Does uveitis increase the risk of age-related wet macular degeneration? A Mendelian randomization study.

IF 1.8 4区医学 Q2 OPHTHALMOLOGY

International journal of ophthalmology Pub Date : 2025-08-18 eCollection Date: 2025-01-01 DOI:10.18240/ijo.2025.08.09

Rui-Hua Jing, Deng-Ke Zhou, Zhuo-Yan Yang, Zhao-Dan Ding, Jia-Hui Deng, Yao Xing, Xiao-Feng Chen

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Abstract

Aim: To use two-sample Mendelian randomization (MR) method to study uveitis causal association with wet age-related macular degeneration (wAMD) risk from the genetic level.

Methods: Two-sample MR analysis was used to assess the causal role of uveitis on wAMD risk, using the 8 genetic variants associated strongly with uveitis as instrumental variables. Besides, eight MR methods [inverse variance weighted (IVW), weighted median, MR-Egger regression, weighted mode, simple mode, robust adjusted profile score (RAPS), contamination inverse-variance weighted method, and debiased inverse-variance weighted method] were used to get the whole causal estimate for multiple instrumental single nucleotide polymorphism (SNPs). The MR analysis was based on Europeans.

Results: Uveitis was related to a higher risk of wAMD [odds ratio (OR): 1.08, 95% confidence interval (CI) 1.03-1.12; P=1.03×10^-3] with the IVW method. No heterogeneity and directional pleiotropy were detected. On the contrary, no significant results were detected in reverse MR analysis.

Conclusion: Uveitis is related to an increased risk of wAMD. Due to the high blindness rate of wAMD, understanding and controlling the risk factors of AMD is of great significance for reducing its incidence and early diagnosis and treatment.

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葡萄膜炎会增加老年性湿性黄斑变性的风险吗？孟德尔随机化研究。

目的：采用双样本孟德尔随机化（MR）方法从遗传水平研究葡萄膜炎与湿性年龄相关性黄斑变性（wAMD）风险的因果关系。方法：采用双样本MR分析，以8种与葡萄膜炎密切相关的遗传变异作为工具变量，评估葡萄膜炎与wAMD风险的因果关系。采用反方差加权法（IVW）、加权中位数法（weighted median）、MR- egger回归法（MR- egger regression）、加权模式法（weighted mode）、简单模式法（simple mode）、稳健校正谱评分法（robust adjusted profile score， RAPS）、污染反方差加权法（anti -variance weighted method）和去偏反方差加权法（debiased anti -variance weighted method）等8种MR方法，对多个仪器单核苷酸多态性（snp）进行了整体因果估计。核磁共振分析是基于欧洲人。结果：葡萄膜炎与wAMD的高风险相关[优势比（OR）： 1.08, 95%可信区间（CI） 1.03-1.12；P=1.03×10-3]用IVW法。未发现异质性和方向性多效性。相反，在反向MR分析中没有检测到显著结果。结论：葡萄膜炎与wAMD发病风险增加有关。由于wAMD致盲率高，了解和控制AMD的危险因素对降低其发病率和早期诊断和治疗具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of ophthalmology Medicine-Ophthalmology

CiteScore

2.50

自引率

7.10%

发文量

3141

审稿时长

4-8 weeks

期刊介绍： · International Journal of Ophthalmology-IJO (English edition) is a global ophthalmological scientific publication and a peer-reviewed open access periodical (ISSN 2222-3959 print, ISSN 2227-4898 online). This journal is sponsored by Chinese Medical Association Xi’an Branch and obtains guidance and support from WHO and ICO (International Council of Ophthalmology). It has been indexed in SCIE, PubMed, PubMed-Central, Chemical Abstracts, Scopus, EMBASE , and DOAJ. IJO JCR IF in 2017 is 1.166. IJO was established in 2008, with editorial office in Xi’an, China. It is a monthly publication. General Scientific Advisors include Prof. Hugh Taylor (President of ICO); Prof.Bruce Spivey (Immediate Past President of ICO); Prof.Mark Tso (Ex-Vice President of ICO) and Prof.Daiming Fan (Academician and Vice President, Chinese Academy of Engineering. International Scientific Advisors include Prof. Serge Resnikoff (WHO Senior Speciatist for Prevention of blindness), Prof. Chi-Chao Chan (National Eye Institute, USA) and Prof. Richard L Abbott (Ex-President of AAO/PAAO) et al. Honorary Editors-in-Chief: Prof. Li-Xin Xie(Academician of Chinese Academy of Engineering/Honorary President of Chinese Ophthalmological Society); Prof. Dennis Lam (President of APAO) and Prof. Xiao-Xin Li (Ex-President of Chinese Ophthalmological Society). Chief Editor: Prof. Xiu-Wen Hu (President of IJO Press). Editors-in-Chief: Prof. Yan-Nian Hui (Ex-Director, Eye Institute of Chinese PLA) and Prof. George Chiou (Founding chief editor of Journal of Ocular Pharmacology & Therapeutics). Associate Editors-in-Chief include: Prof. Ning-Li Wang (President Elect of APAO); Prof. Ke Yao (President of Chinese Ophthalmological Society) ; Prof.William Smiddy (Bascom Palmer Eye instituteUSA) ; Prof.Joel Schuman (President of Association of University Professors of Ophthalmology,USA); Prof.Yizhi Liu (Vice President of Chinese Ophtlalmology Society); Prof.Yu-Sheng Wang (Director of Eye Institute of Chinese PLA); Prof.Ling-Yun Cheng (Director of Ocular Pharmacology, Shiley Eye Center, USA). IJO accepts contributions in English from all over the world. It includes mainly original articles and review articles, both basic and clinical papers. Instruction is Welcome Contribution is Welcome Citation is Welcome Cooperation organization International Council of Ophthalmology(ICO), PubMed, PMC, American Academy of Ophthalmology, Asia-Pacific, Thomson Reuters, The Charlesworth Group, Crossref,Scopus,Publons, DOAJ etc.