International journal of ophthalmology最新文献

{"title":"Pars plana vitrectomy with tissue plasminogen activator for traumatic submacular hemorrhage.","authors":"Wilson X Wang, Kishan G Patel, Henok Getahun, Srishti Ramamurthy, Howard Chen, Raja Narayanan, Rajendra S Apte","doi":"10.18240/ijo.2025.09.22","DOIUrl":"10.18240/ijo.2025.09.22","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate visual outcomes of pars plana vitrectomy (PPV) combined with tissue plasminogen activator (tPA)-induced clot lysis and pneumatic displacement for submacular hemorrhage (SMH) in a cohort of closed-globe trauma patients.</p><p><strong>Methods: </strong>A retrospective, multicenter interventional case series involving 7 eyes of 7 patients who underwent PPV with subretinal tPA administration for SMH secondary to closed-globe injury were conducted. The primary outcome measure was the change in Snellen visual acuity.</p><p><strong>Results: </strong>The mean age of patients was 32y (range: 21-51y), with a mean follow-up duration of 4.6mo (range: 1.1-14.9mo). The average best-corrected visual acuity (BCVA) was 20/1020 at baseline and 20/114 at the final visit, respectively (<i>P</i>=0.025). Preoperative BCVA was not a significant predictor of final BCVA (<i>r</i>=0.102, <i>P</i>=0.827). Final BCVA did not differ significantly between patients who underwent PPV within 14d of symptom onset and those who underwent surgery after 14d (<i>P</i>=0.57). All eyes received SF₆ or C₃F₈ gas tamponade.</p><p><strong>Conclusion: </strong>Surgical intervention involving tPA-mediated clot lysis and pneumatic displacement may yield visual benefits in trauma-induced SMH without underlying retinal vascular disease; however, larger prospective studies are warranted to confirm these findings.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 9","pages":"1797-1802"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of repetitive bilateral suprachoroidal expulsive hemorrhage after anti-glaucoma surgeries.","authors":"Xian Zhang, Rong Liu, Yang-Yang Du, Chao Ye, Ke Liu, Yun Li","doi":"10.18240/ijo.2025.09.23","DOIUrl":"10.18240/ijo.2025.09.23","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 9","pages":"1803-1805"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning applications for diabetic retinopathy and retinopathy of prematurity diseases diagnosis: a systematic review.","authors":"Elizabeth Ndunge Mutua, Bernard Shibwabo Kasamani, Christoph Reich","doi":"10.18240/ijo.2025.08.23","DOIUrl":"10.18240/ijo.2025.08.23","url":null,"abstract":"<p><p>To review the existing deep learning applications for diagnosing diabetic retinopathy and retinopathy of prematurity diseases, the available public retinal databases for the diseases and apply the International Journal of Medical Informatics (IJMEDI) checklist were assessed the quality of included studies; an in-depth literature search in Scopus, Web of Science, IEEE and ACM databases targeting articles from inception up to 31^st January 2023 was done by two independent reviewers. In the review, 26 out of 1476 articles with a total of 36 models were included. Data size and model validation were found to be challenges for most studies. Deep learning models are gaining focus in the development of medical diagnosis tools and applications. However, there seems to be a critical issue with most of the studies being published, with some not including information about data sources and data sizes which is important for their performance verification.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1594-1602"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous endophthalmitis due to <i>Klebsiella pneumoniae</i> liver abscess: a retrospective study of clinical course, treatment pattern, and prognosis.","authors":"Gyu Chul Chung, Dong Sun Kim, Ji Eun Lee, Iksoo Byon, Sung Who Park, Han Jo Kwon, EunAh Kim","doi":"10.18240/ijo.2025.08.18","DOIUrl":"10.18240/ijo.2025.08.18","url":null,"abstract":"<p><strong>Aim: </strong>To report the demographic and systemic characteristics of patients, clinical progression of endophthalmitis, and the efficacy of various treatment strategies, with a focus on identifying key factors for preserving vision in eyes with endogenous endophthalmitis due to <i>Klebsiella pneumoniae</i> (<i>K. pneumoniae</i>) liver abscess.