International Journal of Molecular Sciences最新文献_第5页

Increased Plasma Levels of Thrombin-Cleaved Osteopontin in Patients with Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-03-19 DOI: 10.3390/ijms26062781

Kazuaki Aoki, Fumihiro Kawakita, Koichi Hakozaki, Hideki Kanamaru, Reona Asada, Hidenori Suzuki, pSEED Group

{"title":"Increased Plasma Levels of Thrombin-Cleaved Osteopontin in Patients with Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage.","authors":"Kazuaki Aoki, Fumihiro Kawakita, Koichi Hakozaki, Hideki Kanamaru, Reona Asada, Hidenori Suzuki, pSEED Group","doi":"10.3390/ijms26062781","DOIUrl":"10.3390/ijms26062781","url":null,"abstract":"Osteopontin (OPN), a matricellular protein, is produced as a full-length OPN (FL-OPN) and cleaved by thrombin, thus generating the N-terminal half of OPN (OPN N-half) with new functions. Although plasma FL-OPN levels have been associated with neurovascular events after aneurysmal subarachnoid hemorrhage (SAH), plasma OPN N-half levels have never been investigated. In this study, prospective clinical data and plasma samples were collected from 108 consecutive SAH patients with ruptured aneurysms undergoing acute treatment via surgery, and FL-OPN and OPN N-half levels were measured in plasma with a particular focus on delayed cerebral infarction (DCIn), which has the greatest impact on outcomes. Plasma FL-OPN and OPN N-half levels were intercorrelated and significantly higher in patients with DCIn at days 10-12 post-SAH; a greater area under the receiver-operating characteristic curve was observed for OPN N-half levels, with a cut-off value of 70.42 pmol/L. Multivariate analyses revealed that plasma OPN N-half levels of ≥70.42 pmol/L at days 10-12 were independently associated with DCIn development (adjusted odds ratio, 5.65; 95% confidence interval, 1.68-18.97; p = 0.005). Based on the findings of this study and previous reports, an increase in the OPN N-half level may be indicative of a protective mechanism against DCIn development, and, thus, it holds promise as a new therapeutic target against DCIn after aneurysmal SAH.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 6","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated Analysis of Bulk and Single-Cell RNA Sequencing Data Reveal a Novel Prognostic Signature of Combining Cuproptosis- and Ferroptosis-Related Genes in Hepatocellular Carcinoma.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-03-19 DOI: 10.3390/ijms26062779

Hua Wei, Jiaxin Peng

{"title":"Integrated Analysis of Bulk and Single-Cell RNA Sequencing Data Reveal a Novel Prognostic Signature of Combining Cuproptosis- and Ferroptosis-Related Genes in Hepatocellular Carcinoma.","authors":"Hua Wei, Jiaxin Peng","doi":"10.3390/ijms26062779","DOIUrl":"10.3390/ijms26062779","url":null,"abstract":"As a common malignancy, hepatocellular carcinoma (HCC) proliferation and metastasis could be promoted by ferroptosis and cuproptosis. In this study, we screened out the differentially expressed cuproptosis- and ferroptosis-related genes (CFRGs) and identified the 17 informative prognosis-associated genes. A CFRG scoring model was constructed based on the subtypes identified by consensus clustering analysis and principal component analysis (PCA). Furthermore, the immune profile, expression of immune checkpoint genes (ICGs) and drug susceptibility were also compared between the two CFRG score groups. The results showed that patients with a high CFRG score had higher survival probabilities. The correlation analysis suggested that CFRG scores were negatively correlated with activated CD4.T.cell. The expression patterns of thirty ICGs and the half-maximal inhibitory concentration (IC50) values of 128 drugs displayed significant differences between the two CFRG score groups. A statistically significant difference in the efficacy of sorafenib was found between the two CFRG score groups. Moreover, based on multivariate COX regression analysis and weighted gene co-expression network analysis (WGCNA), we screened DLAT and SLC2A1 as signature genes. Molecular docking analysis revealed that DLAT and SLC2A1 had a strong binding affinity toward camptothecin, rapamycin, dactolisib, and luminespib. The correlation between the CFRG score and single-cell characteristics was further explored. The study depended on our understanding of the biological function of CFRGs in HCC and provided new insights for developing treatment strategies.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 6","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Identification of Novel Therapeutic Biomarkers in Rheumatoid Arthritis: A Combined Bioinformatics and Integrated Multi-Omics Approach.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-03-19 DOI: 10.3390/ijms26062757

