International Journal of Nephrology最新文献

{"title":"Comparative Performance of the ANCLA Risk Score and Established Prognostic Models for Predicting ESKD in ANCA-Associated Glomerulonephritis: A Latin American Cohort.","authors":"Joaquín Rodelo-Ceballos, Mauricio Restrepo-Escobar, Mayra Estacio, Carlos Muñoz-Vahos, Alejandra Taborda","doi":"10.1155/ijne/5595479","DOIUrl":"10.1155/ijne/5595479","url":null,"abstract":"<p><strong>Background: </strong>Prognostic tools for kidney outcomes in ANCA-associated vasculitis (AAV) were developed mainly in European and North American populations, and their performance in Hispanic populations remains less well characterized. ANCA in Latin America (ANCLA) was previously developed and internally validated in a Colombian cohort to predict end-stage kidney disease (ESKD).</p><p><strong>Objective: </strong>To compare the prognostic performance of ANCLA with the Berden classification, Renal Risk Score (RRS), Mayo Clinic Chronicity Score (MCCS), and the ANCA Kidney Risk Score (AKRiS) for ESKD prediction in ANCA-associated glomerulonephritis.</p><p><strong>Methods: </strong>This secondary comparative analysis used the previously described ANCLA derivation cohort of 164 adults with biopsy-proven pauci-immune necrotizing and/or crescentic glomerulonephritis treated from 2011 to 2024 at a tertiary referral center in Colombia. The five prognostic systems were evaluated in the same population using Kaplan-Meier analyses, Harrell's C-index, and 1- and 2-year ROC analyses. Pairwise AUC differences between ANCLA and each comparator were formally assessed.</p><p><strong>Results: </strong>During a median follow-up of 12.9 months, 63 patients (38.4%) progressed to ESKD. ANCLA showed the most favorable overall discrimination (C-index 0.801; AUC 0.890 at 1 year and 0.896 at 2 years), followed by AKRiS (C-index 0.760) and RRS (0.749); MCCS (0.673) and Berden (0.640) showed lower discrimination. ANCLA had significantly higher AUCs than MCCS and Berden at both horizons, whereas differences versus AKRiS and RRS were smaller. ESKD occurred in 7.3% of the ANCLA low-risk group and 82.5% of the very-high-risk group.</p><p><strong>Conclusion: </strong>In this high-risk, predominantly Hispanic Latin American cohort, ANCLA showed the most favorable short-term discrimination, while AKRiS and RRS also performed well. Independent external validation remains necessary.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2026 ","pages":"5595479"},"PeriodicalIF":1.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Standard Base Excess in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Study.","authors":"Mingming Li, Yuxia Li, Jingru Lan, Mei Feng, Jun Lyu, Xuling Li","doi":"10.1155/ijne/8851195","DOIUrl":"10.1155/ijne/8851195","url":null,"abstract":"<p><strong>Background: </strong>Standard base excess (SBE) is a pivotal indicator of metabolic acid-base status and has been associated with adverse outcomes in critically ill patients. Nevertheless, the evidence regarding its association with mortality risk in sepsis-associated acute kidney injury (SA-AKI) remains limited.</p><p><strong>Methods: </strong>The present study utilized the MIMIC-IV database and comprised 16,842 adult patients with SA-AKI. Patients were stratified into quartiles based on SBE levels. The association between SBE and 28-day and 180-day all-cause mortality was evaluated using Cox proportional hazards models. Restricted cubic spline analysis was performed to assess potential nonlinear relationships. Multivariable adjustments and subgroup analyses were conducted to ensure the robustness of the findings.</p><p><strong>Results: </strong>Multivariate Cox regression analysis demonstrated that patients in the higher SBE quartiles had significantly lower risks of 28-day and 180-day mortality compared to those in the lowest quartile. Kaplan-Meier survival curves and restricted cubic spline analysis further confirmed a significant association between SBE levels and mortality risk, with evidence of a nonlinear relationship. Subgroup analyses showed different interaction effects between the primary and secondary outcomes.</p><p><strong>Conclusions: </strong>SBE was associated with mortality risk in patients with SA-AKI, with lower levels of SBE being associated with worse outcomes. As a routine blood gas parameter, SBE may serve as a useful indicator for risk stratification and prognostic assessment in this population.