Chih Chiang Benjamin Lam, Theresia Mina, Wubin Xie, Yanwen Dorrain Low, Yik Weng Yew, Xiaoyan Wang, Elio Riboli, Paul Elliott, Jimmy Lee, Joanne Ngeow, Eng Sing Lee, Marie Loh, John C Chambers
{"title":"The relationships between sleep and adiposity amongst multi-ethnic Asian populations: a cross-sectional analysis of the Health for Life in Singapore (HELIOS) study.","authors":"Chih Chiang Benjamin Lam, Theresia Mina, Wubin Xie, Yanwen Dorrain Low, Yik Weng Yew, Xiaoyan Wang, Elio Riboli, Paul Elliott, Jimmy Lee, Joanne Ngeow, Eng Sing Lee, Marie Loh, John C Chambers","doi":"10.1038/s41366-024-01666-5","DOIUrl":"10.1038/s41366-024-01666-5","url":null,"abstract":"<p><strong>Background: </strong>Short sleep duration and poor sleep quality have been associated with obesity. Asian populations report shorter sleep duration compared to other groups. We therefore aimed to explore the relationships between sleep duration, sleep quality, dozing, daytime napping, snoring, insomnia and adiposity in a multi-ethnic Asian population, and investigate the potential contribution of disturbed sleep to the risk of obesity amongst Asian populations.</p><p><strong>Methods: </strong>We studied 8876 participants of the HELIOS study, a multi-ethnic population-based cohort comprising Chinese, Malay, and Indian Asian men and women living in Singapore. Sleep traits and psychological symptoms were assessed using validated tools which included the Pittsburg Sleep Quality Index, Generalised Anxiety Disorder-7, and Patient Health Questionnaire-9. We employed multivariable regression models to examine the associations between sleep and adiposity, while also conducting sub-group and sensitivity analyses to strengthen the reliability of our results.</p><p><strong>Results: </strong>The 8876 participants were 69.3% Chinese, 12.5% Malays, and 18.2% Indians, with mean age: 51.7 ± 11.8 years (standard deviation). Malays had the shortest sleep duration, while Chinese had the best sleep quality. Short sleep duration, poor sleep quality, and snoring were associated with higher BMI and waist circumference, independent of age, sex, ethnicity, and various confounding factors (education, household income, current smoking, regular alcohol drinking status, presence of diabetes and hypertension, and markers for anxiety and depression; P < 0.005). The estimated population attributable fraction for short sleep and snoring as contributors to obesity were 6.6% (95% CI: 2.5-10.6%) and 18.6% (95% CI: 17.0-20.2%), respectively.</p><p><strong>Conclusion: </strong>Sleep duration, sleep quality, and snoring are associated with adiposity in a multi-ethnic Asian population of Chinese, Malays, and Indians. Our findings suggest that a substantial portion of obesity in Asian populations could be averted through public health interventions aimed at improving sleep duration and quality.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"596-604"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Elevated serum pepsinogen level predicts postoperative nausea and vomiting and pain in females with obesity following laparoscopic sleeve gastrectomy.","authors":"Min Hou, Lina Wu, Zhuoqi Wei, Shuwen Jiang, Huaxi Wang, Wenhui Chen, Ruixiang Hu, Bingsheng Guan, Lyujia Cheng, Jianxue Wang, Songhao Hu, Cunchuan Wang, Junchang Zhang, Zhiyong Dong, Jingge Yang, Qingran Lin, Wah Yang","doi":"10.1038/s41366-024-01688-z","DOIUrl":"10.1038/s41366-024-01688-z","url":null,"abstract":"<p><strong>Background: </strong>Postoperative nausea and vomiting (PONV) is the most common side effect after laparoscopic sleeve gastrectomy (LSG), affecting patients' postoperative recovery and increasing the medical and economic burden. This study aimed to analyze the relationship between serum pepsinogen and PONV.</p><p><strong>Methods: </strong>Patients with obesity who underwent LSG in our center between January 2021 and December 2022 were divided into PONV and NoPONV groups and analyzed retrospectively. Binary logistic regression analysis was used to determine the independent risk factors for PONV.</p><p><strong>Results: </strong>219 female patients were enrolled, with an average BMI of 36.74 ± 8.34 kg/m<sup>2</sup> and aged 32.61 ± 6.18 years. PONV occurred in 157 patients (71.7%). The influencing factors of PONV with different severity were analyzed, and the results showed that the severity of postoperative pain (χ2 = 13.169, p-values = 0.004), PGI (χ2 = 14.625, p-values = 0.002), PGII (χ2 = 25.916, p-values = 0.000), and PGR (χ2 = 17.697, p-values = 0.001) had statistical significance. Binary logistic regression showed that PGI was a risk factor for PONV with a OR (ng/mL) value of 1.013 (95% CI: 1.001-1.024, p-values = 0.037), while PGR was a protective factor for PONV with an OR(ng/mL) value of 0.952 (95% CI: 0.925-0.979, p-values = 0.001).</p><p><strong>Conclusions: </strong>The incidence of PONV after LSG is high. Higher PGI may be a risk factor for promoting PONV after LSG. The higher the preoperative PGI, the later the onset of PONV; the longer the duration, the more serious the degree.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"665-672"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephan Wueest, Chiara Scaffidi, Pim P van Krieken, Nils K Konrad, Christian Koch, Ioannis G Lempesis, Jonas Fullin, Konstantinos N Manolopoulos, Steffen Böttcher, Gijs H Goossens, Matthias Blüher, Daniel Konrad
