International Journal of PharmTech Research最新文献_第6页

Formulation and Evaluation of Pediatric Paracetamol ElixirUsing Natural Colorant 使用天然着色剂的小儿扑热息痛酏剂的配方及评价

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130307

Mamatha Tirunagari, Nagadivya Nerella, Anupama Koneru, Madihah, S. Sarfaraz, M. Mushtaq

引用次数: 0

Pharmacognostical Investigation of Andrographis paniculata(Green Chiretta) and Crystallization of the Bioactivecomponent Andrographolide 穿心莲的生药学研究及生物活性成分穿心莲内酯的结晶

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130207

Myrene R. Dsouza, Sapam Athoibi, S. Prabha

{"title":"Pharmacognostical Investigation of Andrographis paniculata\u0000(Green Chiretta) and Crystallization of the Bioactive\u0000component Andrographolide","authors":"Myrene R. Dsouza, Sapam Athoibi, S. Prabha","doi":"10.20902/ijptr.2019.130207","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130207","url":null,"abstract":"Andrographis paniculata (Family: Acanthaceae) is one the most commonly used ethno-medicinal plants in certain parts of Asia and European countries. The phytochemical analysis of the leaves of A. paniculata in aqueous, methanolic, ethanolic, hydromethanolic (1:1) and hydroethanolic (1:1) extracts revealed the presence of carbohydrates, amino acid, alkaloids, saponins, tannins, flavonoids, terpenoids, glycosides, xanthoproteins and phenols. The total phenolic, flavonoid contents and FRAP values were found to be highest in the hydromethanolic extract i.e., 0.23 ± 0.008 mg GAE/g of FWt, 0.031± 0.00 mg QE/g FWt and1.261 ± 0.03 mM FeSO4 respectively. Invitro antioxidant capacity by linear regression analysis was measured by assaying DPPH radical and H2O2 scavenging capacities. The respective IC50 values of the hydromethanolic extract of the plant were found to be 86.51 μg/ml and 298.27 μg/ml. The IC50 values for in vitro anti-inflammatory activities were evaluated by heat induced protein denaturation (IC50 diclofenac = 574.06 μg/ml, IC50 APE = 179.7 μg/ml) and RBC membrane stabilization assay (IC50 diclofenac = 337.64 μg/ml, IC50 APE = 143.07 μg/ml). The IC50 values for in vitro anti-diabetic activities were evaluated by α-amylase inhibition (IC50 acarbose = 379.71 μg/ml, IC50 APE = 328.54 μg/ml). In addition, glucose diffusion was also monitored. Antimicrobial activity of the extracts was studied against common pathogens using well diffusion method. The purification of Andrographolide was carried out using different physical separation techniques such as extraction and crystallization followed by drying.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"15 1","pages":"40-50"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89603769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Comprehensive Review on The Estimation of EmtricitabineIndividually and in Combination With other Drugs 恩曲他滨单用及联用评价综述

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130102

Rubina Shaheen, Dr S. H. Rizwan

引用次数: 0

An Innovative Method For Estimation Of Metformin HCl andAcarbose in Pharmaceutical Products and Seperation ofMetformin Impurities By RP-HPLC 药品中盐酸二甲双胍和阿卡波糖含量测定及二甲双胍杂质的反相高效液相色谱分离新方法

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130210

Jalil K. Shaikh, M. AjayBabu, M. Farooqui, Ummul Khair Asema Syed

{"title":"An Innovative Method For Estimation Of Metformin HCl and\u0000Acarbose in Pharmaceutical Products and Seperation of\u0000Metformin Impurities By RP-HPLC","authors":"Jalil K. Shaikh, M. AjayBabu, M. Farooqui, Ummul Khair Asema Syed","doi":"10.20902/ijptr.2019.130210","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130210","url":null,"abstract":"A Simple, rapid, cost effective, stability indicating RP-HPLC method has been developed for separation of Metformin HCl, its related impurities and Acarbose. Validated the method for simultaneous estimation of Metformin (MF) and Acarbose (ACB) in its novel combination of tablet formulation with Metformin 500 mg and Acarbose 50 mg. Metformin HCl is an orally-administered biguanide, anti-hyperglycemic agent, used in the management of non-insulin dependent diabetes mellitus. Acarbose is an oligosaccharide, used orally for the treatment of type 2 diabetes mellitus. The separation was achieved by using isocratic mobile phase consisting of mixture of phosphate buffer : acetonitrile (27:73 v/v), using Hypersil APS2 column, (250 x 4.6 mm x 5m) column at flow rate 2.0 mL/min. The detection was carried out at 210 nm with 20 μl of injection volume. The column temperature was maintained at 35 °C. The retention time (RT) of MF, its related impurities and ACB were found to be RT 2.6 min for 1-Cynogaunidine (RC A), 6.0 for Metformin (MF), 8.5 for 1-Methylbigaunidine (RC B), 10.4 for N,N-Dimethyl-1,3,5-triazine-2,4,6-triamine(RC C), and 12.2 min for Acarbose (ACB). The approach was found to be linear with the concentration of 5-25 μg/ml and 2.515μg/ml and correlation coefficient was 0.999 for MF and ACB respectively. The assay of estimated compounds was found to be 99.19% and 99.08% w/v and mean accuracy 100.66%, 101.59% for MF and ACB respectively. The developed method was validated as per ICH guidelines. The degradation products were well resolved from main peak. The validation was performed for various parameters like specificity, linearity, precision, accuracy and robustness studies. The method was found to be capable for simultaneous quantification of Metformin and Acarbose in its combination drug.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"143 1","pages":"71-79"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79507156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Drug Release Kinetics from Sustained ReleaseMatrix Tablets of Acyclovir using Natural Polymer Obtainedfrom Colocasia Esculenta 用天然聚合物研究阿昔洛韦缓释基质片的释药动力学