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2026 ","pages":"8851195"},"PeriodicalIF":1.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13596010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Mineral Metabolism Abnormalities and Vascular Access Complications Among Maintenance Hemodialysis Patients in Ethiopia.","authors":"Daniel Rebuma Bekele, Tsegay Berhane Gebregiorgis, Alemayehu Abebe Guji, Kedir Negesso Tukeni","doi":"10.1155/ijne/4669522","DOIUrl":"10.1155/ijne/4669522","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease-mineral and bone disorder (CKD-MBD) contributes to vascular calcification and cardiovascular morbidity among maintenance hemodialysis patients. Mineral metabolism abnormalities, particularly hyperphosphatemia and secondary hyperparathyroidism, may adversely affect vascular access patency and increase vascular access-related complications. However, data from sub-Saharan Africa remain limited. This study evaluated the association between abnormalities in mineral metabolism and vascular access complications among maintenance hemodialysis patients in Ethiopia.</p><p><strong>Methods: </strong>A facility-based cross-sectional study was conducted among 302 maintenance hemodialysis patients in Addis Ababa, Ethiopia. Sociodemographic, clinical, and laboratory data were collected using structured questionnaires and medical record review. Mineral metabolism parameters included serum calcium, serum phosphorus, and intact parathyroid hormone (iPTH) levels. Vascular access complications were assessed clinically and from dialysis records. Multivariable logistic regression analysis was performed to identify factors independently associated with vascular access complications.</p><p><strong>Results: </strong>The mean age of participants was 52.6 ± 14.2 years, and 59.0% were male. Vascular access complications were identified in 72 (23.8%) participants. Hyperphosphatemia, hypocalcemia, and elevated iPTH were present in 28.0%, 27.7%, and 47.4% of patients, respectively. Patients with vascular access complications had significantly higher mean serum phosphorus levels and iPTH concentrations compared with those without complications (<i>p</i> < 0.05). In multivariable analysis, hyperphosphatemia (adjusted odds ratio [AOR] = 2.41, 95% CI: 1.32-4.39), elevated iPTH (AOR = 2.87, 95% CI: 1.58-5.21), and dialysis duration > 24 months (AOR = 1.94, 95% CI: 1.08-3.47) were independently associated with vascular access complications.</p><p><strong>Conclusions: </strong>Abnormalities in mineral metabolism were significantly associated with vascular access complications among maintenance hemodialysis patients in Ethiopia. Hyperphosphatemia and elevated iPTH emerged as important independent predictors of vascular access dysfunction. Strengthening CKD-MBD management and optimizing mineral metabolism control may help reduce vascular access complications and improve dialysis outcomes in resource-limited settings.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2026 ","pages":"4669522"},"PeriodicalIF":1.9,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serological Profile of Hepatitis B, C, and D and Factors Associated With Hepatitis B Exposure and Vaccination Among Hemodialysis Patients in Northeastern Brazil.","authors":"Lucas Lima da Silva, Jurema Correia Mota, Alanna Calheiro Dos Santos, Vanessa Duarte da Costa, Giselle Prado do Nascimento, Julia Trece Marques, Juliana Custodio Miguel, Alexandre Braga Liborio, Danielle Malta Lima, Jeová Keny Baima Colares, Vanessa Salete de Paula, Livia Melo Villar","doi":"10.1155/ijne/4932261","DOIUrl":"10.1155/ijne/4932261","url":null,"abstract":"<p><strong>Introduction: </strong>Hemodialysis patients are at increased risk for viral hepatitis due to treatment-related exposures and transmission routes, potentially worsening liver and kidney disease. However, updated regional data in Brazil are scarce. This study evaluated the seroprevalence of hepatitis B, C, and D viruses (HBV, HCV, and HDV) and analyzed risk factors associated with HBV infection among patients undergoing hemodialysis in Northeast Brazil.