International journal of ophthalmology最新文献

{"title":"Real time video-based gaze tracking for detecting subtle deviation angle change in abducens nerve palsy.","authors":"Natalia Christina Angsana, Amelia Devy Indriasari, Indra Tri Mahayana","doi":"10.18240/ijo.2025.09.13","DOIUrl":"10.18240/ijo.2025.09.13","url":null,"abstract":"<p><strong>Aim: </strong>To measure abducens nerve palsy patients' visual angle using real time video-based gaze tracking system.</p><p><strong>Methods: </strong>This research was a cross-sectional study. The subjects were taken by convenience sampling technique in the Neuro-ophthalmology department at Sardjito General Hospital Yogyakarta, Indonesia, and had met the inclusion and exclusion criteria. The visual angle measurements were performed using an eye tracker with a computer webcam (GENICULA system/Gaze Tracking Artificial Intelligence for Ocular Motor Palsy). The analytical method used was the Mann-Whitney test to compare the visual angle between the abducens nerve palsy group and the healthy eye group. The Wilcoxon test was used to see the significance of differences in visual angle improvement in abducens nerve palsy patients.</p><p><strong>Results: </strong>A total of 39 subjects participated, with a mean age of 46.54±15.67y; 17 were male and 22 were female. The visual angle was 20.88±3.76 in the abducens nerve palsy group (<i>n</i>=39 eyes) and 23.10±2.91 in the normal group (<i>n</i>=39 eyes, <i>P</i>=0.011). The visual angle improvement of abducens nerve palsy before and after cured was statistically significant (<i>P</i>=0.039).</p><p><strong>Conclusion: </strong>The real time video-based gaze tracking system is easy to use, efficient, and accurate. A slight decrease in visual angle measurement can be detected using this GENICULA system and therefore it is important for diagnosis slight deviation in abducens nerve palsy.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 9","pages":"1713-1717"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rebalancing translaminar pressure difference: a novel glaucoma surgery-a pilot trial in non-human primates.","authors":"Chen Xin, Qing Sang, Shen Wu, Rui-Qi Pang, Dan-Ting Lin, Huai-Zhou Wang, Ning Lu, Ning-Li Wang","doi":"10.18240/ijo.2025.09.02","DOIUrl":"10.18240/ijo.2025.09.02","url":null,"abstract":"<p><strong>Aim: </strong>To propose a novel glaucoma surgery for rebalancing translaminar pressure difference.</p><p><strong>Methods: </strong>Three non-human primates with normal eyes and two with laser-induced glaucoma underwent the novel surgical procedure. Cannulation of the subarachnoid space was performed after completion of routine vitrectomy steps. An XEN 45 implant was inserted into the created puncture to communicate between the vitreous body and subarachnoid space. Intraocular pressure (IOP), fundus photography, and spectral-domain optical coherence tomography were assessed at baseline and regular intervals during follow-up.</p><p><strong>Results: </strong>All operated eyes showed IOP reduction in the first postoperative month. Two (2/3) normal eyes and one (1/2) glaucomatous eye maintained lower IOP until 18mo after operation. The XEN 45 implant remained positioned through the lamina cribrosa in all normal eyes but was not detected in two glaucomatous eyes. Complications observed in this study included retinal vascular bleeding in 1/3 normal eyes and XEN implant dislocation in all 2 glaucomatous eyes.</p><p><strong>Conclusion: </strong>Subarachnoid space cannulation and mini-shunt implantation may contribute to IOP reduction, possibly by rebalancing translaminar pressure difference and enhancing aqueous humor drainage. The development of a suitable mini-shunt requires further investigation.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 9","pages":"1619-1625"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-onset bull's eye maculopathy due to hydroxychloroquine in rheumatoid arthritis and myasthenia gravis.","authors":"Ali Kasiri, Mostafa Feghhi, Ali Ansari, Rozhin Kasiri, Mohammad Sadegh Mirdehghan, Abbas Mohammadi, Mohammad Armin Kasiri","doi":"10.18240/ijo.2025.09.25","DOIUrl":"10.18240/ijo.2025.09.25","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 9","pages":"1809-1811"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One year clinical outcomes with a novel canaloplasty device in mild to severe open angle glaucoma.","authors":"Iden M Amiri, Heran W Gebreyesus, Nathan Grove, Jennifer L Patnaik, Malik Y Kahook, Leonard K Seibold","doi":"10.18240/ijo.2025.09.08","DOIUrl":"10.18240/ijo.2025.09.08","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the one-year clinical outcomes of a novel canaloplasty device used in combination with cataract extraction (CE) in patients with mild to severe open angle glaucoma (OAG).