International journal of epidemiology最新文献

{"title":"Software Application Profile: TIDAL-Tool to Implement Developmental Analysis of Longitudinal data.","authors":"Alex S F Kwong, Amelia Edmondson-Stait, Eileen Xu, Ellen J Thompson, Richard M A Parker, Ahmed Elhakeem, Liana Romaniuk, Rebecca M Pearson, Kate Tilling, Thalia C Eley, Andrew M McIntosh, Heather C Whalley","doi":"10.1093/ije/dyaf095","DOIUrl":"10.1093/ije/dyaf095","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 4","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ensuring target trials and target estimands are on target for intended use populations.","authors":"Katy J L Bell, Ellie Medcalf, Fiona F Stanaway","doi":"10.1093/ije/dyaf138","DOIUrl":"https://doi.org/10.1093/ije/dyaf138","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 4","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal clarity in statistical software.","authors":"Maurice N Korf, Nan Van Geloven, Jesse H Krijthe, Jeremy A Labrecque","doi":"10.1093/ije/dyaf136","DOIUrl":"10.1093/ije/dyaf136","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 4","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile: The Nijmegen Exercise Study (NES).","authors":"Koen M van der Sluijs, Esmée A Bakker, Merle C A Schoofs, Janneke I A Vloet, André L M Verbeek, Maria T E Hopman, Dick H J Thijssen, Thijs M H Eijsvogels","doi":"10.1093/ije/dyaf092","DOIUrl":"10.1093/ije/dyaf092","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 4","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiplicity corrections in life sciences: challenges and consequences.","authors":"Otília Menyhárt, Balázs Győrffy","doi":"10.1093/ije/dyaf098","DOIUrl":"10.1093/ije/dyaf098","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 4","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term exposure to ambient air pollution and the incidence of nonalcoholic fatty liver disease: a cohort study.","authors":"Yi-Chuan Chen, Shih-Chun Pan, Wei-Shan Chin, Chih-Da Wu, Yue Leon Guo","doi":"10.1093/ije/dyaf101","DOIUrl":"10.1093/ije/dyaf101","url":null,"abstract":"<p><strong>Background: </strong>Nonalcoholic fatty liver disease (NAFLD) affects approximately one-third of adults and may progress to advanced fibrosis and hepatocellular carcinoma. Epidemiologic studies linking air pollution to NAFLD incidence remain limited. This study examined associations between long-term exposure to ambient air pollution and NAFLD incidence.</p><p><strong>Methods: </strong>The study included 62 660 adults in Taiwan undergoing health examinations from 1996 to 2016. NAFLD was diagnosed through liver ultrasonography; individual characteristics and medical history were obtained from questionnaires. Residential township data estimated exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2), and carbon monoxide (CO). Time-dependent Cox regression was conducted to assess associations between air pollution and NAFLD incidence.</p><p><strong>Results: </strong>The overall NAFLD incidence was 53.0 cases per 1000 person-years. Adjusted models showed positive associations between air pollutants and NAFLD. Compared with low exposure to both PM2.5 and NO2, the adjusted hazard ratio (HR) [95% confidence interval (CI)] for high exposure to both was 1.25 (1.19-1.31). Similarly, compared with low exposure to both PM2.5 and CO, the adjusted HR (95% CI) was 1.12 (1.07-1.17) for low PM2.5 and high CO, and 1.28 (1.22-1.33) for high exposure to both.</p><p><strong>Conclusion: </strong>Long-term exposure to PM2.5 and traffic-related air pollutants, including NO2 and CO, may increase the risk of developing NAFLD.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 4","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood cancer incidence around nuclear installations in Great Britain, 1995-2016.","authors":"Bethan Davies, Frédéric B Piel, Aina Roca-Barceló, Anna Freni Sterrantino, Hima Iyathooray Daby, Marta Blangiardo, Daniela Fecht, Frank de Vocht, Paul Elliott, Mireille B Toledano","doi":"10.1093/ije/dyaf107","DOIUrl":"10.1093/ije/dyaf107","url":null,"abstract":"<p><strong>Background: </strong>Concerns remain about the potential harmful health impact of nuclear installations. Historical clusters of leukaemia and non-Hodgkin's lymphoma (LNHL) in children living near Sellafield and Dounreay installations in Great Britain remain aetiologically unexplained, and the sites remain under surveillance. We assess the risk of LNHL, central nervous system (CNS) and all solid tumours in children aged 0-14 years living within 25 km of nuclear installations in Great Britain, between 1995 and 2016.