</p><p><strong>Methods: </strong>This study corresponds to a cross-sectional evaluation of 293 patients from two hemodialysis clinics. Serological markers (HBsAg, anti-HDV, anti-HBc, anti-HBs, and anti-HCV) were analyzed by chemiluminescence, and the quantification of viral load was measured by real-time PCR. Sociodemographic and risk-related characteristics were collected via questionnaire. Statistical analyses included chi-square and Fisher tests (<i>p</i> < 0.05).</p><p><strong>Results: </strong>The prevalence of hepatitis B (HBsAg+) and hepatitis C (anti-HCV+) was 2.4% and 4.1%, respectively. Regarding hepatitis B serological status, 17.2% presented markers of exposure (HBsAg and/or anti-HBc+), 35.6% were susceptible, and 47.1% had probable vaccine-induced immunity (isolated anti-HBs+). Male sex was associated with HBV exposure, whereas female sex was associated with susceptibility (<i>p</i> < 0.001 and <i>p</i> = 0.036, respectively). Younger age (≤ 50 years) was related to vaccination status (<i>p</i> = 0.027). A history of jaundice was associated with HBV exposure (<i>p</i> = 0.030) and lower vaccination rates (<i>p</i> = 0.034), and psychotropic substance use with incomplete vaccination status (<i>p</i> = 0.014). Complete vaccination coverage (anti-HBs+ and/or ≥ 3 doses on the vaccination card) was low (51.2%), particularly among drug users. No anti-HDV reactivity was detected among HBsAg-positive individuals.</p><p><strong>Conclusion: </strong>HBV and HCV prevalence was higher than the national average in hemodialysis, with gender disparities between exposed and susceptible and low vaccination coverage, especially in drug users. Although no anti-HDV reactivity was found, investigating hepatitis D in this population remains relevant to improving understanding of its geographical distribution and clinical impact. It is recommended to reinforce screening, vaccination, and safety protocols in hemodialysis clinics.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2026 ","pages":"4932261"},"PeriodicalIF":1.9,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric Lanthanum Deposition in Advanced CKD: An Underrecognized Diagnostic Pitfall in Refractory Anemia and Mucosal Injury.","authors":"Yoshitaka Furuto, Daiki Yoshino, Iori Ejima, Sayako Ikeda, Akio Namikawa, Dai Sato, Yuko Shibuya","doi":"10.1155/ijne/2324899","DOIUrl":"10.1155/ijne/2324899","url":null,"abstract":"<p><p>Lanthanum carbonate is a noncalcium phosphate binder used in advanced chronic kidney disease (CKD), especially in dialysis populations. Gastroduodenal lanthanum deposition is now a recognized histopathologic finding, but its clinical importance is heterogeneous. The central clinical question is not whether lanthanum can be found in the mucosa but when deposition should be interpreted as a possible contributor to mucosal injury and, otherwise, unexplained bleeding-anemia phenotypes. Available evidence supports a spectrum from incidental histologic deposition to a smaller clinically meaningful subset associated with melena, occult or chronic upper gastrointestinal blood loss, iron deficiency, recurrent transfusion requirement, or erythropoiesis-stimulating agent (ESA) hyporesponsiveness. Characteristic whitish lesions are useful endoscopic clues, but deposition can also occur in nonwhitish or minimally abnormal mucosa. Histopathology typically shows histiocyte-rich accumulation of granular eosinophilic or light-brown material, sometimes with a foreign-body-type reaction. A plausible subset-specific pathway links mucosal deposition and macrophage activation to epithelial injury, chronic microbleeding, iron-restricted erythropoiesis, and increased ESA requirements. Clinically meaningful disease is most plausible when exposure history, phenotype, mucosal context, biopsy findings, and-when observed-improvement after lanthanum withdrawal converge. Deposition alone does not establish causality, and the true prevalence of clinically meaningful disease remains unknown. Nevertheless, in selected patients with advanced CKD and refractory anemia, deliberate review of current and prior phosphate-binder exposure, appropriate gastric biopsy even when endoscopy is nondiagnostic, and reassessment after discontinuation may reveal a potentially reversible diagnostic contributor.