Metabolic syndrome in the association of BMI and trajectory of depressive symptoms in middle-aged and elderly population: a cohort study from China.

IF 3.8 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity Pub Date : 2025-07-11 DOI:10.1038/s41366-025-01845-y

Yue Dong, Qihang Hu, Yahui Wang, Yuzhi Xi, Zhijun Chai

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引用次数: 0

Abstract

Objectives: This study aimed to investigate the cross-sectional and longitudinal relationship between BMI and depressive symptoms among adults aged over 45 and further explore the mediating role of metabolic syndrome.

Subjects/methods: Our data were drawn from the China Health and Retirement Longitudinal Study. BMI was categorized into: underweight (≤18.5 kg/m²), healthy weight (18.5-23.0 kg/m²), overweight (23.0-27.5 kg/m²), and obesity (≥27.5 kg/m²). The Group-based trajectory modeling was used to identify trajectories of depressive symptoms. The logistic regression models were performed to estimate the odds ratio (OR) and 95% confidence intervals (95% CI) between BMI and depressive symptoms.

Results: A total of 13,422 participants were enrolled in the cross-sectional analysis and 10,136 individuals were included in the longitudinal study. Two trajectories of depressive symptoms were identified: low-stable trajectory and high-ascending trajectory. Individuals with underweight exhibited higher risks of depressive symptoms (OR = 1.20, 95% CI: 1.01-1.43) and were more likely to follow the high-ascending trajectory (OR = 1.29, 95% CI: 1.04-1.61) compared with those with healthy weight. Conversely, participants with overweight and obesity had reduced risks of depressive symptoms (overweight: OR = 0.87, 95% CI: 0.80-0.95; obesity: OR = 0.83, 95% CI: 0.74-0.94) and were less likely to follow the high-ascending trajectory (overweight: OR = 0.85, 95% CI: 0.76-0.95; obesity: OR = 0.85, 95% CI: 0.72-0.99). Furthermore, metabolic syndrome accounted for 31.87% of the association between BMI and depressive symptoms and 50.60% of the association between BMI and depressive symptom trajectory.

Conclusions: Underweight was a risk factor for depressive symptoms and high-ascending trajectory of depressive symptoms. Medical professionals should pay attention to the mental status of middle-aged and older adults with underweight and interventions of improving metabolic syndrome could protect mental health.

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代谢综合征与中老年人群BMI和抑郁症状轨迹的关系：一项来自中国的队列研究

目的：本研究旨在探讨45岁以上成人BMI与抑郁症状的横断面和纵向关系，并进一步探讨代谢综合征的中介作用。研究对象/方法：我们的数据来自中国健康与退休纵向研究。BMI分为体重过轻（≤18.5 kg/m2）、健康体重（18.5 ~ 23.0 kg/m2）、超重（23.0 ~ 27.5 kg/m2）、肥胖（≥27.5 kg/m2）。使用基于组的轨迹模型来识别抑郁症状的轨迹。采用logistic回归模型估计BMI与抑郁症状之间的比值比（OR）和95%置信区间（95% CI）。结果：共有13422名参与者参加了横断面分析，10136人被纳入了纵向研究。确定了抑郁症状的两种轨迹：低稳定轨迹和高上升轨迹。与体重正常的个体相比，体重过轻的个体表现出更高的抑郁症状风险（OR = 1.20, 95% CI: 1.01-1.43），并且更有可能遵循高上升轨迹（OR = 1.29, 95% CI: 1.04-1.61）。相反，超重和肥胖的参与者抑郁症状的风险降低(超重：OR = 0.87, 95% CI: 0.80-0.95；肥胖：OR = 0.83, 95% CI: 0.74-0.94)，且不太可能遵循高上升轨迹(超重：OR = 0.85, 95% CI: 0.76-0.95；肥胖：OR = 0.85, 95% CI: 0.72-0.99)。代谢综合征在BMI与抑郁症状的关联中占31.87%，在BMI与抑郁症状轨迹的关联中占50.60%。结论：体重过轻是抑郁症状和抑郁症状高上升轨迹的危险因素。医学界应重视中老年体重过轻者的心理状况，改善代谢综合征的干预措施可保护心理健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Obesity 医学-内分泌学与代谢

CiteScore

10.00

自引率

2.00%

发文量

221

审稿时长

3 months

期刊介绍： The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.