International Journal of Nephrology最新文献

{"title":"Cognition and Implementation of Disaster Preparedness among Japanese Dialysis Facilities.","authors":"Hidehiro Sugisawa,&nbsp;Toshio Shinoda,&nbsp;Yumiko Shimizu,&nbsp;Tamaki Kumagai","doi":"10.1155/2021/6691350","DOIUrl":"https://doi.org/10.1155/2021/6691350","url":null,"abstract":"<p><strong>Introduction: </strong>Few quantitative studies have explored disaster preparedness in dialysis facilities worldwide. This study examined the levels of disaster preparedness and their related factors in dialysis facilities in Japan.</p><p><strong>Methods: </strong>We conducted a mail survey using a self-administered questionnaire for key persons responsible for disaster preparedness in dialysis facilities (<i>N</i> = 904) associated with the Japanese Association of Dialysis Physicians. Levels of disaster preparedness were evaluated by the implementation rates of four domains: (1) patient, (2) administration, (3) network, and (4) safety. Additionally, we focused on cognitive factors related to disaster preparedness, such as risk perception, outcome expectancy, self-efficacy, self-responsibility, and support from the surroundings.</p><p><strong>Results: </strong>A total of 517 participants answered the survey (response rate: 57.2%). Implementation rates differed according to the domains of disaster preparedness. While the average implementation rate of the safety domain was 81.8%, each average implementation rate was 57.9%, 48.3%, and 38.4% for the administration, network, and patient domains, respectively. The study found that self-efficacy and support from the surroundings of the participants were significantly associated with the four domains of disaster preparedness. Alternatively, risk perception and support from surroundings were significantly associated with one particular domain each.</p><p><strong>Conclusion: </strong>Our results suggest that boosting self-efficacy and support from surroundings among key persons of disaster preparedness in dialysis facilities may contribute to the advancement of the different domains of disaster preparedness.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2021 ","pages":"6691350"},"PeriodicalIF":2.1,"publicationDate":"2021-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38854574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Method for the Measurement of International Normalized Ratio in Hemodialysis Patients with Heparin-Locked Tunneled Dialysis Catheters.","authors":"Céline B Seghers, Kristien Ver Elst, Jolien Claessens, Steven Weekx, Sigrid Vermeiren, Manu Henckes","doi":"10.1155/2020/7586437","DOIUrl":"10.1155/2020/7586437","url":null,"abstract":"<p><strong>Background: </strong>To measure International Normalized Ratio (INR) in hemodialysis patients with tunneled dialysis catheters (TDCs), blood sampling is frequently obtained via the catheter at the start of the session. INR measurements via finger-prick point of care testing (POCT) and via blood sampling taken from the dialysis circuit are evaluated as alternatives.</p><p><strong>Methods: </strong>In 14 hemodialysis patients with TDCs, treated with vitamin K antagonists (VKA), INR measurements via POCT were compared with plasma INR samples taken via the catheter at the start of dialysis and via the dialysis circuit after 30 and 60 minutes during 3 nonconsecutive dialysis sessions.</p><p><strong>Results: </strong>Blood samples taken at the start of dialysis at the catheter site were frequently contaminated with heparin originating from the locking solution (unfractionated heparin concentration (UFH) >1.0 IU/ml in 13.2%). POCT INR at the start of dialysis was not different from plasma INR after 30 and 60 minutes (Wilcoxon test <i>p</i>=0.113, <i>n</i> = 37, and <i>p</i>=0.631, <i>n</i> = 36, respectively). Moreover, there was no difference between POCT INR at the start of dialysis and POCT INR after 30 and 60 minutes (Wilcoxon test <i>p</i>=0.797 and <i>p</i> = 0.801, respectively; <i>n</i> = 36). Passing and Bablok regression equation was used, <i>y</i> = 0.460 + 0.733x; <i>n</i> = 105. Treatment decisions based on these 2 methods showed a very good overall agreement (kappa = 0.810; 95% CI: 0.732-0.889; <i>n</i> = 105).