</p><p><strong>Methods: </strong>This study reviewed patients diagnosed with mild to severe OAG, who underwent canaloplasty with the STREAMLINE® Surgical System combined with CE. The primary outcome was surgical success, defined as achieving ≥20% intraocular pressure (IOP) reduction and/or a reduction of ≥1 glaucoma medication compared to baseline. Secondary outcomes included mean IOP, average number of glaucoma medications, and best-corrected distance visual acuity (BCDVA). Data was collected preoperatively and at multiple postoperative time points up to one year.</p><p><strong>Results: </strong>A total of 68 eyes of 47 patients were included with mean age was 73.1±7.0y and 60% were females. Surgical success at one year was achieved in 68.8% of eyes, with 67.6% success in mild, 80.0% in moderate, and 66.7% in severe OAG cases. IOP was significantly reduced from a baseline of 16.1±0.5 to 14.7±0.4 mm Hg at one year (<i>P</i>=0.0004). The number of medications decreased significantly in all eyes from a baseline of 1.2±0.1 to 0.6±0.1 at one year (<i>P</i><0.0001). When stratified by glaucoma severity, only the mild group experienced a statistically significant decrease from a baseline of 1.1±0.1 to 0.4±0.1 (<i>P</i><0.0001). BCDVA improved significantly from baseline to one year. No sight-threatening complications were reported.</p><p><strong>Conclusion: </strong>Canaloplasty using the STREAMLINE® surgical system combined with CE effectively reduces IOP at one year in mild to severe OAG with minimal complications. IOP lowering efficacy, reduction in IOP lowering medications, and safety in moderate to severe OAG require further study.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 9","pages":"1673-1680"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundus blood flow density changes in the smoking population by artificial intelligence-based optical coherence tomography angiography.","authors":"Ling-Yu Zhang, Qing-Jian Li, Qiang Zhou, Yu Zhang, Yan Liu, Zhi-Liang Wang, Pei Zhang","doi":"10.18240/ijo.2025.09.01","DOIUrl":"10.18240/ijo.2025.09.01","url":null,"abstract":"<p><strong>Aim: </strong>To determine whether chronic smoking affects fundus blood flow density using optical coherence tomography angiography (OCTA) based on artificial intelligence (AI).</p><p><strong>Methods: </strong>All participants underwent a comprehensive ophthalmological examination in this study. The subjects were categorized into two groups: control and smoker. Fundus data obtained through the novel OCTA device were compared.</p><p><strong>Results: </strong>Utilizing deep learning denoising techniques removed background noise and smoothed vessel surfaces. OCTA showed a significant decrease in fundus blood flow density after AI-based denoising on the right eyes of 36 smokers (36 males, average age 44.17±9.85y) and age- and sex-matched participants who never smoked. The thickness of the retina in both control and smoker groups failed to show any statistically significant differences. Smoking was associated with decreased blood flow density in the macula and the optic disk.</p><p><strong>Conclusion: </strong>Utilizing AI-based denoising to improve the sensitivity of OCTA images can be highly beneficial.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 9","pages":"1613-1618"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of IgG4-related ophthalmic disease with bone destruction presenting as unilateral painful blepharitis.","authors":"Yuki Tanaka, Satoru Kase, Yoshihiro Matsuno, Shinichi Nakazato, Susumu Ishida","doi":"10.18240/ijo.2025.09.26","DOIUrl":"10.18240/ijo.2025.09.26","url":null,"abstract":"","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 9","pages":"1812-1814"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of multi-omics data reveals dysregulated RNA methylation in retinal pigment epithelium drives age-related macular degeneration.","authors":"Ya-Jun Gong, Zhi-Lin Zou, Kai-Rui Qiu, Qiang Wang, Xiao-Lai Zhou","doi":"10.18240/ijo.2025.09.03","DOIUrl":"10.18240/ijo.2025.09.03","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the role of RNA methylation in retinal pigment epithelial (RPE) cells in age-related macular degeneration (AMD).