International journal of epidemiology最新文献

Current trends in stroke events, mortality, and case fatality in Switzerland: an epidemiologic update 瑞士卒中事件、死亡率和病死率的当前趋势：流行病学更新

IF 7.7 2区医学

International journal of epidemiology Pub Date : 2025-06-12 DOI: 10.1093/ije/dyaf087

Martin Hänsel, Emanuel Mauch, Charlotte Micheloud, Andreas R Luft, Krassen Nedeltchev, Marcel Arnold, Susanne Wegener

{"title":"Current trends in stroke events, mortality, and case fatality in Switzerland: an epidemiologic update","authors":"Martin Hänsel, Emanuel Mauch, Charlotte Micheloud, Andreas R Luft, Krassen Nedeltchev, Marcel Arnold, Susanne Wegener","doi":"10.1093/ije/dyaf087","DOIUrl":"https://doi.org/10.1093/ije/dyaf087","url":null,"abstract":"Background Stroke is a major cardiovascular disease. The last epidemiologic update of stroke events, mortality, and case fatalities (CF) in Switzerland was performed in 2004. Between 2004 and 2017, traditional- and non-traditional cardiovascular risk factors changed, life expectancy increased, stroke units were implemented, and stroke treatment standardized. Therefore, we present an update of Swiss stroke epidemiology. Methods Data were obtained from two databases, the Federal Hospital Discharge Statistics (HOST, n = 1 470 259) and the Cause of Death (CoD) database (n = 66 971), to analyze stroke diagnoses coded according to I60-I64 (ICD 10) in 2017 in Switzerland. Discharge- and event rates for stroke, in- and out-of-hospital CF, and mortality were calculated. Results In 2017, there were 26 032 stroke discharges in Switzerland (45% women) compared to 13 996 discharges in 2004. The age-standardized event rate per 100 000 increased in women/men from 119.7/178.7 in 2004 to 265.1/396.7 in 2017. However, the absolute number of stroke deaths decreased between 2004 and 2017 from 3569 (60% women) to 2816 (59% women). The overall sex-stratified mortality rate approximately halved between 2004 and 2017 in women (from 77.5 to 38.5/100 000) and men (from 56.1 to 27.2/100 000). The overall CF halved between 2004 and 2017 from 22.7% to 10.5% and was higher in women (13.4%) compared to men (8.0%). Conclusions Compared to 2004, the rates of stroke events and discharges have increased in Switzerland. However, the overall CF rate and overall sex-stratified mortality rate has approximately halved. This suggests, among other factors, increased recognition and better treatments for stroke.","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"12 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stage-standardized and stage-specific survival among men with prostate cancer in the Nordic countries 2004-16: the NORDCAN survival studies. 2004- 2016年北欧国家前列腺癌患者分期标准化和分期特异性生存率：NORDCAN生存研究

IF 7.7 2区医学

International journal of epidemiology Pub Date : 2025-06-11 DOI: 10.1093/ije/dyaf082

Signe Benzon Larsen,Frida E Lundberg,Søren Friis,Helgi Birgisson,Therese M-L Andersson,Gerda Engholm,Paul C Lambert,Klaus Brasso,David Pettersson,Elínborg Ólafsdóttir,Tom Børge Johannesen,Simon M Kønig,Anna L V Johansson,Lina Steinrud Mørch

{"title":"Stage-standardized and stage-specific survival among men with prostate cancer in the Nordic countries 2004-16: the NORDCAN survival studies.","authors":"Signe Benzon Larsen,Frida E Lundberg,Søren Friis,Helgi Birgisson,Therese M-L Andersson,Gerda Engholm,Paul C Lambert,Klaus Brasso,David Pettersson,Elínborg Ólafsdóttir,Tom Børge Johannesen,Simon M Kønig,Anna L V Johansson,Lina Steinrud Mørch","doi":"10.1093/ije/dyaf082","DOIUrl":"https://doi.org/10.1093/ije/dyaf082","url":null,"abstract":"BACKGROUNDProstate cancer survival varies across Nordic countries, potentially reflecting variation in stage distribution at diagnosis. To highlight the variation in the diagnostic intensity of prostate cancer, we outlined the differences in stage distributions at diagnosis across these countries. Specifically, we evaluated whether the variation in cancer survival could be attributed to differences in stage at diagnosis.METHODSIn this population-based cohort study, we identified 243 893 men diagnosed with prostate cancer from 2004 to 2016 in Denmark, Iceland, Norway, and Sweden. Country-specific stage distributions at diagnosis were obtained from individual cancer registry records provided by the NORDCAN collaboration. Relative survival and 95% confidence intervals (CIs) were estimated by using the Pohar Perme estimator. Stage-standardized relative survival was estimated by applying pre-weighting based on the stage distribution of the entire Nordic cohort.RESULTSThe stage distribution of prostate cancer varied between the Nordic countries, with the highest proportion of early-stage (0-I) cases in Sweden and the highest proportion of advanced-stage (IV) cases in Denmark. When adjusting for differences in stage distribution (i.e. stage standardization), the 5-year relative survival improved in Denmark and Norway within the study period (2004-17), increasing from 83.9% (95% CI, 83.2-84.6) and 91.4% (95% CI, 90.8-92.0) to 87.3 (95% CI, 86.5-88.2) and 93.4% (95% CI, 92.8-94.1). Conversely, the 5-year relative survival declined in Sweden from 90.6% (95% CI, 90.3-91.0) to 88.5% (95% CI, 88.0-89.1).CONCLUSIONThe distinct differences in stage distributions between the Nordic countries substantially contributed to the variation in prostate cancer survival.","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"178 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Increased risk of subsequent antiphospholipid syndrome in patients with endometriosis. 更正：子宫内膜异位症患者随后出现抗磷脂综合征的风险增加。