</p><p><strong>Conclusions: </strong>Measuring plasma INR via the TDC at the start of dialysis should be abandoned. Measuring POCT INR via a finger prick at the start or even after 30 to 60 minutes is an alternative. The most elegant alternative is to take plasma INR samples via the dialysis circuit 30 minutes or later after the start of the dialysis.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2020 ","pages":"7586437"},"PeriodicalIF":2.1,"publicationDate":"2020-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39151891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Prognosis of Hyperferritinemia Induced by Intravenous Iron Therapy in Patients Undergoing Maintenance Hemodialysis: A 10-Year, Single-Center Study.","authors":"Sayako Maeda,&nbsp;Ryo Konishi,&nbsp;Takuya Morinishi,&nbsp;Yoko Shimizu,&nbsp;Haruomi Nishio,&nbsp;Koji Takaori","doi":"10.1155/2020/8864400","DOIUrl":"https://doi.org/10.1155/2020/8864400","url":null,"abstract":"<p><p>Optimal ferritin level in hemodialysis patients between Japan and other countries is controversial. Long-term side effects of iron supplementation in these patients remain unclear. We aimed to elucidate whether past hyperferritinemia in hemodialysis patients was associated with high risk of death and cerebrovascular and cardiovascular diseases (CCVDs). This small retrospective cohort study included approximately 44 patients unintentionally supplemented with excessive intravenous iron. A significantly higher risk of CCVDs was observed in patients with initial serum ferritin levels ≥1000 ng/mL than in the remaining patients. High ferritin levels slowly decreased to <300 ng/mL in a median of 24.2 (10.5-46.5) months without treatment. However, compared with the remaining patients, only patients whose ferritin levels did not decrease to <300 ng/mL steadily had a significantly higher risk of all-cause death (hazard ratio, 9.6). Long-term hyperferritinemia due to intravenous iron therapy is a risk factor for death in maintenance hemodialysis patients. For a prolonged better prognosis, intravenous iron should be carefully administered so as to avoid hyperferritinemia in patients with hemodialysis.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2020 ","pages":"8864400"},"PeriodicalIF":2.1,"publicationDate":"2020-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38767733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Transplant Pathology: Demographic Features and Histopathological Analysis of the Causes of Graft Dysfunction.","authors":"Shaarif Bashir,&nbsp;Mudassar Hussain,&nbsp;Azhar Ali Khan,&nbsp;Usman Hassan,&nbsp;Khawaja Sajid Mushtaq,&nbsp;Maryam Hameed,&nbsp;Usman Ayub Awan","doi":"10.1155/2020/7289701","DOIUrl":"https://doi.org/10.1155/2020/7289701","url":null,"abstract":"<p><strong>Background: </strong>Renal transplant has emerged as a preferred treatment modality in cases of end-stage renal disease; however, a small percentage of cases suffer from graft dysfunction.</p><p><strong>Aim: </strong>To evaluate the renal transplant biopsies and analyze the various causes of graft dysfunction.</p><p><strong>Materials and methods: </strong>163 renal transplant biopsies, reported between 2014 and 2019 and who fulfilled the inclusion criteria, were evaluated with respect to demographics, clinical, histological, and immunohistochemical features.</p><p><strong>Results: </strong>Of 163 patients, 26 (16%) were females and 137 (84%) were males with a mean age of 34 ± 7 years. 53 (32.5%) cases were of rejection (ABMR and TCMR), 1 (0.6%) was borderline, 15 were of IFTA, and rest of 94 cases (57.7%) belonged to the others category. SCr (serum creatinine) in cases of rejection was 3.85 ± 0.55 mg/dl. Causes of early graft dysfunction included active ABMR (7.1 ± 4.7 months), acute TCMR (5.5 months), and acute tubular necrosis (after 6 ± 2.2 months of transplant) while the causes of late rejection were CNIT and IFTA (34 ± 4.7 and 35 ± 7.8 months, respectively).</p><p><strong>Conclusion: </strong>Renal graft dysfunction still remains a concerning area for both clinicians and patients. Biopsy remains the gold standard for diagnosing the exact cause of graft dysfunction and in planning further management.