International Journal of PharmTech Research最新文献_第5页

Liquid Chromatographic Methods for Anti-tubercular Agents:An Overview 抗结核药物的液相色谱方法综述

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130104

Deepika Bairagee

引用次数: 0

Medication Errors in Hospitals Training:A Practical Approach to Pharmacy Practice 医院用药差错培训:药剂学实践的实践途径

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130319

Bapna Rajendra Singh, N. R. Kumar, S. Sumit, Magarde Pooja, Avanija Sahu, Jain Meeta

引用次数: 0

Advancement in treating Cardiac Diseases using CardiacDevice CardiacDevice治疗心脏病的研究进展

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130312

Vikas Sharma, Akhalesh Kumar, Kartik Singhal, C. Majee, Salahuddin

{"title":"Advancement in treating Cardiac Diseases using Cardiac\u0000Device","authors":"Vikas Sharma, Akhalesh Kumar, Kartik Singhal, C. Majee, Salahuddin","doi":"10.20902/ijptr.2019.130312","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130312","url":null,"abstract":"From the origin of ancient Vedas or Shastras; there was an awareness of artificial intelligence but in different meanings. In present scenario, one has to perform a lot of research for the production of works relating with artificial intelligence. Basically, artificial intelligence is a huge group of skills from advanced machines used for finding the solutions of different fields i.e. in pharma fields or non-pharma fields. The problem of heart failure or heart attack is very big health issue which is assisted with more than 23 million peoples worldwide. Heart failure can be held due to the vasoconstriction or improper pumping mechanism of ventricles. Heart failure heart logic device is a new tsunami in the healthcare system for cardiac devices. This device is in two different forms which are as (ICD) implantable cardioverter defibrillator and other oneiscardiac resynchronization therapy defibrillator (CRT-D). Heart logic heart failure diagnostic device contains multiple sensors to track physiological functioning of the heart. There are Heart sound sensors which checks signs of elevated filling pressure and weakened ventricular contraction. There are also a sensor for checking pulmonary edema. Respiration sensor is used to monitor the rapid shallow breathing system which is associated with shortness of breath. Heart rate sensors check the heart rate and arrhythmia conditions. This device can predict heart failure events weeks before they happen. This artificial intelligence assisted device is showing the sensitivity in more than 70% of peoples to save the valuable lives of the human beings.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"12 1","pages":"217-222"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90203005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Stability Indicating RP-HPLC Method forDetermination of Chlorthalidone, Telmisartan and Cilnidipinein Bulk and Tablet Dosage Form 稳定性指示反相高效液相色谱法测定氯噻酮、替米沙坦、西尼地平原料药和片剂的含量

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130106

S. Sultana, P. Salomi, T. Vimalakkannan, K. Reddy

{"title":"A New Stability Indicating RP-HPLC Method for\u0000Determination of Chlorthalidone, Telmisartan and Cilnidipine\u0000in Bulk and Tablet Dosage Form","authors":"S. Sultana, P. Salomi, T. Vimalakkannan, K. Reddy","doi":"10.20902/ijptr.2019.130106","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130106","url":null,"abstract":"In present study, accurate, precise, rapid and sensitive stability indicting HPLC-UV method has been established for quantification of Telmisartan, Cilnidipine and Chlorthalidone simultaneously in Tablet and bulk. Telmisartan, Cilnidipine and Chlorthalidone were resoluted on Sunsil C18 column (4.6mmx250mm; 5μm) using mobile phase containing Acetonitrile and Potassium dihydrogen phosphate in 50:50(v/v) ratio with flow rate of 1ml/min at 238 nm. Concentrations were linear over the range of 40-120 μg/ml for Telmisartan, 10-30 μg/ml for Cilnidipine and 6.25-18.75 μg/ml for Chlorthalidone. The percentage recovery was found to be 99.70-100.51% for Telmisartan, 98.41-100.49% for Cilnidipine and 99.34-100.48% for Chlorthalidone. % RSD for peak area was 0.069% for Telmisartan, 0.058% for Cilnidipine and 0.057% for Chlorthalidone shows that the proposed method is precise. Force-degradation studies have not shown any observable change in the results and hence the proposed method is stability indicating and hence the method is suitable for routine analysis of Telmisartan, Cilnidipine and Chlorthalidone in bulk and tablet dosage form.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"3 1","pages":"44-51"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87359547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short term Functional outcome of Harris HIP Score fromOpen Reduction Internal Fixation action(ORIF Intertrochanter) 切开复位内固定术(ORIF)对Harris髋关节评分的短期功能影响

