International Journal of Gynecology & Obstetrics最新文献

{"title":"Invited Abstracts","authors":"","doi":"10.1002/ijgo.70501","DOIUrl":"https://doi.org/10.1002/ijgo.70501","url":null,"abstract":"","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":"171 S2","pages":"42-71"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1002/ijgo.70501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy outcomes of gestational diabetes mellitus treated before versus after 24 weeks: A comparison of Carpenter-Coustan and IADPSG criteria.","authors":"Santikorn Gorsagun, Ninlapa Pruksanusak, Alan Frederick Geater","doi":"10.1002/ijgo.70572","DOIUrl":"https://doi.org/10.1002/ijgo.70572","url":null,"abstract":"<p><strong>Objective: </strong>To compare pregnancy outcomes between early and standard treatment of gestational diabetes mellitus (GDM) diagnosed using the Carpenter-Coustan criteria and to assess the impact of applying the International Association of Diabetes and Pregnancy Study Group (IADPSG) fasting plasma glucose (FPG) threshold.</p><p><strong>Methods: </strong>This retrospective cohort study included singleton pregnancies diagnosed with GDM between March 2013 and January 2023. Cases were categorized as early GDM (diagnosed before 24 weeks' gestation) or standard GDM (diagnosed at or after 24 weeks). Maternal and perinatal outcomes were compared, and the impact of substituting an FPG ≥ 92 mg/dL threshold was evaluated.</p><p><strong>Results: </strong>Of the 1291 cases, 357 were early and 934 were standard GDM. Early treatment did not increase adverse perinatal outcomes compared to standard treatment, except for a modestly longer neonatal hospital stay and a slightly higher neonatal birthweight. The early group had higher rates of chronic hypertension, family history of diabetes, hypertensive disorders of pregnancy (HDP), and higher pre-pregnancy body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters), but insulin treatment rates were similar. In the standard group, FPG ≥ 95 mg/dL was associated with higher neonatal intensive care unit (NICU) admission (18.5% vs. 12.4%, P = 0.03) and neonatal hypoglycemia (4.1% vs. 1.6%, P = 0.04), while FPG ≥ 92 mg/dL did not show significant differences. However, multivariate analysis revealed that FPG ≥ 92 mg/dL was independently associated with NICU admission (adjusted odds ratio [aOR] 1.67; 95% confidence interval [CI], 1.16-2.39). Early GDM, chronic hypertension, and BMI ≥ 25 were significant predictors of HDP.</p><p><strong>Conclusion: </strong>Early treatment using the Carpenter-Coustan criteria did not increase adverse neonatal outcomes. An FPG ≥ 92 mg/dL may identify standard GDM cases at higher risk for neonatal complications.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National policies for screening and early detection of breast cancer around the globe: Practices, barriers, and solutions.","authors":"Versha Pleasant, Charulata Bapaye, Femke Delporte, Maria Jose Del Rio Vigil, Hema Divakar, Gustavo Ferreiro Delgado, Nestor Cesar Garello, Serigne Modou Kane Gueye, Charmaine Clarisse T Gutierrez, Paola Iturralde-Roses-Priego, Christian Jackisch, Sharon Mass, Christine Solbach","doi":"10.1002/ijgo.70545","DOIUrl":"https://doi.org/10.1002/ijgo.70545","url":null,"abstract":"<p><p>Breast cancer represents a significant burden of disease for women across the globe. Screening has been demonstrated to decrease breast cancer-related mortality. However, many nations do not have population breast cancer screening programs, which are key to early detection and can decrease mortality rates. In 2024, the International Federation of Gynecology and Obstetrics (FIGO) established the Committee on Breast Health to raise awareness about breast disease, advocate for improved prevention and treatment, and promote best practices. This manuscript aims to review national policies in screening and early detection across 7 of the countries represented in the FIGO Committee on Breast Health: Chile, Germany, India, Mexico, the Philippines, Senegal, and the United States. Policies for population screening for breast cancer are reviewed and compared across countries, as well as efforts in risk stratification. A framework for addressing population screening for breast cancer is also proposed that acknowledges resource and infrastructure limitations across nations. These efforts represent a critical step in addressing breast cancer-related mortality worldwide.