International Reviews of Immunology最新文献_第2页

Macrophage: A key player in neuropathic pain. 巨噬细胞神经性疼痛的关键角色

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-04-25 DOI: 10.1080/08830185.2024.2344170

Ying Ye, Hao Cheng, Yan Wang, Yan Sun, Li-Dong Zhang, Jun Tang

引用次数: 0

Cerebral malaria pathogenesis: Dissecting the role of CD4+ and CD8+ T-cells as major effectors in disease pathology 脑疟疾发病机制：剖析 CD4+ 和 CD8+ T 细胞作为主要效应因子在疾病病理学中的作用

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-04-15 DOI: 10.1080/08830185.2024.2336539

Indu Sharma, Poonam Kataria, Jyoti Das

引用次数: 0

Boosting immune responses in lung tumor immune microenvironment: A comprehensive review of strategies and adjuvants. 增强肺部肿瘤免疫微环境中的免疫反应：策略与佐剂综述。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-03-25 DOI: 10.1080/08830185.2024.2333275

Fei Gao, Xiaoqing You, Liu Yang, Xiangni Zou, Bowen Sui

{"title":"Boosting immune responses in lung tumor immune microenvironment: A comprehensive review of strategies and adjuvants.","authors":"Fei Gao, Xiaoqing You, Liu Yang, Xiangni Zou, Bowen Sui","doi":"10.1080/08830185.2024.2333275","DOIUrl":"https://doi.org/10.1080/08830185.2024.2333275","url":null,"abstract":"The immune system has a substantial impact on the growth and expansion of lung malignancies. Immune cells are encompassed by a stroma comprising an extracellular matrix (ECM) and different cells like stromal cells, which are known as the tumor immune microenvironment (TIME). TME is marked by the presence of immunosuppressive factors, which inhibit the function of immune cells and expand tumor growth. In recent years, numerous strategies and adjuvants have been developed to extend immune responses in the TIME, to improve the efficacy of immunotherapy. In this comprehensive review, we outline the present knowledge of immune evasion mechanisms in lung TIME, explain the biology of immune cells and diverse effectors on these components, and discuss various approaches for overcoming suppressive barriers. We highlight the potential of novel adjuvants, including toll-like receptor (TLR) agonists, cytokines, phytochemicals, nanocarriers, and oncolytic viruses, for enhancing immune responses in the TME. Ultimately, we provide a summary of ongoing clinical trials investigating these strategies and adjuvants in lung cancer patients. This review also provides a broad overview of the current state-of-the-art in boosting immune responses in the TIME and highlights the potential of these approaches for improving outcomes in lung cancer patients.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Th17 cells: A new target in kidney disease research. Th17 细胞：肾病研究的新目标

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-03-05 DOI: 10.1080/08830185.2024.2321901

Tao Zhang, Hongyan Huo, Yinghui Zhang, Jie Tao, Junzheng Yang, Xianglu Rong, Yiqi Yang

引用次数: 0

Orchestration of immune response by innate lymphoid cell subtype 2 at various tumor microenvironment, a suitable target for cancer immunotherapy. 先天性淋巴细胞亚型 2 在各种肿瘤微环境中协调免疫反应，是癌症免疫疗法的合适靶点。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2023-08-21 DOI: 10.1080/08830185.2023.2247021