{"title":"Expression of p53 in human adipose tissue correlates positively with FAS and BMI.","authors":"Stephan Wueest, Chiara Scaffidi, Pim P van Krieken, Nils K Konrad, Christian Koch, Ioannis G Lempesis, Jonas Fullin, Konstantinos N Manolopoulos, Steffen Böttcher, Gijs H Goossens, Matthias Blüher, Daniel Konrad","doi":"10.1038/s41366-024-01691-4","DOIUrl":"10.1038/s41366-024-01691-4","url":null,"abstract":"<p><p>Activation of Fas (CD95) in adipocytes inhibits browning and may contribute to body weight gain in mice. Moreover, Fas expression in white adipose tissue (WAT) correlates positively with body mass index (BMI) in humans. However, molecular pathways involved in the inhibitory effect of Fas on energy metabolism remain incompletely understood. Herein, we report that protein levels of the tumor suppressor p53 were reduced in primary white adipocytes of adipocyte-specific Fas-knockout mice. Moreover, Fas ligand (FasL) treatment increased p53 concentrations in cultured adipocytes and decreased mitochondrial oxygen consumption in control but not in p53-depleted cells, indicating that Fas activation reduces energy expenditure in a p53-dependent manner. In line, in differentiated human mesenchymal stem cells and WAT derived from different anatomical depots, FAS expression was positively associated with p53. Furthermore, p53 expression in human subcutaneous and visceral WAT correlated positively with BMI, whereas its expression in visceral WAT was inversely associated with insulin sensitivity (as assessed by hyperinsulinemic-euglycemic clamp). Taken together, our data suggest that Fas regulates p53 expression in adipocytes, and may thereby affect body weight gain and insulin sensitivity.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"737-741"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proposed shorter duration protocols for measuring resting energy expenditure utilizing whole-room indirect calorimetry.","authors":"Russell Rising, Hannah D Kittrell, Jeanine B Albu","doi":"10.1038/s41366-024-01667-4","DOIUrl":"10.1038/s41366-024-01667-4","url":null,"abstract":"<p><strong>Background: </strong>Sixty minutes is currently the shortest testing duration for 24-h resting energy expenditure (24-h REE) utilizing whole-room indirect calorimetry.</p><p><strong>Objective: </strong>Show that recalculated 30-min extrapolated 24-h REE from previously published 60-min metabolic data are valid.</p><p><strong>Methods: </strong>Propane consumption linearity was determined through an 8-h combustion test. Thereafter, metabolic data for 24-h extrapolated ventilation rates of oxygen (VO<sub>2</sub>; l/d), carbon dioxide (VCO<sub>2</sub>; l/d), respiratory quotient (RQ; VCO<sub>2</sub>/VO<sub>2</sub>), and REE (MJ/d) from ten 60-min propane combustion tests were recalculated to reflect a 30-min testing duration. A similar analysis was performed utilizing data from 60-min subject metabolic measurements within a whole-room indirect calorimeter (4597 liters) specific for measuring resting energy expenditure (REE). Statistical (p < 0.05) comparisons between recalculated and original 60-min metabolic data were determined by SPSS (version 29).</p><p><strong>Results: </strong>Propane consumption during a combustion test was found to be linear for up to 8-h. Furthermore, no differences existed between propane stoichiometry and combustion for any of the extrapolated 24-h metabolic parameters when recalculated from 60-min propane combustion data to reflect a 30-min duration. Finally, similar results were obtained for all recalculated subject metabolic data.</p><p><strong>Conclusions: </strong>Recalculated extrapolated 24-h metabolic data derived from a 30-min testing duration appear to be valid. This suggests that whole-room indirect calorimetry could be an adjunct for various weight loss or other programs where accurate metabolic measurements are required.