International Journal of Gynecology & Obstetrics最新文献

{"title":"Laparoscopic sclerotherapy for ovarian endometriomas during surgery for deep endometriosis: Outcomes of a 134-patient cohort.","authors":"Adrien Crestani, Benjamin Merlot, Paul-Henri Goualard, Clothilde Huet, Zoe Husson, Thomas Dennis, Isabella Chanavaz-Lacheray, Horace Roman","doi":"10.1002/ijgo.70201","DOIUrl":"https://doi.org/10.1002/ijgo.70201","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate postoperative fertility outcomes and recurrence rates in patients undergoing laparoscopic ethanol sclerotherapy for endometriomas, combined with the resection of deep endometriosis lesions.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at the Franco-European Multidisciplinary Endometriosis Institute (IFEMEndo), Clinique Tivoli-Ducos, Bordeaux, France. The study included 134 patients who underwent laparoscopic surgical resection of deep endometriosis lesions and ethanol sclerotherapy for endometriomas ≥40 mm, between October 2019 and September 2023. The procedure involved aspiration of cyst contents followed by 96% ethanol instillation. The main outcomes measured were fertility rates, endometrioma recurrence, anti-Müllerian hormone (AMH) levels, and postoperative complications.</p><p><strong>Results: </strong>The mean patient age was 31.8 ± 4.6 years, with 39 (29%) experiencing infertility. Preoperative AMH levels averaged 2.96 ± 2.02 ng/mL and decreased significantly postoperatively (mean difference 1.1 ng/mL, P = 10^-8). Severe postoperative complications occurred in 4.5% of patients, none attributed to ethanol sclerotherapy. After surgery, 78 patients expressed a desire to conceive and 45 (57%) achieved pregnancy, with 19 (42%) being spontaneous. The mean time to pregnancy was 13 ± 9 months. Cumulative pregnancy rates were 55.5% at 24 months and 78.8% at 36 months. Predictors of pregnancy included higher preoperative AMH levels (hazard ratio [HR] 1.35, P = 0.008) and absence of prior abdominal surgery (HR 0.32, P = 0.007). Recurrence of endometriomas was observed in 17 (16.5%) patients over a median follow-up of 23 months.</p><p><strong>Conclusion: </strong>In this cohort of patients treated with laparoscopic ethanol sclerotherapy during resection surgery for deep endometriosis, the procedure was safe, with satisfactory pregnancy and recurrence rates comparable to other ablative techniques.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effectiveness and pregnancy outcomes of the \"incise and suture\" versus \"fold and suture\" methods in hysteroscopic-assisted laparoscopic treatment of previous cesarean scar defect: A retrospective cohort study.","authors":"Shiying Wu, Weiwei Hu, Xiangyang Zeng, Shuijing Yi, Xuanning Wang, Qi Zhang, Hua Wang, Yueran Li, Jianfa Jiang, Songshu Xiao","doi":"10.1002/ijgo.70191","DOIUrl":"https://doi.org/10.1002/ijgo.70191","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical efficacy of the hysteroscopic-assisted laparoscopic incised-suture versus folded-suture methods at the cesarean incision site for the treatment of previous cesarean scar defects (PCSD) and to evaluate pregnancy outcomes.</p><p><strong>Methods: </strong>This was a retrospective analysis of 95 patients with PCSD who underwent hysteroscopic-assisted laparoscopic surgery between June 2021 and September 2024 at the Third Xiangya Hospital of Central South University.</p><p><strong>Results: </strong>There were no significant differences in population characteristics such as age and number of cesarean sections (P > 0.05). The folded-suture group had shorter operation time (39.03 ± 1.17 vs. 60.28 ± 1.14 min, P < 0.001) and volume of intraoperative hemorrhage (5.00, 2.00 vs. 20.00, 10.00 mL, P < 0.001). There were no statistically significant variations in the cure or effective rates regarding menstrual abnormalities between the two groups at 3 months, 6 months, 1-year post-surgery and the terms of overall clinical efficacy (P > 0.05). The overall effective rates for the incised- and folded-suture groups were 76.4% and 75.0%, respectively. In comparison to the incised-suture group, the desire to maintain postoperative fertility in the folded-suture group was significantly greater (odds ratio [OR] 8.33, 95% confidence interval [CI]: 2.27-30.58, P < 0.001), and the average time after surgery to pregnancy was shorter (5.60 ± 0.72 vs. 11.00 ± 2.70 months, P < 0.05). No substantial difference was observed in the pregnancy outcomes between the two groups.</p><p><strong>Conclusion: </strong>Hysteroscopic-assisted laparoscopic cesarean incised and folded suturing are both effective, with folded suturing being more safe and more suitable for patients requiring short-term fertility.