International Journal of Obesity最新文献

{"title":"Compositional analyses of accelerometer-measured 24-h movement behaviors among adults with normoglycemia, pre-diabetes phenotypes, and diabetes: a population-based study.","authors":"Jincheng Rong, Mandy Ho, Pui Hing Chau","doi":"10.1038/s41366-026-02162-8","DOIUrl":"https://doi.org/10.1038/s41366-026-02162-8","url":null,"abstract":"<p><strong>Background: </strong>Sleep, sedentary behavior (SB), light-intensity physical activity (LIPA), and moderate-to-vigorous physical activity (MVPA) collectively constitute a 24-h day. This study used compositional data analysis (CoDA), an approach appropriate for data composed of mutually exclusive parts of a whole, to examine the associations of 24-h movement behaviors with pre-diabetes phenotypes (isolated-impaired fasting plasma glucose [i-IFG], isolated-impaired glucose tolerance [i-IGT], and combined IFG + IGT) and diabetes.</p><p><strong>Methods: </strong>This cross-sectional study analyzed 1222 participants from the National Health and Nutrition Examination Survey 2005-2006. Time spent in SB, LIPA, and MVPA was measured via accelerometer, and sleep duration was determined via self-report. The glycemic status was classified as normoglycemia, pre-diabetes (i-IFG, i-IGT, or combined IFG + IGT), or diabetes based on the American Diabetes Association criteria. The CoDA was performed, adjusting for age, sex, education, and smoking status.</p><p><strong>Results: </strong>The study sample had a mean age of 41.02 (SD = 12.97) years and comprised 47.22% males. On average, participants spent 6.8 h in sleep, 9.4 h in SB, 7.3 h in LIPA, and 0.5 h in MVPA over a 24-h day. None of the four movement behaviors was associated with i-IFG (all p > 0.05). In contrast, SB was detrimentally associated with i-IGT (OR [95% CI] = 3.49 [1.10, 11.09], p = 0.038), and MVPA was favorably associated with combined IFG + IGT (OR [95% CI] = 0.57 [0.45, 0.71], p < 0.001). For diabetes, more time spent in sleep (OR [95% CI] = 0.47 [0.25, 0.88], p = 0.025) or MVPA (OR [95% CI] = 0.55 [0.39, 0.77], p = 0.005), and less time spent in SB (OR [95% CI] = 2.33 [1.07, 5.08], p = 0.037), were each associated with lower odds.</p><p><strong>Conclusions: </strong>Findings of this study provide insights for the development of integrated 24-h movement recommendations to optimize diabetes prevention and management. Notably, the associations with 24-h movement behaviors appeared to differ across distinct pre-diabetes phenotypes, providing preliminary evidence for precision prevention strategies.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The joint association of health-enhancing walking and healthful diet with central obesity: a longitudinal repeated-measures study.","authors":"Wei Liang, Xiaoyu Li, Fei Jing, Zhihao Xie, Xiuli Zhao, Qi Chen, Yufeng Zhao, Guangyu Lu","doi":"10.1038/s41366-026-02165-5","DOIUrl":"https://doi.org/10.1038/s41366-026-02165-5","url":null,"abstract":"<p><strong>Objectives: </strong>Overweight is a global health crisis linked to chronic diseases. Traditional indicators like BMI have limitations, whereas novel central obesity indices are superior for assessing obesity-related health risks. We aim to explore the joint association of health-enhancing walking and healthful diet with central obesity.</p><p><strong>Methods: </strong>This study utilized data from the 100-Day Walking Program in Bozhou City (2022-2024). Daily step counts were tracked using dedicated pedometers. Central obesity indices, including the waist-to-weight index (WWI), conicity index (C-Index), and body shape index (ABSI), along with body composition parameters, were measured using a body composition analyzer. Linear mixed-effects models and generalized estimating equations were employed to assess the associations of daily steps with the obesity indices and weight loss success, respectively.</p><p><strong>Results: </strong>Among 3 503 participants, the median average daily step count was 12 675. Each 1000-step increment was associated with reductions of 0.014 in WWI, 0.002 in C-Index, and 0.001 in ABSI. Exposure-response curves demonstrated a general decline in these indices with increasing steps. These inverse associations were significantly more pronounced in participants with higher dietary quality scores. In the joint analysis, participants with both higher step counts and higher dietary quality exhibited significantly lower central obesity indices than the reference group with low levels of both. Moreover, each 1000-step increase was associated with a 4% higher probability of successful short-term weight loss.</p><p><strong>Conclusion: </strong>Increasing daily steps is associated with improved central obesity indices and short-term weight loss success, particularly among participants with higher dietary quality.