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the diagnostic potential of CA-125 and miRNA levels in endometriosis: A narrative review.","authors":"Taha Shokrnejad-Namin, Neda Farzizadeh, Zahra Najmi, Morteza Amoozgar, Amirali Hariri, Elnaz Amini, Arezoo Khosravi, Ali Zarrabi","doi":"10.1002/ijgo.70554","DOIUrl":"https://doi.org/10.1002/ijgo.70554","url":null,"abstract":"<p><p>Endometriosis, a common and complex gynecologic disorder, continues to pose a challenge to clinicians in diagnosis process due to its complexity. The aim of this review was to examine cancer antigen-125 (CA-125) and microRNAs (miRNAs) as biomarkers in endometriosis pathophysiology and their investigational potential roles in clinical diagnostics and prognostics. In this narrative review, a variety of studies are reviewed, including cross-sectional, case-control, and prospective designs, examining a broad spectrum of patient demographics, clinical features, and biomarker (CA-125 and miRNA) expression levels. While frequently elevated in endometriosis, CA-125 is limited by low specificity and sensitivity, preventing its use as a standalone diagnostic tool; its primary utility remains in monitoring established disease and, adjunctively, with other clinical parameters. miRNAs have gained attention as molecular regulators implicated in the disease process, suggesting potential avenues for noninvasive diagnostics and a better understanding of pathogenesis. The combined analysis of biomarker panels, rather than single markers, may present a shift towards more personalized strategies. The convergence of CA-125 and miRNA research represents a promising advance, potentially leading to more accurate diagnostics and personalized treatment. Future research should focus on standardizing methodologies, expanding study cohorts, and integrating findings into clinical practice to fully harness the potential of these biomarkers.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Communications","authors":"","doi":"10.1002/ijgo.70502","DOIUrl":"https://doi.org/10.1002/ijgo.70502","url":null,"abstract":"","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":"171 S2","pages":"72-120"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1002/ijgo.70502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is pathological fetal Doppler cerebroplacental ratio (CPR) associated with adverse delivery outcomes in pregnancies complicated by fetal growth restriction undergoing labor induction? A retrospective cohort study.","authors":"Nofar Bar Noy-Traub, Eden Friedman, Shaked Yarza, Eynit Grinblatt, Tal Biron-Shental, Shmuel Arnon, Michal Kovo, Dorit Ravid, Sivan Farladansky-Gershnabel","doi":"10.1002/ijgo.70573","DOIUrl":"https://doi.org/10.1002/ijgo.70573","url":null,"abstract":"<p><strong>Objective: </strong>The optimal delivery approach for fetal growth restriction (FGR) with pathological cerebroplacental ratio (CPR) remains uncertain. This study evaluated the association between isolated pathological CPR (<5th percentile) and delivery outcomes, specifically the rate of cesarean delivery (CD) due to non-reassuring fetal heart rate (NRFHR), in FGR cases undergoing induction of labor (IOL).</p><p><strong>Methods: </strong>In this retrospective cohort study (2014-2023), pregnancies with FGR (estimated fetal weight < 10th percentile) undergoing IOL were stratified by CPR values: pathological (<5th percentile) and normal CPR. Exclusion criteria included multiple gestations, abnormal umbilical artery or ductus venosus Doppler, abnormal non-stress test or biophysical profile, major fetal anomalies, and genetic disorders.</p><p><strong>Results: </strong>Among 432 FGR, 86 had pathological CPR. This group had higher rates of second-trimester human chorionic gonadotropin (HCG) >2.5 multiples of the median (11.7% vs. 3.8%, P = 0.01) and delivered earlier (37.1 vs. 38.0 weeks, P < 0.01). Overall CD rates and CD due to NRFHR were comparable between groups (19.8% vs. 18.8%, P = 0.84; 14.0% vs. 15.9%, P = 0.66, respectively). Neonates with pathological CPR had lower birthweights (2174 ± 279 g vs. 2279 ± 278 g, P < 0.01) and higher neonatal intensive care unit (NICU) admission rates (17.4% vs. 9.2%, P = 0.03). Logistic regression analysis adjusted for potential confounders showed no independent association between pathological CPR and increased risk of CD due to NRFHR (P = 0.74).