International Journal of Gynecology & Obstetrics最新文献

{"title":"α2,3-Sialyltransferase (ST3Gal1) regulates endometrioid-type epithelial ovarian cancer cell migration and invasion via VEGF-R2/JAK2/STAT3 signaling cascades.","authors":"Wei-Ting Chao, Chia-Hao Liu, Szu-Ting Yang, Chen-Hao Lin, Liang-Wei Wang, Peng-Hui Wang","doi":"10.1002/ijgo.71057","DOIUrl":"https://doi.org/10.1002/ijgo.71057","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the role of ST3 β-galactoside α-2,3-sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF-R2) in endometrioid-type epithelial ovarian cancer (E-OC) because aberrant α2,3-sialylation mediated by ST3Gal1 and VEGF-R2-related angiogenesis is linked with tumor progression.</p><p><strong>Methods: </strong>ST3Gal1 and VEGF-R2 expression levels were analyzed in E-OC tissues and cell lines. ST3Gal1 knockdown and ST3Gal1 inhibitor soyasaponin I (SsaI) treatment were performed to evaluate the effects of altered sialylation on the VEGF-R2 pathway, downstream Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling, and cell migration/invasion. Co-immunoprecipitation experiments were conducted to confirm the interaction between ST3Gal1 and VEGF-R2. The combination of SsaI and VEGF-R2 inhibitors was assessed using in vitro and in vivo studies.</p><p><strong>Results: </strong>High ST3Gal1 expression was associated with advanced E-OC stage and poorer overall survival in a univariable analysis; however, it did not retain independent prognostic significance in a multivariable analysis. ST3Gal1 knockdown reduced VEGF-R2 expression and inhibited downstream JAK2/STAT3 signaling and suppressed tumor cell migration and invasion. SsaI treatment reduced VEGF-R2 signaling and impaired metastatic potential in vitro. The combined inhibition of ST3Gal1 and VEGF-R2 reduced tumor growth in vivo.</p><p><strong>Conclusions: </strong>Targeting ST3Gal1-mediated α2,3-sialylation disrupts VEGF-R2 signaling and suppresses metastatic behavior in E-OC models. Although clinical associations suggest a potential link with adverse outcomes, larger studies are required to clarify its independent prognostic significance. Combined inhibition of ST3Gal1 and VEGF-R2 reduced tumor growth in vivo; these findings support further investigations of ST3Gal1 as a potential therapeutic target in E-OC.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does sonographic visual biofeedback before or during the second stage of labor improve outcomes? A meta-analysis.","authors":"Chen Nahshon, Nadav Cohen, Yael Goldberg, Neta Boms, Ofer Lavie, Amit Damti, Reuven Kedar, Ariel Zilberlicht","doi":"10.1002/ijgo.71053","DOIUrl":"https://doi.org/10.1002/ijgo.71053","url":null,"abstract":"<p><strong>Background: </strong>Effective pushing during the second stage of labor is critical for optimal birth outcomes, but many women-especially those under epidural analgesia-struggle with reduced pelvic sensation and pushing efficacy. Transperineal ultrasound is widely used to assess labor progression, and visual biofeedback has shown promise in improving physical and psychological outcomes in other fields. However, its application during labor remains underexplored.</p><p><strong>Objective: </strong>This study assesses the effect of sonographic visual biofeedback before and during labor on obstetric outcomes.</p><p><strong>Method: </strong>We performed an electronic search using MEDLINE with the OvidSP interface PUBMED, Embase, Web of Science, and Cochrane Library up to August 13, 2024. We included experimental and non-experimental studies, comprising randomized controlled and observational (case-control, cohort, and cross-sectional) studies assessing the effect of sonographic visual biofeedback on delivery outcomes. Four references comprising 457 patients were eventually included. Primary data collection was performed using standardized data extraction procedures, with disagreements being settled by discussion. Analysis was conducted using RevMan 5.4 (Cochrane Collaboration, Oxford, UK).</p><p><strong>Results: </strong>Visual biofeedback is associated with a more pronounced change in angle of progression (AoP) measurements when comparing resting state to active pushing (mean difference [MD] 5.04 [95% confidence interval [CI] 1.42-8.66], P = 0.006, I² = 63%), and the overall AoP while pushing was notably greater in the visual feedback group (MD 9.23 [95% CI 0.94-17.53], P = 0.03, I² = 76%). There were no statistically significant differences in mode of delivery, duration of second stage of labor, rates of intact perineum, and incidence of second- and third-degree perineal tears. A significant reduction in episiotomies among patients who received visual feedback was observed (OR 0.42 [95%CI 0.24-0.76], P = 0.004, I² = 0%).