International Journal of PharmTech Research最新文献

Phytochemical Characterization of Natural Dye Extractedfrom Senna siamea Pods 番泻豆荚天然染料的植物化学特性研究

International Journal of PharmTech Research Pub Date : 2020-04-10 DOI: 10.4236/oalib.1106148

S. Patil, D. D. Kurlapkar, D. K. Gaikwad

{"title":"Phytochemical Characterization of Natural Dye Extracted\u0000from Senna siamea Pods","authors":"S. Patil, D. D. Kurlapkar, D. K. Gaikwad","doi":"10.4236/oalib.1106148","DOIUrl":"https://doi.org/10.4236/oalib.1106148","url":null,"abstract":"An increasing eco-consciousness among peoples has been shifting the use of\u0000natural dyes for textile dyeing and in other realms too as food, pharmaceuticals and cosmetics.\u0000The present study was focussed on aqueous extraction of natural dye from the pod husk of\u0000Senna siamea (Lam.) H.S. Irwin & Barneby, its characterization through spectroscopic (UVVIS\u0000and FT-IR) and chromatographic (GC-MS/ LC-MS) technique. It was noticed that the\u0000percent recovery was 16%, while FTIR results indicates different functional groups present in\u0000the dye, total 16 constituents were identified in the GC-MS analysis of Senna dye such as DFructose,\u00003-O-methyl-, Stigmast-5-en-3-ol,oleate, Benzaldehyde,2-hydroxy-4-methyl-, 3'-\u0000Methoxybenzo[1',2'-b]-1,4-, Tetrapentacontane, n-Hexadecanoic acid, 2,3-Dihydroxypropyl\u0000elaidate 3-Hydroxy-4-methoxybenzoic acid, 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6, 4-\u0000Hydroxy-2-methylacetophenone, Hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl), Maltol,\u0000Methyl 14-methyl-eicosanoate, Bis(2-ethylhexyl) phthalate, 9,12-Octadecadienoic acid (Z,Z)-,\u00002,3-dihydro, Benzeneacetaldehyde, and the LCMS analysis exhibits the presence of 20 major\u0000bioactive compounds among these N-Cyclohexane carbonyl pentadecylamine, Docosanedioic\u0000acid, Emmotin A, 3α,12α-Dihydroxy-5β-chol-7-en-24-oic Acid, 4-Hydroxyphenylglyoxylate,\u0000Hexadecyl Acetyl Glycerol, 2-oxo-nonadecanoic acid, 1-Monopalmitin, Spisulosine and N,Ndimethyl-\u0000Safingol showed highest retention time. Thus the Senna dye is a rich source of\u0000natural bioactive compounds.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81699421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effectiveness of Honey and Moist Exposed Burn Ointment(MEBO) in Epithelial-Burns of Grade II 蜂蜜湿润暴露烧伤软膏(MEBO)治疗II级上皮性烧伤的疗效

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130110

Susilawaty, I. Lister, E. Fachrial, Ermi Girsang

{"title":"Effectiveness of Honey and Moist Exposed Burn Ointment\u0000(MEBO) in Epithelial-Burns of Grade II","authors":"Susilawaty, I. Lister, E. Fachrial, Ermi Girsang","doi":"10.20902/ijptr.2019.130110","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130110","url":null,"abstract":"Second degree burns treatment plays an important role in healing burns. Many people use Moist Exposed Burn Ointment (MEBO), an oil-based ointment that has been proposed for the treatment of ideal burns, and honey has also been used for the treatment of burns in several clinical trials and provides good results. This study aims to determine the ratio of honey and MEBO effectiveness in epithelialization of second degree burns.Methodsby using the true experiment research method or pure experiment with RAL (Complete Random Design). Results The results showed that giving honey to healing burns gave the best results where there were significant differences (p <0.05) in the formation of collagen fibers and the amount of blood vessel formation compared to MEBO, but in the results of measurements of the extent of burns and epithelial formation did not showed a significant difference (p> 0.05) between honey and MEBO.Conclusion/ConclusionsThe conclusion is that giving honey gives better and more effective results in the formation of collagen fibers and blood vessel formation compared to MEBO. Therefore honey can be an option for the community in dealing with second degree burns, and further research needs to be done on signal transduction (molecular biology) related to wound healing in three phases, namely the inflammatory phase (eg interleukin 2, 6 and others). others), proliferation phase (eg EGF, PDGF, TGF-ẞ) and remodeling phase (eg BMP2).","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"119 1","pages":"88-96"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78547543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Knowledge, Awareness and Perception ofStudents regarding COVID-19 and its related activities: AQuestionnaire based Survey 学生对COVID-19及其相关活动的知识、意识和感知评估:基于问卷的调查