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive cross-sectional study of CIN prevalence, HPV genotyping, genetic alterations, and microbiota as molecular biomarkers for early cervical cancer detection: A pilot clinical study among women in Russia.","authors":"Alexander Romanishin, Bogdan Efimenko, Dmitriy Katserov, Mikhail Agapov, Viktor Kakotkin, Ksenia Rubina, Tatiana Zadorkina, Ekaterina Semina","doi":"10.1002/ijgo.70090","DOIUrl":"https://doi.org/10.1002/ijgo.70090","url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationships between HPV genotypes, vaginal microbiota, oncogenic mutations, and cervical intraepithelial neoplasia (CIN) to develop a risk assessment model for predicting CIN.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted on 264 women living in the Kaliningrad region, assessing CIN presence, HPV genotypes, vaginal microbiota composition, and mutations in key oncogenes.</p><p><strong>Results: </strong>HPV genotypes 16, 31, 33, 35, 58, and 66 were identified as the most prevalent among patients with HPV infections. However, in a multifactorial model, only HPV genotypes 16 and 58 demonstrated a significant association with high-grade squamous intraepithelial lesions and above. Genetic analysis revealed mutations in TP53 and ERBB2 genes in 20 and 17 patients, respectively, with TP53 mutations showing a notable correlation with CIN progression. Two patients with diagnoses of \"Negative for Intraepithelial Lesion or Malignancy\" carried the TP53 R248W mutation, a well-established neoplasia-related variant, highlighting its potential as a predictor of precancerous conditions. Increased copy numbers of human DNA and Enterobacteriaceae DNA correlated with low-grade squamous intraepithelial lesions, though many DNA-derived features displayed instability in logistic regression models, suggesting the need for further validation.</p><p><strong>Conclusion: </strong>These findings suggest that although HPV genotypes, genetic mutations, and microbiota profiles may serve as markers for CIN, their predictive reliability requires further investigation. The present study represents the first large-scale exploration of these factors conducted within the Russian female population.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Infertility and fertility treatment options in sub-Saharan Africa","authors":"Abraham Fessehaye Sium,&nbsp;Wondimu Gudu,&nbsp;Delayehu Bekele","doi":"10.1002/ijgo.70198","DOIUrl":"10.1002/ijgo.70198","url":null,"abstract":"&lt;p&gt;The region of sub-Saharan Africa carries one of the highest burden of infertility in the world. Lack of access to ideal treatment options, economic constraints, gaps in understanding the relationship between infertility and psychosocial well-being in the context of the region, and inadequate attention from policy makers further makes infertility a unique and challenging problem in this region of Africa. This Special collection covers Infertility and fertility treatment options in sub-Saharan Africa. The intention of this collection was to gather articles that present evidence on the magnitude of infertility, its impact on psychosocial well-being of individuals affected by it, and current initiatives (mainly creating access to in vitro fertilization [IVF] care) that can be adopted to address infertility as a major public health problem in the sub-Saharan Africa region.&lt;/p&gt;&lt;p&gt;The special collection includes 11 contributions. It begins with two review articles, synthesizing evidence on the outlook of oncofertility care in Africa and male infertility in sub-Saharan Africa. In the first article, Odhiambo and Muteshi&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; review existing literature on oncofertility in Africa. Then, Muteshi and Chesire&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; present prevalence of male infertility in sub-Saharan Africa and suggest on evaluation and management approaches. Next, we present four clinical articles, reporting on studies from sub-Saharan Africa that take a deep dive into the prevalence of infertility, psychosocial impact of infertility, and techniques of IVF care. On the practice of IVF care, Mekuria et al.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; discusses valuable data on cost-effective IVF protocols. In two separate articles, Balandya et al.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt;, and Teklemicheal and Gebreyohannes&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; provide national data on the prevalence of infertility in Tanzania and Ethiopia, respectively. In the last clinical article, Araya et al.