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2026 ","pages":"2324899"},"PeriodicalIF":1.9,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13509423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148828438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dialysis Adequacy and Quality of Life Among Haemodialysis Patients: Does Facility Type Matter? A Comparison Between Government and Private Centres in Klang Valley, Malaysia.","authors":"Voon Son Wong, Yong Xiang Tong, Pooi Pooi Leong, Li Lian Tay, Norazinizah Ahmad Miswan, Teck Han Ng, Waye Hann Kang","doi":"10.1155/ijne/7175945","DOIUrl":"10.1155/ijne/7175945","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with end-stage kidney disease (ESKD) receiving haemodialysis (HD) face a substantial burden of physical and psychological challenges, with dialysis adequacy recognised as a key determinant of quality of life (QoL). The number of HD patients in Malaysia continues to grow, with more than half receiving treatment at private dialysis centres. This study compares dialysis adequacy and QoL between patients attending government and private HD centres in Klang Valley, Malaysia.</p><p><strong>Materials and methods: </strong>An observational cross-sectional study was conducted in three private and two government dialysis centres in Selangor, Malaysia, between August and December 2024. Data were collected from 294 HD patients using a structured questionnaire on sociodemographic and clinical information, alongside the KDQOL-36. Good dialysis adequacy was defined a priori as single-pool Kt/V > 1.2, with a stricter threshold of Kt/V > 1.5 examined as a sensitivity analysis.</p><p><strong>Results and discussion: </strong>Private HD centre patients were significantly older (<i>p</i> < 0.001) but had lower dialysis vintage (<i>p</i> < 0.001), lower Kt/V (<i>p</i> < 0.001) and higher iPTH levels (<i>p</i> = 0.033). Government HD centre patients had significantly better physical functioning (<i>p</i> < 0.001) and SF-12 physical scores (<i>p</i> = 0.019). At the primary threshold (Kt/V > 1.2), the independent predictors of good dialysis adequacy after multivariable adjustment were female gender (OR = 2.37, 95% CI 1.10-5.09, <i>p</i> = 0.027), treatment at a government centre (OR = 3.60, 95% CI 1.32-9.86, <i>p</i> = 0.013) and lower dry weight (OR = 0.96 per kg, 95% CI 0.93-0.98, <i>p</i> < 0.001). These predictors were unchanged in the sensitivity analysis at Kt/V > 1.5, in which higher educational attainment additionally predicted poorer adequacy. Dialysis adequacy was not independently associated with QoL; physical QoL was predicted by younger age and shorter dialysis vintage and mental QoL by female gender and Malay ethnicity.</p><p><strong>Conclusions: </strong>Government HD centre patients in Malaysia had significantly better dialysis adequacy than those in private centres. Female gender and government centre affiliation were independent predictors of good Kt/V, whereas higher dry weight was associated with poorer adequacy. Most KDQOL domains were comparable between facility types, though government centre patients reported better physical functioning and physical component scores. These findings highlight the need for regulatory oversight of dialysis practice standards across facility types and suggest that individualised prescription optimisation, particularly to patient body size, is an important target for improving dialysis adequacy in Malaysia.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2026 ","pages":"7175945"},"PeriodicalIF":1.9,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating Renal Fibrosis: The Emerging Role of Hepatocyte Growth Factor.","authors":"Annalia Ferrer, Joshua Kim, Arleigh-Ann Byer, Mohamed Ahmed","doi":"10.1155/ijne/6821899","DOIUrl":"10.1155/ijne/6821899","url":null,"abstract":"<p><strong>Introduction and rationale: </strong>Hepatocyte growth factor (HGF) is a multifunctional protein that is associated with cellular growth and expansion. HGF has been known to be heavily expressed in renal tissue and for its role in wound healing and tissue proliferation. This review article aimed to investigate the pathogenesis of HGF in renal fibrosis in addition to its relationship with interconnected inflammatory diseases such as hypertension and diabetes.</p><p><strong>Methods: </strong>Several online databases such as PubMed and Google Scholar were used up to 2025 to identify and compare studies that looked at the relationship between renal fibrosis and HGF in preclinical and clinical settings.