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2020 ","pages":"7289701"},"PeriodicalIF":2.1,"publicationDate":"2020-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7289701","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38854680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional Interaction of Thyroid-Kidney Organs in Disease States.","authors":"Fateme Shamekhi Amiri","doi":"10.1155/2020/5248365","DOIUrl":"https://doi.org/10.1155/2020/5248365","url":null,"abstract":"<p><strong>Purpose: </strong>Thyroid hormones play an important role in growth, development, and physiology of the kidney. The kidney plays a key role in the metabolism, degradation, and excretion of thyroid hormones and its metabolites. The aim of this study is to investigate the prevalence of disease states of thyroid-kidney organs and detecting the correlation between thyroid and kidney function abnormalities.</p><p><strong>Materials and methods: </strong>In this retrospective study, a total of forty-five patients with thyroid and kidney dysfunction were investigated. Clinical features, laboratory data at initial presentation, management, and outcomes were collected. The paper has been written based on searching PubMed and Google Scholar to identify potentially relevant articles or abstracts. Median, percentage, mean ± standard deviation (SD), and the two-tailed <i>t</i>-test were used for statistical analyses. The correlation between variables was assessed by Pearson's, Spearman's correlation tests and regression analyses.</p><p><strong>Results: </strong>The mean ± SD of age of study patients was 48.2 ± 22.93 years (ranging from 1 to 90 years). There was no correlation between serum thyroid-stimulating hormone, free thyroxine levels with estimated glomerular filtration rate, and proteinuria. No association between antimicrosomal antibodies with estimated glomerular filtration rate was seen. Cardiovascular disease was the most common complication of overt hypothyroidism in kidney dysfunction patients.</p><p><strong>Conclusion: </strong>The present study showed more prevalence of primary hypothyroidism in comparison with other thyroid dysfunctions in patients with kidney dysfunction. Reduced mean values of thyroid function profiles after treatment suggest that this thyroid disease should be considered and ameliorated with thyroid hormone replacement therapy in patients with kidney disease.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2020 ","pages":"5248365"},"PeriodicalIF":2.1,"publicationDate":"2020-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/5248365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38735036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Urine Dilution Ability between Adult Dominant Polycystic Kidney Disease, Other Chronic Kidney Diseases, and Healthy Control Subjects: A Case-Control Study.","authors":"M H Malmberg,&nbsp;F H Mose,&nbsp;E B Pedersen,&nbsp;J N Bech","doi":"10.1155/2020/4108418","DOIUrl":"https://doi.org/10.1155/2020/4108418","url":null,"abstract":"<p><p>The final dilution of urine is regulated via aquaporin-2 water channels in the distal part of the nephron. It is unclear whether urine dilution ability in autosomal dominant polycystic kidney disease patients (ADPKD patients) differs from other patients with similar degree of impaired renal function (non-ADPKD patients). The purpose of this case control study was to measure urine dilution ability in ADPKD patients compared to non-ADPKD patients and healthy controls. <i>Methods</i>. Eighteen ADPKD, 16 non-ADPKD patients (both with chronic kidney disease, stage I-IV), and 18 healthy controls received an oral water load of 20 ml/kg body weight. Urine was collected in 7 consecutive periods. We measured free water clearance (C_H2O), urine osmolality, urine output, fractional excretion of sodium, urine aquaporin2 (u-AQP2), and urine epithelial sodium channel (u-ENaC). Blood samples were drawn four times (at baseline, 2 h, 4 h, and 6 hours after the water load) for analyses of plasma osmolality, vasopressin, renin, angiotensin II, and aldosterone. Brachial and central blood pressure was measured regularly during the test. <i>Results</i>. The three groups were age and gender matched, and the patient groups had similar renal function. One hour after water load, the ADPKD patients had an increased C_H2O compared to non-ADPKD patients (2.97 ± 2.42 ml/min in ADPKD patients vs. 1.31 ± 1.50 ml/min in non-ADPKD patients, <i>p</i>0.029). The reduction in u-AQP2 and u-ENaC occurred earlier in ADPKD than in non-ADPKD patients. Plasma concentrations of vasopressin, renin, angiotensin II, and aldosterone and blood pressure measurements did not show any differences that could explain the deviation in urine dilution capacity between the patient groups. <i>Conclusions</i>. ADPKD patients had a higher C_H2O than non-ADPKD patients after an oral water load, and u-AQP2 and u-ENaC were more rapidly reduced than in non-ADPKD patients. Thus, urine-diluting capacity may be better preserved in ADPKD patients than in non-ADPKD patients.