International Ophthalmology Clinics最新文献_第3页

Laser-based Refractive Surgery: A Review of Select Clinical Challenges and Future Directions. 基于激光的屈光手术：临床挑战和未来发展方向综述。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000568

Dennis Akrobetu, Roberto Pineda

{"title":"Laser-based Refractive Surgery: A Review of Select Clinical Challenges and Future Directions.","authors":"Dennis Akrobetu, Roberto Pineda","doi":"10.1097/IIO.0000000000000568","DOIUrl":"https://doi.org/10.1097/IIO.0000000000000568","url":null,"abstract":"Advances in laser-based corneal refractive surgery have allowed for a diverse array of surgical options available to patients seeking vision correction and contact lens/glasses-free independence. The most common laser-based corneal refractive surgeries include laser-assisted in situ keratomileusis (LASIK), photorefractive keratectomy (PRK), and small incision lenticule extraction (SMILE). Although advancements in technology have been made, select clinical challenges such as higher-order aberrations, postoperative ectasia, diffuse lamellar keratitis (DLK)/central toxic keratopathy (CTK), and pressure-induced interlamellar stromal keratitis (PISK) remain as postrefractive issues to be addressed in laser-based corneal refractive surgery. Recent improvements in preoperative evaluation, the development of instrumentation to measure and treat higher-order optical aberrations, and new techniques for the treatment of presbyopia all serve as unique avenues for innovation in the field. Despite its many advances, laser-based corneal refractive surgery has specific clinical limitations that may be better addressed through lens-based refractive techniques.","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"65 3","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Diabetes Mellitus on the Corneal Microenvironment and the Impact of the Donor Diabetic State on Corneal Transplant Outcomes. 糖尿病对角膜微环境的影响及供体糖尿病状态对角膜移植结果的影响

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000571

Yilin Feng, Reza Dana

引用次数: 0

Sterile Intraocular Inflammation Following Intravitreal Injections: Pathogenesis, Clinical Features, and Management. 玻璃体注射后无菌性眼内炎症：发病机制、临床特征和处理。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000580

Saghar Bagheri, Dimitrios P Ntentakis, Maria Emfietzoglou, Helia Ashourizadeh, Nicole Grinspan, Ioanna Ploumi, Grayson W Armstrong, John B Miller

{"title":"Sterile Intraocular Inflammation Following Intravitreal Injections: Pathogenesis, Clinical Features, and Management.","authors":"Saghar Bagheri, Dimitrios P Ntentakis, Maria Emfietzoglou, Helia Ashourizadeh, Nicole Grinspan, Ioanna Ploumi, Grayson W Armstrong, John B Miller","doi":"10.1097/IIO.0000000000000580","DOIUrl":"https://doi.org/10.1097/IIO.0000000000000580","url":null,"abstract":"Intravitreal injections have revolutionized the treatment of retinal diseases, yet there are possible complications, such as noninfectious intraocular inflammation, a complication that may threaten vision and mimic infectious endophthalmitis. This review synthesizes current knowledge on inflammation after intravitreal therapy, with particular focus on sterile intraocular inflammation and retinal vasculitis associated with anti-VEGF agents such as brolucizumab and newer complement inhibitors like pegcetacoplan. The pathogenesis is multifactorial, involving patient-specific immune responses, drug-specific properties including aggregation or impurities, and deviations in preparation or delivery techniques. Clinical presentations range from anterior uveitis and vitritis to occlusive retinal vasculitis. Visual outcomes vary and depend on prompt recognition and appropriate management. Epidemiologic data show variable incidence across agents, with brolucizumab demonstrating higher rates of inflammation compared with ranibizumab or aflibercept. Treatment includes corticosteroids and discontinuation of the offending agent, with rare cases requiring surgical intervention. As the therapeutic landscape expands, heightened awareness and standardized evaluation of postinjection inflammation are critical to improving safety and preserving vision.","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"65 3","pages":"63-70"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refractory Macular Hole Surgery: A Review of Recent Surgical Innovations. 难治性黄斑裂孔手术：近期手术创新综述。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000579

Ryan S Meshkin, Dean Eliott

引用次数: 0

The Role of Inflammation in Age-Related Macular Degeneration. 炎症在老年性黄斑变性中的作用。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000578

James Harris, David Wu

引用次数: 0

Innovations in Big Data and Omics Towards Phenome-Wide and Genome-Wide Association Studies for Retinal Disease. 视网膜疾病全现象和全基因组关联研究的大数据和组学创新