</p><p><strong>Conclusion: </strong>Visual feedback might influence maternal pushing behavior and enhance pushing efficacy, potentially reducing obstetrical interventions such as episiotomies. Additional prospective randomized studies are needed to definitively determine the effect of visual biofeedback on a wide range of obstetric outcomes. Such research could help refine the use of this technique and potentially improve the labor experience and outcomes for many women. The study protocol can be assessed at the PROSPERO International prospective register of systematic reviews (www.crd.york.ac.uk/PROSPERO, registration number CRD42024570484).</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective cost-effectiveness analysis of carbetocin for the prevention of postpartum hemorrhage after vaginal birth: Evidence from a tertiary maternity center in France.","authors":"Solène Poyet, Manon Degez, Youssouf Compaoré, Emilie Misbert, Norbert Winer, Vincent Dochez","doi":"10.1002/ijgo.71029","DOIUrl":"https://doi.org/10.1002/ijgo.71029","url":null,"abstract":"<p><strong>Objective: </strong>Prophylactic oxytocin (5-10 IU) after vaginal birth is a grade A recommendation in France. During cesarean delivery, carbetocin is increasingly used as an alternative to oxytocin to reduce the risk and burden of postpartum hemorrhage (PPH). Its role after vaginal birth remains uncertain, largely because of higher costs. This study assessed the cost-effectiveness of carbetocin for PPH prevention in vaginal deliveries.</p><p><strong>Methods: </strong>We performed a retrospective single-center, observational before-after cohort study with a medico-economic component in a French tertiary maternity unit. All women who delivered vaginally between January 1 and March 31, 2024 (oxytocin period), and between November 1, 2024, and January 31, 2025 (carbetocin period), were included. These two periods corresponded to the institutional protocol change replacing oxytocin with carbetocin for prophylaxis of postpartum hemorrhage after vaginal delivery.</p><p><strong>Results: </strong>A total of 1404 women were analyzed (702 per group). The overall PPH rate was similar between groups (9.0% vs. 7.8%). Severe PPH (≥1000 mL) occurred less frequently with carbetocin than with oxytocin (1.3% vs. 3.0%, P = 0.0244). Weighted mean costs per patient were €17.28 in the carbetocin group and €9.07 in the oxytocin group, with a mean difference of €8.11 (95% confidence interval [CI]: 0.31-15.48). The incremental cost-effectiveness ratio (ICER) was €511.87 per severe PPH avoided.</p><p><strong>Conclusion: </strong>Despite higher drug costs, prophylactic carbetocin significantly reduced severe PPH compared with oxytocin and showed favorable cost-effectiveness in vaginal deliveries. These findings support carbetocin as a valuable alternative for PPH prevention in this setting.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous uterine rupture of an unscarred uterus in the second trimester: A case report.","authors":"Nour Bakhache, Erica Pascoal, Leah Drost, Alysha Nensi, Michael Ricci, Carmen McCaffrey","doi":"10.1002/ijgo.71054","DOIUrl":"https://doi.org/10.1002/ijgo.71054","url":null,"abstract":"","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Randomized Trial of Combined Cabergoline And Coasting in Preventing Ovarian Hyperstimulation Syndrome During in Vitro Fertilization/intracytoplasmic Sperm Injection Cycles.","authors":"","doi":"10.1002/ijgo.71061","DOIUrl":"https://doi.org/10.1002/ijgo.71061","url":null,"abstract":"<p><strong>Retraction: </strong>Y.A. Bassiouny, D.M.R. Dakhly, Y.A. Bayoumi, N.A. Salaheldin, H.A. Gouda, and A.A. Hassan, \"Randomized Trial of Combined Cabergoline And Coasting in Preventing Ovarian Hyperstimulation Syndrome During In Vitro Fertilization/intracytoplasmic Sperm Injection Cycles,\" International Journal of Gynecology & Obstetrics 140, no. 2 (2018): 217-222, https://doi.org/10.1002/ijgo.12360. This retraction has been issued for the above article, published online on 21 October 2017 in Wiley Online Library (wileyonlinelibrary.com), by agreement between the journal Editor-in-Chief, Michael Geary; and John Wiley & Sons Ltd. A third party expressed concerns about the randomization allocation process, noting that the reported methodology does not appear to reflect the standards of a randomized clinical trial. When asked for clarification, the authors provided their study data and explanation. However, the editorial team and publisher did not feel that the answers and data alleviated the concerns with the methodology. While the work may have been undertaken in good faith, it does not meet the minimum standards to constitute a randomized study. As a result, the data and conclusions are considered unreliable, and therefore the article must be retracted.