Immunological processes of enhancers and suppressors of long non-coding RNAs associated with brain tumors and inflammation.

IF 4.3 4区 医学 Q2 IMMUNOLOGY
International Reviews of Immunology Pub Date : 2024-05-01 Epub Date: 2023-11-17 DOI:10.1080/08830185.2023.2280581
Hossein Tahmasebi Dehkordi, Fatemeh Khaledi, Sorayya Ghasemi
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引用次数: 0

Abstract

Immunological processes, such as inflammation, can both cause tumor suppression and cancer progression. Moreover, deregulated levels of long non-coding RNA (lncRNA) expression in the brain may cause inflammation and lead to the growth of tumors. Like other biological processes, the immune system's role in cancer is complicated, varies, and can help or hurt the cancer's maintenance. According to research, inflammation and brain cancer are correlated via several signaling pathways. A variety of lncRNAs have recently been revealed to influence cancer by modulating inflammatory pathways. As a result, lncRNAs have the potential to influence carcinogenesis, tumor formation, or tumor suppression via an increase or decrease in inflammation functions. Although the study and targeting of lncRNAs have made great progress in the treatment of cancer, there are definitely limitations and challenges. Using new technologies like nanocarriers and cell-penetrating peptides (CPPs) to target treatments without hurting healthy body tissues has shown to be very effective. In this review article, we have collected significantly related lncRNAs and their inhibitory or stimulating roles in inflammation and brain cancer for the first time. However, there are limitations, such as side effects and damage to normal tissues. With the advancement of new targeting technologies, these lncRNAs may be candidates for the specific targeting therapy of brain cancers by limiting inflammation or stimulating the immune system against them in the future.

与脑肿瘤和炎症相关的长链非编码rna的增强子和抑制子的免疫过程。
免疫过程,如炎症,既可以抑制肿瘤又可以导致癌症进展。此外,大脑中长链非编码RNA (lncRNA)表达水平的失调可能引起炎症并导致肿瘤的生长。像其他生物过程一样,免疫系统在癌症中的作用是复杂的,多变的,可以帮助或损害癌症的维持。根据研究,炎症和脑癌通过几种信号通路相互关联。最近发现多种lncrna通过调节炎症途径影响癌症。因此,lncRNAs有可能通过增加或减少炎症功能来影响致癌、肿瘤形成或肿瘤抑制。尽管lncrna的研究和靶向治疗在癌症治疗方面取得了很大进展,但也存在一定的局限性和挑战。使用纳米载体和细胞穿透肽(CPPs)等新技术来靶向治疗而不伤害健康的身体组织已被证明是非常有效的。在这篇综述文章中,我们首次收集到显著相关的lncrna及其在炎症和脑癌中的抑制或刺激作用。然而,也有局限性,比如副作用和对正常组织的损伤。随着新的靶向技术的进步,这些lncrna可能成为未来脑癌特异性靶向治疗的候选者,通过限制炎症或刺激免疫系统来对抗它们。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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