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130306

Dharmendra Solanki, Mohit Motiwale, S. Mahapatra

引用次数: 0

A Review on unexplored Plants for Recurrent AphthousStomatitis 复发性口腔溃疡植物研究进展

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130316

K. Babu, R. Narayanan

引用次数: 0

Trauma Analysis Related Injury Severity Score (Triss) inPredicting the Prognosis of Politrauma Patients in AdamMalik General Hospital 相关损伤严重程度评分(Triss)对AdamMalik总医院颅脑损伤患者预后的预测分析

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130111

R. Gunawan, Heru Rahmadhany, I. D. Winanto

引用次数: 0

Formulation, Optimization and In-vitro Evaluation of FastDissolving Oral films of Metoclopramide Hydrochloride bySolvent Casting method 溶剂铸造法快速溶出盐酸甲氧氯普胺口服膜的制备、优化及体外评价

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130314

Chandrajeet Kumar Yadav, Manish Karn, P. Yadav, R. Mehta

{"title":"Formulation, Optimization and In-vitro Evaluation of Fast\u0000Dissolving Oral films of Metoclopramide Hydrochloride by\u0000Solvent Casting method","authors":"Chandrajeet Kumar Yadav, Manish Karn, P. Yadav, R. Mehta","doi":"10.20902/ijptr.2019.130314","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130314","url":null,"abstract":"The Present study aimed to prepare fast dissolving oral films (FDFs) of metoclopramide hydrochloride, because of its application in emesis condition where fast onset of action and avoidance of water is highly desirable. Moreover, this dosage form is highly useful in pediatrics, geriatrics and unconscious patients. FDFs were prepared by solvent casting technique with film forming polymers HPMC, PVA & Sodium alginate in varying concentrations with excipients like SLS as surfactant, Glycerol as plasticizer, citric acid as saliva stimulating agent, Sodium Saccharin as sweetening agent. The film of 2×3 cm was prepared by casting into a petridish of calculated size and dried in dryer at temperature 40˚c. The In-Vitro evaluation of characteristics like Film Thickness, Weight Variation, disintegration time, dissolution study, surface pH, content uniformity was studied. The best formulation was found to be F5 containing polymer PVA and Sodium alginate in the ratio 2:1, with disintegration time 24 seconds, and dissolution profile of 75% in 60 seconds and 90% in 90 seconds. The content uniformity of all the formulations was found to be within the limit (98-101%). The disintegration time of all the formulations was found to be below 30 seconds except F4 (26 sec.). Thus, fast dissolving Films of Metoclopramide hydrochloride can be successfully formulated and will be used as a novel drug dosage form for paediatric and geriatric with improved patient compliance and enhanced bioavailability.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"249 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76627200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial and Antioxidant Activity of Newly KeratinolyticBacteria, Azotobacter chroococcum B4 新型角朊溶解菌-绿球菌偶氮菌B4的抗菌及抗氧化活性研究

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130215

J. Mamangkey, D. Suryanto, E. Munir, A. Z. Mustopa

{"title":"Antibacterial and Antioxidant Activity of Newly Keratinolytic\u0000Bacteria, Azotobacter chroococcum B4","authors":"J. Mamangkey, D. Suryanto, E. Munir, A. Z. Mustopa","doi":"10.20902/ijptr.2019.130215","DOIUrl":"https://doi.org/10.20902/ijptr.2019.130215","url":null,"abstract":"Keratinolyticbacteria of A. chrocoocum B4 was evaluated for its potential of antibacterial and antioxidant activity. Kirby-Bauer method was used to know antibacterial potential of B4 againtsStaphylococcus aureus, S. epidermidis, Bacillus cereus, Bacillus pumilus, Bacillus subtilis, Listeria monocytogenes, Proteus sp., enteropathogenicEscherichia coli, Enterobactersakazakii, and Salmonella enterica. Antioxydant test was done using DPPH radical scavenging activity assay with ascorbic acid as a controll. In this study, hydrolysate of pellet, dialysis, and fraction 25 of B4 keratinase purification of previous study was used for antibacterial and antioxidant test. The result showed that B4 hydrolysatesinhibited Gram positive pathogenic bacteria such as Staphylococcus aureus and Listeria monocytogenes, and Gram negative Enterobacter sakazakii. All hydrolysates showed to have antioxidant properties in which fraction 25 showed higher compared to that of others. This study showed poultry waste-derived keratinase of B4 might be useful as supplementary protein, antibacterial, and antioxidant in the animal feed formulations.","PeriodicalId":14252,"journal":{"name":"International Journal of PharmTech Research","volume":"193 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73665973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Green Stabilization of Clay Soil Using Cement Kiln Dust 水泥窑尘对粘土的绿色稳定研究

International Journal of PharmTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijptr.2019.130113

P. K. R. Rao, C. Rajakumar

引用次数: 0