International Journal of Gynecology & Obstetrics最新文献

{"title":"Laboratory practice in an oncology cryopreservation service: What and how?","authors":"Gerri Emerson,&nbsp;Gillian A. Ryan,&nbsp;Nikhil Purandare","doi":"10.1002/ijgo.70137","DOIUrl":"10.1002/ijgo.70137","url":null,"abstract":"<p>In humans, oocyte and embryo vitrification is a routinely used method for fertility preservation (FP). Sperm vitrification is currently applied to samples with low sperm concentration and volume, whereas slow freezing remains the preferred method for larger sperm volumes. Although ovarian tissue cryopreservation and testicular tissue cryopreservation are not yet routinely used for FP, the cryopreservation methods are a matter of debate. Slow freezing is the most commonly applied method for the ovarian cortex, while ovarian tissue vitrification remains clinically uncertain due to the limited number of successful births. It is important to underline that the guidelines for gametes, embryos, and tissue cryopreservation have a key role for both providers and patients, which is to minimize the risks associated with an unsafe FP choice and cryostorage.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":"169 3","pages":"895-905"},"PeriodicalIF":2.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijgo.70137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy analysis of cervical cancer screening using urine and vaginal self-sampling versus clinician-collected samples: A systematic review and meta-analysis.","authors":"Dong-Mei Li, Qing-Yu Liu, Shao-Long Xue, Xi Zeng, Ming-Rong Qie, Rui Lian","doi":"10.1002/ijgo.70207","DOIUrl":"https://doi.org/10.1002/ijgo.70207","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the present study was to explore the differences in diagnostic performance between vaginal self-sampling, urine self-sampling, and clinician sampling in cervical cancer screening.</p><p><strong>Methods: </strong>Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) 2020, we searched PubMed, Cochrane Library, Web of Science, and Embase. Study quality was assessed with Cochrane Review Manager 5.3. Diagnostic performance was evaluated by pooling sensitivity, specificity, and the area under the summary receiver operating characteristic (SROC) curve using STATA 18.0.</p><p><strong>Results: </strong>The meta-analysis included 15 studies with 3665 participants, all with abnormal cervical cancer screening results. The pooled sensitivity for both self-sampling methods was 0.88 (95% confidence interval [CI]: 0.85, 0.91), the pooled specificity was 0.81 (95% CI: 0.68, 0.89), and the area under the curve (AUC) was 0.92 (95% CI: 0.89, 0.94). For high risk-human papillomavirus (HR-HPV), vaginal self-sampling showed a sensitivity of 0.92 (95% CI: 0.90, 0.94) and specificity of 0.80 (95% CI: 0.58, 0.92), and AUC was 0.93 (95% CI: 0.91, 95); urine self-sampling showed a sensitivity of 0.83 (95% CI: 0.77, 0.88) and specificity of 0.81 (95% CI: 0.65, 0.91), and AUC was 0.88 (95% CI: 0.85, 0.91). For >CIN2 lesions, vaginal self-sampling showed a sensitivity of 0.98 (95% CI: 0.96, 0.99) and specificity of 0.63 (95% CI: 0.48, 0.77), and AUC was 0.98 (95% CI: 0.96, 0.99); urine self-sampling showed a sensitivity of 0.95 (95% CI: 0.91, 0.97) and specificity of 0.62 (95% CI: 0.31, 0.86), and AUC was 0.95 (95% CI: 0.93, 0.97).</p><p><strong>Conclusion: </strong>Vaginal and urine self-sampling for HPV testing show promising diagnostic potential, with vaginal sampling outperforming urine. Both methods have similar sensitivity for detecting lesions >CIN2.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do myomectomies alter third-trimester complications compared with women without myomectomies and uterine fibroids in situ: A retrospective cohort study of an American population database.","authors":"Perrine Ginod, Ahmad Badeghiesh, Haitham Baghlaf, Michael H Dahan","doi":"10.1002/ijgo.70211","DOIUrl":"https://doi.org/10.1002/ijgo.70211","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate population characteristics and pregnancy, delivery, and neonatal complications in women with myomectomy prior to pregnancy versus intramural fibroids in situ.</p><p><strong>Methods: </strong>Retrospective cohort study using hospital discharge data from the Healthcare Cost and Utilization Project Nationwide Inpatient Sample from 2004 to 2014 included. A population of 14 206 pregnancies post-myomectomy and 81 517 with fibroids in situ were analyzed, performing multivariate logistic regression with adjustment.