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Shirodkar cerclage with diluted vasopressin: Feasibility and safety assessment prior to a randomized controlled trial.","authors":"Mohamed Rishard, Kavinda Rajaratne, Asmath Hilmi","doi":"10.1002/ijgo.70735","DOIUrl":"10.1002/ijgo.70735","url":null,"abstract":"","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":"1141-1144"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sex-informed transcriptomic prognostic score for gynecologic cancers: Multiplatform validation and spatial characterization.","authors":"Mauricio A Cuello, Fernán Gómez-Valenzuela, Ignacio Wichmann, Sumie Kato, Carolina Ibañez","doi":"10.1002/ijgo.70650","DOIUrl":"10.1002/ijgo.70650","url":null,"abstract":"<p><strong>Objective: </strong>This study develops and validates a sex-informed transcriptomic prognostic score derived from sex-stratified survival analyses, with a focus on gynecologic malignancies.</p><p><strong>Methods: </strong>This retrospective, computational multi-cohort study analyzed transcriptomic and clinical data from The Cancer Genome Atlas (TCGA; n ≈ 5000) and CPTAC-3 (n = 2191). A 10-gene score was constructed using sex-stratified Cox models and LASSO regression across 20 TCGA tumor types. Prognostic performance was evaluated using hazard ratios and time-dependent AUCs at 1, 3, and 5 years. Analyses followed a four-phase design: discovery in TCGA, internal cross-cancer validation, external validation in independent cohorts (MSK-IMPACT, CPTAC-3, and LIHC-FR), and biological validation using single-cell and spatial transcriptomic data from formalin-fixed paraffin-embedded tissues. Patients were stratified into high- and low-risk groups based on the median gene-expression score, with optimal cutpoints determined using maximally selected rank statistics where indicated. While the discovery analyses were sex-stratified, the final 10-gene score is sex-agnostic and applicable to both sexes.</p><p><strong>Results: </strong>The score showed strong prognostic discrimination (hazard ratio = 2.15; 95% confidence interval 1.60-2.88; P < 0.001), with areas under the curve ranging from 0.69 to 0.72 across timepoints. It remained robust across datasets and analytic platforms. In gynecologic tumors, high-score regions colocalized with fibroblast-rich, immune-depleted areas, reflecting transcriptional programs of stromal remodeling and immune exclusion linked to immunotherapy resistance.</p><p><strong>Conclusion: </strong>This sex-informed, spatially validated score provides a reproducible and biologically interpretable framework for transcriptomic risk stratification in gynecologic cancers. By capturing immune-evasive and aggressive tumor states, it might inform biomarker-guided clinical trials and support context-appropriate implementation of precision oncology strategies.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":"741-756"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145523378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Household air pollutant exposure and anemia prevalence among pregnant women in five countries of the West African Region.","authors":"Michael Mensah, Sampson Opoku, Rahmatu Babah, Ernest Obeng Nsiah","doi":"10.1002/ijgo.70655","DOIUrl":"10.1002/ijgo.70655","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the relationship between household air pollutant exposure and the prevalence of anemia among pregnant women in five West African countries.</p><p><strong>Methods: </strong>This cross-sectional secondary analysis used data of 3292 pregnant women aged 15-49 from Demographic and Health Surveys (DHS) in West Africa. Anemia was the primary outcome variable. Household air pollution (HAP) exposure was categorized according to cooking fuel type (low, medium, or high polluting), and it included household tobacco smoke. Stata 17 was used for data cleaning and analyses. The analyses included frequency and percentage calculations, χ²-tests, and logistic regression. Crude odds ratio (cORs) and adjusted odds ratios (aORs), along with prevalence ratios (PRs) and 95% confidence intervals (CIs) were reported, with statistical significance set at 0.05.</p><p><strong>Results: </strong>The prevalence rate of anemia among the pregnant women was 54.59% (n = 1797/3292). Factors significantly related to anemia levels included country (P < 0.001), religion (P < 0.001), marital status (P = 0.016), and education (P < 0.05). Lower household wealth (P < 0.001), lack of electricity (P < 0.001), and unemployment (P < 0.001) were significantly related to higher anemia rates. Significant associations were observed between HAP and anemia in Ghana and Nigeria, with environmental and geographic factors also influencing the risk. Women in Ghana (aOR = 1.92; 95% CI: 1.42-2.56; P < 0.01) and Nigeria (aOR = 3.11; 95% CI: 2.48-3.91; P < 0.01) had higher odds of anemia compared to Cameroon, as did women in their second trimester (aOR = 2.26; 95% CI: 1.89-2.70; P < 0.001) and third trimester (aOR = 2.04; 95% CI: 1.69-2.45; P < 0.001).