International Reviews of Immunology最新文献_第2页

WC1-mediated co-stimulation in γδ T cells: Insights from ruminants and perspectives for human immunotherapy. wc1介导的γδ T细胞共刺激：反刍动物的见解和人类免疫治疗的观点。

IF 5.4 4区医学

International Reviews of Immunology Pub Date : 2026-05-01 Epub Date: 2026-04-06 DOI: 10.1080/08830185.2026.2650138

Rümeysa Berra Karataş, Furkan Ayaz, Esra Aydemir

{"title":"WC1-mediated co-stimulation in γδ T cells: Insights from ruminants and perspectives for human immunotherapy.","authors":"Rümeysa Berra Karataş, Furkan Ayaz, Esra Aydemir","doi":"10.1080/08830185.2026.2650138","DOIUrl":"10.1080/08830185.2026.2650138","url":null,"abstract":"Gamma-delta (γδ) T cells, which bridge innate and adaptive immunity, are attractive candidates for immunotherapy. Significant interspecies differences exist, particularly between humans and ruminants. In ruminants, γδ T cells are a major circulating population characterized by the Workshop Cluster 1 (WC1) family, a unique set of Scavenger Receptor Cysteine-Rich (SRCR) co-receptors. WC1 molecules function dually as pattern recognition receptors (PRRs) and essential co-stimulators for the γδ T cell receptor (TCR). Specific WC1 isoforms (e.g. WC1.1+, WC1.2+) are associated with distinct functional predispositions, within a broader functional plasticity observed in both human and murine γδ T cell subsets. This review compares human and ruminant γδ T cell biology, proposing the WC1 co-stimulatory system as a functional paradigm for next-generation human T cell therapies. \"WC1-inspired\" synthetic receptors could provide more physiological, sustained activation, potentially overcoming key therapeutic limitations such as antigen escape and severe toxicity. Despite translational challenges, including the lack of a direct human WC1 ortholog, the ruminant model provides a critical potential for designing more durable and context-responsive immunotherapies.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"184-201"},"PeriodicalIF":5.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive review on immunotherapy for hepatocellular carcinoma: Current status and future perspectives. 肝细胞癌免疫治疗综述：现状与展望。

IF 5.4 4区医学

International Reviews of Immunology Pub Date : 2026-01-01 Epub Date: 2026-01-14 DOI: 10.1080/08830185.2026.2614779

Swetha Pulakuntla, Gouthami Kuruvalli, Mrinalini Mohan, Nagajyothi Pc, Jaesool Shim, Vaddi Damodara Reddy

{"title":"Comprehensive review on immunotherapy for hepatocellular carcinoma: Current status and future perspectives.","authors":"Swetha Pulakuntla, Gouthami Kuruvalli, Mrinalini Mohan, Nagajyothi Pc, Jaesool Shim, Vaddi Damodara Reddy","doi":"10.1080/08830185.2026.2614779","DOIUrl":"10.1080/08830185.2026.2614779","url":null,"abstract":"Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, remains a major global health concern due to its high incidence and mortality rates. Although advances in surgery, chemotherapy, and radiotherapy have improved management, the prognosis for advanced-stage HCC remains poor. Immunotherapy has emerged as a transformative approach, aiming to harness and modulate the immune system to target malignant cells more effectively. This review provides an updated overview of immunotherapeutic strategies in HCC, highlighting key modalities such as immune checkpoint inhibitors (ICIs), neoantigen-based vaccines, and tumor mutational burden (TMB) as predictive biomarkers of treatment response. Particular attention is given to ICIs targeting PD-1/PD-L1 and CTLA-4 pathways, as well as novel immune targets under investigation to overcome therapeutic resistance.Despite encouraging clinical outcomes, significant challenges persist, including immune evasion mechanisms, limited response rates, treatment resistance, and the complexity of the immunosuppressive tumor microenvironment. Addressing these obstacles requires integrating genomic insights, artificial intelligence-driven biomarker discovery, and rational combinatorial strategies that pair ICIs with targeted agents, chemotherapy, or radiotherapy to enhance immune activation. Future directions emphasize the development of precision immunotherapy guided by molecular profiling and predictive biomarkers to improve patient stratification and treatment efficacy. This review consolidates current progress, identifies key limitations, and outlines emerging avenues to optimize the future landscape of HCC immunotherapy.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"132-148"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leptin in metabolic-immune crosstalk: Mechanisms of T cell regulation and implications for autoimmune disease therapy. 瘦素在代谢-免疫串扰中的作用：T细胞调节机制及其对自身免疫性疾病治疗的影响。