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130206

Charles Meliala, Pranajaya Dharma Kadar, Husnul Fuad Akbar

{"title":"Short term Functional outcome of Harris HIP Score from\u0000Open Reduction Internal Fixation action\u0000(ORIF Intertrochanter)","authors":"Charles Meliala, Pranajaya Dharma Kadar, Husnul Fuad Akbar","doi":"10.20902/ijptr.2019.130206","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130206","url":null,"abstract":"BackgroundIntertrochanter fracture is commonly found in geriatric and young active patient and it can affects the overall health system. The death rate of intertrochanter fracture has increased by 1 person in 1 year with mortality rate of around 14-36%.ObjectiveTo find out the functional evaluation by Harris hip score from the action of open reduction internal fixation (ORIF) on the intertrochanter femur fractures. Material and Methods-A total of 42subjects were used in the study. The study wasanobservationalanalytic study with no retrospective pairing and with a crossectional approach, whichaimedtoanalyzetheclinical outcomeoftheHarris HipScore after performed ORIF intertrochanter femurfracture. In thiscase, the control group are healthy femur from the same patient. Unpaired T-Test is use if normal distributed data aquired, otherwise Mann-Whitney is the option. The affordable populationofthe study waspatientswho were operated using internal fixation due to intertrochanter femur fracture measures in January 2012 June 2018.Results-In this case the distribution of the number of intertrochanter femur fracture samples was 42 subjects with 14 women (33.3%) and 28 men (66.7%). The youngest age of the study subjects was 17 years and the oldest age of the research subjects was 82 years with a mean and standard deviation of 60.77 ± 18.23 years, there were significant differences in outcomes of the clinical score of the hip score of the action Open reduction internal fixation (ORIF ) in the case of intertrochanter fracture femur, with a significance value of 0.0001 (<0.05).Conclusion-From the results of the statistical analysis of the outcome of the clinical hip score score of ORIF compared to the healthy side in the case of intertrochanter femur fractures, there is a significant result (15.1%) between ORIF actions compared to the healthy side in the case of intertrochanter fracture femur, with p value <0,0001.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"3 1","pages":"35-39"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82161050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of HPTLC method for theanalysis of Olmutinib in Bulk drug 原料药奥尔穆替尼hplc分析方法的建立与验证

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130105

B. Khandare

{"title":"Development and validation of HPTLC method for the\u0000analysis of Olmutinib in Bulk drug","authors":"B. Khandare","doi":"10.20902/ijptr.2019.130105","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130105","url":null,"abstract":"This paper describes a simple, precise, rapid and accurate high- performance thin layer chromatographic (HPTLC) method for determination of Olmutinib in bulk drug. Chroma to graphic separation was per formed on aluminium plates precoated with silicagel60F254 as the stationary phase using solvent system consisted of chloro form: methanol: (9:1v/v). After the application of bands using CAMAG Automatic TLC Sampler 4, the plate was developed in the solvent system up to 70 mm in CAMAGT win Trough Chamber. This solvent system was found to give compact spot for Olmutinib with Rfvalue of 0.32±0.02. The spots were scanned at 267.68nm. The calibration curves were linear with co-relation coefficient of 0.995 for Olmutinib. Linear regression analysis showed good linearity in the concentration range of 100- 1100 ng per spot. The method was validated in terms of Precision, specificity, and Linearity. The average recovery of the standards in the samples was found to be 99.65% at the same time we have checked the C.V. values of Reproducibility, intra-day and inter-day tabulated further. The proposed method can be successfully applied to determine the drug content of bulk drug.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82771026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Mupirocin Nimosomal Gel forTopical Drug Delivery System 局部给药系统用莫匹罗星尼莫体凝胶的研制与评价