</p><p><strong>Methods: </strong>We used a Poisson regression model to estimate the expected number of cases of each cancer type at the community-level in the study population, we present standardized incidence ratios compared to the national population. We used a hierarchical Poisson regression model to estimate the adjusted incidence rate ratios for each cancer type by distance between the community of residence and nearest nuclear installation.</p><p><strong>Results: </strong>We found no evidence of elevated incidence of LNHL, CNS, or all solid tumours in children resident in communities in proximity to nuclear sites. Within the 25-km zone, there was no evidence of an increased risk of childhood cancer in communities closer to installations.</p><p><strong>Conclusion: </strong>In post-1994 data, there was no evidence of an increased risk of childhood cancers in communities within 25 km of nuclear installations in Great Britain. Previously raised risks are no longer evident.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 4","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile: The Girona Heart Registry.","authors":"Irene R Dégano, Nuria Herrera-Marín, Isaac Subirana, Anna Camps-Vilaró, Álvaro Hernáez, Joan Sala, Rafael Masià, Rafel Ramos, Roberto Elosua, Jaume Marrugat","doi":"10.1093/ije/dyaf116","DOIUrl":"10.1093/ije/dyaf116","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 4","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic opioids in pregnancy and placental malperfusion-related disorders: a population-based cohort study.","authors":"Jonathan Brett, Claudia Bruno, Bianca Varney, Alys Havard, Antonia Shand, Krista F Huybrechts, Helga Zoega","doi":"10.1093/ije/dyaf137","DOIUrl":"10.1093/ije/dyaf137","url":null,"abstract":"<p><strong>Background: </strong>Analgesic opioid use in pregnancy could increase the risk of disorders related to placental malperfusion, but this relationship is incompletely characterized. We aimed to study the causal association between analgesic opioids in pregnancy and placental abruption, pre-eclampsia, preterm birth, and fetal growth restriction (FGR).</p><p><strong>Methods: </strong>We conducted a population-based cohort study of pregnancies resulting in birth at ≥20 weeks of gestation between July 2013 and December 2019 in New South Wales, Australia. Linked data on pregnancy, births, medication dispensation, and health services were used. Opioid exposure was defined as at least one opioid dispensation from the last menstrual period to birth. We stratified analyses by exposure in early (≤20 weeks) and/or late (>20 weeks) pregnancy and opioid type by using non-exposed pregnancies as a comparator. We estimated risks by using Cox proportional-hazards models and time-varying exposure, adjusting for demographics, comorbidities, and other medications.</p><p><strong>Results: </strong>Among 509 971 births, 32 266 (6.3%) had an opioid dispensation. We observed modestly increased risks with any opioid exposure for placental abruption [adjusted hazard ratio (HR) 1.22, 95% confidence interval (CI) 1.06-1.41] and preterm birth (adjusted HR 1.23, 95% CI 1.18-1.28), but not for pre-eclampsia (adjusted HR 1.06, 95% CI 0.99-1.13) or FGR (adjusted HR 0.95, 95% CI 0.88-1.02). Risks of abruption were the most elevated when exposure occurred in both early and late pregnancy (adjusted HR 1.76, 95% CI 1.30-2.40) and for preterm birth when exposure occurred in late-only pregnancy (adjusted HR 1.36, 95% CI 1.27-1.45). Monotherapy with both codeine and oxycodone was associated with elevated risks of abruption and preterm birth.</p><p><strong>Conclusion: </strong>In this population-based cohort study, we observed modestly increased risks of preterm birth and placental abruption after analgesic opioid use in pregnancy, driven by codeine and oxycodone-the two most frequently used opioids.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12342150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile: the Danish National Birth Cohort from foetal life to young adulthood.","authors":"Katrine Strandberg-Larsen,Luise Cederkvist,Anne Aakjær,Anne Ahrendt Bjerregaard,Nis Brix,Bjarke Feenstra,Inger Kristine Meder,Ellen A Nohr,Sjurdur F Olsen,Sandra Søgaard Tøttenborg,Cecilia Høst Ramlau-Hansen,Anne-Marie Vangsted,Anne-Marie Nybo Andersen","doi":"10.1093/ije/dyaf083","DOIUrl":"https://doi.org/10.1093/ije/dyaf083","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"25 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}