Rajdeep Roy, Tanmoy Das, Nabendu Biswas

{"title":"Orchestration of immune response by innate lymphoid cell subtype 2 at various tumor microenvironment, a suitable target for cancer immunotherapy.","authors":"Rajdeep Roy, Tanmoy Das, Nabendu Biswas","doi":"10.1080/08830185.2023.2247021","DOIUrl":"10.1080/08830185.2023.2247021","url":null,"abstract":"Innate lymphoid cells are a mixed population of cells and critical regulators of our innate immune system. According to recent scientific literature, tissue resident innate lymphoid cell subtype 2 has been recognized as an important player of type 2 inflammatory responses, involved in different human malignancies like pancreatic, lung, acute myeloid leukemia, gastrointestinal tract cancer, etc. The current reports have revealed that, among the three main ILC sub types, subtype 2 (ILC 2), as the key regulator of initiating the type 2 inflammatory responses at the tumor microenvironment (TME). This activation of ILC-2 is a very important step for the specific downstream functioning of ILC-2. Priming of ILC-2 with different chemokines involves different cytokine secretion from the activated ILC-2 like IL-4, IL-5, IL-13, IL-9 which induce type 2 inflammatory responses involved in the complex interaction with other immune cells like NK cell, Cytotoxic T cell, MDSC and Treg cell. At the initial stage, ILC-2 activation through IL-33 may induce the anti-tumorigenic effect mediated by ILC-2/eosinophil axis. However, it is also evident that PDG2 (Prostaglandin D2)-mediated activation of ILC-2 induces the ILC-2/MDSC immune suppressive pro-tumorigenic niche at the TME. Here, in this review, we have summarized the function of ILC-2 on cancer immunity based on recent scientific work which indicates ILC-2 plays a dual role and orchestrates the immune responses toward type 2 immunity in different cancer settings.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10031627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholesterol: A friend to viruses. 胆固醇病毒的朋友

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2024-02-19 DOI: 10.1080/08830185.2024.2314577

Yingchun Wang, Lifen Gao

引用次数: 0

Natural and genetically-modified animal models to investigate pulmonary and extrapulmonary manifestations of COVID-19. 研究 COVID-19 肺部和肺外表现的天然和基因改造动物模型。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2022-06-25 DOI: 10.1080/08830185.2022.2089666

Shikha Tiwari, Garima Goel, Ashok Kumar

{"title":"Natural and genetically-modified animal models to investigate pulmonary and extrapulmonary manifestations of COVID-19.","authors":"Shikha Tiwari, Garima Goel, Ashok Kumar","doi":"10.1080/08830185.2022.2089666","DOIUrl":"10.1080/08830185.2022.2089666","url":null,"abstract":"Coronavirus disease-19 (COVID-19), a pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), is a primarily respiratory tract disease. Suitable animal models for COVID-19 are required to study various aspects of pathogenesis, drug discovery, effective and safe vaccine development. Several laboratory animals including, non-human primates, hamsters, ferrets, transgenic mice, and zebrafish, have been used and proven their significance experimentally. Currently available animal models of SARS-CoV-2 can be broadly classified into two categories 1) natural animal models 2) genetically-modified that exhibit different degrees of susceptibility of SARS-CoV-2, tissue damage in respiratory and other organ systems. Not all the available animal models mimic COVID-19-like phenotype completely. Therefore, understanding various aspects of COVID-19 requires different animal models. In this review article, we provide an update on the immune response and clinical manifestations observed in naturally occurring and genetically-modified animals of COVID-19. We then review the transmission, viral replication, lung pathology, immunological aspects, and extrapulmonary phenotypes observed in various animal models. In the end, we put forth our perspective on the anticipated uses, disadvantages, and limitations of each type of animal model.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40399161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Circulating and intestinal regulatory T cells in inflammatory bowel disease: A systemic review and meta-analysis. 炎症性肠病中的循环和肠道调节性 T 细胞：系统回顾与荟萃分析

IF 4.3 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2023-08-24 DOI: 10.1080/08830185.2023.2249525

Shihao Duan, Yubin Cao, Pingrun Chen, Yi Yang, Yan Zhang

{"title":"Circulating and intestinal regulatory T cells in inflammatory bowel disease: A systemic review and meta-analysis.","authors":"Shihao Duan, Yubin Cao, Pingrun Chen, Yi Yang, Yan Zhang","doi":"10.1080/08830185.2023.2249525","DOIUrl":"10.1080/08830185.2023.2249525","url":null,"abstract":"Regulatory T cells (Tregs) play an important immunosuppressive role in inflammatory bowel disease (IBD). However, findings on the quantitative and functional changes of intestinal and circulating Tregs in patients with IBD are rather contradictory. We therefore conducted a meta-analysis on this issue. The pooled effect was assessed using the standardized mean difference (SMD) with a 95% confidence interval (CI), and subgroup analyses were performed to investigate heterogeneity. This analysis included 764 IBD (402 UC and 362 CD) patients and 341 healthy controls (HCs) pooled from 17 eligible studies. The percentage of circulating Tregs was significantly decreased in active IBD patients compared to HCs (SMD = -0.95, p < 0.001) and inactive IBD patients (SMD = -0.80, p < 0.001). There was no difference in the percentage of circulating Tregs between inactive IBD patients and HCs. The suppressive function of circulating Tregs was impaired in active IBD patients according to limited data (SMD = -0.75, p = 0.02). Besides, the percentage of intestinal Tregs was significantly higher in inflamed regions than in non-inflamed regions (SMD = 0.85, p < 0.001). Our study quantitatively summarized the quantitative and functional changes of Tregs and supported the therapeutic potential of Tregs in IBD. Moreover, additional research into the functions and characteristics of intestinal Tregs in IBD is needed.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10435129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemokines: A key driver for inflammation in protozoan infection. 趋化因子:原生动物感染炎症的关键驱动因素。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2023-11-19 DOI: 10.1080/08830185.2023.2281566