</p><p><strong>Results: </strong>Post-myomectomy patients were younger, with lower body mass index, higher in vitro fertilization use, more commonly Caucasians or Hispanics, and had higher rates of pregestational diabetes, smoking, illicit drug use, previous cesarean delivery, and multiple gestations, compared with the in-situ fibroid (ISF) group. Post-myomectomy patients had decreased rates of gestational hypertension (adjusted odds ratio [aOR] 0.87, 95% confidence interval [CI] 0.77-0.97), eclampsia (aOR 0.76, 95% CI 0.32-0.81), gestational diabetes (aOR 0.83, 95% CI 0.77-0.90), spontaneous vaginal deliveries (aOR 0.09, 95% CI 0.08-0.11), postpartum hemorrhage (aOR 0.77, 95% CI 0.68-0.88), and intrauterine fetal death (aOR 0.64, 95% CI 0.43-0.97). Conversely, they had increased risks of placenta previa (aOR 1.40, 95% CI 1.20-1.64), preterm delivery (aOR 1.16, 95% CI 1.07-1.24), cesarean section (aOR 8.64, 95% CI 7.71-9.69), uterine rupture (aOR 2.21, 95% CI 1.31-3.74), transfusions (aOR 1.79, 95% CI 1.59-2.02), and congenital anomalies (aOR 2.35, 95% CI 2.01-2.75).</p><p><strong>Conclusions: </strong>The ISF group experienced different complications than the post-myomectomy group. Pregnancies post-myomectomy could benefit from additional screening or interventions during pregnancy to reduce complications from malplacentation and ensure delivery in specialized centers to mitigate risks. Patients should be counseled regarding these potential risks. Increased understanding of the role of myomectomies on reproductive outcomes requires further prospective studies.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Resuturing versus expectant Management for Perineal Wound Dehiscence: A systematic review.","authors":"Rebecca J McDonald, Peter T Khoo, J Oliver Daly, Debjyoti Karmakar","doi":"10.1002/ijgo.70175","DOIUrl":"https://doi.org/10.1002/ijgo.70175","url":null,"abstract":"<p><strong>Background and objective: </strong>Perineal wound dehiscence is a common complication of vaginal birth that impacts maternal well-being and quality of life. This systematic review compares early resuturing with expectant management in the treatment of perineal wound dehiscence.</p><p><strong>Methods: </strong>We searched Ovid MEDLINE, CINAHL, and PubMed databases, and hand-searched recent reviews and relevant studies. Human prospective and retrospective studies, randomized controlled trials (RCTs), and case series evaluating early resuturing within the postnatal period were included. Two reviewers independently assessed the studies for outcomes and risk of bias. The primary outcome was healing time; secondary outcomes included dyspareunia, long-term symptoms, functional outcomes, infection rates, and anal sphincter injury.</p><p><strong>Results: </strong>Thirteen studies (1987-2022) were included: three RCTs, four prospective cohort studies or case series, and six retrospective studies-heterogeneity in study designs and outcomes limited data synthesis. Early resuturing was associated with reduced healing time, particularly for wounds not involving the anal sphincter, but increased the risk of complications such as fistula formation. Many studies emphasized meticulous preoperative wound care.</p><p><strong>Conclusions: </strong>Limited evidence suggests that early resuturing may reduce healing time without increasing wound infection risk. However, the increased risk of complications necessitates cautious application and highlights the importance of preoperative wound care. Further robust research is needed, although challenging to conduct. Alternative analytical methods, such as data mining and decision tree algorithms, should be explored. Based on current evidence, clinicians should carefully individualize recommendations on the benefits and risks of early resuturing.