International Reviews of Immunology最新文献_第3页

Gut microbiome as a treatment in colorectal cancer. 将肠道微生物组作为结直肠癌的治疗手段。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1080/08830185.2024.2312294

Murad Khan, Suleman Shah, Wahid Shah, Ikram Khan, Hamid Ali, Ijaz Ali, Riaz Ullah, Xiufang Wang, Arshad Mehmood, Yanli Wang

{"title":"Gut microbiome as a treatment in colorectal cancer.","authors":"Murad Khan, Suleman Shah, Wahid Shah, Ikram Khan, Hamid Ali, Ijaz Ali, Riaz Ullah, Xiufang Wang, Arshad Mehmood, Yanli Wang","doi":"10.1080/08830185.2024.2312294","DOIUrl":"10.1080/08830185.2024.2312294","url":null,"abstract":"Background: The gut microbiome plays a role in the development and progression of colorectal cancer (CRC).Aim and objective: This review focuses on whether the gut microbiome is involved in the development and regulation of the host immune system.Methods: The gut microbiome can influence the production and activity of immune cells and molecules that help to maintain the integrity of the intestinal barrier and prevent inflammation. Gut microbiota modulates the anti-cancer immune response. The gut microbiota can influence the function of immune cells, like T cells, that recognize and eliminate cancer cells. Gut microbiota can affect various aspects of cancer progression and the efficacy of various anti-cancer treatments.Results: Gut microbiota provide promise as a potential biomarker to identify the effect of immunotherapy and as a target for modulation to improve the efficacy of immunotherapy in CRC treatment.Conclusion: The potential synergistic effect between the gut microbiome and anti-cancer treatment modalities provides an interest in developing strategies to modulate the gut microbiome to improve the efficacy of anti-cancer treatment.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating and intestinal regulatory T cells in inflammatory bowel disease: A systemic review and meta-analysis. 炎症性肠病中的循环和肠道调节性 T 细胞：系统回顾与荟萃分析

IF 4.3 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2023-08-24 DOI: 10.1080/08830185.2023.2249525

Shihao Duan, Yubin Cao, Pingrun Chen, Yi Yang, Yan Zhang

{"title":"Circulating and intestinal regulatory T cells in inflammatory bowel disease: A systemic review and meta-analysis.","authors":"Shihao Duan, Yubin Cao, Pingrun Chen, Yi Yang, Yan Zhang","doi":"10.1080/08830185.2023.2249525","DOIUrl":"10.1080/08830185.2023.2249525","url":null,"abstract":"Regulatory T cells (Tregs) play an important immunosuppressive role in inflammatory bowel disease (IBD). However, findings on the quantitative and functional changes of intestinal and circulating Tregs in patients with IBD are rather contradictory. We therefore conducted a meta-analysis on this issue. The pooled effect was assessed using the standardized mean difference (SMD) with a 95% confidence interval (CI), and subgroup analyses were performed to investigate heterogeneity. This analysis included 764 IBD (402 UC and 362 CD) patients and 341 healthy controls (HCs) pooled from 17 eligible studies. The percentage of circulating Tregs was significantly decreased in active IBD patients compared to HCs (SMD = -0.95, p < 0.001) and inactive IBD patients (SMD = -0.80, p < 0.001). There was no difference in the percentage of circulating Tregs between inactive IBD patients and HCs. The suppressive function of circulating Tregs was impaired in active IBD patients according to limited data (SMD = -0.75, p = 0.02). Besides, the percentage of intestinal Tregs was significantly higher in inflamed regions than in non-inflamed regions (SMD = 0.85, p < 0.001). Our study quantitatively summarized the quantitative and functional changes of Tregs and supported the therapeutic potential of Tregs in IBD. Moreover, additional research into the functions and characteristics of intestinal Tregs in IBD is needed.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10435129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet extracellular vesicles: Darkness and light of autoimmune diseases. 血小板细胞外囊泡：自身免疫性疾病的黑暗与光明

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2023-06-23 DOI: 10.1080/08830185.2023.2225551

Jingru Chen, Miao Wang, Ying Zhang, Fenglin Zhu, Yanqiu Xu, Guoxiang Yi, Runxiu Zheng, Bin Wu