IF 5.4 4区医学

International Reviews of Immunology Pub Date : 2026-01-01 Epub Date: 2026-06-30 DOI: 10.1080/08830185.2026.2672518

Yuezheng Xiao, Haijing Wu, Fanghan Ji, Huiming Zhang

{"title":"Leptin in metabolic-immune crosstalk: Mechanisms of T cell regulation and implications for autoimmune disease therapy.","authors":"Yuezheng Xiao, Haijing Wu, Fanghan Ji, Huiming Zhang","doi":"10.1080/08830185.2026.2672518","DOIUrl":"10.1080/08830185.2026.2672518","url":null,"abstract":"Leptin, a multifunctional hormone primarily secreted by adipose tissue, plays a crucial role in regulating body weight, appetite, energy expenditure, and metabolic processes. Beyond regulating metabolic pathways, leptin demonstrates notable immunoregulatory capabilities. It modulates a wide range of biological functions, including glycemic control, hematopoietic processes, and bone metabolism. The discovery of leptin has significantly advanced our understanding of the crosstalk between metabolic homeostasis and immune system functionality. Recent research highlights its critical role in immune responses, particularly in modulating T lymphocytes. This hormone transmits nutritional signals to the immune system, promoting pro-inflammatory Th1 and Th17 responses while inhibiting anti-inflammatory Treg cell proliferation. Consequently, it is a pivotal regulator integrating metabolic signals to control the balance between inflammation and immune tolerance. In this review, we will synthesize the latest advancements in leptin research, leptin receptor signaling, the hormone's impact on T cells and immune responses, as well as its potential pathogenic roles in autoimmune diseases, including Systemic Lupus Erythematosus (SLE), psoriasis, vitiligo, and other autoimmune disorders. Our objective is to provide a comprehensive analysis of leptin's properties and its unique roles in autoimmune conditions, with the aim of providing new insights into effective and holistic therapeutic strategies.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"290-303"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148360779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upregulation of ADAM10 reinforces CD8⁺ T cells toward exhaustion in the TME. ADAM10的上调加强了CD8+ T细胞在TME中的衰竭。

IF 5.4 4区医学

International Reviews of Immunology Pub Date : 2026-01-01 Epub Date: 2026-05-13 DOI: 10.1080/08830185.2026.2669732

Ahmed M E Abdalla, Yu Miao, Yasir A Taha, Ning Meng, Chenxi Ouyang

{"title":"Upregulation of ADAM10 reinforces CD8+ T cells toward exhaustion in the TME.","authors":"Ahmed M E Abdalla, Yu Miao, Yasir A Taha, Ning Meng, Chenxi Ouyang","doi":"10.1080/08830185.2026.2669732","DOIUrl":"10.1080/08830185.2026.2669732","url":null,"abstract":"Using cytotoxic CD8+ T cell-mediated cellular immunity has shown considerable efficacy in cancer treatment. However, the effectiveness of these cells against solid tumors is limited by the presence of an immunosuppressive tumor microenvironment (TME), which constitutes complex networks of regulatory pathways and resistance mechanisms. Given its critical role in TME deterioration through shedding of immunosuppressive molecules from tumor and immune cell surfaces, the upregulation of A Disintegrin and Metalloproteinase 10 (ADAM10) expression can reinforce CD8+ T cells into a state of exhaustion. This paper highlights the influence of ADAM10 and its proteolytic products on the primary pathways of CD8+ T cell exhaustion, including the expression of immune checkpoint molecules and modification across CD8+ T cell transcriptional, metabolic, and nutritional states. We remain optimistic about the critical role of ADAM10 in cytokine-induced T cell exhaustion, recruitment of immunosuppressive cells into the TME, and CD8+ T cell death/survival. Gaining significant insights into these processes may offer new strategies to advance CD8+ T cell-mediated cancer therapy.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"255-270"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147929630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing IBD therapy: Insights into contemporary treatment strategies. 革命性的IBD治疗：对当代治疗策略的见解。

IF 2.9 4区医学

International Reviews of Immunology Pub Date : 2026-01-01 Epub Date: 2025-09-30 DOI: 10.1080/08830185.2025.2563522