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130407

Monika, A. S. Bisht

引用次数: 0

Clinico-Epidemiological Features of Melasma : ARetrospective Study from Dermatology-VenereologyDepartment of Education Center Hospital in West Sumatera,Indonesia 黄褐斑的临床流行病学特征:来自印度尼西亚西苏门答腊教育中心医院皮肤性病科的回顾性研究

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130411

S. Yenny

引用次数: 0

Analytical Method development and Validation of Lamivudinein Formulation by using Reversed Phase Ultra PerformanceLiquid Chromatography 拉米夫定处方的反相高效液相色谱分析方法的建立与验证

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130201

Anshul Kumar, C. Majee, Vivek Namdev

引用次数: 0

Formulation and Evaluation of Roflumilast Fast dissolvingTablets employing Lepidium sativum mucilage using 23Factorial design 采用23因子设计制备枸橼酸浆液罗氟司特快溶片及评价

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130107

A. Bharathi, K. Sree, D. S. Naik

{"title":"Formulation and Evaluation of Roflumilast Fast dissolving\u0000Tablets employing Lepidium sativum mucilage using 23\u0000Factorial design","authors":"A. Bharathi, K. Sree, D. S. Naik","doi":"10.20902/ijptr.2019.130107","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130107","url":null,"abstract":"To evaluate fast dissolving tablets for Roflumilast employing with novel superdisintegrant using lepidium sativum mucilage by using 23 factorial design.The physical, chemical and micromeritic studies were evaluated for the prepared mucilage. To estabish fast dissolving tablets of Roflumilast with lepidium sativum mucilage ie a superdisinitegrant in different ratios by using direct compression method employing 23 factorial design. All the fast dissolving tablets were evaluated pre compression and post compression parameters like dissolution efficiency (DE%) percent of drug dissolved at 5 min (PD5). The Lepidium sativum mucilage was to be found fine,free flowing crystaline powder and excellent swelling nature in water. The FTIR and DSC studies were indicated to no interactions between roflumilast and Lepidium sativum mucilage. All the formulation batches shows good quality with regrad to drug content (98±0.092 to 100±0.026)hardness(3.4±0.43 to 3.6±0.64)friability (0.21±0.04 to 0.88±0.42). The optimized formulation batch shows less disintegrant time (52±0.24). The In– Vitro wetting time was less (i.e., 90s) in optimized formulation F2. The water absorption ratio of the formulated tablets was found to be in the range of (90.3±0.027 ). The cumulative drug dissolved in the optimized formulation F2 was found to be ( 99%) in 5 min. Lepidium sativum mucilage was found to be a super disintegrant which enhanced the dissolution efficiency when combined with Crospovidone, croscarmellose sodium, and hence it could be used in the formulation of fast dissolving tablets to provide immediate release of the contained drug within 5 min.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"5 1","pages":"52-65"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73223915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of Drying Temperatures on Chemical compounds andAntioxidant properties of Vitex negundo leaves 干燥温度对牡荆叶化学成分及抗氧化性能的影响

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130212

I HadaMasayu, A. Fauziah, K. Pin, Safwan K Ihsan, M. Shalini, J. Fadzureena, M. Azah, I. Sharmizi

