Natalie V Scime, Sonia M Grandi, Joel G Ray, Cindy-Lee Dennis, Mary A De Vera, Hailey R Banack, Simone N Vigod, Alexa Boblitz, Hilary K Brown
{"title":"Pregnancy complications and new-onset maternal autoimmune disease.","authors":"Natalie V Scime, Sonia M Grandi, Joel G Ray, Cindy-Lee Dennis, Mary A De Vera, Hailey R Banack, Simone N Vigod, Alexa Boblitz, Hilary K Brown","doi":"10.1093/ije/dyae115","DOIUrl":"10.1093/ije/dyae115","url":null,"abstract":"<p><strong>Background: </strong>Autoimmune diseases disproportionately impact women and female-specific aspects of reproduction are thought to play a role. We investigated the time-varying association between pregnancy complications and new-onset autoimmune disease in females during the reproductive and midlife years.</p><p><strong>Methods: </strong>We conducted a population-based cohort study of 1 704 553 singleton births to 1 072 445 females in Ontario, Canada (2002-17) with no pre-existing autoimmune disease. Pregnancy complications were preeclampsia, stillbirth, spontaneous preterm birth and severe small for gestational age (SGA). Royston-Parmar models were used to estimate the time-varying association between pregnancy complications and a composite of 25 autoimmune diseases from date of delivery to date of autoimmune disease diagnosis or censoring at death, loss of health insurance, or 31 March 2021. Models were adjusted for baseline socio-demographics, parity and comorbidities.</p><p><strong>Results: </strong>At 19 years (median = 10.9 years of follow-up), cumulative incidence of autoimmune disease was 3.1% in those with a pregnancy complication and 2.6% in those without complications. Adjusted hazard ratio (AHR) curves as a function of time since birth were generally L-shaped. Universally, risks were most elevated within the first 3 years after birth [at 1 year: preeclampsia AHR 1.22, 95% confidence interval (CI) 1.09-1.36; stillbirth AHR 1.36, 95% CI 0.99-1.85; spontaneous preterm birth AHR 1.30, 95% CI 1.18-1.44; severe SGA AHR 1.14, 95% CI 0.99-1.31] and plateaued but remained elevated thereafter.</p><p><strong>Conclusions: </strong>Prior history of pregnancy complications may be an important female-specific risk factor to consider during clinical assessment of females for possible autoimmune disease to facilitate timely detection and treatment.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"53 5","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A cautionary note on the recently proposed ICE Falcon method.","authors":"Arvid Sjölander, Thomas Frisell","doi":"10.1093/ije/dyae131","DOIUrl":"10.1093/ije/dyae131","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"53 5","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charis Bridger Staatz, Iliya Gutin, Andrea Tilstra, Laura Gimeno, Bettina Moltrecht, Dario Moreno-Agostino, Vanessa Moulton, Martina K Narayanan, Jennifer B Dowd, Lauren Gaydosh, George B Ploubidis
{"title":"Midlife health in Britain and the United States: a comparison of two nationally representative cohorts.","authors":"Charis Bridger Staatz, Iliya Gutin, Andrea Tilstra, Laura Gimeno, Bettina Moltrecht, Dario Moreno-Agostino, Vanessa Moulton, Martina K Narayanan, Jennifer B Dowd, Lauren Gaydosh, George B Ploubidis","doi":"10.1093/ije/dyae127","DOIUrl":"10.1093/ije/dyae127","url":null,"abstract":"<p><strong>Background: </strong>Older adults in the USA have worse health and wider socioeconomic inequalities in health compared with those in Britain. Less is known about how health in the two countries compares in mid-life, a time of emerging health decline, including inequalities in health.</p><p><strong>Methods: </strong>We compare measures of current regular smoking status, obesity, self-rated health, cholesterol, blood pressure and glycated haemoglobin using population-weighted modified Poisson regression in the 1970 British Cohort Study (BCS70) in Britain (N = 9665) and the National Longitudinal Study of Adolescent to Adult Health (Add Health) in the USA (N = 12 300), when cohort members were aged 34-46 and 33-43, respectively. We test whether associations vary by early- and mid-life socioeconomic position.