International journal of ophthalmology最新文献

{"title":"Long-term retinal microvascular alterations after endoscopic endonasal surgery in patients with sellar region tumors.","authors":"Sebnem Kaya Ergen, Anil Ergen, Busra Gunduz, Ecem Cemre Ceylan, Sevgi Subasi, Melih Caklili, Burak Cabuk, Ihsan Anik, Savas Ceylan","doi":"10.18240/ijo.2025.08.13","DOIUrl":"10.18240/ijo.2025.08.13","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate retinal microcirculation changes at the 3^rd and 12^th months following endoscopic endonasal surgery in patients with sellar region tumors using optical coherence tomography angiography (OCT-A).</p><p><strong>Methods: </strong>This prospective longitudinal observational study included 78 eyes of 39 patients with sellar tumors and 78 eyes of 39 age- and gender-matched healthy controls. Standard automated perimetry and OCT-A were performed preoperatively and at 3- and 12-month follow-ups. Visual field (VF) recovery was assessed using mean deviation (MD) values, and correlations between preoperative structural parameters and postoperative visual outcomes were analyzed.</p><p><strong>Results: </strong>Baseline OCT-A values revealed significantly reduced papillary and foveal vessel densities in almost all quadrants in sellar tumor patients compared to controls (<i>P</i><0.05, respectively). While VF MD values improved significantly postoperatively (<i>P</i><0.001), no significant improvement was observed in microvascular vessel density or retinal nerve fiber layer (RNFL) thickness (<i>P</i>>0.05, respectively); instead, a tendency toward reduction was noted over 12mo. Correlation analysis between postoperative MD values and preoperative parameters showed a strong positive correlation with the superior quadrant of papillary vessel density (<i>r</i>=0.703, <i>P</i><0.001) and RNFL thickness (<i>r</i>=0.518, <i>P</i><0.001).</p><p><strong>Conclusion: </strong>Although decompressive surgery improves visual function, retinal microvascular alterations appear to deteriorate over time. These findings suggest that irreversible neurovascular damage occurs despite surgical intervention, emphasizing the importance of early diagnosis and treatment in patients with chiasmal compression. OCT-A may serve as a valuable prognostic tool for assessing structural and functional recovery in these patients.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1515-1521"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obtusifolin ameliorates dry eye model in rats by reducing inflammation and blocking MAPK/NF-κB pathways.","authors":"Dan Zhu, Xiao-Yang Wu, Liang-Chang Li","doi":"10.18240/ijo.2025.08.02","DOIUrl":"10.18240/ijo.2025.08.02","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the functions and potential mechanisms of obtusifolin in dry eye disease (DED) in a rat model.</p><p><strong>Methods: </strong>A rat DED model was established <i>via</i> topical administration of benzalkonium chloride (BAC), followed by administration of obtusifolin. Conjunctival irritation score and tear production were measured to evaluate DED symptoms. Enzyme-linked immunosorbent assay (ELISA) was employed for determining inflammatory cytokine levels in rat conjunctiva. Periodic acid-Schiff staining and corneal fluorescein staining were implemented for assessing goblet cell numbers and corneal epithelial defects, respectively. Western blotting showed zonula occludens-1 (ZO-1), matrix metalloproteinase-9 (MMP-9), and mitogen-activated protein kinase (MAPK)/nuclear factor kappa B (NF-κB) signaling-related protein levels in the conjunctiva.</p><p><strong>Results: </strong>Topical application of obtusifolin alleviated conjunctival irritation and enhanced tear production in BAC-induced DED rats. Obtusifolin attenuated conjunctival inflammatory response and goblet cell loss as well as corneal epithelial barrier disruption in DED rats. Obtusifolin suppressed extracellular signal-regulated kinase (ERK), p38, and NF-κB phosphorylation in the conjunctiva of DED rats.</p><p><strong>Conclusion: </strong>Obtusifolin ameliorates DED in rats possibly by alleviating inflammation <i>via</i> the inactivation of MAPK/NF-κB signaling.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1426-1432"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does uveitis increase the risk of age-related wet macular degeneration? A Mendelian randomization study.","authors":"Rui-Hua Jing, Deng-Ke Zhou, Zhuo-Yan Yang, Zhao-Dan Ding, Jia-Hui Deng, Yao Xing, Xiao-Feng Chen","doi":"10.18240/ijo.2025.08.09","DOIUrl":"10.18240/ijo.2025.08.09","url":null,"abstract":"<p><strong>Aim: </strong>To use two-sample Mendelian randomization (MR) method to study uveitis causal association with wet age-related macular degeneration (wAMD) risk from the genetic level.