&lt;span&gt;&lt;sup&gt;6&lt;/sup&gt;&lt;/span&gt; describes qualitatively analyzed data on the lived experience of women with infertility in Ethiopia. Towards the end, the special collection displays five brief communications. In the first two brief communications, Sium et al.&lt;span&gt;&lt;sup&gt;7, 8&lt;/sup&gt;&lt;/span&gt; narrate the success story of establishing a public IVF center in Ethiopia and the role of south-to-south collaboration in its sustainability as a center with high-performing IVF services. Next, Gudu and Sium&lt;span&gt;&lt;sup&gt;9&lt;/sup&gt;&lt;/span&gt; highlight the importance of qualitative research in advancing fertility treatment services in sub-Saharan Africa. Nsahlai&lt;span&gt;&lt;sup&gt;10&lt;/sup&gt;&lt;/span&gt; provides a situational analysis of IVF in Cameroon. The special issue concludes with the last brief communication by Muteshi,&lt;span&gt;&lt;sup&gt;11&lt;/sup&gt;&lt;/span&gt; which describes premature ovarian insufficiency as an unrecognized cause of sub-fertility in Africa.&lt;/p&gt;&lt;p&gt;Editing this Special Collection was a rewarding experience for us. It is our hope that the articles in","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":"169 3","pages":"906-907"},"PeriodicalIF":2.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijgo.70198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does symphysiolysis during pregnancy affect obstetric outcomes?","authors":"Hila Shalev-Ram, Yael Rosental, Gal Cohen, Hanoch Schriber, Michal Kovo, Tal Biron-Shental, Gil Shechter-Maor","doi":"10.1002/ijgo.70178","DOIUrl":"https://doi.org/10.1002/ijgo.70178","url":null,"abstract":"<p><strong>Objective: </strong>Symphysiolysis Is Often Experienced by Pregnant Women and Is Known to Cause Considerable Pain and Occasional Anxiety. However, Information on Obstetrical and Neonatal Outcomes Is Limited. Our Objective Was to Compare Obstetrical and Neonatal Outcomes, and Labor Characteristics, between Women with or without Symphysiolysis.</p><p><strong>Methods: </strong>This retrospective cohort study included all women with singleton pregnancies without previous cesarean delivery who attempted vaginal delivery at ≥37 weeks in a tertiary hospital from 2013 to 2021. The cohort was divided into women diagnosed with symphysiolysis during pregnancy and a control group of women without the diagnosis. Maternal and delivery characteristics, as well as obstetric and neonatal adverse outcomes were compared between the groups. Nulliparous and multiparous women were analyzed separately. Adjusted odds ratios with 95% confidence intervals were calculated, controlling for confounding variables.</p><p><strong>Results: </strong>A total of 15 557 nulliparous and 27 477 multiparous women were included. Among them, 233 (1.5%) nulliparous and 515 (1.9%) multiparous women had a diagnosis of symphysiolysis. As compared with controls, women with symphysiolysis tended to be younger (27.5 ± 4.4 vs. 28.5 ± 5.0 years, P = 0.002 for nulliparous, 31.1 ± 4.9 vs. 32.2 ± 4.8 years, P < 0.001 for multiparous), have higher body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters) prior to pregnancy (25.0 ± 5.2 vs. 23.5 ± 5.0, P < 0.001 and 25.3 ± 5.5 vs. 25.3 ± 5.5, P < 0.001, respectively), and a higher prevalence of smoking during pregnancy (7.3% vs. 4.4%, P = 0.036, and 9.3% vs. 4.7%, P < 0.001, respectively). There were no between-group differences in obstetric outcomes, including second stage of labor duration, rate of vacuum extraction, cesarean delivery, perineal laceration, or adverse neonatal outcome. Moreover, there were no significant differences observed between the groups in terms of rates of Apgar scores <7 at 5 min, arterial pH <7.1, or admissions to the neonatal intensive care unit.</p><p><strong>Conclusion: </strong>The risk of obstetrical or neonatal complications during labor for individuals with symphysiolysis are not increased.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can shoulder dystocia be predicted before operative vaginal delivery using a score that includes ultrasonographic head-perineum distance measurement?","authors":"Paul Renon, Elodie Drumez, Maeva Sanchez, Julien Labreuche, Charles Garabedian","doi":"10.1002/ijgo.70184","DOIUrl":"https://doi.org/10.1002/ijgo.70184","url":null,"abstract":"<p><strong>Objective: </strong>The main study objective was to develop a novel shoulder dystocia (SD) prediction score using ultrasound-based head-perineum distance measured before an operative vaginal delivery (OVD).