International Journal of Gynecology & Obstetrics最新文献

{"title":"Measurement of thiol/disulfide homeostasis and ischemic modified albumin levels in patients with uterine leiomyomas.","authors":"Bengü Nur Bariş Akcan, Büşra Karagöz Yikilmaz, Uğurcan Zorlu, Özcan Erel, Salim Neşelioğlu, Esra Özyurt, Özlem Moraloğlu Tekin, Burak Elmas","doi":"10.1002/ijgo.16098","DOIUrl":"https://doi.org/10.1002/ijgo.16098","url":null,"abstract":"<p><strong>Objective: </strong>The aim is to contrast the serum levels of thiol-disulfide homeostasis and ischemic modified albumin between patients with leiomyoma and healthy individuals and to assess the impact of oxidative stress on the etiopathogenesis of leiomyoma.</p><p><strong>Methods: </strong>In this prospective case-control study, a total of 154 participants were included, consisting of 77 cases diagnosed with leiomyoma and 77 healthy individuals without leiomyoma. The demographic characteristics and ultrasonographic findings of the participants were recorded, and parameters such as albumin, ischemia-modified albumin, and thiol-disulfide homeostasis were evaluated. The results obtained from the analyses were compared between the two groups.</p><p><strong>Results: </strong>No significant differences were observed in the demographic characteristics between the groups. A significant difference was observed between the leiomyoma and control groups regarding serum albumin parameters, serum ischemic modified albumin, and serum dynamic thiol-disulfide parameters (P < 0.001). No significant difference was found in the ratios of disulfide/total thiol, disulfide/native thiol, native thiol/total thiol (P > 0.05).</p><p><strong>Conclusion: </strong>There was a notable contrast in the levels of albumin, ischemic modified albumin, albumin/ischemic modified albumin ratio, total thiol, native thiol, and disulfide between individuals with uterine leiomyomas and healthy individuals in the control group. Oxidative stress is believed to play a causative role in the etiopathogenesis of uterine leiomyomas.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Takayasu's arteritis in pregnancy: A case report and literature review.","authors":"Apeksha Bista, Durga Thapa, Prawesh Neupane, Swati Gupta, Shreyashi Aryal, Jyotshna Sharma","doi":"10.1002/ijgo.16089","DOIUrl":"https://doi.org/10.1002/ijgo.16089","url":null,"abstract":"<p><p>Takayasu's arteritis (TA) is a rare, chronic inflammatory disease of unknown cause, primarily affecting young women in their reproductive years. It can result in the narrowing and occlusion of arteries and the formation of aneurysms in arteries, especially those related to the aorta, creating significant risks during pregnancy. Women with TA are more susceptible to cardiovascular complications, including hypertension and heart failure, which can negatively affect both maternal and fetal health. This case report details a 23-year-old pregnant woman diagnosed with TA during the first trimester, presenting with symptoms of fainting and pulselessness in her right upper limb. Doppler imaging of the right upper limb confirmed the diagnosis. Treatment for TA was initiated alongside comprehensive antenatal care. In the third trimester, she also developed gestational hypertension. And at 36 weeks of gestation, due to placenta previa and preterm premature rupture of membranes, an emergency cesarean section was performed. Timely medical intervention resulted in a favorable outcome, with an uneventful postpartum recovery. This case highlights the need for early diagnosis and collaborative care in pregnant women with TA to ensure better outcomes for both mother and child. Understanding the clinical aspects of TA is essential for effective management and improved prognosis.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of different progestogens in women with first threatened miscarriage: A network meta-analysis.","authors":"Hongqiong Zhao, Wei He, Chunyu Xia, Zhu Yang","doi":"10.1002/ijgo.15987","DOIUrl":"https://doi.org/10.1002/ijgo.15987","url":null,"abstract":"<p><p>Threatened miscarriage is defined as early vaginal bleeding before 12 weeks of gestational age and can occur in any pregnancy regardless of maternal age, race, comorbidities, lifestyle, or socioeconomic status, and about one-quarter of threatened miscarriages proceed to complete miscarriage. To assess the relative effectiveness and safety of different progestogens in women with first threatened miscarriage, using a network meta-analysis. A systematic search was conducted in PubMed, EMBASE, and Cochrane Library databases from inception to April 2023. Randomized controlled trials (RCTs) assessing the effectiveness or safety of placebo or different progestogens for the treatment