</p><p><strong>Methods: </strong>Two-sample MR analysis was used to assess the causal role of uveitis on wAMD risk, using the 8 genetic variants associated strongly with uveitis as instrumental variables. Besides, eight MR methods [inverse variance weighted (IVW), weighted median, MR-Egger regression, weighted mode, simple mode, robust adjusted profile score (RAPS), contamination inverse-variance weighted method, and debiased inverse-variance weighted method] were used to get the whole causal estimate for multiple instrumental single nucleotide polymorphism (SNPs). The MR analysis was based on Europeans.</p><p><strong>Results: </strong>Uveitis was related to a higher risk of wAMD [odds ratio (OR): 1.08, 95% confidence interval (CI) 1.03-1.12; <i>P</i>=1.03×10^-3] with the IVW method. No heterogeneity and directional pleiotropy were detected. On the contrary, no significant results were detected in reverse MR analysis.</p><p><strong>Conclusion: </strong>Uveitis is related to an increased risk of wAMD. Due to the high blindness rate of wAMD, understanding and controlling the risk factors of AMD is of great significance for reducing its incidence and early diagnosis and treatment.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1484-1489"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of fibrosis formation following glaucoma filtration surgery.","authors":"Wei-Dao Zhang, Xin Li, Jun Feng, Jie Chen","doi":"10.18240/ijo.2025.08.21","DOIUrl":"10.18240/ijo.2025.08.21","url":null,"abstract":"<p><p>Glaucoma filtration surgery (GFS) stands as the most effective intervention for reducing intraocular pressure, a critical component in glaucoma management. Despite its pivotal role, the scarring of the filtration bleb remains the primary impediment to successful GFS outcomes. Perioperative utilization of antimitotics, while frontline in combating fibrosis and modulating the wound healing process, carries the risk of vision-threatening complications. Given the complexity of the wound healing cascade and the potential insufficiency of targeting a single molecule, there is an imperative to expand therapeutic modalities through combination therapies. This review offers a comprehensive elucidation of the fibrogenesis post-GFS, a synthesis unprecedented in the available literature, and aims to inform the broadening of therapeutic strategies for GFS.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1579-1586"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanopore targeted sequencing identifies pathogens in patients with postoperative endophthalmitis.","authors":"Xin-Lei Hao, Man Yuan, Ming Wang, Ai-Si Fu, Jia-Shuang Gu, Bing-Qian Yang, Wei Jin, An-Huai Yang","doi":"10.18240/ijo.2025.08.17","DOIUrl":"10.18240/ijo.2025.08.17","url":null,"abstract":"<p><strong>Aim: </strong>To estimate if nanopore targeted sequencing (NTS) could identify pathogens causing postoperative endophthalmitis and further determine the feasibility of clinical application of NTS.</p><p><strong>Methods: </strong>A total of 55 patients (55 eyes) with postoperative endophthalmitis were retrospectively included in this study with their medical records. Intraocular fluid samples were examined by NTS and microbial culture. All included patients had undergone examinations including measurement of best corrected visual acuity (BCVA) and intraocular pressure (IOP), slit-lamp biomicroscopy, and indirect ophthalmoscopy; additionally, they underwent B-ultrasound, anterior segment photography, and fundus photography if necessary.</p><p><strong>Results: </strong>Among 55 patients with postoperative endophthalmitis, the age was 65.25±15.04y and there were 30 female (54.54%) patients. Forty-one (74.54%) vitreous humor samples and fourteen (25.45%) aqueous humor samples were sent for both NTS and microbial culture. NTS had a notable higher detection rate than microbial culture in detecting pathogens (90.91% <i>vs</i> 38.18%, <i>χ</i> ²=33.409, <i>P</i><0.001). NTS exhibited high sensitivity of pathogen detection in both microbial culture positive and negative samples (100% and 85.29%, respectively). In 16 of 21 (76.19%) patients who showed culture-positivity, their results corresponded with those of NTS. Moreover, in