</p><p><strong>Methods: </strong>In this single-center, retrospective case series of 18 patients with endogenous endophthalmitis due to <i>K. pneumoniae</i> liver abscess were analyzed. Ophthalmologic features of endophthalmitis at early, intermediate and advanced stages were obtained from eyes with endophthalmitis of different severities. Prompt vitrectomy was considered primarily for all eyes except for very early endophthalmitis. Intravitreal injections of antibiotics were performed in eyes with endophthalmitis in the very early stages and in eyes where vitrectomy was not available, and additional control of infection was needed after vitrectomy. Evisceration was performed in eyes with corneoscleral perforation, advanced endophthalmitis, perforation with preseptal or orbital cellulitis, uncontrolled infection, or severe pain with no vision.</p><p><strong>Results: </strong>Mean (±standard deviation) age of the 18 patients with endophthalmitis was 64.5±12.2 (range: 32-84)y, and 14 patients (77.8%) were males. Endophthalmitis tended to involve the retinal parenchyma first and then progressed into the vitreous cavity and anterior segments. However, it presented a tendency to cause massive subretinal abscesses even after vitrectomy with silicone oil tamponade. Very high intraocular pressure with new vessels on the iris (41.7%) were also commonly observed. Although all but three patients had systemic disease such as diabetes or hypertension, visual prognosis after treatment did not appear to depend significantly on underlying comorbidities. A final best-corrected visual acuity better than 20/60 was achieved only when lesions were detected very early, with relatively good initial visual acuity, likely reflecting lower bacterial inoculation in the eye.</p><p><strong>Conclusion: </strong>Detection of early endophthalmitis lesions appears to be the only way to preserve good vision in patients with <i>K. pneumoniae</i> liver abscesses. Therefore, proper guidelines for ophthalmologic screening remain to be established for subjects at a high risk of endophthalmitis.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1553-1560"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nd:YAG laser peripheral iridotomy for reverse pupillary block: a case report.","authors":"Ze-Yu Zhang, Zhi-Qiao Liang, Yong-Zhen Bao","doi":"10.18240/ijo.2025.08.25","DOIUrl":"10.18240/ijo.2025.08.25","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1606-1609"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optical coherence tomography angiography.","authors":"Yan-Mei Shi, Xiao Xie, Wen-Qi Wang, Xiao-Meng Yuan, Zhi-Ping Zhang, Hong-Yan Wang, Jie Meng, Ze-Hao Kong, Xia Jing, Ting-Ting Liu","doi":"10.18240/ijo.2025.08.10","DOIUrl":"10.18240/ijo.2025.08.10","url":null,"abstract":"<p><strong>Aim: </strong>To quantitatively assess central macular thickness (CMT), macular neovascularization (MNV) area, vascular tortuosity (VT), and vascular dispersion (VDisp) in neovascular age-related macular degeneration (nAMD), type 1 and type 2 MNV, by means of optical coherence tomography (OCT) and OCT angiography (OCTA) techniques.</p><p><strong>Methods: </strong>In this retrospective and observational case series, patients were classified into type 1 or type 2 MNV groups. A comprehensive panel of OCT and OCTA metrics was evaluated, including CMT, MNV area, VT, and VDisp. All subjects underwent a standardized intravitreal conbercept (IVC) regimen [3+<i>pro re nata</i> (PRN)] with a 12-month follow-up. MNV area was obtained by manual measurements with OCTA software, and VT and VDisp were calculated by automated analysis with Image J software.</p><p><strong>Results: </strong>A total of 101 participants were included, with 51 patients in the type 1 MNV group (mean age 67.32±9.12y) and 50 patients in the type 2 MNV group (mean age 64.74±5.21y). The mean number of IVC injections was 3.98±1.53 for type 1 MNV and 3.73±0.81 for type 2 MNV. Both subtypes exhibited significant improvements in visual acuity, accompanied by marked reductions in CMT and MNV area (<i>P</i><0.05) at 12mo after treatment. In type 2 MNV, VT significantly decreased (<i>P</i><0.05), whereas no significant change was observed in VT for type 1 MNV. VDisp did not significantly changed in either sybtypes. Moreover, in type 1 MNV, final best-corrected visual acuity (BCVA) using logMAR correlated positively with both pre- and post-treatment CMT, while in type 2 MNV, a significant positive correlation was found between the number of injections and final CMT.