{"title":"Effect of Drying Temperatures on Chemical compounds and\u0000Antioxidant properties of Vitex negundo leaves","authors":"I HadaMasayu, A. Fauziah, K. Pin, Safwan K Ihsan, M. Shalini, J. Fadzureena, M. Azah, I. Sharmizi","doi":"10.20902/ijptr.2019.130212","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130212","url":null,"abstract":"The effect of drying temperature on the leaves of Vitex negundo was determined. Three levels of temperatures (40, 50 and 60°C) were used in the presented study. The initial moisture content of the leaves was 69.98%. Continuous drying at the above mentioned temperature levels was conducted to determine the drying time required to achieve equilibrium moisture content. The quality of dried leaves was evaluated based on the quantity of agnuside, a major compound in V. negundo using HPLC analysis. The fastest drying of the leaves was achieved at 60°C, followed by at 50°C, but HPLC results showed that dried V. negundo suffered at 40% reduction in agnuside content when drying at 60°C as compared to at 40°C. Slight reduction of agnuside was found in the sample dried at 50°C as compared to at 40°C. Whereas, antioxidant results showed that V. negundo leaves have significant level of phenolic content and the effect of drying at higher temperature has significantly reduce the amount of phenolics in V. negundo leaves. Total phenolic content of V. negundo leaves was highest at 50 °C drying temperature. Based on the findings of this work, the best convection oven drying condition for V. negundo leaves was at 50°C with the highest agnuside concentration of 502.224 mg/L and phenolic content of 286.7 ± 11.0 mg GAE/100g.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"15 1","pages":"94-102"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72786907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Azo benzimidazole - A biologically active scaffold 偶氮苯并咪唑-一种生物活性支架

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130305

K. Pakeeraiah, S. Mohanty, K. Eswar, K. Raju

引用次数: 2

Isolation, Characterization & Phytochemical Screening,Analytical Method Development and Validation for theDetermination of Catechins in B.ciliata by RP HPLC Method 毛纤毛虫中儿茶素的分离、表征及植物化学筛选、分析方法的建立及RP - HPLC测定方法的验证

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130203

Ndvr Saradhi, N. Gopal, C. Chetty, K. Sushmitha

引用次数: 0

Effect of different biopesticides on mortality and theirsynergetic effect on the fecundity of Tribolium castaneum(Herbst, 1797) 不同生物农药对褐刺虫死亡率的影响及其对繁殖力的协同效应(Herbst, 1997)

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130303

Muhammad Musa Khan, J. A. Siddiqui, Rana Muhammad Kaleem Ullah, M. F. Raza

{"title":"Effect of different biopesticides on mortality and their\u0000synergetic effect on the fecundity of Tribolium castaneum\u0000(Herbst, 1797)","authors":"Muhammad Musa Khan, J. A. Siddiqui, Rana Muhammad Kaleem Ullah, M. F. Raza","doi":"10.20902/ijptr.2019.130303","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130303","url":null,"abstract":"Tribolium castaneum is an important stored grain pest. T. castaneum not only caused heavy losses in stored grain products, but it also becomes resistant to many pesticides, which makes pests more important. Synergism is an important tool to reduce the risk of the development of resistance. This study was designed to investigate the toxicity, synergism effect, and effect of the combination of different biopesticides on the fecundity of T. castaneum Results showed that among six biopesticides (Spinosad, Abamectin, Azadiractin, Rosemary oil, Metarhizium anisopliae, and Verticillium lecanii) the spinosad, rosemary oil, and M. anisopliae exerted maximum percent mortality. When these pesticides were mixed and used to assess the synergistic effect. Results revealed that spinosad + Rosemary oil was the most effective combination, and exerting caused more mortality as compared to spinosad + M. anisopliae and rosemary oil + M. anisopliae. Results also showed that the number of eggs laid per day was also recorded less in the insects which were exposed to spinosad + rosemary oil as compared to other treatments. The percent reproductive control was about 43% in spinosad + Rosemary oil combination as compared to other treatments. This study showed that the use of different pesticides with a different mode of action in small concentration can be more effective than a single pesticide with high concentration. This technique will effectively deal with pesticide resistance and also economical for the store owners.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"2 1","pages":"142-152"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82123468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2