Pooja Kushwaha, Rahila Qureshi, Nooruddin Khan, Sangita Mukhopadhyay

{"title":"Revolutionizing IBD therapy: Insights into contemporary treatment strategies.","authors":"Pooja Kushwaha, Rahila Qureshi, Nooruddin Khan, Sangita Mukhopadhyay","doi":"10.1080/08830185.2025.2563522","DOIUrl":"10.1080/08830185.2025.2563522","url":null,"abstract":"Inflammatory bowel disease (IBD) varies in prevalence globally. Recent rise in IBD cases mirrors evolving health landscape due to urbanization and lifestyle changes worldwide. Existing drugs for IBD include aminosalicylates, corticosteroids, Immunomodulators, biologics, JAK inhibitors, and antibiotics. Although these medications are effective in managing symptoms and remission, these present several with limitations. Side effects such as nausea, infections, and liver toxicity are common, and some patients may develop resistance or lose response over time. Additionally, biologics can be costly, and immunosuppressive drugs raise concerns about long-term safety along increased risk of infection. Importantly, approximately 10% to 30% of the IBD patients do not respond to conventional treatments such as corticosteroids, immunosuppressants, or biologic therapies. Research continues to explore new treatments to address these limitations and improve outcomes for individuals with IBD. This review is an attempt to critically evaluate the currently available treatments for IBD underlining their limitations, and the pressing demand for innovative strategies. Further, we delve into the rationale behind peptide-based therapies, emphasizing their potential to modulate inflammation and promote mucosal healing. The work also highlights promising outcomes from recent preclinical and clinical studies underscoring the pivotal role of peptides in IBD management.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"1-25"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles and mononuclear phagocyte axis: Interactions shaping immune responses. 细胞外囊泡和单核吞噬细胞轴：形成免疫反应的相互作用。

IF 2.9 4区医学

International Reviews of Immunology Pub Date : 2026-01-01 Epub Date: 2025-10-03 DOI: 10.1080/08830185.2025.2563523

Tulio J Lopera, Gloria Vásquez, Mauricio Rojas, Diana Castaño

{"title":"Extracellular vesicles and mononuclear phagocyte axis: Interactions shaping immune responses.","authors":"Tulio J Lopera, Gloria Vásquez, Mauricio Rojas, Diana Castaño","doi":"10.1080/08830185.2025.2563523","DOIUrl":"10.1080/08830185.2025.2563523","url":null,"abstract":"Extracellular vesicles (EVs), nano-sized particles enclosed by a lipid membrane, play a pivotal role in cell-to-cell communication as essential mediators in various biological processes and diseases. Despite their ability to interact with multiple targets, EVs notably demonstrate a high affinity for specialized cells within the extracellular environment, particularly mononuclear phagocytes. The interaction between EVs and mononuclear phagocytes significantly affects the profile of these cells. Several factors, including vesicle cargo, size, parental cell origin, involved receptors, and the specific endocytic pathway, influence EVs' consequences and subsequent responses. Key components of mononuclear phagocytes, monocytes and macrophages, play a crucial role in the innate immune system, contributing to tissue damage, repair, remodeling, inflammation, homeostasis maintenance, and disease progression. Despite extensive research on EVs in various health and disease contexts, their precise impact on mononuclear phagocytes remains incompletely understood. Therefore, this review explores EVs' role in modulating monocyte and macrophage profiles and functions across different scenarios. It emphasizes that EVs actively shape the phenotype of these mononuclear phagocytes to maintain homeostasis and regulatory functions, but also induce pro-inflammatory polarization in infectious diseases, systemic inflammation, and autoimmunity. Simultaneously, during neoplastic or tumor development, the EV-mononuclear phagocyte axis prompts imbalanced responses, combining pro- and anti-inflammatory outcomes. These findings confirm EVs as promising tools for therapeutic strategies to modulate mononuclear phagocyte functions in diverse pathological settings.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"26-46"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoregulation by DC and T cells in psoriasis with probable immunotherapeutic approaches. DC和T细胞对银屑病的免疫调节及其可能的免疫治疗方法。

IF 5.4 4区医学

International Reviews of Immunology Pub Date : 2026-01-01 Epub Date: 2026-04-27 DOI: 10.1080/08830185.2026.2650139

