered balance between different components of the immune system. This review aims to comprehensively synthesize the immunogenetics and immunopathology of ABD, particularly concerning ocular involvement, summarizing the current understanding of the molecular mechanisms underlying the disease.

adamantiades - behet葡萄膜炎的免疫发病机制:遗传学和分子机制的研究进展。
adamantiades - behet病(ABD)是一种慢性炎症性疾病,表现为全身性血管炎,特征为复发性口腔和生殖器溃疡、皮肤病变和葡萄膜炎。自从最初发现与HLA-B51变异相关的强遗传易感性以来,许多关于免疫发病机制的研究已经得到阐明。目前对该疾病的理解涉及缺陷抗原加工、环境触发因素和免疫系统不同组成部分之间改变的平衡之间复杂的相互作用。本文旨在全面综合ABD的免疫遗传学和免疫病理学,特别是与眼部受累有关的研究,总结目前对ABD分子机制的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Ophthalmology Clinics
International Ophthalmology Clinics Medicine-Ophthalmology
CiteScore
1.40
自引率
0.00%
发文量
94
期刊介绍: International Ophthalmology Clinics is a valuable resource for any medical professional seeking to stay informed and up-to-date regarding developments in this dynamic specialty. Each issue of this quarterly publication presents a comprehensive review of a single topic in a new or changing area of ophthalmology. The timely, tightly focused review articles found in this publication give ophthalmologists the opportunity to benefit from the knowledge of leading experts in this rapidly changing field.
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