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive outcomes after expectant management of enhanced myometrial vascularity secondary to first trimester retained products of conception: A follow-up study.","authors":"Anjeza Xholli, Umberto Scovazzi, Ambrogio P Londero, Filippo Molinari, Isabella Perugi, Alessandra De Ponti, Angelo Cagnacci","doi":"10.1002/ijgo.70213","DOIUrl":"https://doi.org/10.1002/ijgo.70213","url":null,"abstract":"","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"mHealth use during pregnancy: A systematic review.","authors":"Mei-Fei Hsieh, Valerie Slavin, Mei-Zen Huang, Hsiu-Hung Wang, Hsiu-Fen Hsieh","doi":"10.1002/ijgo.70205","DOIUrl":"https://doi.org/10.1002/ijgo.70205","url":null,"abstract":"<p><strong>Background: </strong>The use of mobile health (mHealth) therapies during pregnancy has aroused increasing attention. The objective of this study was to systematically evaluate the effects of mHealth interventions on pregnant women's quality of life and pregnancy outcomes, with specific attention to psychosocial health.</p><p><strong>Search strategy: </strong>We performed a systematic review of the literature published between 2013 and 2023 from eight databases.</p><p><strong>Selection criteria: </strong>English-language original articles released in 2013-2023 on the use of modern technology in caring for pregnant women, and articles with the subject matter pregnant and financially independent women.</p><p><strong>Data collection and analysis: </strong>The data focused on the intervention parameters defined as those that increase the frequency of medical examination attendance, including follow-up, and improve the level of health education, compliance with medical preventive procedures, and participation in health events.</p><p><strong>Main results: </strong>Our results demonstrated that the quality of life of pregnant women using mHealth improved in the specified areas. These interventions, including various tools such as text messaging, voice calls, mobile applications, and wearable devices, have been shown to improve maternal and fetal health outcomes, particularly in low-resource settings, by providing educational resources, monitoring maternal and fetal health status, and increasing adherence to treatment plans.</p><p><strong>Conclusion: </strong>The implementation of mHealth interventions during pregnancy can enhance the overall quality of healthcare and provide more promising pregnancy outcomes. Further investigation is needed to find the optimum types of mHealth intervention and how they can be integrated into existing healthcare systems.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy after cancer: FIGO Best practice advice","authors":"Cynthia Maxwell,&nbsp;Sumaiya Adam,&nbsp;Lina Bergman,&nbsp;Surabhi Nanda,&nbsp;Valerie Tiempo Guinto,&nbsp;Noa Popovits-Hadari,&nbsp;Maisah Al-Bakri,&nbsp;Ifeyinwa Nwokoro,&nbsp;Fionnuala McAuliffe,&nbsp;Inge Peters,&nbsp;Catherine Nelson-Piercy,&nbsp;Frederic Amant,&nbsp;Melanie Nana,&nbsp;Graeme Smith,&nbsp;Jonathan Berek,&nbsp;Orla McNally,&nbsp;Long Nguyen-Hoang,&nbsp;Virna P. Medina-Palmezano,&nbsp;Sharleen O'Reilly,&nbsp;Francisco Ruiloba,&nbsp;Pat O'Brien,&nbsp;Bo Jacobsson,&nbsp;Sarikapan Wilailak,&nbsp;Liona C. Poon","doi":"10.1002/ijgo.70139","DOIUrl":"10.1002/ijgo.70139","url":null,"abstract":"<p>Advances in cancer care have led to a growing number of cancer survivors globally. As cancer increasingly affects women and people of reproductive age, more individuals will be experiencing pregnancy after completing cancer treatment. This Best Practice Advice manuscript describes the epidemiology of pregnancy after cancer, recommended clinical evaluation before pregnancy, key components of pregnancy care for cancer survivors, considerations for delivery planning and postpartum care, and suggested steps for future health and prevention.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":"169 3","pages":"1119-1126"},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijgo.70139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of sentinel node mapping and molecular classification in endometrial cancer staging.","authors":"Giorgio Bogani, Valentina Chiappa, Giuseppe Marino, Simone Bruni, Lorenzo Ceppi, Luca Sorrentino, Umberto Leone Roberti Maggiore, Benedetta Zambetti, Biagio Paolini, Francesco Raspagliesi","doi":"10.1002/ijgo.70206","DOIUrl":"https://doi.org/10.1002/ijgo.70206","url":null,"abstract":"<p><p>Sentinel node mapping has gained popularity in surgical staging of endometrial cancer, providing a less invasive alternative to lymphadenectomy for staging purpose. Recent advances in molecular classification have deepened our understanding of endometrial cancer, leading to more personalized approaches in diagnosis and treatment. This review