Sharmistha Kundu, Rajat Paul, Kaustav Chakraborty

{"title":"Immunoregulation by DC and T cells in psoriasis with probable immunotherapeutic approaches.","authors":"Sharmistha Kundu, Rajat Paul, Kaustav Chakraborty","doi":"10.1080/08830185.2026.2650139","DOIUrl":"10.1080/08830185.2026.2650139","url":null,"abstract":"Psoriasis is a chronic, immune-mediated inflammatory disorder with systemic implications beyond its cutaneous manifestations. Its pathogenesis involves a complex interplay between genetic predisposition, environmental triggers, and immune dysregulation. The sustained crosstalk between dendritic cells (DCs) and T cells, which orchestrates the initiation and perpetuation of psoriatic inflammation. Plasmacytoid DCs, activated by nucleic acid-LL37 complexes, produce interferon-α that promotes myeloid DC maturation. These DCs secrete IL-12, IL-23, and TNF-α, driving differentiation of naïve T cells into Th1, Th17, and Th22 subsets. Effector T cells subsequently release cytokines such as IFN-γ, IL-17, and IL-22, which promote keratinocyte hyperproliferation, impaired differentiation, neutrophil recruitment, and angiogenesis. This DC-T cell axis forms a self-amplifying inflammatory loop that underpins disease chronicity. Conventional systemic agents, including methotrexate, cyclosporine, and retinoids, have demonstrated efficacy but are limited by nonspecific immunosuppression and significant toxicities. Advances in immunology have identified the IL-23/Th17 pathway as a pivotal therapeutic target, enabling the development of biologics and small-molecule inhibitors. Monoclonal antibodies targeting TNF-α, IL-12/23, IL-17, and IL-23 have revolutionized management, achieving high rates of sustained clearance with improved safety profiles. Additional strategies, such as PDE4 and JAK/STAT inhibitors, offer oral alternatives with targeted immunomodulation. Novel approaches, including tolerogenic DC therapy and neuroimmune modulation, hold promise for refining treatment and addressing disease heterogeneity. Effective immunotherapeutic strategies must therefore balance skin clearance with reduction of systemic inflammation and long-term comorbidity risk. Integrating mechanistic insights into DC-T cell interactions with emerging therapies provides a framework for personalized, safer, and more durable disease control.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"213-228"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria in the immune system: Therapeutic potential from mitochondria transfer. 免疫系统中的线粒体：线粒体转移的治疗潜力。

IF 2.9 4区医学

International Reviews of Immunology Pub Date : 2026-01-01 Epub Date: 2025-11-17 DOI: 10.1080/08830185.2025.2577986

Thao Hoang Nhu Le, Van Thi Tuong Nguyen

{"title":"Mitochondria in the immune system: Therapeutic potential from mitochondria transfer.","authors":"Thao Hoang Nhu Le, Van Thi Tuong Nguyen","doi":"10.1080/08830185.2025.2577986","DOIUrl":"10.1080/08830185.2025.2577986","url":null,"abstract":"Mitochondria serve as the powerhouses of living cells, supplying energy and essential building blocks for cellular activities. The immune system exhibits a dynamic and active characteristic within the body, wherein immune cells are constantly activated and primed for pathogens without causing harmful effects on the self-body. These characteristics necessitate that immune cells function effectively and correctly, supported by a sufficient energy supply and metabolism from the mitochondria. Mitochondrial dysfunction leads to immune dysregulation, resulting in inappropriate inflammation, autoimmunity, immunodeficiency, and hypersensitive responses, all of which contribute to the development of illness and disease. Recent studies on mitochondrial transfer in immune cells indicate that mitochondrial replacement could emerge as a promising tool for rectifying immune cell function. This review will emphasize the role of mitochondria in various immune cell types and explore how mitochondrial dysfunction can result in pathogenesis in different conditions. We also discuss the potential application of mitochondrial transfer and transplantation to- and from immune cells in the context of health and disease.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"47-76"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145540577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between circulating inflammatory cytokine levels and the risk of polymyositis: A bidirectional Mendelian randomization study. 循环炎症细胞因子水平与多发性肌炎风险之间的关系：一项双向孟德尔随机研究。

IF 5.4 4区医学

International Reviews of Immunology Pub Date : 2026-01-01 Epub Date: 2026-03-30 DOI: 10.1080/08830185.2026.2650140