</p><p><strong>Results: </strong>US adults had higher levels of obesity, high blood pressure and high cholesterol. Prevalence of poor self-rated health and current regular smoking was worse in Britain. We found smaller socioeconomic inequalities in mid-life health in Britain compared with the USA. For some outcomes (e.g. smoking), the most socioeconomically advantaged group in the USA was healthier than the equivalent group in Britain. For other outcomes (hypertension and cholesterol), the most advantaged US group fared equal to or worse than the most disadvantaged groups in Britain.</p><p><strong>Conclusions: </strong>US adults have worse cardiometabolic health than British counterparts, even in early mid-life. The smaller socioeconomic inequalities and better overall health in Britain may reflect differences in access to health care, welfare systems or other environmental risk factors.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"53 5","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elizabeth M Lawrence,Elyssa A Trani,Kurtis M Anthony,Robert A Hummer,Tiffany Jensen,Sylvie Tuder,Laura R Loehr,Kathleen Mullan Harris,Eric A Whitsel
{"title":"Data Resource Profile: Add Health Mortality Outcomes Surveillance.","authors":"Elizabeth M Lawrence,Elyssa A Trani,Kurtis M Anthony,Robert A Hummer,Tiffany Jensen,Sylvie Tuder,Laura R Loehr,Kathleen Mullan Harris,Eric A Whitsel","doi":"10.1093/ije/dyae121","DOIUrl":"https://doi.org/10.1093/ije/dyae121","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"1 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Food, health, and climate change: can epidemiologists contribute further?","authors":"Walter Willett, Marco Springmann","doi":"10.1093/ije/dyae109","DOIUrl":"https://doi.org/10.1093/ije/dyae109","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"53 5","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan M Andrews, Christine W Bang, Vanessa Didelez, Janine Witte, Ronja Foraita
{"title":"Software application profile: tpc and micd-R packages for causal discovery with incomplete cohort data.","authors":"Ryan M Andrews, Christine W Bang, Vanessa Didelez, Janine Witte, Ronja Foraita","doi":"10.1093/ije/dyae113","DOIUrl":"10.1093/ije/dyae113","url":null,"abstract":"<p><strong>Motivation: </strong>The Peter Clark (PC) algorithm is a popular causal discovery method to learn causal graphs in a data-driven way. Until recently, existing PC algorithm implementations in R had important limitations regarding missing values, temporal structure or mixed measurement scales (categorical/continuous), which are all common features of cohort data. The new R packages presented here, micd and tpc, fill these gaps.</p><p><strong>Implementation: </strong>micd and tpc packages are R packages.</p><p><strong>General features: </strong>The micd package provides add-on functionality for dealing with missing values to the existing pcalg R package, including methods for multiple imputations relying on the Missing At Random assumption. Also, micd allows for mixed measurement scales assuming conditional Gaussianity. The tpc package efficiently exploits temporal information in a way that results in a more informative output that is less prone to statistical errors.</p><p><strong>Availability: </strong>The tpc and micd packages are freely available on the Comprehensive R Archive Network (CRAN). Their source code is also available on GitHub (https://github.com/bips-hb/micd; https://github.com/bips-hb/tpc).</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"53 5","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sirwan K L Darweesh, Roel C H Vermeulen, Bastiaan R Bloem
{"title":"Paraquat and Parkinson's disease: has the burden of proof shifted?","authors":"Sirwan K L Darweesh, Roel C H Vermeulen, Bastiaan R Bloem","doi":"10.1093/ije/dyae126","DOIUrl":"https://doi.org/10.1093/ije/dyae126","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"53 5","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hmwe H Kyu, Jorge R Ledesma, Christopher J L Murray
{"title":"The Global Burden of Disease Study tuberculosis estimates from the Institute for Health Metrics and Evaluation.","authors":"Hmwe H Kyu, Jorge R Ledesma, Christopher J L Murray","doi":"10.1093/ije/dyae122","DOIUrl":"https://doi.org/10.1093/ije/dyae122","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"53 5","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}