IF 6.4 2区医学

International journal of epidemiology Pub Date : 2025-06-11 DOI: 10.1093/ije/dyaf134

引用次数: 0

Cohort Profile: The Mecha Health and Demographic Surveillance System (Mecha HDSS), Northwest Ethiopia. 队列简介：机甲健康和人口监测系统（机甲HDSS），埃塞俄比亚西北部。

IF 6.4 2区医学

International journal of epidemiology Pub Date : 2025-06-11 DOI: 10.1093/ije/dyaf122

Mesafint Molla Adane, Mulusew Andualem Asemahagn, Higemengist Astatkie Gebrie, Daniel Mekonnen, Tilahun Belete Mossie, Yeshalem Mulugeta, Animut Taddele Dagnaw, Yosef Wasihun, Netsanet Fentahun, Yeshigeta Gelaw Birhanu

引用次数: 0

Isolated clubfoot in the Northern Territory of Australia: birth prevalence and population description. 澳大利亚北部地区孤立的内翻足：出生患病率和人口描述。

IF 5.9 2区医学

International journal of epidemiology Pub Date : 2025-06-11 DOI: 10.1093/ije/dyaf121

Kelly Paterson, Ruth Barker, Sean Taylor, Alan Clough

{"title":"Isolated clubfoot in the Northern Territory of Australia: birth prevalence and population description.","authors":"Kelly Paterson, Ruth Barker, Sean Taylor, Alan Clough","doi":"10.1093/ije/dyaf121","DOIUrl":"10.1093/ije/dyaf121","url":null,"abstract":"Background: Clubfoot prevalence in the Aboriginal and Torres Strait Islander population (hereafter Indigenous population) is reportedly higher than globally. This study enumerates and describes the isolated (also 'idiopathic') clubfoot population in Australia's Northern Territory (NT), where 30% of the population is Indigenous.Methods: In this retrospective study, medical records were searched to identify all cases in the NT born in 2009-22 inclusive. Birth prevalence was calculated by using established methods. Logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs) comparing characteristics of Indigenous with non-Indigenous babies with clubfoot.Results: The birth prevalence of isolated clubfoot (150 cases/53 591 births) was 2.80/1000 (95% CI: 2.35-3.25). For 109 Indigenous babies, the prevalence was five times higher (5.99, 95% CI: 4.87-7.12) than for non-Indigenous babies (1.16, 95% CI: 0.84-1.56) and three times higher in Indigenous males (4.11, 95% CI: 3.35-4.86) than females (1.42, 95% CI: 0.96-1.88). Among babies with clubfoot, Indigenous babies with clubfoot were more likely to be male (OR = 2.68; 95% CI: 1.22-5.90; P = 0.014), from remote or very remote localities (OR = 14.24; CI: 5.98-33.90; P < 0.001), and have younger mothers (OR = 13.88; 95% CI: 3.90-49.39; P < 0.001).Conclusion: The prevalence of isolated clubfoot in Australia's NT is higher than global estimates and other Australian reports, and disproportionately affects Indigenous babies. An Australian clubfoot register would be invaluable to improve the national understanding of prevalence patterns. Given the disproportionate prevalence in Indigenous babies, culturally responsive service provision, clinical outcomes, and experiences of their families warrant investigation.","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 4","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water fluoridation as a population strategy for reducing oral health inequalities: high-dimensional effect heterogeneity analysis using machine learning. 水氟化作为减少口腔健康不平等的人口策略：使用机器学习的高维效应异质性分析。

IF 6.4 2区医学

International journal of epidemiology Pub Date : 2025-06-11 DOI: 10.1093/ije/dyaf080