Jiang Shao, Jinjiao Xie, Xiaoli Zheng, Xiongyan Luo, Anji Xiong

{"title":"Association between circulating inflammatory cytokine levels and the risk of polymyositis: A bidirectional Mendelian randomization study.","authors":"Jiang Shao, Jinjiao Xie, Xiaoli Zheng, Xiongyan Luo, Anji Xiong","doi":"10.1080/08830185.2026.2650140","DOIUrl":"10.1080/08830185.2026.2650140","url":null,"abstract":"Background: Analyses of the association between circulating inflammatory cytokine levels and polymyositis (PM) remains challenging because of the limitations of traditional observational studies. Therefore, we used Mendelian randomization (MR) to assess the causal relationship between the levels of 41 circulating inflammatory cytokines and the risk of PM.Methods: Using pooled data from genome-wide association studies (GWASs), we performed two-way MR analyses on two individual samples containing data for circulating inflammatory modulators (n = 8,186) and PM (n = 213,264) in patients of European ancestry. We used a random-effects inverse variance-weighted (IVW) method for our primary analysis and performed sensitivity and multiplicity analyses using MR-Egger, weighted-median, MR pleiotropy residual sum and outlier (MR-PRESSO), and Cochran's Q tests.Results: The results showed that decreased circulating levels of granulocyte colony stimulating factor (GCSF) were associated with an increased risk of PM with an odds ratio (OR) of 0.31 (95% confidence interval [CI]: 0.13-0.74, p = 0.009). PM was also associated with increased circulating levels of interleukin (IL)-13 and IL-7, with OR values of 1.03 (95% CI = 1.01-1.06, p = 0.012) and 1.03 (95% CI = 1.01-1.06, p = 0.018), respectively, and decreased circulating levels of IL-1RA (OR, 0.97; 95% CI: 0.94-0.99, p = 0.040).Conclusion: These findings suggest that GCSF plays an important role in the pathogenesis of PM and that PM also affects the expression of the cytokines IL-13, IL-7, and IL-1RA. Further studies are required to determine whether these biomarkers can be used to prevent or treat PM.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"203-212"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome-based strategies to enhance CAR-T cell therapy for systemic lupus erythematosus: A promising new frontier. 基于外泌体的策略增强CAR-T细胞治疗系统性红斑狼疮：一个有前途的新领域。

IF 5.4 4区医学

International Reviews of Immunology Pub Date : 2026-01-01 Epub Date: 2026-05-09 DOI: 10.1080/08830185.2026.2669734

Binbin Li, Ruifan Wen, Kimsor Hong, Feifeng Wu, Jueyi Mao, Xin Zhou, Haotian Xie, Xinying Qiu, Tasnim Azad, Jidong Tian, Liang Zhang, Chuan Wen

{"title":"Exosome-based strategies to enhance CAR-T cell therapy for systemic lupus erythematosus: A promising new frontier.","authors":"Binbin Li, Ruifan Wen, Kimsor Hong, Feifeng Wu, Jueyi Mao, Xin Zhou, Haotian Xie, Xinying Qiu, Tasnim Azad, Jidong Tian, Liang Zhang, Chuan Wen","doi":"10.1080/08830185.2026.2669734","DOIUrl":"10.1080/08830185.2026.2669734","url":null,"abstract":"Dysregulated B lymphocyte activation plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE), making it a promising target for therapeutic intervention. Chimeric antigen receptor T cell (CAR-T) therapy, specifically targeting CD19-positive B cells, has shown potential in selectively eliminating aberrant B cells, offering a path toward sustained remission and even complete eradication of SLE. However, the broad immunosuppressive effects and cytotoxicity associated with CAR-T therapy pose significant challenges to its application in autoimmune disease treatment. Recent advances in extracellular vesicle biology, particularly exosomes, have highlighted their potential as a cell-free therapeutic platform due to their superior biocompatibility, plasticity, and ability to modulate immune responses. CAR-T-derived or engineered exosomes represent a potential cell-free alternative to reduce cellular dose and toxicity while preserving efficacy in SLE. This review provides a comprehensive analysis of the current landscape of CAR-T cell therapy in autoimmune diseases, with a focus on its safety, effectiveness, and potential in treating SLE. Furthermore, it explores the emerging role of exosomes as a promising adjunct to traditional CAR-T therapy, offering novel perspectives and therapeutic strategies for SLE management.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":" ","pages":"271-289"},"PeriodicalIF":5.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0