Muhammad Hamza Tariq, Dia Advani, Buttia Mohamed Almansoori, Maithah Ebraheim AlSamahi, Maitha Faisal Aldhaheri, Shahad Edyen Alkaabi, Mira Mousa, Nupur Kohli

{"title":"The Identification of Novel Therapeutic Biomarkers in Rheumatoid Arthritis: A Combined Bioinformatics and Integrated Multi-Omics Approach.","authors":"Muhammad Hamza Tariq, Dia Advani, Buttia Mohamed Almansoori, Maithah Ebraheim AlSamahi, Maitha Faisal Aldhaheri, Shahad Edyen Alkaabi, Mira Mousa, Nupur Kohli","doi":"10.3390/ijms26062757","DOIUrl":"10.3390/ijms26062757","url":null,"abstract":"Rheumatoid arthritis (RA) is a multifaceted autoimmune disease that is marked by a complex molecular profile influenced by an array of factors, including genetic, epigenetic, and environmental elements. Despite significant advancements in research, the precise etiology of RA remains elusive, presenting challenges in developing innovative therapeutic markers. This study takes an integrated multi-omics approach to uncover novel therapeutic markers for RA. By analyzing both transcriptomics and epigenomics datasets, we identified common gene candidates that span these two omics levels in patients diagnosed with RA. Remarkably, we discovered eighteen multi-evidence genes (MEGs) that are prevalent across transcriptomics and epigenomics, twelve of which have not been previously linked directly to RA. The bioinformatics analyses of the twelve novel MEGs revealed they are part of tightly interconnected protein-protein interaction networks directly related to RA-associated KEGG pathways and gene ontology terms. Furthermore, these novel MEGs exhibited direct interactions with miRNAs linked to RA, underscoring their critical role in the disease's pathogenicity. Overall, this comprehensive bioinformatics approach opens avenues for identifying new candidate markers for RA, empowering researchers to validate these markers efficiently through experimental studies. By advancing our understanding of RA, we can pave the way for more effective therapies and improved patient outcomes.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 6","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding Neovascularization in Glioblastoma: Insights from the Current Literature.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-03-19 DOI: 10.3390/ijms26062763

Mariagiovanna Ballato, Emanuela Germanà, Gabriele Ricciardi, Walter Giuseppe Giordano, Pietro Tralongo, Mariachiara Buccarelli, Giorgia Castellani, Lucia Ricci-Vitiani, Quintino Giorgio D'Alessandris, Giuseppe Giuffrè, Cristina Pizzimenti, Vincenzo Fiorentino, Valeria Zuccalà, Antonio Ieni, Maria Caffo, Guido Fadda, Maurizio Martini

{"title":"Understanding Neovascularization in Glioblastoma: Insights from the Current Literature.","authors":"Mariagiovanna Ballato, Emanuela Germanà, Gabriele Ricciardi, Walter Giuseppe Giordano, Pietro Tralongo, Mariachiara Buccarelli, Giorgia Castellani, Lucia Ricci-Vitiani, Quintino Giorgio D'Alessandris, Giuseppe Giuffrè, Cristina Pizzimenti, Vincenzo Fiorentino, Valeria Zuccalà, Antonio Ieni, Maria Caffo, Guido Fadda, Maurizio Martini","doi":"10.3390/ijms26062763","DOIUrl":"10.3390/ijms26062763","url":null,"abstract":"Glioblastomas (GBMs), among the most aggressive and resilient brain tumors, characteristically exhibit high angiogenic potential, leading to the formation of a dense yet aberrant vasculature, both morphologically and functionally. With these premises, numerous expectations were initially placed on anti-angiogenic therapies, soon dashed by their limited efficacy in concretely improving patient outcomes. Neovascularization in GBM soon emerged as a complex, dynamic, and heterogeneous process, hard to manage with the classical standard of care. Growing evidence has revealed the existence of numerous non-canonical strategies of angiogenesis, variously exploited by GBM to meet its ever-increasing metabolic demand and differently involved in tumor progression, recurrence, and escape from treatments. In this review, we provide an accurate description of each neovascularization mode encountered in GBM tumors to date, highlighting the molecular players and signaling cascades primarily involved. We also detail the key architectural and functional aspects characteristic of the GBM vascular compartment because of an intricate crosstalk between the different angiogenic networks. Additionally, we explore the repertoire of emerging therapies against GBM that are currently under study, concluding with a question: faced with such a challenging scenario, could combined therapies, tailored to the patient's genetic signatures, represent an effective game changer?","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 6","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Minimizes Ex Vivo Reservoirs from Patients.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-03-19 DOI: 10.3390/ijms26062772