</p><p><strong>Methods: </strong>This retrospective unicentric study (Lille, France) included all cases of OVD of singleton pregnancies from March 2019 to October 2020, with cephalic presentation and > 37 weeks of gestation, for which intrapartum sonography was performed. A multiclass-penalized logistic regression model was used to develop the SD prognostic score, with missing values imputed by multiple imputations.</p><p><strong>Results: </strong>Among the 1708 patients with OVD, 773 who underwent ultrasound for head-perineum distance were included. SD occurred in 99 cases (12.8%). The SD's predicting factors (and their weights) included the following: maternal age younger than 28 years (3 points); multiparous (4 points); induced labor (4 points); gestational diabetes (3 points); and head-perineum distance without pressure (≤20 mm [-2 points], using 21-30 mm as reference, 31-40 mm [2 points], 41-50 mm [4 points], 51-60 mm [6 points], and >60 mm [8 points]). Three patient risk subgroups were categorized as score range (occurrence percentage) as low risk: < 3 (< 10%), high risk: 3-8 (10%-20%), and very high risk: > 8 (> 20%).</p><p><strong>Conclusion: </strong>The developed scoring system may help predict SD occurrence during OVD using five delivery room parameters. Replication with other populations and prospective cohorts will be needed for validation.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous leiomyomatosis: A case report and narrative literature review.","authors":"Beatriz Teixeira, Mafalda Castro Neves, Francisca Fonseca, José Pinheiro Torres, José Teixeira, Antónia Costa","doi":"10.1002/ijgo.70195","DOIUrl":"https://doi.org/10.1002/ijgo.70195","url":null,"abstract":"<p><p>In the present study, we report a case of intravenous leiomyomatosis with intracardiac extension. A subsequent extensive literature review was initiated in order to characterize this entity in terms of clinical manifestations, diagnosis and treatment strategies. We performed a literature search in PubMed, Webscience and Scopus using the MeSH term \"intravenous leiomyomatosis\" and included case reports, case series and retrospective studies published in the last 10 years. A total of 74 articles, with a total of 672 cases of intravenous leiomyomatosis were included. The average age at diagnosis was 45.5 years and 92% of the cases were reported in Asian countries. A total of 21% of the patients were asymptomatic. The most frequent symptoms included perception of pelvic mass, dyspnea, abnormal uterine bleeding and palpitations. In 55% of cases there was a preoperative suspicion of the diagnosis. In 61%, the lesion was confined to the pelvic cavity and in 35% there was extension beyond the renal veins (including intracardiac extension). When there was a preoperative diagnosis, the surgical team usually included elements from gynecology, vascular surgery and/or cardiac surgery. The treatment consisted of one-stage surgery in 86% of cases, with complete resection in 90%. The recurrence rate was 12%. Intravenous leiomyomatosis can have a nonspecific presentation which, combined with its rarity, requires a high degree of suspicion. The challenges in its treatment and follow-up arise from its surgical complexity and the absence of guidelines. The objective of this review was to compile the most recent cases reported to better characterize this rare entity thereby achieving optimal management.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicystic peritoneal mesothelioma in the myometrium during pregnancy: A case report and literature review.","authors":"Yutong Chen, Huizhi Wang, Wentong Zhao, Ying Wu, Min Zhu, Xueli Zhang, Yunshuang Liu","doi":"10.1002/ijgo.70187","DOIUrl":"https://doi.org/10.1002/ijgo.70187","url":null,"abstract":"<p><p>Multicystic peritoneal mesothelioma (MCPM) is a rare tumor originating from mesothelial cells, primarily affecting women of reproductive age and typically found in the pelvic peritoneum. Its occurrence in the myometrium is extremely rare. Currently, there have been no reported cases of MCPM in the myometrium during pregnancy, and existing clinical guidelines do not provide specific management recommendations for this condition. This article aimed to explore the diagnosis, management, and treatment for MCPM in the myometrium during pregnancy, thereby providing a valuable reference for clinicians dealing with similar cases.