{"title":"Platelet extracellular vesicles: Darkness and light of autoimmune diseases.","authors":"Jingru Chen, Miao Wang, Ying Zhang, Fenglin Zhu, Yanqiu Xu, Guoxiang Yi, Runxiu Zheng, Bin Wu","doi":"10.1080/08830185.2023.2225551","DOIUrl":"10.1080/08830185.2023.2225551","url":null,"abstract":"Autoimmune diseases are characterized by a breakdown of immune tolerance, leading to inflammation and irreversible end-organ tissue damage. Platelet extracellular vesicles are cellular elements that are important in blood circulation and actively participate in inflammatory and immune responses through intercellular communication and interactions between inflammatory cells, immune cells, and their secreted factors. Therefore, platelet extracellular vesicles are the \"accelerator\" in the pathological process of autoimmune diseases; however, this robust set of functions of platelet extracellular vesicles has also prompted new advances in therapeutic strategies for autoimmune diseases. In this review, we update fundamental mechanisms based on platelet extracellular vesicles communication function in autoimmune diseases. We also focus on the potential role of platelet extracellular vesicles for the treatment of autoimmune diseases. Some recent studies have found that antiplatelet aggregation drugs, specific biological agents can reduce the release of platelet extracellular vesicles. Platelet extracellular vesicles can also serve as vehicles to deliver drugs to targeted cells. It seems that we can try to silence or inhibit microRNA carried by platelet extracellular vesicles transcription and regulate the target cells to treat autoimmune diseases as platelet extracellular vesicles can transfer microRNA to other cells to regulate immune-inflammatory responses. Hopefully, the information presented here will provide hope for patients with autoimmune diseases.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10051307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune cell profiling of preeclamptic pregnant and postpartum women by single-cell RNA sequencing. 通过单细胞 RNA 测序分析先兆子痫孕妇和产后妇女的免疫细胞图谱。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2022-11-11 DOI: 10.1080/08830185.2022.2144291

Jing Hu, Qi Guo, Congcong Liu, Qian Yu, Yuan Ren, Yueni Wu, Qin Li, Yuezhen Li, Juntao Liu

{"title":"Immune cell profiling of preeclamptic pregnant and postpartum women by single-cell RNA sequencing.","authors":"Jing Hu, Qi Guo, Congcong Liu, Qian Yu, Yuan Ren, Yueni Wu, Qin Li, Yuezhen Li, Juntao Liu","doi":"10.1080/08830185.2022.2144291","DOIUrl":"10.1080/08830185.2022.2144291","url":null,"abstract":"Preeclampsia (PE), a leading cause of maternal and fetal morbidity and mortality, is closely related to the immune system alterations. However, little is known about the landscape and heterogeneity of maternal immune system at single-cell level among PE patients. In this study, peripheral blood mononuclear cells (PBMCs) were isolated from three early-onset preeclamptic pregnant women and two healthy control, respectively. Single-cell RNA sequencing was performed on 10× genomics platform and single-cell transcriptomes were obtained to characterize immune cell subgroups at the pregnant and postpartum stages. In total, 80,429 single-cell transcriptomes were obtained. 19 cellular compositions were identified, which were categorized into six cell types including T cells, natural killer (NK) cells, B cells, monocytes, plasmacytoid dendritic cells and conventional dendritic cells. There were excessive activation of B cells, monocytes and NK cells in PE patients at the pregnant stage based on comparative analysis. Lower immune response activation was noticed in CD4+ and CD8+ T cells in PE patients, especially the low-activation of memory T cells at the pregnant and postpartum stages. PE patients showed high activation of B cells in pregnancy persisted postpartum and lower activation of memory T cells, indicating their persistent effects on the pathogenesis and recurrence risk of PE. This study provide a broad characterization of the single-cell transcriptome of PBMCs in PE, which contributes to identification of immune imbalance for its monitoring and treatment.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40683868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

HCMV miR-UL70-3p downregulates the rapamycin-induced autophagy by targeting the autophagy-related protein 9A (ATG9A). HCMV miR-UL70-3p 通过靶向自噬相关蛋白 9A (ATG9A) 下调雷帕霉素诱导的自噬。

IF 4.3 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2024-01-02 DOI: 10.1080/08830185.2023.2296488