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2020 ","pages":"4108418"},"PeriodicalIF":2.1,"publicationDate":"2020-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4108418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38735035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Kidney Injury Caused by Obstructive Nephropathy.","authors":"Jonathan S Chávez-Iñiguez,&nbsp;Goretty J Navarro-Gallardo,&nbsp;Ramón Medina-González,&nbsp;Luz Alcantar-Vallin,&nbsp;Guillermo García-García","doi":"10.1155/2020/8846622","DOIUrl":"https://doi.org/10.1155/2020/8846622","url":null,"abstract":"<p><p>Acute kidney injury secondary to obstructive nephropathy is a frequent event that accounts for 5 to 10% of all acute kidney injury cases and has a great impact on the morbidity and mortality in those affected. The obstruction in the urinary tract has a profound impact on kidney function due to damage produced by ischemic and inflammatory factors that have been associated with intense fibrosis. This pathology is characterized by its effects on the management of fluids, electrolytes, and the acid-base mechanisms by the renal tubule; consequently, metabolic acidosis, hyperkalemia, uremia, and anuria are seen during acute kidney injury due to obstructive nephropathy, and after drainage, polyuria may occur. Acute urine retention is the typical presentation. The diagnosis consists of a complete medical history and should include changes in urinary voiding and urgency and enuresis, history of urinary tract infections, hematuria, renal lithiasis, prior urinary interventions, and constipation. Imaging studies included tomography or ultrasound in which hydronephrosis can be seen. Management includes, in addition to drainage of the obstructed urinary tract system, providing supportive treatment, correcting all the metabolic abnormalities, and initiating renal replacement therapy when required. Although its recovery is in most cases favorable, it seems to be an undervalued event in nephrology and urology. This is because it is mistakenly believed that the resolution and recovery of kidney function is complete once the urinary tract is unobstructed. It can have serious kidney sequelae. In this review, we report the epidemiology, incidence, pathophysiological mechanisms, diagnosis, and treatment of acute kidney injury due to obstructive nephropathy.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2020 ","pages":"8846622"},"PeriodicalIF":2.1,"publicationDate":"2020-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8846622","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38708521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyponatraemia as a Predictor of Mortality in Medical Admissions in Ghana: A Comparative Study.","authors":"Elliot Koranteng Tannor,&nbsp;Martin Agyei,&nbsp;Abena Y Tannor,&nbsp;Afua Ofori,&nbsp;Emmanuel Akumiah,&nbsp;Yasmin Adoma Boateng","doi":"10.1155/2020/3145843","DOIUrl":"https://doi.org/10.1155/2020/3145843","url":null,"abstract":"<p><strong>Background: </strong>Hyponatraemia is the most common electrolyte abnormality in hospital admissions. It occurs in a quarter of medical admissions in Ghana, and it is associated with high mortality. Mortality has been suggested to be due to the underlying medical condition and not necessarily the hyponatraemia. We set out to compare the outcomes of patients with documented hyponatraemia as compared to those with normonatraemia in terms of mortality and length of hospital stay.</p><p><strong>Methods: </strong>We conducted a comparative analysis of patients with hyponatraemia and those with normonatraemia on the medical ward at the Komfo Anokye Teaching Hospital between May 2018 and December 2018. The medical diagnoses, demographics, and laboratory data of the patients were recorded. Participants' age and gender were matched. Student's <i>t</i>-test was used to test for differences in continuous variables when parametric and Wilcoxon signed-rank test for nonparametric variables. Multiple logistic regression was used to identify predictors of in-hospital mortality. A <i>p</i> value of <0.05 was considered statistically significant.