of threatened miscarriage were eligible for inclusion, including dydrogesterone (oral), progesterone (oral, vaginal, rectal), and 17-α-hydroxyprogesterone (intramuscular). A Bayesian network meta-analysis with Markov chain Monte-Carlo simulation was performed in this study. A pairwise meta-analysis was carried out by synthesizing studies that compared the same interventions using a fixed-effects model. The primary outcome was the percentage of miscarriage (defined as delivery before 24 weeks of gestation) and preterm birth (defined as birth before 37 weeks of gestation), and the secondary outcomes were live birth rate, congenital abnormalities, neonatal outcomes (low birth weight <2500 g), and adverse events. The risk of bias was assessed by using the Cochrane Risk of Bias Tool. In total, 18 RCTs with six different interventions were included. Oral dydrogesterone can reduce the risk of miscarriage compared with both placebo (odds ratio [OR] 0.5, 95% confidence interval [CI] 0.32-0.76) and vaginal progesterone (OR 0.57, 95% CI 0.36-0.89) in women with first threatened miscarriage. In women with first threatened miscarriage, oral progesterone also reduced the risk of miscarriage compared with placebo (OR 0.61, 95% CI 0.39-0.93). However, from the available evidence, there was no statistically significant difference between progestogens and placebo in preterm birth, congenital abnormality, and live birth rate. Oral dydrogesterone was safe and better at reducing miscarriage than vaginal progesterone and placebo for women with first threatened miscarriage, and better at reducing miscarriage compared with placebo for women with threatened miscarriage.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation Of Maternal And Fetal Findings In Patients With Pemphigoid Gestationis.","authors":"Nihan Erdoğan Atalay, Funda Dağıstanlı, Hayal Uzelli Şimşek, Eray Caliskan","doi":"10.1002/ijgo.16086","DOIUrl":"https://doi.org/10.1002/ijgo.16086","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the maternal and fetal outcomes of 12 pregnant women diagnosed with pemphigoid gestationis, in conjunction with a review of the literature.</p><p><strong>Methods: </strong>A retrospective review was conducted on the medical records of 12 patients diagnosed with pemphigoid gestationis who presented  between January 2014 and January 2024.</p><p><strong>Results: </strong>Twelve pregnant patients with pemphigoid gestationis were included in the study. The disease manifested during the first pregnancy in six patients. Mean maternal age was 30 years, mean gestational age at delivery was 33 weeks, and mean birth weight was 2146 g. Neonatal lesions were identified in two neonates. Intrauterine growth restriction, starting at an average of 33 weeks of gestation, was observed in four patients. Oligohydramnios was noted in two patients, hypertension in one patient, placental abruption in one patient, and gestational diabetes mellitus in one patient. During pregnancy, five patients were treated with oral steroids, six patients with intravenous steroids, and nine patients with topical steroids. Neonatal intensive care unit admission occurred in six neonates, and maternal intensive care unit admission was required for one patient.</p><p><strong>Conclusion: </strong>Patients with pemphigoid gestationis are at significant risk for severe maternal morbidity and adverse fetal outcomes in both the antepartum and postpartum periods. Early diagnosis of vesiculobullous lesions and close monitoring as high-risk pregnancies through a multidisciplinary approach are recommended.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in physiological indicators between twin and singleton pregnancy.","authors":"Siyu Liu, Huifeng Shi, Shiyu He, Lanxin Hu, Yangyu Zhao","doi":"10.1002/ijgo.16097","DOIUrl":"https://doi.org/10.1002/ijgo.16097","url":null,"abstract":"<p><strong>Objective: </strong>It has been widely reported that there are physiological differences between twin and singleton pregnancies, as evidenced by physiological indicators examined during prenatal period. However, not all physiological indicators have been evaluated. Physiological indicators of twin pregnancies still refer to the standards of single pregnancies and lack precise variation intervals. Therefore, our study compared and analyzed the differences in physiological indicators between twin and singleton pregnancies.</p><p><strong>Methods: </strong>Retrospective cohort data of deliveries at Peking University Third Hospital from January 1, 2012, to February 8, 2021, were utilized. Information of pregnant women, including maternal characteristics, 49 physiological indicators examined during four periods (postpartum, first, second, and third trimester), and pregnancy complications, was extracted from medical records. Mann-Whitney test and multiple linear regressions were conducted to evaluate the differences in physiological indicators between twin and singleton pregnancies and to demonstrate their variation trend throughout gestation.