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipedema and shear-wave elastography: under-specification of ROI acquisition limits anatomical interpretation.","authors":"Jose Luis Simarro","doi":"10.1038/s41366-026-02163-7","DOIUrl":"https://doi.org/10.1038/s41366-026-02163-7","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From maximal weight loss to required weight loss: a call to action for weight management in gynecologic practice.","authors":"Rodrigo Orozco, Pablo Romero, Santiago Palacios","doi":"10.1038/s41366-026-02166-4","DOIUrl":"https://doi.org/10.1038/s41366-026-02166-4","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative multi-omics analysis of DNA methylome and transcriptome in a tyrosine kinase inhibitor LPM4870108-induced rat model of obesity","authors":"Baiyang Yuan,&nbsp;Xuan Jin,&nbsp;Chunmei Li,&nbsp;Hongbo Wang,&nbsp;Jingwei Tian,&nbsp;Sijin Duan","doi":"10.1038/s41366-026-02157-5","DOIUrl":"10.1038/s41366-026-02157-5","url":null,"abstract":"Obesity is a serious multifactorial disease that involves epigenetic mechanisms like DNA methylation. Tyrosine kinase inhibitors (TKIs), originally synthesized and approved for cancer therapy, have recently been linked to the regulation of obesity. We evaluated whether LPM4870108, a small-molecule TKI with antitumor efficacy, contributes to obesity via DNA methylation. LPM4870108 (TKI) was administered orally to rats at 0, 1.25, 2.5, or 5.0 mg/kg (for 28 days, twice daily). Body weights (BWs) and food intake were recorded daily. After 28 days of administration, ventromedial hypothalamus (VMH) tissues were collected for whole-genome transcriptomic and methylation sequencing to identify candidate genes. The mRNA expression and promoter methylation of candidate genes were analyzed by real-time RT-PCR and pyrosequencing, respectively. Protein levels of DNA methyltransferases (DNMTs) were determined by Western blot. LPM4870108 treatment substantially increased food intake and BW. Whole-genome transcriptomic and methylation profiling identified 415 differentially expressed genes (DEGs) and 124,935 differentially methylated regions (DMRs) within the VMH of LPM4870108-treated rats. The transcriptomic results were combined with whole-genome methylation sequencing data, followed by further verification via RT-PCR and pyrosequencing, through which the obesity-related candidate gene arginine vasopressin (AVP) was identified. Among all DEGs, AVP showed the most prominent change, with a negative association between its promoter methylation and mRNA expression level. Reduced protein expression of DNA methyltransferase 3A (DNMT3A) in the VMH was also detected in LPM4870108-treated rats. These findings indicate that LPM4870108-stimulated hyperphagia and weight gain were associated with DNA hypomethylation and concomitant upregulation of the AVP gene.","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":"50 9","pages":"2034-2044"},"PeriodicalIF":5.4,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-intensity interval training improves myocardial work and cardiac function in women with obesity: a randomized controlled study.","authors":"Caroline Ferraz Simões, Higor Barbosa Reck, João Carlos Locatelli, Gustavo Henrique de Oliveira, Victor Hugo de Souza Mendes, Rogério Toshiro Passos Okawa, Jamie O'Driscoll, Jorge Mota, Wendell Arthur Lopes","doi":"10.1038/s41366-026-02158-4","DOIUrl":"https://doi.org/10.1038/s41366-026-02158-4","url":null,"abstract":"<p><p>The purpose of this study was to investigate the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on cardiac function and myocardial work (MW) in women with obesity. Twenty-five women with obesity (Age: 28 ± 5 years, BMI: 35.03 ± 3.19 kg/m²) were randomized to 8 weeks of either HIIT (n = 11, 4×4-min at 85-95% of HR_max) or MICT (n = 14, 41-min at 65-75% of HR_max). Cardiac function and strains were evaluated using two-dimensional speckle tracking echocardiography. MW indices were computed via dedicated software. HIIT significantly improved myocardial efficiency, as evidenced by a reduction in global wasted work (GWW [d = 0.64, p = 0.042]) and an increase global work efficiency (GWE [d = 0.83, p = 0.005]). Both HIIT and MICT reduced left ventricular global longitudinal strain (GLS, p = 0.017 for HIIT; p = 0.023 for MICT), left atrial (LA) contraction (p < 0.001 for both), LA conduit (p = 0.002 for both), LA reservoir (p = 0.003 for HIIT; p < 0.001 for MICT), and LA stiffness (p = 0.004 for HIIT, p = 0.031 for MICT). HIIT and MICT both improved myocardial deformation in women with obesity. However, only HIIT improved myocardial efficiency, suggesting a potential superiority for targeting subclinical cardiac dysfunction in this population.