</p><p><strong>Conclusion: </strong>In FGR pregnancies undergoing IOL, isolated pathological CPR is not associated with an increased risk of cesarean delivery for NRFHR. However, these fetuses remain at higher risk for NICU admissions, emphasizing the need for individualized management and close monitoring.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FIGO committee opinion: Environmental drivers of obstetric health and early childhood development.","authors":"Nathaniel DeNicola, Emily Lasher, Abena BakenRa, Rashmi Joglekar, Jun Zhang, Annette Hasenburg, Krishnendu Gupta, Ditas Decena, Francisco Edna, David Graham, Edward Morris, Blami Dao, Tracey Woodruff","doi":"10.1002/ijgo.70549","DOIUrl":"https://doi.org/10.1002/ijgo.70549","url":null,"abstract":"<p><p>Environmental exposures are increasingly recognized as critical, yet underappreciated, determinants of reproductive, perinatal, and early childhood health. Developed through a structured consensus process and grounded in systematic evidence review, this FIGO committee opinion provides a comprehensive synthesis of the current evidence linking environmental toxicants-including air pollution, endocrine-disrupting chemicals, heavy metals, and climate-related stressors-to common obstetric outcomes such as preterm birth, hypertensive disorders of pregnancy, gestational diabetes, and impaired fetal growth, as well as to early childhood outcomes including neurodevelopmental delay, metabolic disease, and atopic conditions. This article also outlines common biological mechanisms, such as endocrine disruption, oxidative stress, epigenetic modification, and placental dysfunction, and provides clinicians with actionable guidance for integrating environmental health into reproductive care through screening, counseling, and advocacy. Special attention is paid to the role of social and structural inequities in amplifying exposure risks and health disparities. By linking environmental drivers to familiar clinical outcomes, this guidance empowers obstetricians and allied professionals to engage in preventive care that safeguards maternal and child health across the life course. FIGO calls on reproductive health professionals to embrace this leadership role-not only in clinical practice, but in shaping policies that protect current and future generations.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of obstetric fistulas and associated factors among women of reproductive age in Ethiopia: Systematic review and meta-analysis.","authors":"Aster Shiferaw, Getachew Tilaye Mihiret, Mastewal Yechale Mihret","doi":"10.1002/ijgo.70566","DOIUrl":"https://doi.org/10.1002/ijgo.70566","url":null,"abstract":"<p><strong>Objectives: </strong>Obstetric fistula is a complication occurring in childbearing women. It is a major problem in developing countries and results in poor childhood development and limited use of obstetric care. The aim of this study was to show the pooled prevalence of knowledge of obstetric fistulas among reproductive age women.</p><p><strong>Method: </strong>Several databases and websites were searched to find articles. Studies conducted on the knowledge of obstetric fistula and associated factors in women of reproductive age in Ethiopia up to February 20, 2023, were included.</p><p><strong>Data collection and analysis: </strong>The Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument for cross-sectional study was used for quality assessment, and the Preferred Reporting Items for Systematic reviews and Meta-Analysis guidelines were used for review. Seven studies were included in total. Pooled prevalence was calculated using a random effect model, and subgroup analysis was carried out. Egger's and Begg's tests were used to assess for publication bias. Finally, tests were conducted to determine the impact of related factors on obstetric fistula knowledge.