Raj Kumar Khalko, Abhishek Pandeya, Sangeeta Saxena, Sunil Babu Gosipatala

{"title":"HCMV miR-UL70-3p downregulates the rapamycin-induced autophagy by targeting the autophagy-related protein 9A (ATG9A).","authors":"Raj Kumar Khalko, Abhishek Pandeya, Sangeeta Saxena, Sunil Babu Gosipatala","doi":"10.1080/08830185.2023.2296488","DOIUrl":"10.1080/08830185.2023.2296488","url":null,"abstract":"Human cytomegalovirus (HCMV) is a representative β-herpesvirus that establishes persistent infections in humans, and exhibits high seropositivity rates in adults. It has co-evolved with its human host and employs various strategies to evade antiviral mechanisms by utilizing a significant portion of its genome. HCMV-encoded proteins and miRNAs have been implicated in regulating these mechanisms, enabling viral survival within the human body. During viral infections, autophagy, a conserved catabolic process essential for cellular homeostasis, acts as an antiviral defense mechanism. Multiple studies have reported that HCMV can modulate autophagy through its proteins and miRNAs, thereby influencing its survival within the host. In this study, we showed the potential involvement of HCMV miRNAs in cellular autophagy. We employed various bioinformatic tools to predict putative HCMV miRNAs that target autophagy-related genes and their corresponding cellular autophagy genes. Our results show that the 3'UTR of autophagy-related genes, including ATG9A, ATG9B, ATG16L2, SQSTM1, and EIF2AK2, harbors potential binding sites for hcmv-miR-UL70-3p. Experimental manipulation involving ectopic expression of hcmv-miR-UL70-3p demonstrated a significant reduction in rapamycin-induced autophagy, with ATG9A as its functional target. These findings establish that hcmv-miR-UL70-3p acts as an autophagy inhibitor by suppressing the expression of ATG9A.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139074015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boosting immune responses in lung tumor immune microenvironment: A comprehensive review of strategies and adjuvants. 增强肺部肿瘤免疫微环境中的免疫反应：策略与佐剂综述。

IF 4.3 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2024-03-25 DOI: 10.1080/08830185.2024.2333275

Fei Gao, Xiaoqing You, Liu Yang, Xiangni Zou, Bowen Sui

{"title":"Boosting immune responses in lung tumor immune microenvironment: A comprehensive review of strategies and adjuvants.","authors":"Fei Gao, Xiaoqing You, Liu Yang, Xiangni Zou, Bowen Sui","doi":"10.1080/08830185.2024.2333275","DOIUrl":"10.1080/08830185.2024.2333275","url":null,"abstract":"The immune system has a substantial impact on the growth and expansion of lung malignancies. Immune cells are encompassed by a stroma comprising an extracellular matrix (ECM) and different cells like stromal cells, which are known as the tumor immune microenvironment (TIME). TME is marked by the presence of immunosuppressive factors, which inhibit the function of immune cells and expand tumor growth. In recent years, numerous strategies and adjuvants have been developed to extend immune responses in the TIME, to improve the efficacy of immunotherapy. In this comprehensive review, we outline the present knowledge of immune evasion mechanisms in lung TIME, explain the biology of immune cells and diverse effectors on these components, and discuss various approaches for overcoming suppressive barriers. We highlight the potential of novel adjuvants, including toll-like receptor (TLR) agonists, cytokines, phytochemicals, nanocarriers, and oncolytic viruses, for enhancing immune responses in the TME. Ultimately, we provide a summary of ongoing clinical trials investigating these strategies and adjuvants in lung cancer patients. This review also provides a broad overview of the current state-of-the-art in boosting immune responses in the TIME and highlights the potential of these approaches for improving outcomes in lung cancer patients.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Th17 cells: A new target in kidney disease research. Th17 细胞：肾病研究的新目标

IF 4.3 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2024-03-05 DOI: 10.1080/08830185.2024.2321901

Tao Zhang, Hongyan Huo, Yinghui Zhang, Jie Tao, Junzheng Yang, Xianglu Rong, Yiqi Yang

引用次数: 0

Single-cell RNA sequencing of peripheral blood mononuclear cells from pregnant women with Systemic lupus erythematosus. 对患有系统性红斑狼疮的孕妇的外周血单核细胞进行单细胞 RNA 测序。

IF 4.3 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2024-07-27 DOI: 10.1080/08830185.2024.2376649