</p><p><strong>Results and conclusion: </strong>HGF was shown to reduce the progression of renal fibrosis through mechanisms such as transforming growth factor-β (TGF-β) antagonism, enhancement of endothelial repair, and promotion of extracellular matrix (ECM) degradation. The results indicate that HGF shows promising results on slowing the progression of renal fibrosis. However, the lack of studies using human models to research the antifibrotic effects of HGF as well as the associated risk of HGF in developing diabetes, insulin resistance, and hypertension calls for further investigations about future applications of HGF to treat renal fibrosis.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2026 ","pages":"6821899"},"PeriodicalIF":1.9,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13507705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148828446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Auricular Acupressure on Pruritus, Xerostomia, and Fatigue in Patients Undergoing Hemodialysis: A Clinical Trial in Southeastern Iran.","authors":"Ehsan Behjat Jabari, Mansooreh Azizzadeh Forouzi, Batool Tirgari, Yunes Jahani, Tori Canillas Dufau, Mohammad Setayesh","doi":"10.1155/ijne/9943333","DOIUrl":"10.1155/ijne/9943333","url":null,"abstract":"<p><strong>Background: </strong>Itching, dry mouth, and fatigue as common problems in hemodialysis patients affect their quality of life. Auricular acupressure is a traditional Chinese medicine method that elicits reactions such as heat, numbness, expansion, pain, and other forms of stimulation to achieve therapeutic effects. This study aimed to assess the impact of auricular acupressure on alleviating pruritus, xerostomia, and fatigue in patients undergoing hemodialysis in southeastern Iran.</p><p><strong>Method: </strong>This clinical trial study was conducted in Shafa, Samen al-Hojaj, and Javad Al-Aemeh Hospitals. The sample size consisted of 90 individuals who were randomly assigned to either the control or intervention group using a two-stage randomization method (first separated by odd/even dialysis days to prevent contamination, then clusters randomly allocated to groups). The intervention group received auricular acupressure treatment for a duration of 4 weeks, while the control group received routine care. Both groups completed clinical questionnaires, including the Visual Analog Scale (VAS), the Summated Xerostomia Inventory (SXI), and the Fatigue Severity Scale (FSS), before and after the intervention. The collected data were analyzed using SPSS26, employing both parametric and nonparametric tests, with a significance level set at 0.05.</p><p><strong>Results: </strong>The study findings indicated that auricular acupressure had a significant impact on the patients in the intervention group. The pruritus score decreased from 6.11 ± 2.32 to 3.18 ± 2.74, a reduction of 2.93 points (<i>p</i> < 0.001). The xerostomia score decreased from 19.64 ± 3.46 to 15.62 ± 5.29, a decrease of 4.02 points (<i>p</i> < 0.001). Additionally, the fatigue score decreased from 51.73 ± 8.53 to 43.16 ± 11.00, a reduction of 8.57 points (<i>p</i> < 0.001). On the other hand, the control group had no significant differences in the scores of uremic pruritus (<i>p</i> = 0.47), xerostomia (<i>p</i> = 0.82), and fatigue (<i>p</i> = 0.98) before and after the intervention.</p><p><strong>Conclusion: </strong>The results of the study demonstrated the impact of auricular acupressure on alleviating pruritus, xerostomia, and fatigue. This complementary medicine technique can be considered as a cost-effective, safe, acceptable, and noninvasive nursing care option for patients undergoing hemodialysis. Nurses can incorporate auricular acupressure into their practice to provide holistic care for patients undergoing hemodialysis. <b>Trial Registration:</b> Iranian Registry of Clinical Trials: IRCT20151107024919N14.