</p><p><strong>Conclusion: </strong>This study shows that conbercept treatment significantly improves visual acuity and macular structure in both type 1 and type 2 MNV with reductions in CMT and MNV area. The significant reduction in VT in type 2 MNV suggests its potential as a biomarker for disease activity. The findings imply the quantitative assessment useful for the stratification, prognostication, and personalized management of MNV in nAMD.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1490-1497"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical outcome of a transposed lateral pendular flap for the reconstruction of medial and central lower lid defects.","authors":"Yomna Amr Alahmadawy, Radwa Taher Elzanaty, Shaimaa Abdelsalam Arfeen","doi":"10.18240/ijo.2025.08.04","DOIUrl":"10.18240/ijo.2025.08.04","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the outcome and the degree of patient satisfaction with the reconstruction of full-thickness medial and central lower lid defects using a pendular flap of the remaining lateral part of the lower lid.</p><p><strong>Methods: </strong>Totally 20 patients with full thickness medial or central lower lid defects that could not be repaired by direct closure with or without cantholysis. A sliding full-thickness composite flap was created from the lateral part of the remaining lid to cover the defect. The posterior lamella of the induced lateral defect was repaired by either a periosteal flap alone or in combination with a free tarsal graft. Postoperative cosmetic and functional outcomes were evaluated.</p><p><strong>Results: </strong>The mean age of the patients was 46.3±18.1y (20-70y). The defects ranged from 30%-80% of the lid width and resulted from the excision of lid tumors in 11 patients (55%) and from trauma in 9 (45%) patients. Postoperative complications included one case of lateral graft ectropion, 2 cases of lid retraction and 3 cases of marginal graft necrosis. Most of the patients had an acceptable final cosmetic outcome.</p><p><strong>Conclusion: </strong>Reconstruction of moderate-sized defects in the medial/central lower lid <i>via</i> a sliding flap yielded acceptable cosmetic and functional outcomes with high patient satisfaction. Large defects ≥50% of the horizontal length are at greater risk of complications. Reconstruction of medial defects by this technique was associated with a greater incidence of complications.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1450-1455"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiology and management of uveitis-glaucoma-hyphema syndrome: a comprehensive review.","authors":"Jing-Ting Luo, Zhao-Xun Feng, Cong Wang","doi":"10.18240/ijo.2025.08.22","DOIUrl":"10.18240/ijo.2025.08.22","url":null,"abstract":"<p><p>The uveitis-glaucoma-hyphema (UGH) syndrome, initially described in 1978, presents as an iatrogenic complication associated with contact between intraocular implant and ocular tissue. This syndrome encompasses a spectrum of clinical manifestations, including intraocular inflammation, elevated intraocular pressure, and recurrent hemorrhage. Advances in cataract surgery techniques reduced the incidence of early intraocular lens (IOL) dislocation while inversely increased rates of delayed dislocation. The primary etiology of UGH syndrome is IOL subluxation. Weakness of the ciliary zonules or unstable IOL fixation techniques may predispose the eye to iris-lens contact. Other contributing factors include Soemmering's ring formation, abnormal iris and ciliary body anatomy, positional changes, and improper positioning of glaucoma implants. Clinical examination and imaging modalities such as ultrasound biomicroscopy and anterior segment optical coherence tomography supports diagnosis of UGH. Treatment options range from observation and medical therapies to invasive procedures such as laser therapy, IOL repositioning, or replacement. Endoscopy provides direct visualization for identifying causes intraoperatively, aiding in tailored surgical approaches towards minimal intervention. In conclusion, UGH syndrome poses a complex clinical challenge, emphasizing the importance of understanding its etiology, accurate diagnosis, and personalized management strategies to mitigate its impact on visual function and ensure favorable outcomes.