Lin-Chun Chang, Michael T Yin, Gregory M Laird, Kristen D Ritter, Jayesh G Shah, Asim K Debnath

{"title":"A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Minimizes Ex Vivo Reservoirs from Patients.","authors":"Lin-Chun Chang, Michael T Yin, Gregory M Laird, Kristen D Ritter, Jayesh G Shah, Asim K Debnath","doi":"10.3390/ijms26062772","DOIUrl":"10.3390/ijms26062772","url":null,"abstract":"The persistence of latent HIV-1 proviruses in CD4+ T cells is a major obstacle to curing HIV. The \"shock and kill\" strategy involves reversing latency with latency-reversing agents (LRAs) and selectively inducing cell death in infected cells. However, current LRAs have shown limited efficacy in eliminating the ex vivo HIV reservoir and thus failed in clinical study. In this study, we repurposed PZ703b, a pro-apoptotic protein degrader initially developed for anti-leukemia therapy, to target HIV eradication. PZ703b induced the degradation of Bcl-2 and Bcl-xL, activating the non-canonical NF-kB pathway and caspases cascade, resulting in latency reversal and the selective apoptosis of infected cells. The treatment of ex vivo CD4+ T cells from ART-suppressed HIV-1 patients led to approximately a 50% reduction in the replication-competent reservoir. While this result does not reach the threshold required for a complete cure, it demonstrates the potential of a dual degrader of Bcl-2/Bcl-xL in reversing HIV latency and inducing selective cell death. Our study provides a proof-of-concept for using dual degraders of Bcl-2/Bcl-xL as a novel category of LRAs in therapeutic strategies aimed at reducing HIV reservoirs. This approach may pave the way for the further exploration of targeted interventions to eliminate the HIV-inducible reservoir.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 6","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Alcoholic Fatty Liver Disease (NAFLD) Management in the Community.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-03-19 DOI: 10.3390/ijms26062758

Yongsoo Park, Kyung Soo Ko, Byoung Doo Rhee

{"title":"Non-Alcoholic Fatty Liver Disease (NAFLD) Management in the Community.","authors":"Yongsoo Park, Kyung Soo Ko, Byoung Doo Rhee","doi":"10.3390/ijms26062758","DOIUrl":"10.3390/ijms26062758","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) has frequently been associated with obesity, type 2 diabetes (T2D), and dyslipidemia, all of which are shared by increased insulin resistance. It has become the most common liver disorder in Korea as well as in developed countries and is therefore associated with an increased health burden of morbidity and mortality. It has an association with T2D, and T2D increases the risk of cirrhosis and related complications. NAFLD encompasses a disease continuum from simple steatosis to non-alcoholic steatohepatitis which is characterized by faster fibrosis progression. Although its liver-related complication is estimated to be, at most, 10%, it will be a leading cause of cirrhosis and hepatocellular carcinoma soon in Korea. Although the main causes of death in people with NAFLD are cardiovascular disease and extra-hepatic malignancy, advanced liver fibrosis is a key prognostic marker for liver-related outcomes and can be assessed with combinations of non-invasive tests in the community. A number of components of metabolic syndrome involved could be another important prognostic information of NAFLD assessed easily in the routine care of the community. There is a few approved therapies for NAFLD, although several drugs, including antioxidants, attract practitioners' attention. Because of the modest effect of the present therapeutics, let alone complex pathophysiology and substantial heterogeneity of disease phenotypes, combination treatment is a viable option for many patients with NAFLD in the Korean community. Comprehensive approach taking healthy lifestyle and weight reduction into account remain a mainstay to the prevention and treatment of NAFLD.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 6","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of Gut Microbiota and Short-Chain Fatty Acid Production by Simulated Gastrointestinal Digests from Microalga Chlorella vulgaris.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-03-19 DOI: 10.3390/ijms26062754

