Combined Treatment of Sodium Butyrate and Bromelain Enhanced Anticancer Effects in Colorectal Cancer Cell Lines: A Promising Therapeutic Approach.

IF 4.9 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-10-08 DOI:10.3390/ijms26199803

Rocío Olivera-Salazar, Pedro Villarejo Campos, Rocío Barrueco Gutiérrez, Luz Vega-Clemente, Luis Javier Serrano, Soledad García Gómez-Heras, Damián García-Olmo, Mariano García-Arranz

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Abstract

Colorectal cancer (CRC) is one of the most prevalent and lethal cancers worldwide, with few effective treatment options and substantial associated side effects. As a result, there is growing interest in therapeutic alternatives that reduce toxicity. Natural compounds such as sodium butyrate (NaB), a microbial metabolite of dietary fiber, and bromelain, a proteolytic enzyme from pineapple, have shown individual anticancer properties. However, their combined effect in CRC remains underexplored. This study investigates the synergistic potential of NaB and bromelain in colorectal cancer cell lines, focusing on their ability to inhibit proliferation, induce apoptosis, and modulate key molecular pathways. Findings reveal that co-treatment enhances antitumor activity in vitro, suggesting a promising and safer therapeutic strategy for CRC.

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丁酸钠和菠萝蛋白酶联合治疗可增强结直肠癌细胞系的抗癌作用：一种有前景的治疗方法。

结直肠癌（CRC）是世界上最普遍和最致命的癌症之一，几乎没有有效的治疗选择和大量的相关副作用。因此，人们对降低毒性的替代疗法越来越感兴趣。天然化合物，如丁酸钠（NaB），一种膳食纤维的微生物代谢物，菠萝蛋白酶，一种来自菠萝的蛋白水解酶，已经显示出单独的抗癌特性。然而，它们在结直肠癌中的联合作用仍未得到充分探讨。本研究探讨了NaB和菠萝蛋白酶在结直肠癌细胞系中的协同作用潜力，重点研究了它们抑制增殖、诱导凋亡和调节关键分子通路的能力。研究结果表明，联合治疗增强了体外抗肿瘤活性，为CRC提供了一种更有前景和更安全的治疗策略。

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来源期刊

International Journal of Molecular Sciences 化学-化学综合

自引率

10.70%

发文量

13472

审稿时长

1.7 months

期刊介绍： The International Journal of Molecular Sciences (ISSN 1422-0067) provides an advanced forum for chemistry, molecular physics (chemical physics and physical chemistry) and molecular biology. It publishes research articles, reviews, communications and short notes. Our aim is to encourage scientists to publish their theoretical and experimental results in as much detail as possible. Therefore, there is no restriction on the length of the papers or the number of electronics supplementary files. For articles with computational results, the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material (including animated pictures, videos, interactive Excel sheets, software executables and others).