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"731-736"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"BMI trajectory of 8,155,894 Japanese adults from exhaustive health checkup data: the contributions of age-related changes in height and weight.","authors":"Naoki Uemura, Yuki Nishida, Satoshi Sasaki, Yosuke Yamada, Tatsuhiko Anzai, Kunihiko Takahashi, Keita Yamauchi, Fuminori Katsukawa","doi":"10.1038/s41366-024-01694-1","DOIUrl":"10.1038/s41366-024-01694-1","url":null,"abstract":"<p><p>This study aimed to clarify the trajectory of BMI alongside age-related changes in height and weight among Japanese adults. Data from annual health checkups between 2015 and 2020 by the Japan Health Insurance Association were retrospectively analyzed. A total of 4,777,891 men and 3,378,003 women (age 35-69 years) were stratified into 14 subgroups based on sex and 5-year age categories. We used linear mixed-effects model to estimate values for each outcome, with six-time points (2015-2020) as the independent variable. Mean BMI changes were positive across all subgroups, indicating a trend of increasing BMI (men, 0.02 to 0.14 kg/m<sup>2</sup>/year; women, 0.05 to 0.16 kg/m<sup>2</sup>/year). In younger subgroups, the changed were relatively large, with the weight transitions mirroring those of BMI. However, the mean changes were negative (men, -0.06 kg/year; women, -0.01 kg/year) in the oldest subgroups. Height reduction increased with age across subgroups (men, -0.14 to -0.03 cm/year; women, -0.18 to -0.01 cm/year). In conclusion, BMI tended to increase with age in both sexes across all age groups of Japanese adults. The increase in BMI appeared to be influenced by weight gain in young to middle age, whereas height reduction influenced increased BMI in older age groups.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"742-745"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mimmi Karlsson, Johan Ottosson, Spencer Clarkson, Klas Sjöberg
{"title":"Anemia in patients ten years after bariatric surgery.","authors":"Mimmi Karlsson, Johan Ottosson, Spencer Clarkson, Klas Sjöberg","doi":"10.1038/s41366-024-01675-4","DOIUrl":"10.1038/s41366-024-01675-4","url":null,"abstract":"<p><strong>Background: </strong>More than 10% of the global population has a BMI above 35. Bariatric surgery is an efficient way to treat this condition. Unfortunately, there is a risk of nutritional deficiencies. The number of studies after a longer time span is scarce. The aim of this study was to determine the occurrence of anaemia five and ten years after bariatric surgery and how it was related to substitution therapy.</p><p><strong>Patients and methods: </strong>Registry data from individuals having primary bariatric surgery in the Scandinavian Obesity Surgery Registry (SOReg) from 2007 to 2022 and with a follow-up at five or ten years was retrieved. Demographic data including weight, as well as method of surgery, Hb levels, supplementation, PPI use and stomal ulcerations were recorded.</p><p><strong>Results: </strong>In total, 39,992 individuals (mean age 41 years, range 18-74, 77% women) could be included. The majority, 78%, had undergone laparoscopic Roux-en-Y gastric bypass. After five years, 2838/13,944 women (20.3%) and 456/4049 men (11.2%) had anaemia. After ten years, 644/3400 women (18.9%) and 178/947 men (18.8%) had anaemia. The use of oral iron increased from 40 to 45%, and the need for parenteral iron intake increased from 5 to 11%.</p><p><strong>Conclusions: </strong>Anaemia is a significant but manageable condition five and ten years after bariatric surgery. Despite the prescription of oral iron supplements to 45% ten years after surgery, the Hb levels could still not be fully restored. Consequently, the importance of follow-up visits and continuous supplementation is emphasised.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"612-618"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Holly L McClung, P Matthew Bartlett, Barry A Spiering, Stephen A Foulis, Tyler E Oliver, Leila A Walker, Vy T Nguyen, Susan P Proctor, James P McClung, Kathryn M Taylor
{"title":"Science behind policy: implementing a modern circumference-based body fat equation with a physical fitness threshold is associated with lower musculoskeletal injury risk.","authors":"Holly L McClung, P Matthew Bartlett, Barry A Spiering, Stephen A Foulis, Tyler E Oliver, Leila A Walker, Vy T Nguyen, Susan P Proctor, James P McClung, Kathryn M Taylor","doi":"10.1038/s41366-024-01701-5","DOIUrl":"10.1038/s41366-024-01701-5","url":null,"abstract":"<p><strong>Background: </strong>Body composition influences physical fitness (PF) and risk of musculoskeletal injury (MSKI). Assessing the relationship between body fat (BF), PF and MSKI risk in a large diverse military population may provide evidence basis informing health-care policies, practices, and programs for military and civilian populations.