</p><p><strong>Results: </strong>A total of 40 746 cases were included (38 320 singleton pregnancy cases and 2426 twin pregnancy cases). In twin pregnancies, 16 indicators related to red blood cells, platelets, coagulation function, protein, creatinine, and blood lipids exhibited distinctions compared to singleton pregnancies throughout gestation. The results remained stable regardless of maternal complications.</p><p><strong>Conclusion: </strong>Twin and singleton pregnancies are in distinct physiological conditions. It is of great necessity to establish specific reference intervals for twin pregnancies. Further study is needed to investigate the impact of physiological indicators on predicting adverse outcomes in twin pregnancies.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Mifepristone and misoprostol versus misoprostol alone for induction of labor in women with intrauterine fetal death: A meta-analysis and systematic review.","authors":"Shanzay Akhtar, Hammad Amjad, Mobeen Abid, Muhammad Farhan","doi":"10.1002/ijgo.16105","DOIUrl":"https://doi.org/10.1002/ijgo.16105","url":null,"abstract":"","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnant women's dietary patterns and knowledge of gestational weight gain: A cross-sectional study.","authors":"Chun Mei Zhang, Fang Fang Gao, Xin Xin Guo, Fei Su","doi":"10.1002/ijgo.16116","DOIUrl":"https://doi.org/10.1002/ijgo.16116","url":null,"abstract":"","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of interpregnancy interval on the risk for cesarean delivery following prior vaginal delivery.","authors":"David Chromey, Henry Lesser, Celia Gray, Priyanka Pawar, A Dhanya Mackeen","doi":"10.1002/ijgo.16083","DOIUrl":"https://doi.org/10.1002/ijgo.16083","url":null,"abstract":"","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FIGO at 70: Navigating challenges in the global women's health landscape.","authors":"Anne-Beatrice Kihara","doi":"10.1002/ijgo.16117","DOIUrl":"https://doi.org/10.1002/ijgo.16117","url":null,"abstract":"","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of anti-inflammatory dietary supplements on pelvic pain in females with endometriosis: A GRADE-assessed systematic review and meta-analysis of RCTs.","authors":"Fatemeh Naeini, Fatemeh Davari Tanha, Hastimansooreh Ansar, Mohammad Javad Hosseinzadeh-Attar","doi":"10.1002/ijgo.16103","DOIUrl":"https://doi.org/10.1002/ijgo.16103","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis, the most perplexing gynecologic condition, impairs the quality of life because it is usually accompanied by persistent severe acyclic pelvic pain and infertility as its two main symptoms. The majority economic burden of endometriosis is due to infertility and pelvic pain. Therefore, alleviating pelvic pain in patients with endometriosis is a necessity.</p><p><strong>Objectives: </strong>The present systematic review and meta-analysis aimed to summarize evidence about the effects of anti-inflammatory dietary supplements on pelvic pain in females with endometriosis.</p><p><strong>Search strategy: </strong>PubMed, Scopus, and Web of Science as online databases were systematically searched by relevant keywords up to December 2023.</p><p><strong>Selection criteria: </strong>Randomized controlled clinical trials (RCTs) with either a parallel or crossover design conducted in adults with endometriosis were selected.</p><p><strong>Data collection and analysis: </strong>Random effect analysis was used to run meta-analysis. Subgroup analyses were run to detect heterogeneity sources. Quality assessment was done by revised Cochrane Collaboration tool II. The certainty of evidence was evaluated by the GRADE tool.</p><p><strong>Main results: </strong>A significant decrease in pelvic pain following supplementation with anti-inflammatory dietary supplements was detected. Also, anti-inflammatory dietary supplements could significantly decline pelvic pain in patients with endometriosis when the age of the participants was ≥32 years, the duration of supplementation was >8 weeks, the type of intervention was anti-inflammatory vitamins, the stage of endometriosis of study participants was > II, and baseline body mass index (BMI) of the participants was >23 kg/m².</p><p><strong>Conclusions: </strong>Use of anti-inflammatory dietary supplements in females with endometriosis results in a remarkable decrease in pelvic pain.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}