An insight into COVID-19 host immunity at single-cell resolution.

IF 4.3 4区医学 Q2 IMMUNOLOGY

International Reviews of Immunology Pub Date : 2024-12-21 DOI:10.1080/08830185.2024.2443420

Supratim Ghosh, Ankita Chatterjee, Arindam Maitra

引用次数: 0

Abstract

Host immunity helps the body to fight against COVID-19. Single-cell transcriptomics has provided the scope of investigating cellular and molecular underpinnings of host immune response against SARS-CoV-2 infection at high resolution. In this review, we have systematically described the virus-induced dysregulation of relative abundance as well as molecular behavior of each innate and adaptive immune cell type and cell state during COVID-19 infection and for different vaccinations, based on single-cell studies published in last three-four years. Identification and characterization of these disease-associated specific cell populations might help to design better, efficient, and targeted therapeutic avenues.

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在单细胞分辨率下洞察COVID-19宿主免疫。

宿主免疫有助于身体对抗COVID-19。单细胞转录组学为高分辨率研究宿主对SARS-CoV-2感染免疫反应的细胞和分子基础提供了范围。在这篇综述中，我们基于过去3 - 4年发表的单细胞研究，系统地描述了在COVID-19感染和不同疫苗接种期间，病毒诱导的每种先天和适应性免疫细胞类型和细胞状态的相对丰度失调以及分子行为。识别和表征这些疾病相关的特定细胞群可能有助于设计更好、更有效和更有针对性的治疗途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Reviews of Immunology 医学-免疫学

CiteScore

11.00

自引率

4.00%

发文量

期刊介绍： This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).