</p><p><strong>Objective: </strong>Evaluate the validity of expedient methods to estimate BF (e.g., circumference-based equation (CBE) and bioelectrical impedance analysis (BIA)) and investigate relationships between BF and PF with MSKI risk in a large diverse population.</p><p><strong>Methods: </strong>Participants were 1904 active-duty Soldiers (643 F) representing Army demographics sex, race/ethnicity (R/E), and age. PF, defined as the most recent Army Combat Fitness Test (ACFT) score and incidence of MSKI, were obtained from Army records. BF was determined by dual-energy x-ray absorptiometry (%BF<sub>DXA</sub>), bioelectrical impedance analysis (%BF<sub>BIA</sub>), and CBE using 3-site (Hodgdon, %BF<sub>HE</sub>) and 1-site (Taylor-McClung, %BF<sub>TM</sub>) equations. Results were stratified by race and sex, to evaluate differences in accuracy of estimated %BF (weighted root mean squared error from %BF<sub>DXA</sub>). Associations of BF and PF with MSKI risk were evaluated with logistic regression.</p><p><strong>Results: </strong>CBE and BIA underestimated %BF compared to %BF<sub>DXA</sub>. %BF<sub>BIA</sub> differed from %BF<sub>DXA</sub> overall and by sex. %BF<sub>TM</sub> underestimation was uniform across both sex and R/E compared to %BF<sub>DXA</sub>. Mean differences from %BF<sub>DXA</sub> by sex (M;F) were lower when measured by %BF<sub>TM</sub> (4.38; 4.59) compared to %BF<sub>HE</sub> (5.88; 4.39). Individuals had a greater likelihood of MSKI if they failed BF standards (odds ratio 1.32). Scoring ≥ 540 total on ACFT exhibited a 31% (95% CI: 0.52, 0.92) lower MSKI risk during the following 12 months than those with a lower score.</p><p><strong>Conclusions: </strong>A single-site BF equation (%BF<sub>TM</sub>) maintained similar accuracy across the Soldier population by sex, age, and R/E. Implementing a PF score threshold in lieu of passing Army BF standards was associated with lower MSKI risk.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"723-730"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Elliott, Judy Bauer, Cassie McDonald, Simone Gibson
{"title":"Exploring dietitians' experiences caring for patients living with obesity in acute care: a qualitative study.","authors":"Andrea Elliott, Judy Bauer, Cassie McDonald, Simone Gibson","doi":"10.1038/s41366-024-01697-y","DOIUrl":"10.1038/s41366-024-01697-y","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a modifiable risk factor associated with hospital-associated complications. Recent studies show there is a high prevalence of patients with obesity presenting to hospital and evidence indicates that people living with obesity should receive diet advice from a dietitian; however, patients often do not receive this care in acute settings.</p><p><strong>Aim: </strong>The primary aim of this study was to explore the experiences of dietitians caring for patients living with obesity in acute hospital settings.</p><p><strong>Methods: </strong>A multi-site qualitative study was conducted from October 2021 to November 2023 in Melbourne, Australia. Constructivist grounded theory methodology informed sampling and data collection. Semi-structured interviews were undertaken with dietitians working in acute care. Data were analysed using open coding and constant comparison underpinned by Charmaz's framework.</p><p><strong>Results: </strong>Interviews were conducted with 25 dietitians working across four hospitals. The theory developed from the data describes an enculturated decision-making process whereby acute clinical dietitians are limiting acute nutrition care for people living with obesity in hospital. The theory includes five interdependent categories that influence clinical decision-making and practice: (1) culture of professional practice, (2) science and evidence, (3) acknowledgement of weight bias and stigma, (4) dietitian-led care and (5) hospital systems and environment.</p><p><strong>Conclusion: </strong>The findings from this study provide new insights as to why dietitians may not be providing acute nutrition care for people living with obesity. Strategic leadership from clinical leaders and education providers together with the lived experience perspectives of people with obesity is needed to shift the culture of dietetic professional practice to consider all nutrition care needs of patients living with obesity who are accessing acute hospitals for health care.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"698-705"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sofia Scataglini, Lisanne Dellaert, Lien Meeuwssen, Ellen Staeljanssens, Steven Truijen
