International Journal of PharmTech Research最新文献_第4页

Epidemiology of Osteosarcoma : Single Center Study inIndonesia 骨肉瘤的流行病学:印度尼西亚的单中心研究

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130112

David Kalim, Andriandi

{"title":"Epidemiology of Osteosarcoma : Single Center Study in\u0000Indonesia","authors":"David Kalim, Andriandi","doi":"10.20902/ijptr.2019.130112","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130112","url":null,"abstract":"ObjectiveTo assess osteosarcoma epidemiology in Haji Adam Malik General Hospital. Material and MethodsThis study is a retrospective descriptive study with a crosssectional approach. Patient with musculoskeletal tumour (especially osteosarcoma) in Haji Adam Malik Hospital from January 2012 to Desember 2017 period, got their age, gender, musculoskeletal tumour type, biopsy result, tumour sites, treatment completion, metastasis and amputation status recorded from their medical record. Result-Primary bone tumors is the most cases and found in 50% of musculoskeletal tumors followed by soft tissue tumors and metastatic bone disease. Male (60%) have slightly higher prevalence than female in (40%). The incidence of primary bone tumors shows osteosarcoma, GCT, and osteochondroma are in the top three with 63%, 13%, and 6% respectively. Specifically for osteosarcoma, male and female have 1.9 : 1 prevalence ratio. The most common sites for osteosarcoma is distal the femur (45%) and proximal tibia (29%). About 63% of patients undergo complete treatment and with 55% recorded with metastasis in the first diagnosis and amputation was performed in 89% of patients. ConclusionPrimary bone tumors dominate the data with 50% for musculoskeletal tumors followed by 31% soft tissue tumors and 19% metastatic bone disease. The incidence of musculoskeletal tumors shows that men are slightly higher than women in 60% and 40%. The incidence of primary bone tumors shows osteosarcoma, giant cell tumor, and osteochondroma are in the top three with 63%, 13%, and 6% respectively.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"244 1","pages":"105-108"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73644670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin Microbiota in Atopic Dermatitis 特应性皮炎的皮肤微生物群

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130409

J. Saiful, S. Yenny

{"title":"Skin Microbiota in Atopic Dermatitis","authors":"J. Saiful, S. Yenny","doi":"10.20902/ijptr.2019.130409","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130409","url":null,"abstract":"In human body, the skin is the largest organ that has the function of mediating contact with the outside world and providing our body first line of defense against all kinds of pathogens, poisons and dangerous environments. The role of skin which are physical and immunological, supported by the microbial community that inhabits the skin. Skin microbiota contributes to barrier function by competing with pathogens and dealing with immune cells in the skin, to modulate local and systemic immune responses. Skin microbiota and immune mediators, for example complement system, have two-way interactions, and this shows that commensal microbes must be considered an important part of healthy skin. Many evidence shows that the composition of microbiota, especially in the intestines and also on the skin, can have a major influence on an individual's health. The influence of gut microbiota and its influence on the immune response has been widely studied, but the link of skin microbiota, immune response and certain skin diseases has not been widely discussed in the literature. Skin microbiota is expected to be affected in certain dermatological conditions, such as in psoriasis and in atopic dermatitis, which further shows the importance of the skin microbial community for human health. Understanding of skin microbiota role in pathogenesis of atopic dermatitis is still needed.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76405633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Characteristics of PSOAS Abscess in Patient withTuberculosis spondylitis from 2016 to 2018 in Haji AdamMalik General Hospital Medan 棉兰Haji AdamMalik总医院2016 - 2018年结核性脊柱炎患者PSOAS脓肿特征

