Intergenerational associations between maternal body mass index before or during pregnancy with offspring metabolomics: a systematic review and meta-analysis.
Huan Hu, Yue Yang, Yongping Zhang, Ling-Jun Li, Jinhong Liu, Ruochen Du, Jinrui Xiong, Zimeng Chen, Peng Huang, Mengjiao Liu
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引用次数: 0
Abstract
Objectives: In this systematic review, we aimed to investigate the association of maternal body mass index (BMI) before or during pregnancy and the metabolic profiles of offspring in the life course.
Methods: We searched six databases: PubMed, Ovid Embase, MEDLINE, Web of Science, Wan Fang data and China National Knowledge Infrastructure, which yielded 3584 unduplicated articles, and after the full-text screening, 12 observational and three intervention studies met the inclusion criteria. Ten studies assessed pre-pregnancy BMI (ppBMI), whereas the remaining used booking BMI during antenatal visits. Most studies (10 out of 15) examined newborn metabolomics, four in early-mid childhood, and only one in adolescents and adults. The number of mother-offspring pairs ranged from 57 to 10,251, and the age of the population ranged from 15 to 44.
Results: We found that maternal BMI before or during pregnancy was positively associated with adverse offspring metabolomic profiles, characterized by lipids (higher triglyceride, total cholesterol and lower high-density lipoprotein-cholesterol), amino acids (higher branched-chain amino acids and aromatic amino acids), carbohydrate-related metabolites (higher glucose and insulin). Studies on lipids have the most consistent results in both observational and intervention studies. The impact of maternal BMI on offspring metabolomics exerted from birth till adolescence and young adulthood.
Conclusions: Our study highlights a potential intergenerational association between maternal BMI and offspring metabolomic profiles. Interventions on maternal BMI before or during pregnancy showed the potential to reverse the adverse changes in offspring's metabolic profiles, but long-term health benefits warrant to be verified.
目的：在这篇系统综述中，我们旨在研究孕前或孕中母亲体重指数（BMI）与后代生命过程中代谢谱的关系。方法：检索PubMed、Ovid Embase、MEDLINE、Web of Science、万方数据和中国国家知识基础设施6个数据库，共收录无重复文章3584篇，经全文筛选，12项观察性研究和3项干预性研究符合纳入标准。10项研究评估了孕前BMI (ppBMI)，而其余研究则在产前检查时预订BMI。大多数研究（15个研究中有10个）检查了新生儿代谢组学，4个在儿童早期中期，只有1个在青少年和成人。母子对的数量从57对到10251对不等，人口年龄从15岁到44岁不等。结果：我们发现母亲在怀孕前或怀孕期间的BMI与不良的后代代谢组学特征呈正相关，其特征是脂质（较高的甘油三酯、总胆固醇和较低的高密度脂蛋白-胆固醇）、氨基酸（较高的支链氨基酸和芳香氨基酸）、碳水化合物相关代谢物（较高的葡萄糖和胰岛素）。关于脂质的研究在观察性和干预性研究中都有最一致的结果。母亲BMI对后代代谢组学的影响从出生一直持续到青春期和青年期。结论：我们的研究强调了母亲BMI和后代代谢组谱之间潜在的代际关联。在怀孕前或怀孕期间对母亲BMI的干预显示有可能逆转后代代谢谱的不利变化，但长期健康益处有待验证。
期刊介绍：
The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders.
We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.
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