</p><p><strong>Methods: </strong>RNA methylation-related gene expression profiles of AMD patient and normal control retinal pigment epithelium were evaluated by single-cell transcriptome from 34 samples (11 from normal donors and 23 from AMD patients). The causal relationship between RNA methylation dysfunction and AMD was analyzed by summary-data-based Mendelian randomization (SMR) using AMD GWAS data and multi-omics quantitative trait loci (QTL), including expression QTLs (eQTLs), protein QTLs (pQTLs), splicing QTLs (sQTLs), and m⁶A-QTLs (mQTLs). Additionally, machine learning models were applied to validate the causal association between RNA methylation dysfunction and AMD using Bulk RNA sequencing data from 31 normal donors and 37 AMD patients.</p><p><strong>Results: </strong>The single-cell transcriptome data analysis revealed massive dysregulation of RNA methylation-related gene expression in the RPE of AMD patients. SMR revealed causal associations between key RNA methylation regulators (<i>METTL3</i>, <i>NSUN6</i>, and <i>MRM1</i>, <i>etc</i>.) and AMD onset. Machine learning models further validated these findings and demonstrated a high accuracy of AMD risk prediction by using the above-identified RNA methylation-related genes: <i>METTL3</i>, <i>NSUN6</i>, and <i>MRM1</i>. Furthermore, <i>METTL3</i> and <i>NSUN6</i> were found to have a protective effect, while <i>MRM1</i> was associated with an increased risk of AMD.</p><p><strong>Conclusion: </strong>The results reveal the implication of dysregulation of RNA methylation-related gene expression in the RPE of AMD patients and further demonstrated a causal association between RNA methylation-related genes (<i>METTL3</i>, <i>NSUN6</i>, and <i>MRM1</i>) and AMD. These findings highlight the importance of RNA methylation in the pathogenesis of AMD and offer potential biomarkers and therapeutic targets for AMD management.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 9","pages":"1626-1639"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on neurotrophic factor for glaucoma: a worldwide bibliometric analysis.","authors":"Sahilah Ermawati, Winastari Yarhanim Triniputri, Muhana Fawwazy Ilyas, Syahnaz Adilla, Shafira Nur Hanifa, Azka Auliarahman","doi":"10.18240/ijo.2025.09.17","DOIUrl":"10.18240/ijo.2025.09.17","url":null,"abstract":"<p><strong>Aim: </strong>To comprehensively investigate the current state of research on the application of neurotrophic factors in glaucoma therapy and identify potential research hotspots.</p><p><strong>Methods: </strong>On September 30, 2023, a literature search was conducted on Scopus using specific keywords related to neurotrophic factors and glaucoma. Of the 918 articles retrieved, 780 met the inclusion criteria. These articles were subsequently analyzed and visualized using Google Sheets, Biblioshiny 3.1, and VosViewer 1.6.18.</p><p><strong>Results: </strong>A total of 780 studies published between 1989 and 2023 were included, and the global publication count showed an upward trend through 2023 (projected to continue rising by 2030). The United States, China, Japan, Italy, and Australia were the most significant contributors to the publication output. Research in this field had been published in 313 journals, spanning categories such as pharmacology and drug development, ophthalmology, genetics and gene therapy, and neuroscience. A total of 2622 authors had contributed to these studies, with the most prolific author publishing 14 articles. The focus of research in this field had evolved sequentially from \"glutamate\" to \"CNTF\" and \"GDNF\", and finally to \"optic nerve injury\". Co-occurrence analysis identified five clusters: glaucoma and ocular health, neuroinflammation in ophthalmology, neuroprotection in ophthalmology, ocular drug delivery, and stem cell therapy. Several areas in this field require further exploration, including the neurophysiological mechanisms underlying glaucoma, ocular drug delivery systems, and the clinical value of specific neurotrophic factors.</p><p><strong>Conclusion: </strong>This study systematically reviews global research trends on neurotrophic factors in glaucoma therapy, clarifying the current research status and future directions.