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130313

John Tuahta P. Sinurat, Pranajaya Dharma Kadar, Reza Mahruzza

{"title":"Characteristics of PSOAS Abscess in Patient with\u0000Tuberculosis spondylitis from 2016 to 2018 in Haji Adam\u0000Malik General Hospital Medan","authors":"John Tuahta P. Sinurat, Pranajaya Dharma Kadar, Reza Mahruzza","doi":"10.20902/ijptr.2019.130313","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130313","url":null,"abstract":"ObjectivePsoas abscess one of rare manifestation of tuberculosis spondylitis. 5% of cases will develop psoas abscess and can increase the number of morbidity and mortality if the diagnosis and treatment were late. Material and Method-This is a cross sectional study to determine characteristics of psoas abscess in patient with tuberculosis spondylitis. The data is taken from patient’s medical record in Haji Adam Malik General Hospital from January 2016 to Desember 2018. The Population of this study is all the patients with tuberculosis spondylitis who come to Emergency Department or Outpatient Clinic. The collected data is tabulated and presented in the form of a frequency distribution diagram or table and analysed descriptively using total sampling. Results-The Subject for this study are 13 patients, within the proportion 5 patients are male (38.5%) and 8 patients are female (61.5%). The data show 5 patients have the ages < 18 years old (38.5%) and 8 patients have the ages > 18 years old (61.5%). All the patients get antituberculosis drugs as non operative treatment and 11 patients (84.6%) get an additional operative treatment for drainage the abscess. The site of psoas abscess in this study, 3 patients developed in thoracolumbal region (21.7%), 7 patients developed in lumbal region (53.8%) and 3 patients developed in lumbosacral region (21.7%). Conclusionfrom this study we conclude that the incidence are happened in female more common than male, it usually affects young adult >18 years old and the common site of psoas abscess is lumbar region.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"52 1 1","pages":"223-228"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77917525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxychloroquine And Dexamethasone Are Both PossibleFor Treatment Of Covid-19 羟氯喹和地塞米松都可能用于治疗Covid-19

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130323

Hamza Khaliha, Ibrahim M Bendalla, Abdulfatah Saed, S. Daw

{"title":"Hydroxychloroquine And Dexamethasone Are Both Possible\u0000For Treatment Of Covid-19","authors":"Hamza Khaliha, Ibrahim M Bendalla, Abdulfatah Saed, S. Daw","doi":"10.20902/ijptr.2019.130323","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130323","url":null,"abstract":"The antimalarial operators chloroquine and hydroxychloroquine have been utilized generally for the treatment of rheumatoid joint inflammation and fundamental lupus erythematosus. These mixes lead to progress of clinical and research facility parameters, however their moderate beginning of activity recognizes them from glucocorticoids and nonsteroidal mitigating operators. Chloroquine and hydroxychloroquine increment pH inside intracellular vacuoles and adjust procedures, for example, protein corruption by acidic hydrolases in the lysosome, get together of macromolecules in the endosomes, and posttranslation change of proteins in the Golgi mechanical assembly. It is suggested that the antirheumatic properties of these mixes results from their obstruction with \"antigen preparing\" in macrophages and other antigen-introducing cells. Acidic cytoplasmic compartments are required for the antigenic protein to be processed and for the peptides to collect with the alpha and beta chains of MHC class II proteins. Thus, antimalarials reduce the arrangement of peptide-MHC protein edifices required to animate CD4+ T cells and result in down-guideline of the safe reaction against autoantigenic peptides. Since this system varies from other antirheumatic drugs, antimalarials are appropriate to supplement these different mixes in blend medicate treatment[1].","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"44 1","pages":"305-308"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91227474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Subcorneal Pustular Dermatosis(Sneddon-Wilkinson Disease): A Rare Case 角膜下脓疱性皮肤病(Sneddon-Wilkinson病):一例罕见病例

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130401

Rina Gustia, Yosse Rizal, Dwi Sepfourteen

{"title":"Subcorneal Pustular Dermatosis\u0000(Sneddon-Wilkinson Disease): A Rare Case","authors":"Rina Gustia, Yosse Rizal, Dwi Sepfourteen","doi":"10.20902/ijptr.2019.130401","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130401","url":null,"abstract":"Subcorneal pustular dermatosis (SPD) is a rare, chronic, recurrent, pustular eruption. It may be difficult to differentiate SPD from Acute Generalized Exanthematous Pustulosis (AGEP) and Generalized Pustular Psoriasis (GPP)just from clinical appeareance. A 48 years old woman with subcorneal pustular dermatosis was reported. She was complained there were tiny blisters containing pus on the reddish patches that felt burning and became widespread to neck, chest, abdomen, arms, groin and legs since 4 days ago. Patient had no history of skin lesion before. From physical examination revealed no other pathologies and on the skin showed erythematous patches with annular lesion, pustules formation that tended to coalesce to form desquamative plaques, erosions, on chest, abdomen, back, arm, buttock and leg. Based on histopathology showed there are subcorneal pustules. The subcorneal pustule is filled with neutrophils and on the dermis, there are mild infiltration of neutrophil cells. This feature revealed to SPD.Clinically it may be difficult to differentiate SPD from AGEP and GPP. Histopathology examination can distinguished these disease,patient was treated with prednisone 40 mg and dapson 100 mg and had improvement after 4 weeks.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"146 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86775318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and characterization of baicalein loadedphytosomes: Assessment of in vitro parameters 黄芩素负载磷脂体的制备与表征:体外参数评估