</p><p><strong>Conclusion: </strong>This study showed a high prevalence of anemia among pregnant women in West Africa and its association with demographic, socioeconomic, and environmental factors, thus highlighting the need for targeted interventions.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":"844-853"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145563824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induced abortion in the world: 2. Present views on pregnancy termination.","authors":"Giuseppe Benagiano, Kristina Gemzell-Danielsson, Marwan Habiba, Salvatore Mancuso, Shantha Shantha-Kumari","doi":"10.1002/ijgo.70679","DOIUrl":"10.1002/ijgo.70679","url":null,"abstract":"<p><p>Abortion was practiced in most cultures for millennia, but was often disapproved and banned. The 20th century witnessed a progressive conditional legalization, often with limitations for the duration of pregnancy. Legalizing abortion was driven by multiple factors, including a desire to limit population growth, the emergence of movements that promoted reproductive freedom, women's empowerment and control over their own bodies, and an increased awareness of the risks inherent in abortions carried out without proper medical care. Today, there is a definite trend towards safer and more efficient abortion methods. Access to abortion care is not universal: in 2022, 970 million women of reproductive age had access to abortion, whereas some 700 million lived under restrictive laws. In many parts of the world abortion rates have increased, while the ethical conflict around abortion remains and views on both sides have polarized and become more entrenched. Whether restrictive legislation reduces the number of women undergoing abortion and whether a realization that addressing the unplanned and unwanted pregnancies can reduce the number of women seeking abortion remains debatable. In conclusion, the 20th century witnessed the contradiction of a surge in both pro- and anti-abortion sentiments.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":"668-673"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145633734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of postoperative intrauterine adhesions and septal remnants following hysteroscopic septum resection: A retrospective study.","authors":"Yannick Hurni, Francesco La Torre, Raquel Saiz-Vivo, Sandra García-Martínez, Nuria Barbany-Freixa, Silvia Cabrera, Alicia Úbeda","doi":"10.1002/ijgo.70672","DOIUrl":"10.1002/ijgo.70672","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the incidence and characteristics of postoperative intrauterine adhesions (IUAs) and septal remnants (SRs) following hysteroscopic septum resection performed without anti-adhesion adjuvant therapies.</p><p><strong>Methods: </strong>This retrospective cohort study included patients with a septate uterus (U2a/U2b, ESHRE/ESGE classification) who underwent hysteroscopic septum resection without anti-adhesion adjuvant therapies between 2014 and 2023. Only patients with second-look hysteroscopy performed within 1-6 months postoperatively were included. Patients with pre-existing intrauterine adhesions, submucosal fibroids, prior septum resection, or adjuvant therapy use were excluded. Primary outcomes were the incidence, location, and type of postoperative IUAs and SRs.</p><p><strong>Results: </strong>A total of 285 patients were included in the analysis. Postoperative IUAs were identified in two (0.7%) cases. SRs were observed in 98 (34.4%) patients, with 21 (7.4%) cases measuring <5 mm, 76 (26.7%) cases between 5-10 mm, and one (0.4%) case exceeding 10 mm. Among the 196 patients who attempted conception postoperatively, 161 (82.1%) achieved pregnancy. A total of 39 (24.2%) patients experienced miscarriage, three (1.9%) had an ectopic pregnancy, and live birth was achieved in 114 (58.2%) cases.</p><p><strong>Conclusion: </strong>Hysteroscopic septum resection without anti-adhesion therapies resulted in a low incidence of IUA and frequent SRs. Routine second-look hysteroscopy may aid early detection and treatment. Further studies are needed to clarify its role in optimizing reproductive outcomes.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":"774-781"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145523341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}