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1587-1593"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular biological characteristics of children with myopia and rapid axial length changes treated with spectacles with highly aspherical lenslets.","authors":"Jing Zhai, Hao Chen, Xin-Jie Ye, Wei-Jun Cai, Li-Jie Hou, Mei-Xiao Shen, Fan Lyu","doi":"10.18240/ijo.2025.08.14","DOIUrl":"10.18240/ijo.2025.08.14","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the ocular biological characteristics of children with myopia and rapid axial length (AL) changes prescribed spectacles with highly aspherical lenslets (HAL).</p><p><strong>Methods: </strong>Data were collected from 156 children (252 eyes) with myopia and HAL treatment who were aged 7-13 and had rapid AL changes. The participants were divided into groups with AL reduction and elongation according to the changes in AL within 6mo. Paired <i>t</i>-tests were used to compare the ocular biological parameters at baseline and after rapid changes post-HAL treatment. Pearson's correlation analysis was used to determine the association between the ocular parameters and AL changes.</p><p><strong>Results: </strong>The ocular biological parameters significantly changed in the children with myopia and rapid AL changes after HAL treatment. In the group with AL reduction, the anterior chamber depth (ACD) and vitreous chamber depth (VCD) decreased. The crystalline lens thickness (CLT) increased, corneal flat keratometry (FK) decreased, and steep keratometry (SK) increased (all <i>P</i><0.001). The eyes in the group with AL elongation had increased ACD and VCD and steepened SK, but the CLT or FK findings were not different. AL change was negatively associated with baseline astigmatism (<i>r</i>=-0.171; <i>P</i>=0.007).</p><p><strong>Conclusion: </strong>In the eyes with HAL treatment, decreased ACD and VCD, thickened CLT, flattened FK, and steepened SK are observed during AL reduction. Lower baseline astigmatism is associated with AL reduction. The AL reduction may suggest the potential efficacy of HAL intervention in myopia control, while providing evidence for optimizing personalized myopia management strategies. Further longitudinal studies are warranted to validate whether rapid AL changes predict sustained treatment efficacy.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1522-1528"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic C-reactive protein levels in patients with geographic atrophy stratified by sex.","authors":"Ramya Gnanaraj, Alan G Palestine, Brandie D Wagner, Jennifer L Patnaik, Talisa E de Carlo Forest, Marc T Mathias, Niranjan Manoharan, Vivian Rajeswaren, Naresh Mandava, Anne M Lynch","doi":"10.18240/ijo.2025.08.11","DOIUrl":"10.18240/ijo.2025.08.11","url":null,"abstract":"<p><strong>Aim: </strong>To determine the differences in levels of systemic C-reactive protein (CRP) in patients with geographic atrophy (GA) and sex-based differences in CRP levels.</p><p><strong>Methods: </strong>Blood samples from patients with GA and controls were collected in a prospective age-related macular degeneration (AMD) registry from August 2014 to June 2021. AMD was confirmed using multimodal imaging and the Beckman and Consensus of Atrophy Meeting criteria for GA. High-sensitivity serum CRP levels were measured using an automated nephelometer. A non-parametric (rank-based) linear regression model was fit with an interaction between sex and GA.</p><p><strong>Results: </strong>There were 97 GA patients and 139 controls, with females comprising 55% and 66% of each cohort, respectively. There is no difference in CRP between cases and controls, with a median (interquartile range) of 1.2 (0.6-2.6) mg/L in GA patients versus 1.3 (0.8-2.9) mg/L in controls (<i>P</i>=0.52). Although females had higher CRP levels compared to males in both the GA and control groups, this difference did not reach statistical significance after adjustment for multiple comparisons.</p><p><strong>Conclusion: </strong>There is no significant difference in systemic CRP levels between GA cases and controls.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 8","pages":"1498-1505"},"PeriodicalIF":1.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}