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating a large language model for identifying key comorbidities in discharge summaries of patients with obesity: a comparative validation study against ICD codes using MIMIC-IV.","authors":"Thanathip Suenghataiphorn, Kanachai Boonpiraks, Vitchapong Prasitsumrit, Narathorn Kulthamrongsri, Pojsakorn Danpanichkul","doi":"10.1038/s41366-026-02145-9","DOIUrl":"https://doi.org/10.1038/s41366-026-02145-9","url":null,"abstract":"<p><strong>Background: </strong>Accurate identification of comorbidities like Type 2 Diabetes Mellitus (T2DM), Hypertension (HTN), Hyperlipidemia (HLD), and Obstructive Sleep Apnea (OSA) is crucial for managing patients with obesity and for large-scale research. While electronic health record discharge summaries contain rich clinical information, manual extraction is resource-intensive. Large Language Models (LLMs) present a potential automated solution.</p><p><strong>Objective: </strong>To evaluate the performance of utilizing LLM in identifying the presence of T2DM, HTN, HLD, and OSA documented within discharge summaries of adult patients with obesity, using administrative ICD codes as the primary reference standard and complete manual review as a secondary sensitivity analysis.</p><p><strong>Methods: </strong>This retrospective validation study used MIMIC-IV data. A random sample of 350 discharge summaries was processed by the LLM for the presence or absence of each target comorbidity. Performance was evaluated against ICD-9/10 coding and against manual review of all 350 discharge summaries using accuracy, precision, recall, and F1-score.</p><p><strong>Results: </strong>The analyzed sample included 350 admissions from 341 unique patients (mean age 59.7 [SD 14.3], 60.4% female). Prevalence based on ICD codes was 45.4% for Type 2 Diabetes Mellitus (T2DM), 60.0% for Hypertension (HTN), 55.4% for Hyperlipidemia (HLD), and 29.4% for Obstructive Sleep Apnea (OSA). In the primary ICD-based analysis, F1-scores ranged from 0.815 to 0.948. In the manual-review sensitivity analysis, accuracy was 0.963 for T2DM, 0.971 for HTN, 0.863 for HLD, and 0.966 for OSA, with F1-scores ranging from 0.879 to 0.981.</p><p><strong>Conclusion: </strong>The LLM showed promising concordance with ICD codes for T2DM, HTN, OSA, and HLD in obesity patient discharge summaries. Further research, including validation against clinical expert review and investigation into reasons for discrepancies, is necessary before considering practical applications.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148411798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of white adipocyte heterogeneity using data-driven microscopy.","authors":"Jieyu Zhang, Christian Simonsson, Ayesha Fawad, Wathik Alsalim, Allan Vaag, Mathis Neuhaus, Karin G Stenkula","doi":"10.1038/s41366-026-02151-x","DOIUrl":"https://doi.org/10.1038/s41366-026-02151-x","url":null,"abstract":"<p><strong>Background: </strong>Recent advancements in single-cell transcriptomic analyses have greatly expanded our understanding of cellular diversity in adipose tissue, indicating transcriptionally distinct subpopulations of adipocytes. Here we sought to rigorously test such heterogeneity at the protein level.</p><p><strong>Methods: </strong>A data-driven imaging platform was tailored to assess cellular protein levels based on immunofluorescence staining in primary adipocytes isolated from human adipose tissue biopsies (abdominal and gluteal adipose tissue from n = four subjects). Isolated adipocytes were co-labeled for GLUT4 and the previously proposed adipocyte subtype markers PLIN1 and DDR2 to assess their relative expression levels.</p><p><strong>Results: </strong>The platform enabled a two-step gating, shape-based filtering approach, which allowed accurate identification of mature adipocytes of a large cell-size range. The software was able to accurately detect hundreds of adipocytes spanning a broad size range. When comparing cells isolated from a single adipose tissue depot and subject, we found that a large proportion of cells had relatively high levels of both DDR2 and PLIN1. No notable differences in GLUT4 levels were observed within this group of cells.</p><p><strong>Conclusions: </strong>The described approach, based on population-wide imaging, could serve as a robust tool to further validate cellular characteristics at a single-cell level. The fact that we detected distinct protein levels of the proposed adipocyte markers may reflect the presence of mature adipocyte subtypes.