Celia Bañares, Samuel Paterson, Dulcenombre Gómez-Garre, Adriana Ortega-Hernández, Silvia Sánchez-González, Carolina Cueva, Miguel Á de la Fuente, Blanca Hernández-Ledesma, Pilar Gómez-Cortés

{"title":"Modulation of Gut Microbiota and Short-Chain Fatty Acid Production by Simulated Gastrointestinal Digests from Microalga Chlorella vulgaris.","authors":"Celia Bañares, Samuel Paterson, Dulcenombre Gómez-Garre, Adriana Ortega-Hernández, Silvia Sánchez-González, Carolina Cueva, Miguel Á de la Fuente, Blanca Hernández-Ledesma, Pilar Gómez-Cortés","doi":"10.3390/ijms26062754","DOIUrl":"10.3390/ijms26062754","url":null,"abstract":"Chlorella vulgaris is a source of potential bioactive compounds that can reach the large intestine and interact with colonic microbiota. However, the effects of consumption of this microalga on gastrointestinal function have scarcely been studied. This paper simulates, for the first time, the passage of C. vulgaris through the gastrointestinal tract, combining the INFOGEST method and in vitro colonic fermentation to evaluate potential effects on the human colonic microbiota composition by 16S rRNA gene sequencing and its metabolic functionality. The results show that the presence of this microalga increased the release of short-chain fatty acids (SCFAs), such as acetic, propionic, butyric, and isobutyric fatty acids, after 48 h colonic fermentation, being indicators of gut health. In correlation with the release of SCFAs, a significant reduction in bacterial groups causing intestinal imbalance, such as Enterobacteriaceae, Enterococcus spp., and Staphylococcus spp., was observed. In addition, digests from C. vulgaris favored intestinal health-related taxa, such as Akkermansia and Lactobacillus. C. vulgaris is, therefore, a promising food ingredient for good intestinal health and the maintenance of a balanced colonic microbiota.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 6","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A New Perspective on the Role of Alterations in Mitochondrial Proteins Involved in ATP Synthesis and Mobilization in Cardiomyopathies.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-03-19 DOI: 10.3390/ijms26062768

Melissa Vázquez-Carrada, María Magdalena Vilchis-Landeros, Héctor Vázquez-Meza, Daniel Uribe-Ramírez, Deyamira Matuz-Mares

{"title":"A New Perspective on the Role of Alterations in Mitochondrial Proteins Involved in ATP Synthesis and Mobilization in Cardiomyopathies.","authors":"Melissa Vázquez-Carrada, María Magdalena Vilchis-Landeros, Héctor Vázquez-Meza, Daniel Uribe-Ramírez, Deyamira Matuz-Mares","doi":"10.3390/ijms26062768","DOIUrl":"10.3390/ijms26062768","url":null,"abstract":"The heart requires a continuous energy supply to sustain its unceasing contraction-relaxation cycle. Mitochondria, a double-membrane organelle, generate approximately 90% of cellular energy as adenosine triphosphate (ATP) through oxidative phosphorylation, utilizing the electrochemical gradient established by the respiratory chain. Mitochondrial function is compromised by damage to mitochondrial DNA, including point mutations, deletions, duplications, or inversions. Additionally, disruptions to proteins associated with mitochondrial membranes regulating metabolic homeostasis can impair the respiratory chain's efficiency. This results in diminished ATP production and increased generation of reactive oxygen species. This review provides an overview of mutations affecting mitochondrial transporters and proteins involved in mitochondrial energy synthesis, particularly those involved in ATP synthesis and mobilization, and it examines their role in the pathogenesis of specific cardiomyopathies.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 6","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Alveolar Echinococcosis-A Neglected Zoonotic Disease Requiring Urgent Attention.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-03-19 DOI: 10.3390/ijms26062784