</p><p><strong>Results: </strong>The pooled prevalence of knowledge of obstetric fistula among reproductive age women was 43.9%. Attending formal education (AOR = 3.74, 95% confidence interval [CI] = 1.43, 6.05), urban residence (AOR = 4.65, 95% CI = 2.79, 6.52), having antenatal care (ANC) history (AOR = 5.69, 95% CI = 2.03, 9.3), having family planning (FP) history (AOR = 2.5, 95% CI = 1.11, 3.9), home distance from health institution that took ≤30 min by foot (AOR = 3.85, 95% CI = 2.47, 5.23), and ever having been pregnant (AOR = 2.68, 95% CI = 1.25, 4.11).</p><p><strong>Conclusion: </strong>In this study, most women of reproductive age did not know anything about obstetric fistulas. Knowledge about obstetric fistulas was strongly associated with living in an urban area, walking ≤30 min to and from a medical facility, having a history of ANC or FP, and having ever been pregnant. Therefore, it is important to advocate for women's education, access to maternity and child health services, communication with medical professionals, and proximity to health facilities.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FIGO statement on respectful care: Addressing disrespectful maternity care.","authors":"Jezid Miranda, Hasmik Bareghamyan, Michelle N S Therrien, Andre Lalonde, Margit Steinholt, Francesca Palestra, Debra Pascali-Bonaro, Mindaugas Kliucinskas, María A Basavilvazo Rodríguez, Garang Ajak, Eliana Amaral, Pius Okong, Birgitta Essèn, Bo Jacobsson, Suellen Miller","doi":"10.1002/ijgo.70513","DOIUrl":"https://doi.org/10.1002/ijgo.70513","url":null,"abstract":"<p><p>The International Federation of Gynecology and Obstetrics (FIGO) Committee on Health Systems Strengthening and Respectful Care recognizes the detrimental effects of disrespectful and abusive practices within maternity care on maternal and neonatal health outcomes. In response, the committee advocates for the implementation of strategic, evidence-based interventions aimed at safeguarding women from substandard and disrespectful treatment during pregnancy, childbirth, and the postpartum period. This statement presents FIGO's recommendations for adopting respectful maternity care into health systems. The proposed policy interventions and clinical strategies are designed to foster compassionate, person-centered, and culturally competent care, thereby contributing to improved maternal and perinatal outcomes globally.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paracetamol (acetaminophen) use during pregnancy and autism risk: Evidence does not support causal association.","authors":"Frank Louwen, Eileen Deuster, Fionnuala M McAuliffe, Bo Jacobsson, Michael Geary, Steven Fleischman, Anne-Beatrice Kihara","doi":"10.1002/ijgo.70577","DOIUrl":"https://doi.org/10.1002/ijgo.70577","url":null,"abstract":"<p><p>Recent political statements linking paracetamol (acetaminophen) use during pregnancy to autism spectrum disorders have created concern among patients and healthcare providers worldwide. This editorial critically examines the scientific evidence, highlighting that the largest and most methodologically rigorous population-based studies employing sibling control analyses demonstrate no causal association between prenatal paracetamol exposure and neurodevelopmental disorders. While some observational studies have suggested potential weak associations, these findings likely reflect confounding by indication and familial genetic factors rather than actual causal relationships. The most robust evidence comes from a Swedish population-based study of 2.48 million children, which found no increased risk when controlling for familial confounding. Major international medical organizations including ACOG, RCOG, and FIGO, and regulatory agencies including the European Medicines Agency continue to recommend paracetamol as the safest analgesic option during pregnancy when clinically indicated. The established risks of untreated pain and fever during pregnancy significantly outweigh theoretical concerns based on methodologically limited studies. Healthcare providers should continue evidence-based counseling while avoiding unnecessary anxiety about this essential medication in obstetric practice.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}