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV vaccination coverage rate in women undergoing conization for cervical intraepithelial neoplasia in Spain: The COVAR study.","authors":"Aureli Torné Blade, María Del Mar Ramírez Mena, Jesús de la Fuente Valero, Raquel Oliva Sánchez, José Quílez Conde, Manuela Sala Ferichola, Jesús Osuna Pérez, Antonio Rivera, Bruno Herrera Bruch, Gonzalo Fernández, Noelia López, María Villarejo, Marta Del Pino Saladrigues","doi":"10.1002/ijgo.70170","DOIUrl":"https://doi.org/10.1002/ijgo.70170","url":null,"abstract":"<p><strong>Objective: </strong>Females subjected to cervical excisional therapy (conization) due to high-grade squamous intraepithelial lesions/cervical intraepithelial neoplasia HSIL/CIN have a higher risk of developing cervical lesions compared to the general population. Research suggests that HPV vaccination may reduce post-treatment HSIL/CIN risk. Since 2014, HPV vaccination is recommended and funded in Spain at regional level for women who had undergone treatment for cervical precancerous lesions (HSIL/CIN2-3 or any other potentially tumoral cytohistological alteration). In 2018, the Ministry of Health standardized the recommendations but the vaccination coverage rate (VCR) for this population has not been published. The COVAR Study aimed to estimate the annual HPV VCR among women undergoing conization for SIL/CIN in Spain and assess sociodemographic and COVID-19 pandemic influence. To estimate the annual HPV vaccination coverage rate (VCR) among women undergoing conization for squamous intraepithelial lesions/cervical intraepithelial neoplasia (SIL/CIN) in Spain and assess the influence of sociodemographics and the COVID-19 pandemic.</p><p><strong>Methods: </strong>This was a multicentric, cross-sectional retrospective study conducted in six Spanish public hospitals from January 1, 2019, to December 31, 2021.</p><p><strong>Results: </strong>Annual HPV VCR was 87.3% (1135/1300), increasing to 89.8% (983/1095) in women with a conization for high-grade SIL (HSIL)/CIN. Among vaccinated women, 30.2% (343/1135) were vaccinated after SIL/CIN diagnosis but before conization and 58.3% (662/1135) were vaccinated after conization; the remaining 11.5% (130/1135) received at least one dose before SIL/CIN diagnosis. Of the conizations, 32.4% (517/1594) were performed during the pre-pandemic period, decreasing to 19.6% (312/1594) during the first COVID-19 restriction period; the annual HPV VCR also decreased (30% [259/865] to 20.7% [179/865], P < 0.001), for women vaccinated after conization.</p><p><strong>Conclusion: </strong>The annual HPV VCR in our population was 87.3%, reflecting effective vaccination strategies. The COVID-19 pandemic substantially impacted the annual percentage of conizations and HPV vaccination.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of cardiac events in pregnant women with cardiac diseases using modified WHO, CARPREG II, and ZAHARA risk assessments in southern Thailand.","authors":"Panisa Poungsuntorn, Chitkasaem Suwanrath, Natthicha Chainarong, Krantarat Peeyananjarassri, Sirichai Cheewatanakornkul, Pongsanae Duangpakdee, Kanjarut Wongwaitaweewong","doi":"10.1002/ijgo.70196","DOIUrl":"https://doi.org/10.1002/ijgo.70196","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the predictive performance of three cardiovascular risk assessment models-modified WHO (mWHO) classification, Cardiac Disease in Pregnancy II (CARPREG II), and Zwangerschap bij Aangeboren Hartafwijking (Pregnancy in Women with Congenital Heart Disease; ZAHARA)-in predicting cardiac events among pregnant women with cardiac diseases.</p><p><strong>Methods: </strong>A retrospective review of medical records was conducted for all pregnant women with cardiac diseases who delivered at Songklanagarind Hospital between January 1, 2011, and December 31, 2022. Pregnancies ending in termination or miscarriage before 24 weeks were excluded. The mWHO, CARPREG II, and ZAHARA classifications were applied to each patient, with ZAHARA used only for congenital cardiac diseases. The discriminative ability of each model was evaluated using the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>Among 333 pregnancies with cardiac diseases (163 congenital and 170 acquired), 100 (30.0%) experienced cardiac events. The AUCs for predicting cardiac events in all cases were 0.774 (95% confidence interval [CI] 0.719-0.826) for CARPREG II and 0.744 (95% CI 0.689-0.799) for mWHO. In acquired cardiac disease, the AUC for mWHO (0.700 [95% CI 0.621-0.779]) was higher than that for CARPREG II (0.677 [95% CI 0.596-0.758]). For congenital cardiac disease, CARPREG II exhibited the best predictive performance, followed by mWHO and ZAHARA, with AUC values of 0.768 (95% CI 0.658-0.877), 0.754 (95% CI 0.653-0.854), and 0.685 (95% CI 0.563-0.806), respectively.</p><p><strong>Conclusion: </strong>CARPREG II demonstrated the highest predictive performance for cardiac events in pregnant women with all cardiac diseases, while ZAHARA exhibited the lowest predictive performance for congenital cardiac diseases.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}