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 9","pages":"1747-1758"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of non-steroidal anti-inflammatory drugs in preventing postoperative macular edema following cataract surgery: a systematic review and Network Meta-analysis.","authors":"Min Lang, Jie Xuan, Xue Li, Ming-Ming Liu, Jie Xu, Ting Liu","doi":"10.18240/ijo.2025.09.15","DOIUrl":"10.18240/ijo.2025.09.15","url":null,"abstract":"<p><strong>Aim: </strong>To assess and rank the efficacy of various non-steroidal anti-inflammatory drugs (NSAIDs) in preventing postoperative macular edema (PME) after cataract surgery.</p><p><strong>Methods: </strong>A comprehensive search was conducted across PubMed, Embase, Cochrane Library, and Web of Science databases. Randomized controlled trials (RCTs) comparing different NSAIDs and control treatments for the prevention of PME were included. Data from the studies were synthesized using the \"gemtc\" package in R. Risk of bias was assessed with the Cochrane RoB 2 tool, and heterogeneity was evaluated using the global <i>I</i> ² statistic. Surface under the cumulative ranking curve (SUCRA) values were calculated for each treatment.</p><p><strong>Results: </strong>Of 132 identified records, 9 RCTs met the inclusion criteria. The Network Meta-analysis indicated that nepafenac had the highest efficacy in preventing PME, followed by artificial tear substitute, ketorolac, diclofenac, and bromfenac. The league table comparisons and rankograms corroborated these findings, with nepafenac consistently ranking highest. Heterogeneity analysis yielded high <i>I</i> ² values, indicating substantial variability across studies.</p><p><strong>Conclusion: </strong>This Network Meta-analysis suggests that nepafenac is the most effective NSAID for preventing PME following cataract surgery. Given the substantial heterogeneity observed, further high-quality RCTs are required to confirm these findings and explore the sources of variability. Clinicians should consider these results when selecting NSAIDs for PME prophylaxis in cataract surgery patients.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 9","pages":"1730-1736"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and prognosis of carcinoma ex pleomorphic adenoma of the lacrimal gland: a comprehensive case series and literature review.","authors":"Run-Zi Yang, Ming-Shen Ma, Rui Liu, Ting-Ting Ren, Jing Li, Nan Wang, Liang-Yuan Xu, Qi-Han Guo, Jian-Min Ma","doi":"10.18240/ijo.2025.09.05","DOIUrl":"10.18240/ijo.2025.09.05","url":null,"abstract":"<p><strong>Aim: </strong>To examine carcinoma ex pleomorphic adenoma (CXPA) and its development to provide information for its clinical assessment and prognosis.</p><p><strong>Methods: </strong>The clinical data of 26 patients with pathologically diagnosed CXPA were included for analysis. The patients' medical histories and data (<i>e.g</i>., gender, age, eye laterality, clinical manifestations, pathologic and immunohistochemical indices, treatments, and prognosis) were recorded.</p><p><strong>Results: </strong>The average age of the 26 patients was 59.6±15.7y. There was no significant difference in the gender distribution. The incidence of CXPA bone destruction was approximately 57.7%, and the incidence of optic nerve involvement and extraocular muscle involvement was approximately 15.4% and 19.2%, respectively. The most common pathological type was adenocarcinoma (34.6%), followed by ductal carcinoma (26.9%). Five patients had recurrence or metastasis (19.2%). The 5-year recurrence-free survival rate was 59.0%. There were no significant differences in survival rates among patients with different pathologic types and stages (<i>P</i>>0.05). Bone destruction, nerve invasion, and peripheral tissue invasion did not significantly affect survival rate (<i>P</i>>0.05). Surgery combined with ¹²⁵I radiation therapy leads to a better survival prognosis (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>CXPA has a variety of pathologic classifications, with characteristics of bone destruction and peripheral tissue invasion. Surgery combined with ¹²⁵I endoradiotherapy is a preferable treatment option. However, long-term follow-up and close observation for recurrence or metastasis should be performed.</p>","PeriodicalId":14312,"journal":{"name":"International journal of ophthalmology","volume":"18 9","pages":"1650-1657"},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}