{"title":"The difference in gait pattern between adults with obesity and adults with a normal weight, assessed with 3D-4D gait analysis devices: a systematic review and meta-analysis.","authors":"Sofia Scataglini, Lisanne Dellaert, Lien Meeuwssen, Ellen Staeljanssens, Steven Truijen","doi":"10.1038/s41366-024-01659-4","DOIUrl":"10.1038/s41366-024-01659-4","url":null,"abstract":"<p><strong>Objective: </strong>A systematic review and meta-analysis were performed following PRISMA 2020 guidelines to identify the difference in gait pattern between adults with obesity and adults with a normal bodyweight assessed with 3D-4D gait analysis (3D-4DGA) devices.</p><p><strong>Methods: </strong>Articles about the spatiotemporal parameters of adults with obesity compared with adults with a normal bodyweight using a 3DGA were sought on the 4th of October 2023 in three different databases (PubMed, Web of Science and IEEE). A total of 3371 articles were found: 2065 with PubMed, 1185 with Web of Science, and 121 with IEEE. The data was screened double-blind. Fourteen case control studies were included in the systematic review and meta-analysis, and for all of them, the risk of bias was determined. Obesity was defined using the BMI, with a range of 30 kg/m² until 54.06 kg/m². Participants from both sexes (35% men and 65% women) were included, and they had an age range of 18-65 years.</p><p><strong>Results and discussion: </strong>The risk of bias was assessed with the Newcastle Ottowa Scale (NOS), and the certainty of evidence was assessed with the Evidence-Based Richtlijn Ontwikkeling (EBRO). The meta-analysis showed a decrease in gait speed and cadence and an increase in stance phase, double stance, and step width. No significant difference was found regarding stride length. In the systematic review, step length, step rate, and swing phase were found to have decreased. Regarding the single stance, step time, CoM, and CoP, no conclusions could be drawn.</p><p><strong>Conclusion: </strong>There is a difference in gait parameters between adults with obesity and adults with a normal bodyweight. Namely, the gait speed, step rate, step length, swing phase is decreased in adults with obesity. However, there is an increase in step width, stance phase, and double stance phase.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"541-553"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jumana Antoun, Cassandra Kfoury, Yara Chamaa, Youmna Saade, Sami El Tannir
{"title":"Acceptance, knowledge, and attitude of family physicians towards obesity as a chronic disease: a multinational cross-sectional study.","authors":"Jumana Antoun, Cassandra Kfoury, Yara Chamaa, Youmna Saade, Sami El Tannir","doi":"10.1038/s41366-024-01693-2","DOIUrl":"10.1038/s41366-024-01693-2","url":null,"abstract":"<p><strong>Background/objectives: </strong>Obesity was previously perceived to be a lifestyle issue; however, it was declared a chronic disease by the American Medical Association (AMA) in 2013. However, family physician's views and actions toward managing obesity remain ambiguous and occasionally conflicting.</p><p><strong>Subjects/methods: </strong>This cross-sectional study explores the acceptance and knowledge of 171 family medicine physicians regarding obesity as a chronic disease. Family physicians were recruited through different channels, including members of professional scientific societies of family medicine that belong to the World Organization of Family Doctors (WONCA) Eastern Mediterranean Regional Office EMRO, a publicly available list of United States (US) family physicians, and authors' personal Facebook and LinkedIn connections. Data was collected across various countries through an anonymous online survey.</p><p><strong>Results: </strong>While most participants acknowledged obesity as a chronic condition with multifactorial origins, there was a notable discrepancy in treatment practices compared to other chronic diseases. A dual perspective emerged, as family physicians often emphasized self-responsibility and behavioral change over medical interventions, potentially hindering effective management. Lower initiation rates for obesity management was exhibited compared to other chronic diseases.</p><p><strong>Conclusion: </strong>There is a gap between recognition and effective management of obesity as a chronic disease within family practice. The findings underscore the need for comprehensive obesity education in medical training to bridge knowledge gaps and reduce weight stigma, enabling physicians to provide optimal care for patients with obesity.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"682-687"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}