Rubika Chauhan, Mrinalini Tiwari, Amrendra Chaudhary, Reva Sharan Thakur, Veena Pande, Jyoti Das

{"title":"Chemokines: A key driver for inflammation in protozoan infection.","authors":"Rubika Chauhan, Mrinalini Tiwari, Amrendra Chaudhary, Reva Sharan Thakur, Veena Pande, Jyoti Das","doi":"10.1080/08830185.2023.2281566","DOIUrl":"10.1080/08830185.2023.2281566","url":null,"abstract":"Chemokines belong to the group of small proteins within the cytokine family having strong chemo-attractant properties. In most cases, the strong immuno-modulatory role of chemokines is crucial for generating the immune response against pathogens in various protozoan diseases. In this review, we have given a brief update on the classification, characterization, homeostasis, transcellular migration, and immuno-modulatory role of chemokines. Here we will evaluate the potential role of chemokines and their regulation in various protozoan diseases. There is a significant direct relationship between parasitic infection and the recruitment of effector cells of the immune response. Chemokines play an indispensable role in mediating several defense mechanisms against infection, such as leukocyte recruitment and the generation of innate and cell-mediated immunity that aids in controlling/eliminating the pathogen. This process is controlled by the chemotactic movement of chemokines induced as a primary host immune response. We have also addressed that chemokine expressions during infection are time-dependent and orchestrated in a systematic pattern that ultimately assists in generating a protective immune response. Taken together, this review provides a systematic understanding of the complexity of chemokines profiles during protozoan disease conditions and the rationale of targeting chemokines for the development of therapeutic strategies.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138046886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiome as a treatment in colorectal cancer. 将肠道微生物组作为结直肠癌的治疗手段。

IF 5 4区医学

International Reviews of Immunology Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1080/08830185.2024.2312294

Murad Khan, Suleman Shah, Wahid Shah, Ikram Khan, Hamid Ali, Ijaz Ali, Riaz Ullah, Xiufang Wang, Arshad Mehmood, Yanli Wang

{"title":"Gut microbiome as a treatment in colorectal cancer.","authors":"Murad Khan, Suleman Shah, Wahid Shah, Ikram Khan, Hamid Ali, Ijaz Ali, Riaz Ullah, Xiufang Wang, Arshad Mehmood, Yanli Wang","doi":"10.1080/08830185.2024.2312294","DOIUrl":"10.1080/08830185.2024.2312294","url":null,"abstract":"Background: The gut microbiome plays a role in the development and progression of colorectal cancer (CRC).Aim and objective: This review focuses on whether the gut microbiome is involved in the development and regulation of the host immune system.Methods: The gut microbiome can influence the production and activity of immune cells and molecules that help to maintain the integrity of the intestinal barrier and prevent inflammation. Gut microbiota modulates the anti-cancer immune response. The gut microbiota can influence the function of immune cells, like T cells, that recognize and eliminate cancer cells. Gut microbiota can affect various aspects of cancer progression and the efficacy of various anti-cancer treatments.Results: Gut microbiota provide promise as a potential biomarker to identify the effect of immunotherapy and as a target for modulation to improve the efficacy of immunotherapy in CRC treatment.Conclusion: The potential synergistic effect between the gut microbiome and anti-cancer treatment modalities provides an interest in developing strategies to modulate the gut microbiome to improve the efficacy of anti-cancer treatment.","PeriodicalId":14333,"journal":{"name":"International Reviews of Immunology","volume":null,"pages":null},"PeriodicalIF":5.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0