examined the interaction between sentinel node mapping and molecular classification in endometrial cancer, emphasizing the clinical implications. Surrogate molecular classification identified four distinct subtypes, each with different patterns of lymphatic spread and metastatic potential, overcoming the Bokhman's historic dualistic classification in type I (endometrioid) and type II (non-endometrioid) endometrial cancer. Accumulating evidence supported that integrating molecular subtypes with sentinel node mapping, would improve the accuracy of lymph node staging, allowing for more tailored therapeutic strategies. The potential for artificial intelligence and machine learning to analyze molecular signatures in real-time may further refine mapping accuracy and enable more individualized treatment plans. The development of novel molecular tracers and targeted therapies for sentinel node biopsy promises to enhance precision and minimize unnecessary lymphadenectomy. The aim of this review was to explore current methodologies, challenges, and future directions, highlighting the increasing role of molecular tools in sentinel node mapping and the personalized management of endometrial cancer.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a novel device for urine-based human papillomavirus screening in low- and middle-income countries.","authors":"Dhanalakshmi Thiyagarajan, Logan Wilder, Alyssa O'Brien, Ariana Layne, Natasha Mehta, Suraj Menon, Eitan Frankowitz, Arya Gandhi, Clare Rogos, Evelyn Antony, Katherine Broderick, Molly Stout, Samuel A Oppong, Emma Lawrence, Julia Kramer, Diane M Harper, Kwaku Asah-Opoku","doi":"10.1002/ijgo.70216","DOIUrl":"https://doi.org/10.1002/ijgo.70216","url":null,"abstract":"","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5-HT₃ receptor antagonists for preventing postoperative nausea and vomiting after gynecological surgery: A systematic review and network meta-analysis.","authors":"Hongxia Xu, Lingyan Rong, Shaohui Yang, Jiankun Xing, Huajun Dong, Huihui Liu, Xiaotao Chen, Lingyan Liu","doi":"10.1002/ijgo.70197","DOIUrl":"https://doi.org/10.1002/ijgo.70197","url":null,"abstract":"<p><strong>Background: </strong>Gynecological surgery is generally associated with a high risk of postoperative nausea and vomiting (PONV), for which a combination of antiemetic therapies is advised, but adherence to these protocols is often low. Given the current reality, a preferred 5-HT₃ receptor antagonist for preventing PONV as a result of gynecological operations might be desirable. However, the efficiency of different 5-HT₃ receptor antagonists in gynecological operations was not clear.</p><p><strong>Objective: </strong>To assess the effectiveness of different 5-HT₃ antagonists in preventing PONV after gynecological surgery.</p><p><strong>Search strategy: </strong>Electronic databases, including PubMed, Embase, the Cochrane Library, and Web of Science, were searched for randomized clinical trials (RCTs) from their inception up to September 20, 2023.</p><p><strong>Selection criteria: </strong>Patients who received only 5-HT₃ antagonists to prevent nausea and vomiting following gynecologic surgical procedures were included. Only RCT articles and English language literature were included.</p><p><strong>Data collection and analysis: </strong>Two investigators independently assessed the study quality and performed data extraction. R software and STATA 17 were used for this network meta-analysis to compare treatments using a frequentist approach.</p><p><strong>Main results: </strong>Palonosetron demonstrated superior efficacy compared with ondansetron, with a significant difference in \"acute nausea,\" \"overall nausea,\" \"acute vomiting,\" \"late vomiting,\" \"late PONV,\" \"overall PONV,\" \"late rescue medicine\" and \">24 h rescue medicine.\" There was a significant difference between palonosetron and ramosetron in \"acute nausea,\" between ramosetron and ondansetron in \">24 h nausea,\" and between granisetron and ondansetron in \"late vomiting.\" Additionally, granisetron and palonosetron are generally ranked higher in the P-score system.</p><p><strong>Conclusions: </strong>In gynecological surgery, palonosetron demonstrated superior efficacy to ondansetron. Granisetron seemed to be the most effective alternative to palonosetron in our study.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}