Rachel Tandias, Leyla Yavuz Saricay, Thomas H Dohlman
{"title":"Innovation in Keratoprostheses: A Review of Modern Devices and Strategies for Preventing and Managing Complications.","authors":"Rachel Tandias, Leyla Yavuz Saricay, Thomas H Dohlman","doi":"10.1097/IIO.0000000000000564","DOIUrl":null,"url":null,"abstract":"<p><p>Decades of research and innovation have led to the development of modern keratoprostheses (KPros) designed to replace the function of the native human cornea. The Boston Keratoprosthesis (B-KPro) Type I remains the most widely used KPro worldwide. Ongoing refinements and modified versions of the B-KPro, as well as novel, fully synthetic devices, aim to enhance durability and biocompatibility, reduce complications, and expand accessibility to KPros across the globe. Innovative strategies such as immunomodulatory therapies, improved biomaterials, and novel drug delivery systems have been explored to address challenges such as retroprosthetic membrane formation, glaucoma, and infectious complications. This review provides an overview of currently available and emerging KPro technology and innovative strategies for preventing and managing KPro-associated complications.</p>","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"65 3","pages":"26-34"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Ophthalmology Clinics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/IIO.0000000000000564","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/2 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Decades of research and innovation have led to the development of modern keratoprostheses (KPros) designed to replace the function of the native human cornea. The Boston Keratoprosthesis (B-KPro) Type I remains the most widely used KPro worldwide. Ongoing refinements and modified versions of the B-KPro, as well as novel, fully synthetic devices, aim to enhance durability and biocompatibility, reduce complications, and expand accessibility to KPros across the globe. Innovative strategies such as immunomodulatory therapies, improved biomaterials, and novel drug delivery systems have been explored to address challenges such as retroprosthetic membrane formation, glaucoma, and infectious complications. This review provides an overview of currently available and emerging KPro technology and innovative strategies for preventing and managing KPro-associated complications.
期刊介绍：
International Ophthalmology Clinics is a valuable resource for any medical professional seeking to stay informed and up-to-date regarding developments in this dynamic specialty. Each issue of this quarterly publication presents a comprehensive review of a single topic in a new or changing area of ophthalmology. The timely, tightly focused review articles found in this publication give ophthalmologists the opportunity to benefit from the knowledge of leading experts in this rapidly changing field.
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