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000569

Seyedeh M Zekavat, Elizabeth J Rossin

{"title":"Innovations in Big Data and Omics Towards Phenome-Wide and Genome-Wide Association Studies for Retinal Disease.","authors":"Seyedeh M Zekavat, Elizabeth J Rossin","doi":"10.1097/IIO.0000000000000569","DOIUrl":"https://doi.org/10.1097/IIO.0000000000000569","url":null,"abstract":"The human retina is a multilayered tissue with diverse embryological origins and is, therefore, a window for assessment of ocular, neurological, vascular, and other systemic conditions. Innovations in big data, particularly involving large population biobanks, have enabled improved data sets that facilitate a better understanding of connections between the retina and systemic health. Retinal fundus and optical coherence tomography imaging data provide rich resources for describing interpretable imaging endophenotypes and evaluating their utility as biomarkers for future ocular and systemic conditions. Furthermore, the addition of genomic data to retinal and ophthalmic information has enabled unbiased discovery of the biological mechanisms driving changes in the retina. Assessment of inherited common and rare variants influencing ocular phenotypes through genome-wide association studies, in silico analyses for gene prioritization, pathway enrichment analysis, and experimental validation may enable the identification of biological targets for therapeutic modulation of retinal microvascular indices, neuronal health, and other imaging biomarkers. Further development of polygenic risk scores for retinal phenotypes enables a personalized medicine approach to quantifying inherited disease risk for an individual. While interpretation of causality from observational associations is difficult, Mendelian randomization (MR) analyses utilizing genomics can help improve understanding of the causal relationship between different phenotypes. Given the routine, noninvasive nature of retinal imaging, the findings from retinal cross-phenotype and genome-wide analysis have the direct potential for application clinically including in diagnosis, monitoring and prevention, and in treatment of both ocular and systemic conditions.","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"65 3","pages":"40-47"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eyeing Opportunity: A Review of Private Equity in Ophthalmology. 寻找机会：眼科私募股权的回顾。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000573

Darren A Chen, Jo-Ann Haney-Tilton

{"title":"Eyeing Opportunity: A Review of Private Equity in Ophthalmology.","authors":"Darren A Chen, Jo-Ann Haney-Tilton","doi":"10.1097/IIO.0000000000000573","DOIUrl":"https://doi.org/10.1097/IIO.0000000000000573","url":null,"abstract":"Private equity (PE) acquisition of ophthalmology practices has grown rapidly, reflecting broader trends in the consolidation of health care services. The driving force behind these acquisitions is the potential for high returns through operational efficiencies, increased bargaining power with insurers, and access to lucrative outpatient procedures. However, PE's impact on the quality and cost of ophthalmic care remains unclear. Studies show mixed results: some report increased use of expensive treatments and higher costs, while others suggest minimal changes in patient outcomes or spending. PE's appeal to ophthalmologists includes capital infusion for practice expansion and improved risk management, though concerns exist over profit-driven incentives possibly compromising patient care. The market for ophthalmology practices remains fragmented, with PE firms capitalizing on consolidation opportunities. Despite the growth, there are challenges to assessing the full impact of PE involvement, particularly due to limited research, nondisclosure agreements, and difficulty in selecting control practices for comparison. While PE acquisitions have been accelerating, recent reports indicate a slowdown in 2024, influenced by factors such as interest rates and federal investigations into the health care sector. The future of PE in ophthalmology will likely depend on market conditions, regulatory changes, and further research into its long-term effects on care quality and physician autonomy.","PeriodicalId":14338,"journal":{"name":"International Ophthalmology Clinics","volume":"65 3","pages":"8-11"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraneoplastic Syndromes in the Orbit and Ocular Adnexa: A Comprehensive Review. 眼眶和眼附件的副肿瘤综合征：综合综述。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000575

Amee D Azad, Suzanne K Freitag

引用次数: 0

Pediatric Noninfectious Intermediate, Posterior, and Panuveitis: A Review. 儿童非感染性中间、后、全葡萄膜炎：综述。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000574

Da Meng, Sandra Hoyek, Lucia Sobrin, Nimesh A Patel

引用次数: 0

Innovation in Keratoprostheses: A Review of Modern Devices and Strategies for Preventing and Managing Complications. 角膜假体的创新：现代设备和预防和处理并发症的策略综述。

International Ophthalmology Clinics Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1097/IIO.0000000000000564

Rachel Tandias, Leyla Yavuz Saricay, Thomas H Dohlman

引用次数: 0