two patients (9.52%), NTS showed a better species resolution than microbial culture; in three patients (14.28%), NTS identified additional pathogens. As for fungus, the positive detection rate of NTS was significantly higher than that of microbial culture (20% <i>vs</i> 3.64%, <i>χ</i> ²=7.066, <i>P</i>=0.008). Also, NTS could detect multi-infection by bacteria and fungi than microbial culture (32.73% <i>vs</i> 0, <i>χ</i> ²=21.522, <i>P</i><0.001). NTS could detect bacteria as well as fungi simultaneously within 48h in all patients. Meanwhile, NTS had a shorter detection time than microbial culture (1.13±0.34 <i>vs</i> 2.67±0.55d, <i>Z</i>=-9.218, <i>P</i><0.001). After the NTS results were obtained, 15 patients received additional intravitreal/intracameral anti-infection treatment. At follow-up, there was a statistically significant improvement in the visual acuity relative to the baseline (<i>Z</i>=-5.222, <i>P</i><0.001).</p><p><strong>Conclusion: </strong>NTS can provide rapid identification and highly sensitive detection of pathogens among patients with postoperative endophthalmitis, which can guide anti-infection treatment and improve visual prognosis.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1544-1552"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple procedure for management of traumatic aphakia, glaucoma and mydriasis.","authors":"Bin Chen, Yan-Ting Li, Yun-Feng Lu","doi":"10.18240/ijo.2025.08.24","DOIUrl":"10.18240/ijo.2025.08.24","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1603-1605"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of asymmetric offset versus pupil centered ablation in refractive surgery.","authors":"Hassan Hashemi, Mojgan Pakbin, Alireza Hashemi, Mohammadreza Aghamirsalim, Mehdi Khabazkhoob","doi":"10.18240/ijo.2025.08.16","DOIUrl":"10.18240/ijo.2025.08.16","url":null,"abstract":"<p><strong>Aim: </strong>To compare the visual and optical outcomes following femtosecond laser <i>in situ</i> keratomileusis (FS-LASIK) using an aberration neutral profile with asymmetric offset (AO) and pupil center (PC) treatments.</p><p><strong>Methods: </strong>In this randomized double-blind clinical trial study, 48 (24 cases) and 38 eyes (19 cases) underwent myopic astigmatism and hyperopic astigmatism LASIK. One eye of each individual was randomly assigned to AO centration and the fellow eye underwent the PC-centered method. The clinical outcomes including uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), safety and efficacy indexes, subjective spherical equivalent (SE) and corneal high-order aberrations (HOAs) were measured at baseline and 6mo postoperatively.</p><p><strong>Results: </strong>In the myopic group, the mean preoperative SE and astigmatism were -4.12±0.87 (-2.88 to -6.00) diopter (D) and -0.88±0.79 (0 to -2.75) D, respectively. In the hyperopic group, the mean preoperative SE and astigmatism were 0.93±0.59 (-0.25 to 2.25) D and -0.73±1.00 (0 to -4.25) D, respectively. At 6mo postoperatively, the safety and efficacy indexes were similar for centration in myopic and hyperopic LASIK groups. In the myopic group, significant changes were found in horizontal trefoil (<i>P</i>=0.041) and oblique trefoil (<i>P</i>=0.031) in favor of AO centration treatment.</p><p><strong>Conclusion: </strong>Femtosecond-LASIK is a safe and efficacious procedure for treatment of myopic and hyperopic astigmatism. AO-centered and PC-centered approaches provide similar visual and refractive outcomes. Myopic astigmatism LASIK with AO centration leads to slightly better corneal aberration outcomes.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1537-1543"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two cases of lamellar macular hole secondary to the rupture of the cystoid inner wall in patients with diabetic macular edema.","authors":"Zhi-Hui Dong, Jia-Yu Zhang, Chao-Yang Zhang, Zhen-Guo Chen, Jing-Fa Zhang","doi":"10.18240/ijo.2025.08.26","DOIUrl":"10.18240/ijo.2025.08.26","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1610-1612"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of interferon regulatory factor 8 dysregulation with dry eye in Sjögren's syndrome.","authors":"Jiao Wang, Guang-Hong Chu, Zi-Huan Wang, Xiao-Yu Cai, Si-Yuan Shi, Qi-Ping Qing, Qi Zhang","doi":"10.18240/ijo.2025.08.05","DOIUrl":"10.18240/ijo.2025.08.05","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the expression of interferon regulatory factors (IRFs) in peripheral blood mononuclear cells (PBMCs) of patients with Sjögren's syndrome-related dry eye (SSDE) and to explore their correlation with clinical features, dendritic cell activation, and serological indicators.