Ali Rostami, Britta Lundström-Stadelmann, Caroline F Frey, Guido Beldi, Anja Lachenmayer, Bill C H Chang, Mohammad Mobin Norouzian, Andrew Hemphill, Robin B Gasser

{"title":"Human Alveolar Echinococcosis-A Neglected Zoonotic Disease Requiring Urgent Attention.","authors":"Ali Rostami, Britta Lundström-Stadelmann, Caroline F Frey, Guido Beldi, Anja Lachenmayer, Bill C H Chang, Mohammad Mobin Norouzian, Andrew Hemphill, Robin B Gasser","doi":"10.3390/ijms26062784","DOIUrl":"10.3390/ijms26062784","url":null,"abstract":"Alveolar echinococcosis (AE) in humans is caused by the larval (metacestode) stage of Echinococcus multilocularis, commonly known as the 'fox tapeworm'. This disease predominantly targets the liver and has an invasive growth pattern, allowing it to spread to adjacent and distant tissues. Due to its gradual progression and tumour-like characteristics, early diagnosis and prompt intervention are crucial, particularly as there are currently no highly effective vaccines or chemotherapeutics against AE. Current estimates suggest that ~10,500 new infections occur annually worldwide; however, more research is required to refine the prevalence and incidence data for both human and animal hosts in endemic areas of the world. This article discusses the biology of E. multilocularis, outlines aspects of the pathogenesis, diagnosis, treatment, and management of AE, reviews its global distribution, annual incidence, and prevalence, highlights the role of molecular parasitology in advancing therapeutic strategies, and presents recommendations for improving the prevention and control of AE in human populations.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 6","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Platelet Dysfunctions in the Pathogenesis of the Hemostatic-Coagulant System Imbalances.

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-03-19 DOI: 10.3390/ijms26062756

Oana-Viola Badulescu, Manuela Ciocoiu, Maria Cristina Vladeanu, Bogdan Huzum, Carmen Elena Plesoianu, Dan Iliescu-Halitchi, Andrei Bojan, Codruta Iliescu-Halitchi, Iris Bararu Bojan

{"title":"The Role of Platelet Dysfunctions in the Pathogenesis of the Hemostatic-Coagulant System Imbalances.","authors":"Oana-Viola Badulescu, Manuela Ciocoiu, Maria Cristina Vladeanu, Bogdan Huzum, Carmen Elena Plesoianu, Dan Iliescu-Halitchi, Andrei Bojan, Codruta Iliescu-Halitchi, Iris Bararu Bojan","doi":"10.3390/ijms26062756","DOIUrl":"10.3390/ijms26062756","url":null,"abstract":"Platelet dysfunction plays a critical role in the pathogenesis of various disorders affecting the hemostatic-coagulant system. This review aims to explore the mechanisms by which platelet dysfunctions contribute to the disruption of hemostasis, leading to an increased risk of both thrombosis and bleeding. Platelets, traditionally known for their role in clot formation, can exhibit altered functionality under pathological conditions such as cardiovascular diseases, metabolic disorders, and autoimmune diseases, impacting their interaction with coagulation factors and vascular endothelium. The review discusses the molecular and cellular mechanisms underlying platelet dysfunction, including aberrations in platelet activation, aggregation, and secretion. It also highlights the interplay between platelets and other components of the coagulation cascade, such as fibrinogen and clotting factors, in maintaining vascular integrity. Moreover, the review examines clinical implications, including how platelet dysfunction can be a contributing factor in conditions like deep vein thrombosis, stroke, and disseminated intravascular coagulation (DIC). Finally, current therapeutic approaches targeting platelet dysfunctions, including antiplatelet agents and emerging therapies, are reviewed to provide insights into potential strategies for managing fluid-coagulation system imbalances. This review underscores the importance of a comprehensive understanding of platelet dysfunction to improve diagnosis and treatment of hemostatic disorders.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 6","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0