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/jptr.2019.120404

K. Zade, A. Jain

引用次数: 0

Lucio Phenomenon mimicking with Vasculo necroticErithema Nodosum Leprosum: A Case Report 模拟卢西奥现象合并血管性坏死性麻风结节性红斑1例

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130321

Dwi Sepfourteen, Tutty Ariani

{"title":"Lucio Phenomenon mimicking with Vasculo necrotic\u0000Erithema Nodosum Leprosum: A Case Report","authors":"Dwi Sepfourteen, Tutty Ariani","doi":"10.20902/ijptr.2019.130321","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130321","url":null,"abstract":"Clinical features of Lucio’s phenomenon (LP), shows a nectorizing erythema, may mimicking Erythema Nodosum leprosum with vasculonecrotic. A 46 years old man presented with diagnosis lepromatous leprosy with Lucio’s phenomenon and diferential diagnosis borderline lepromatous (BL) with vasculonecrotic erithema nodosum leprosum. The patients complained there were painless ulcers on his lower limbs and scrotum, with surrounded by purpuric patches which subsequently became gangrenes and ulcerated for 3 weeks. There was numbness of both hands and feet, the eyelashes, eyebrows baldness since 5 years ago. Patient never got the treatment before. Bacteriological examination showed bacterial index 6+ Histopathology: there were Flattened epidermis by narrow grenz zone, and lymphocyte in perivascular with macrophage. There was endothelial proliferation of capiller. Fite faraco stain showed macrophage infiltration around the perivasculer, with colonization of the endothelial cell by acid fast bacilli and epidermal necrosis and diagnosis as Lepromatous leprosy with Lucio phenomenon. This patient is given adult multiple drug therapy (MDT) therapy, methylprednisolone, neurotrophic vitamins. Lucio’s phenomenon most commonly affects patients with untreated leprosy. Clinically, it may be difficult to differentiate Lucio phenomenon from Erythema nodosum leprosum with vasculonecrotic. In this case, the histopathological examination were colonization of endothelial cell by acid fast bacilli, epidermal necrosis and endothelial proliferation of the vessel.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"19 1","pages":"288-294"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86084241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochemical composition of Marine Red algaChampia parvula (C. Agardh) 海洋红藻parvula (C. Agardh)的生化组成

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130308

R. Vinothkumar, S. Murugesan, M. Kotteswari, N. Shanthi

引用次数: 0

Insights on traditional and modern oil extractions of wheatgerm: Chemical and antimicrobial evaluation 传统和现代小麦胚芽油提取的见解:化学和抗菌评价

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130205

M. Soltan, S. Mahfouz, Eman A. Karam, F. Motawe

引用次数: 1

Seasonal Variations in Antioxidant Activity, Total FlavonoidsContent, Total Phenolic Content, Antimicrobial Activity andSome Bioactive Components of Ficus carica L. in Palestine 巴勒斯坦无花果抗氧化活性、总黄酮含量、总酚含量、抗菌活性及部分生物活性成分的季节变化

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130404

Sireen Radwan, G. Handal, Fuad Rimawi, M. Hanania

{"title":"Seasonal Variations in Antioxidant Activity, Total Flavonoids\u0000Content, Total Phenolic Content, Antimicrobial Activity and\u0000Some Bioactive Components of Ficus carica L. in Palestine","authors":"Sireen Radwan, G. Handal, Fuad Rimawi, M. Hanania","doi":"10.20902/ijptr.2019.130404","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130404","url":null,"abstract":"The genus Ficus is one of the largest genera of angiosperms with more than 800 species. This study aimed at investigating the pharmacological properties of Ficus carica linn. Leaves were collected in two seasons (May and October) and were extracted by Soxhlet extractor with different percentages of methanol-water, ethanol-water and pure water solvents. 100% methanol and 95% ethanol offered the highest yield (about 23%). Those extracts were further extracted/partitioned with nbutanol. May samples showed higher TPC, TFC and AA results than October samples. The ethanolbutanol extract had the highest TPC results (150.7±0.5 mg GA/g extract), while methanol-butanol extract showed the highest results for TFC and AA (350±4.3 mg Rutin/g extract and 368.1±1.9 mg FeSO4/g extract, respectively). Ethanol and methanol extracts were weakly active against E. coli, while the extracts showed good inhibition activity against oral flora, where October samples gave higher activity than May samples. Some components of extracts were analyzed by a newly developed HPLCPDA method. Eight compounds were identified: chlorogenic acid, caffeic acid, syringic acid, coumaric acid, rutin and trans-cinnamic acid. Quercetin was identified after acid hydrolysis of extracts in all sample extracts, while ferulic acid was present in water extract only.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"30 1","pages":"329-340"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74436344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3