</p><p><strong>Methods: </strong>A total of 53 SSDE patients and 62 non-Sjögren's syndrome dry eye (NSSDE) patients were enrolled. Demographic and clinical data were collected, and comprehensive ophthalmic examinations were performed, including the ocular surface disease index (OSDI) questionnaires, Schirmer I test (SIT), tear break-up time (TBUT), corneal fluorescein staining score (CFS), and <i>in vivo</i> confocal microscopy (IVCM). PBMCs were isolated, and IRFs expression levels were analyzed using Western blotting (WB) and quantitative real-time polymerase chain reaction (qRT-PCR). Serological indicators, including antinuclear antibodies (ANA) and anti-Ro60, anti-Ro52, and anti-La autoantibodies, were detected. Statistical analyses evaluated correlations between IRFs expression and clinical parameters.</p><p><strong>Results: </strong>Compared to NSSDE, the relative mRNA and protein expression of the IRF-8 was significantly upregulated in patients with SSDE (<i>P</i><0.001), whereas no significant differences were observed in IRF-1, IRF-3, IRF-5, and IRF-7 (<i>P</i>=0.12, <i>P</i>=0.10, <i>P</i>=0.66, <i>P</i>=0.96). Correlation analysis revealed that IRF-8 expression was positively associated with CFS and OSDI scores (<i>r</i>=0.57, <i>r</i>=0.38, both <i>P</i><0.05). Moreover, IRF-8 expression correlated with corneal dendritic cell (DC) density and size, and the number of dendrites (<i>r</i>=0.43, <i>r</i>=0.40, <i>r</i>=0.65, all <i>P</i><0.05). IRF-8 expression was significantly elevated in patients positive for anti-Ro60, anti-Ro52 and anti-La autoantibodies (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>In SSDE, IRF-8 is upregulated and associated with clinical features, DC activation, and serological indicators. These findings suggest that IRF-8 plays a critical role in SSDE pathogenesis and may serve as a potential therapeutic target for diagnosis and treatment.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1456-1463"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression of myopia among school-aged children in Guangzhou, China.","authors":"Kun Huang, Zhi-Dan Wu, Ze-Hao Chen, Jin Chen, Zhuo-Ming Tang, Rong Lin","doi":"10.18240/ijo.2025.08.19","DOIUrl":"10.18240/ijo.2025.08.19","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the prevalence and characteristics of myopia in school-aged students and effects of environmental and genetic factors on the progression of myopia.</p><p><strong>Methods: </strong>A total of 2422 students aged between 5 and 18y from nine schools in Baiyun District of Guangzhou, China were sampled using a stratified sampling method in 2020. Among them, 1066 students participated in the follow-up survey the following year. Data were obtained based on ocular examinations and a questionnaire survey conducted during two visits. Factors potentially influencing the progression of myopia were analyzed.</p><p><strong>Results: </strong>During the year assessed in this study, the percentage of students with myopia increased from 58.4% to 64.8% (<i>P</i>=0.002). Spherical equivalent (SE) progressed from -1.44±1.91 diopters (D) at baseline to -1.66±1.10 D (<i>P</i>=0.005). A generalized estimating equation (GEE) model revealed that age [adjusted odds ratio (aOR)=1.298, <i>P</i><0.001], residential students (aOR=2.428, <i>P</i>=0.018), parental myopia (one myopic parent: aOR=1.553, both parents myopic: aOR=2.609, <i>P</i><0.001), frequent reading of books or viewing of screens in direct sunlight (aOR=3.502, <i>P</i>=0.023), using only overhead lighting for reading and writing at night (aOR=1.633, <i>P</i>=0.011), parental restrictions on exercise time (aOR=2.286, <i>P</i>=0.012), and having less than 2h of outdoor exercise per day during the past week (aOR=1.584, <i>P</i>=0.019) were all identified as independent risk factors for progression of myopia.</p><p><strong>Conclusion: </strong>Our findings in this study indicate that age, residential students, parental myopia, indoor lighting environment, and physical activity have significant effects on the progression of myopia, providing evidence for further in-depth mechanistic interpretation and efficient intervention strategies for school-age children in this area.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1561-1569"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}