Yusuke Matsuyama, Diep H Ha, Sakura Kiuchi, Andrew J Spencer, Jun Aida, Loc G Do

{"title":"Water fluoridation as a population strategy for reducing oral health inequalities: high-dimensional effect heterogeneity analysis using machine learning.","authors":"Yusuke Matsuyama, Diep H Ha, Sakura Kiuchi, Andrew J Spencer, Jun Aida, Loc G Do","doi":"10.1093/ije/dyaf080","DOIUrl":"https://doi.org/10.1093/ije/dyaf080","url":null,"abstract":"Background: Dental caries is the most prevalent disease worldwide, associated with substantial health inequalities. Water fluoridation is a population strategy shown to effectively prevent dental caries; however, its impact on health inequalities remains inconclusive. We investigated the high-dimensional effect heterogeneity of water fluoridation in preventing dental caries among children in Australia.Methods: Data from the National Child Oral Health Study-a national representative study conducted in 2012-14, linked to the information on lifetime exposure to fluoridated water-were analysed (n = 17 517 children aged 5-14 years). A doubly robust target minimum loss-based estimation was used to estimate the average treatment effect of lifetime exposure to fluoridated water (never exposed versus fully exposed) on the number of tooth surfaces with dental caries. The effect heterogeneity was evaluated by estimating the conditional average treatment effects (CATEs) using the causal forest algorithm, which integrated 47 child demographic, socioeconomic, and parental factors.Results: In total, 58.1% were fully exposed to water fluoridation throughout their lifetime. Water fluoridation was associated with having -0.9 (95% confidence interval: -1.1, -0.8) fewer dental caries incidents. The estimated CATEs were mostly negative and the magnitude substantially varied (median CATE, -0.9; interquartile range, 0.7). Children from lower socioeconomic backgrounds exhibited greater benefits: i.e. the average CATEs ranged from -1.4 for children from a single parent with school-level education and low-income families to -0.8 for children from two parents with tertiary-level education and high-income families.Conclusion: Water fluoridation was associated with lower dental caries and exhibited greater benefits for vulnerable subpopulations.","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 4","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal exposure to ambient temperature and preterm birth: a historical cohort. 产前暴露于环境温度和早产：一个历史队列。

IF 6.4 2区医学

International journal of epidemiology Pub Date : 2025-06-11 DOI: 10.1093/ije/dyaf106

Selin Girgin, Offer Erez, Daniel Nevo, Iaroslav Youssim, Itai Kloog, Raanan Raz

{"title":"Prenatal exposure to ambient temperature and preterm birth: a historical cohort.","authors":"Selin Girgin, Offer Erez, Daniel Nevo, Iaroslav Youssim, Itai Kloog, Raanan Raz","doi":"10.1093/ije/dyaf106","DOIUrl":"10.1093/ije/dyaf106","url":null,"abstract":"Background: Accumulating evidence suggests links between ambient temperature and preterm birth. We aimed to explore susceptible exposure weeks and groups concerning temperature and preterm birth in an innovative methodological approach.Methods: We conducted a historical cohort study of 131 599 singleton live births in Southern Israel in 2005-19. Weekly mean temperatures were assessed based on residential address and a spatiotemporal model. We fitted Cox models with time-dependent covariates and distributed lag non-linear models, adapting them for the challenges of examining prenatal exposures. We further extended the models with time-dependent coefficients to assess variations by preterm birth categories. Finally, we estimated associations of cumulative exposures by using predicted survival curves contrasting realistic exposure trajectories by month of the last menstrual period (LMP).Results: Exposures to high temperatures in gestation Weeks 29-37 were associated with increased preterm birth risk. The highest hazard ratio was 1.04 [95% confidence interval (CI): 1.01-1.07] in Week 37 for the 99th percentile (31°C) compared with the minimum-risk temperature (16°C). There was a strong seasonal pattern in the estimated risk, with pregnancies with LMP in autumn having a higher risk. The average estimated risk by LMP month varied between 6.5% and 7.6% for pregnancies with LMP in March and October, respectively, corresponding to a relative risk of 1.17 (95% CI: 1.07-1.27).Conclusion: The final weeks of the third trimester are the key window for heat exposure in Southern Israel, creating a distinguished estimated risk by LMP month, with the highest risk for pregnancies conceived in the autumn.","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 4","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Data Resource Profile Update: CPRD GOLD. 数据资源配置文件更新：CPRD金。

IF 6.4 2区医学

International journal of epidemiology Pub Date : 2025-06-11 DOI: 10.1093/ije/dyaf077

Maria T Sanchez-Santos, Eleanor L Axson, Daniel Dedman, Antonella Delmestri

引用次数: 0

Data Resource Profile: Whole-Blood DNA Methylation Resource in Generation Scotland (MeGS). 数据资源简介：全血DNA甲基化资源在一代苏格兰（MeGS）。

IF 6.4 2区医学

International journal of epidemiology Pub Date : 2025-06-11 DOI: 10.1093/ije/dyaf091

Rosie M Walker, Daniel L McCartney, Kevin Carr, Michael Barber, Xueyi Shen, Archie Campbell, Elena Bernabeu, Emma Aitken, Angie Fawkes, Nicola Wrobel, Lee Murphy, Heather C Whalley, David M Howard, Mark J Adams, Konrad Rawlik, Pau Navarro, Albert Tenesa, Cathie L Sudlow, David J Porteous, Riccardo E Marioni, Andrew M McIntosh, Kathryn L Evans

引用次数: 0

Cohort Profile: Health Inequalities in Catalonia (the HEALIN cohort). 队列简介：加泰罗尼亚的健康不平等（HEALIN队列）。

IF 6.4 2区医学

International journal of epidemiology Pub Date : 2025-06-11 DOI: 10.1093/ije/dyaf129

Aïda Solé-Auró, Jordi Gumà-Lao, Sergi Trias-Llimós, Agata Carreño Serra, Juan-Francisco Martínez-Cerdá, Iñaki Permanyer

引用次数: 0