</p><p><strong>Results: </strong>Within the study period, 846 patients with documented serum sodium were included in the study. The study involved 406 patients with hyponatraemia and 440 patients with normonatraemia. Serum albumin and protein were significantly lower in the hyponatraemia patients as compared to those with normonatraemia. The mortality rate in patients with hyponatraemia was significantly higher than those with normonatraemia (129 (31.8%) vs. 9 (22.3%); OR 1.62 (95% CI: 1.19-2.22), <i>p</i> = 0.002). In-hospital stay was longer in patients with hyponatraemia than normonatraemia (7 (4-10) vs. 6 (3-10) days) but not statistically significant (<i>p</i> = 0.09). Multiple logistic regression showed that low serum sodium (<i>p</i> < 0.001) and low serum albumin (<i>p</i> = 0.009) were the predictors of in-hospital mortality.</p><p><strong>Conclusion: </strong>Hyponatraemia is associated with significantly higher mortality than normonatraemia and predicts worse prognosis in patients on medical admission. Low serum albumin is also a predictor of mortality in medical admission.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2020 ","pages":"3145843"},"PeriodicalIF":2.1,"publicationDate":"2020-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3145843","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38355935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country\".","authors":"Carlos E Duran,&nbsp;Alejandro Ramírez,&nbsp;Juan G Posada,&nbsp;Johanna Schweineberg,&nbsp;Liliana Mesa,&nbsp;Harry Pachajoa,&nbsp;Mayra Estacio,&nbsp;Eliana Manzi,&nbsp;Vanessa Aros,&nbsp;Lorena Díaz,&nbsp;Victor H Garcia","doi":"10.1155/2020/8706297","DOIUrl":"https://doi.org/10.1155/2020/8706297","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2019/7076326.].</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2020 ","pages":"8706297"},"PeriodicalIF":2.1,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8706297","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38689342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients.","authors":"Ade Yonata,&nbsp;Zulkhair Ali,&nbsp;Taufik Indrajaya,&nbsp;Erial Bahar,&nbsp;Ian Effendi,&nbsp;Novadian Suhaimi,&nbsp;Suprapti Suprapti","doi":"10.1155/2020/8893653","DOIUrl":"https://doi.org/10.1155/2020/8893653","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process. Ultrasound examination of the carotid intima-media thickness (cIMT) is a noninvasive method to assess vascular calcification. This study aimed to analyze the relationship between the activin A serum level and cIMT in patients with CKD at Mohammad Hoesin Hospital, Palembang, Indonesia.</p><p><strong>Methods: </strong>We conducted a hospital-based, cross-sectional study of consecutive CKD patients at the Department of Internal Medicine, Mohammad Hoesin Hospital, from July to November 2019. The level of activin A was measured by enzyme-linked immunosorbent assay. Meanwhile, cIMT measurements were collected by <i>B</i>-mode ultrasound imaging.</p><p><strong>Results: </strong>A total of 55 patients with CKD were included in this investigation. The median serum activin A level in these patients was 236.17 (116.33-283) pg/mL, while the median cIMT was 0.8 (0.6-1.45) mm. A relationship between the serum activin A level and cIMT (<i>r</i>  =  0.449; <i>p</i> = 0.001) was observed. During multivariate analysis with linear regression, triglyceride (<i>p</i> = 0.049), phosphate (<i>p</i> = 0.005), and activin A (<i>p</i> = 0.020) serum levels were factors associated with cIMT.</p><p><strong>Conclusion: </strong>In this study, a relationship between the activin A serum level and cIMT in patients with CKD was identified. Vascular calcification should be screened for in all CKD patients by the measurement of cIMT.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":"2020 ","pages":"8893653"},"PeriodicalIF":2.1,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8893653","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38689343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}