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148411803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of weight loss interventions on liver-related health in children and adolescents with obesity: a systematic review and meta-analyses","authors":"Alexis Couret,&nbsp;Duane Beraud,&nbsp;Gabriel Torbahn,&nbsp;Julia Lischka,&nbsp;Valérie Julian V,&nbsp;Bruno Pereira,&nbsp;James A. King,&nbsp;Armand Abergel,&nbsp;Daniel Weghuber,&nbsp;David Thivel,&nbsp;Gaël Ennequin","doi":"10.1038/s41366-026-02144-w","DOIUrl":"10.1038/s41366-026-02144-w","url":null,"abstract":"Metabolically-dysfunction-associated steatotic liver disease is today rising in prevalence among children and adolescents with obesity. The present Systematic Review and Meta-analysis explores the effect of weight loss interventions, depending on their modality (lifestyle, bariatric surgery or anti-obesity medication) on circulating, imagery-related and histology-related liver parameters in children and adolescents with obesity (aged 5–18 years). After consultation of the main databases (MEDLINE, EMBASE, Web of Science and Google Scholar and the Cochrane Controlled Register of Trials), 145 studies were included, gathering 18609 participants (10539 included in the meta-analysis) allocated to 257 experimental arms (26 diet, 24 medication, 96 multidisciplinary, 39 controls, 16 physical activity, 41 supplementation and 15 surgery). Circulating levels of liver enzymes were found improved in the large majority of the studies (most of them relying on multidisciplinary treatments), with however a lack of positive effect of physical activity programs. Sixty-seven percent of the intervention arms found significant improvements in hepatic fat, with no effect of physical activity interventions according to the meta-analysis. Bariatric Surgery appears as the only modality to improve histology-related parameters. According to the meta-regression, improvements in the Non-alcoholic fatty liver disease Activity Score are associated with the degree of weight loss and Body Mass Index reduction. The present results indicate improved overall liver status in response to weight loss interventions in this population, further studies remain however needed to clarify the effects of physical activity alone. Importantly, results also suggest the necessity to provide adapted and appropriate dietary and multidisciplinary interventions as first line strategies for liver-related health, especially in the context of obesity medication.","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":"50 8","pages":"1647-1665"},"PeriodicalIF":5.4,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148411784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overweight/obesity and gait abnormality: what role does the brain play in the relationship?","authors":"Hao Wang, Jianwei Wang, Qiu Xiao, Hanhan Zhao, Heyang Lu, Min Fan, Weizhong Tian, Yingzhe Wang, Mei Cui, Chen Suo, Tiejun Zhang, Li Jin, Yanfeng Jiang, Xingdong Chen, Kelin Xu","doi":"10.1038/s41366-026-02150-y","DOIUrl":"https://doi.org/10.1038/s41366-026-02150-y","url":null,"abstract":"<p><strong>Background: </strong>Gait is related to weight factors and regulated by the nervous system. Emerging evidence indicates that adiposity impacts brain health. This study explores the relationship between anthropometric indices and gait performance, and investigates the role of brain parameters in the relationship.</p><p><strong>Methods: </strong>This study included 710 community-dwelling older adults from the Taizhou Imaging Study. Nine anthropometric indices were calculated to assess body weight using standard formulas based on measured height, weight, waist circumference (WC), and hip circumference. Gait assessment includes Timed-Up-and-Go tests, Tinetti tests, and quantitative gait assessment conducted with wearable insole devices. 16 quantitative parameters were summarized into five independent gait domains (rhythm, symmetry, phase, pace and variability) using factor analysis. Quantitative susceptibility mapping was used to measure iron levels in cortical regions.</p><p><strong>Results: </strong>Overweight/obesity group (body mass index, BMI ≥ 24 kg/m²) had significantly poorer performance in the phase domain (standardized β = -0.172, P = 0.023), specifically manifested in the percentage of the double support time (standardized β = 0.783, P = 0.028) and stance time (standardized β = 0.422, P = 0.019). They also exhibited higher iron levels of the inferior temporal gyrus (ITG) (standardized β = 0.641, P = 0.021). The metabolic-related anthropometric indices have stronger associations with gait performance and indices of abdominal assessment more closely correlated with iron levels. The iron levels of ITG mediated the association of anthropometric indices (BMI, WC, Waist-to-Height Ratio, abdominal volume index and body roundness index) with the phase domain, with mediation proportions ranging from 8.95% to 13.45%.</p><p><strong>Conclusion: </strong>Increased anthropometric indices are associated with relative prolongation of the stance phase and the iron levels of ITG mediates the associations. Our research offers valuable insights into the neuropathological mechanisms underlying of gait abnormalities in the community-dwelling older adults with overweight/obesity.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148411748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}