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130202

Rajesh Akki, M. Ramya, K. Navyasri, S. Kathirvel

{"title":"Formulation and Evaluation of Mupirocin Nimosomal Gel for\u0000Topical Drug Delivery System","authors":"Rajesh Akki, M. Ramya, K. Navyasri, S. Kathirvel","doi":"10.20902/ijptr.2019.130202","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130202","url":null,"abstract":"The present study was to formulate and evaluate the mupirocin niosomal gel using surfactants span 80 & tween 80 for the preparation of niosomes. Mupirocin entrapped niosomes were prepared by ether injection method and transmembrane pH gradient drug uptake process. Niosomes were prepared by altering the ratios between various non-ionic surfactants (span 80 & tween 80) whereas the concentration of cholesterol and drug was kept constant. The prepared niosomes were characterized for size, shape, entrapment efficiency, invitro drug release studies. The highest entrapment efficiency(99.17%) and drug release (96.14%) was obtained for tween 80 (1:5:5) prepared by transmembrane pH gradient method. The best formulation among the two techniques was selected for incorporated into gel formulation. The prepared niosomal gel and plain gel were subjected to evaluation studies like drug content, invitro drug diffusion studies. The studies were demonstrated that niosomal gel was shown beter pharmacological activity than the conventional mupirocin gel. Based on the results it was concluded that niosomal preparations offers more advantageous than the conventional preparations.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"26 1","pages":"7-17"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82937598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Molecular docking studies of some novel2 & 3-(4-aminobenzamido) benzoic acid derivatives asDHFR inhibitors for treatment of tuberculosis 一些新型2和3-(4-氨基苄胺)苯甲酸衍生物作为治疗结核病的dhfr抑制剂的分子对接研究

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130317

Prashik B. D udhe, H. Bhatt

引用次数: 0

RP-HPLC Method development, Validation and ForcedDegradation for Simultaneous estimation of Benserazide HCland Levodopa in a Marketed Formulation 反相高效液相色谱法建立、验证和强制降解同时测定上市制剂中苯塞拉肼和左旋多巴

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130311

Madhusudan Bhoir, Nutan N. Rao

引用次数: 0

Acne:Clinico-Epidemiological Study In DermatologyVenereology Outpatient Clinic Of Dr. M. Djamil HospitalPadang During January 2016 – December 2018 痤疮:2016年1月- 2018年12月巴东Djamil医院皮肤科性病门诊的临床流行病学研究

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130403

S. Yenny

{"title":"Acne:Clinico-Epidemiological Study In DermatologyVenereology Outpatient Clinic Of Dr. M. Djamil Hospital\u0000Padang During January 2016 – December 2018","authors":"S. Yenny","doi":"10.20902/ijptr.2019.130403","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130403","url":null,"abstract":"Although acne is usually recognized as an adolescent skin disorder, the prevalence of adults with acne is increasing. The clinical and epidemiological data of acne were evaluated with a view to establishing possible contributing etiological factors and observing whether clinical features differ from adolescent acne. Division of Dermatology and Venereology Outpatient Clinic Dr. M. Djamil hospital padang during January 2016 until December 2018.Retrospective study performed in Medical Cosmetic Division of Dermatology and Venereology Outpatient Clinic Dr. M. Djamil hospital padang during January 2016 until December 2018. Data was taken from medical records. Out of 224 patients included in the study 54.01% were women and 45.98 % were men. Majority of the patients had comedonal acne (45.53 %), whereas nodulocystic was the least common (13.39%). Most common predominant site of involvement was cheek (44.20 %), followed by chin (25.45 %), and mandibular area (14.58 %). Family history of acne was present in 57.70 %. Scarring was observed in a 39.2 %. Acne is predominant in women, with the most commonly involved of the cheeks, with the most common type was comedones type. Keyword : Acne, epidemiology, Indonesia, profile.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"19 1","pages":"325-328"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74512035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0