Congcong Liu, Zeyang Yu, Yijun Song, Xiaojie Zhang, Jiuliang Zhao, Qian Yu, Mengtao Li, Yuezhen Li, Juntao Liu

{"title":"Single-cell RNA sequencing of peripheral blood mononuclear cells from pregnant women with Systemic lupus erythematosus.","authors":"Congcong Liu, Zeyang Yu, Yijun Song, Xiaojie Zhang, Jiuliang Zhao, Qian Yu, Mengtao Li, Yuezhen Li, Juntao Liu","doi":"10.1080/08830185.2024.2376649","DOIUrl":"10.1080/08830185.2024.2376649","url":null,"abstract":"Systemic lupus erythematosus (SLE), an autoimmune condition, presents pregnancy-related risks, impacting maternal and fetal health. The immune cell composition and gene expression profiles in pregnant SLE patients, as well as the molecular mechanisms of active SLE patients during pregnancy, remain unclear. In our study, we enrolled 12 patients: three active SLE individuals (SLE-AT group, SLEDAI > 12, non-pregnant women), three inactive SLE individuals (SLE-NP group, SLEDAI ranging 0 to 6, non-pregnant women), three pregnant women with active SLE (SLE-C group, SLEDAI > 12), and three pregnant women with inactive SLE (SLE-NC group, SLEDAI range 0 to 6 score). Transcriptome analysis of peripheral blood mononuclear cells (PBMCs) was conducted using the 10x Genomics technique. We observed upregulation of genes like CCDC15 and TRBV4-2 in T cells and CMPK2, IFIT1, and OAS2 in monocytes in the SLE-C group. Notably, gene sets related to Cell Cycle and IFN Response showed significant differences between the SLE-C and SLE-NC groups in naïve CD8 T cells. Our comparison of immune cell type ratios and transcriptional patterns between active and inactive SLE during pregnancy sheds light on the single-cell level changes in SLE status during pregnancy, offering insights for future SLE prediction and treatment strategies.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141766104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaccine design and development: Exploring the interface with computational biology and AI. 疫苗设计与开发：探索计算生物学和人工智能的接口。

IF 4.3 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2024-07-10 DOI: 10.1080/08830185.2024.2374546

Ananya, Darshan C Panchariya, Anandakrishnan Karthic, Surya Pratap Singh, Ashutosh Mani, Aakash Chawade, Sandeep Kushwaha

引用次数: 0

Breaking the graft-versus-host-disease barrier: Mesenchymal stromal/stem cells as precision healers. 打破移植物抗宿主病屏障：作为精准治疗者的间充质基质/干细胞。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2023-08-28 DOI: 10.1080/08830185.2023.2252007

Mohini Mendiratta, Meenakshi Mendiratta, Sujata Mohanty, Ranjit Kumar Sahoo, Hridayesh Prakash

{"title":"Breaking the graft-versus-host-disease barrier: Mesenchymal stromal/stem cells as precision healers.","authors":"Mohini Mendiratta, Meenakshi Mendiratta, Sujata Mohanty, Ranjit Kumar Sahoo, Hridayesh Prakash","doi":"10.1080/08830185.2023.2252007","DOIUrl":"10.1080/08830185.2023.2252007","url":null,"abstract":"Mesenchymal Stromal/Stem Cells (MSCs) are multipotent, non-hematopoietic progenitor cells with a wide range of immune modulation and regenerative potential which qualify them as a potential component of cell-based therapy for various autoimmune/chronic inflammatory ailments. Their immunomodulatory properties include the secretion of immunosuppressive cytokines, the ability to suppress T-cell activation and differentiation, and the induction of regulatory T-cells. Considering this and our interest, we here discuss the significance of MSC for the management of Graft-versus-Host-Disease (GvHD), one of the autoimmune manifestations in human. In pre-clinical models, MSCs have been shown to reduce the severity of GvHD symptoms, including skin and gut damage, which are the most common and debilitating manifestations of this disease. While initial clinical studies of MSCs in GvHD cases were promising, the results were variable in randomized studies. So, further studies are warranted to fully understand their potential benefits, safety profile, and optimal dosing regimens. Owing to these inevitable issues, here we discuss various mechanisms, and how MSCs can be employed in managing GvHD, as a cellular therapeutic approach for this disease.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10108381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0