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2026 ","pages":"9943333"},"PeriodicalIF":1.9,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Malnutrition, Inflammation, and Residual Kidney Clearance in Peritoneal Dialysis: A Cross-Sectional Analysis.","authors":"Wankawee Jeerangsapasuk, Chayaporn Wichitkul, Thanarak Boonkerd, Siriporn Wisettorn, Aphichat Chatkrailert","doi":"10.1155/ijne/1300185","DOIUrl":"10.1155/ijne/1300185","url":null,"abstract":"<p><strong>Background: </strong>Malnutrition and systemic inflammation are common and interrelated complications in patients undergoing peritoneal dialysis (PD), contributing to poor clinical outcomes. Residual kidney clearance (Kr) may play a protective role in this context, while erythropoietin resistance index (ERI) reflects anemia management challenges influenced by inflammation. This study aimed to investigate the associations of nutritional and inflammatory markers with Kr and ERI in PD patients.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of 47 stable adult PD patients. Nutritional and inflammatory indicators, including Malnutrition Inflammation Score (MIS), serum albumin, and Interleukin-6 (IL-6), were assessed alongside Kr and ERI. Linear regression analysis was used to evaluate associations, and Spearman correlation with bootstrapped 95% confidence intervals determined relationships among clinical variables.</p><p><strong>Results: </strong>The mean age was 62.2 ± 15.5 years; 53.2% were male. The mean MIS was 5.7 ± 2.5, serum albumin 3.29 ± 0.5 g/dL. IL-6 was positively associated with MIS (<i>β</i> = 0.684, <i>p</i> = 0.037). Kr was significantly inversely associated with MIS (<i>β</i> = -0.585, <i>p</i> = 0.040) and positively associated with serum albumin (<i>β</i> = 0.152, <i>p</i> = 0.018). Spearman analysis confirmed significant correlations between Kr and both MIS (<i>r</i> = -0.358, <i>p</i> = 0.008) and albumin (<i>r</i> = 0.343, <i>p</i> = 0.012), and between IL-6 and MIS (<i>r</i> = 0.390, <i>p</i> = 0.004). ERI showed no significant correlations with MIS, albumin, IL-6, or Kr.</p><p><strong>Conclusion: </strong>MIS was significantly associated with IL-6, highlighting the close relationship between malnutrition and systemic inflammation in patients undergoing PD. Higher Kr was associated with a more favorable nutritional inflammatory profile, whereas no significant associations were observed for ERI.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2026 ","pages":"1300185"},"PeriodicalIF":1.9,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spectrum of HIV-Associated Kidney Pathology at a Tertiary Centre in South Africa.","authors":"Anna-Liisa Tonata Kaapangelwa, Thabiet Jardine, Liezel Coetzee, Mogamat-Yazied Chothia","doi":"10.1155/ijne/3219794","DOIUrl":"10.1155/ijne/3219794","url":null,"abstract":"<p><strong>Aim: </strong>South Africa has one of the highest prevalences of human immunodeficiency virus (HIV) infection worldwide. Kidney disease is a common and important complication of HIV. This study describes biopsy-proven kidney pathology in people living with HIV (PLHIV) over 29 years at a South African centre, comparing patterns before and after antiretroviral therapy (ART) rollout.</p><p><strong>Methods: </strong>This retrospective descriptive study included PLHIV who underwent native kidney biopsy at Tygerberg Hospital during the period of 1 January 1992 to 31 December 2020. Patients were categorised by biopsy year into a pre-ART rollout period (before 2004) and a post-ART rollout period (2004 or later).</p><p><strong>Results: </strong>The cohort included 554 PLHIV, mostly biopsied post-ART rollout (90.1%). Mean age was 36.5 years, with a balanced sex distribution. During the post-ART period, 54.8% were on ART at biopsy. HIVAN was diagnosed in 45.7%, of which one-third had an additional histopathological pattern of injury. In the pre-ART rollout period, HIVAN was the most prevalent diagnosis (60.0%), whereas a lower prevalence was observed post-ART rollout (44.1%). During the post-ART rollout period, more than half of patients (55.9%) exhibited only non-HIVAN kidney pathology, with immune-complex-mediated glomerulonephritis (52.7%) and tubulointerstitial disease (39.7%) the most common.</p><p><strong>Conclusion: </strong>This study describes the spectrum of kidney pathology in PLHIV at a South African tertiary centre over nearly three decades, highlighting a significant HIVAN burden overall. We observed a lower proportion of patients with HIVAN following ART rollout, coinciding with an increase in non-HIVAN pathologies like immune complex glomerulonephritis and tubulointerstitial disease.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2026 ","pages":"3219794"},"PeriodicalIF":1.9,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}