International journal of epidemiology最新文献

{"title":"Many thanks to our reviewers for 2023.","authors":"","doi":"10.1093/ije/dyae082","DOIUrl":"https://doi.org/10.1093/ije/dyae082","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile: Healthy Finland Survey.","authors":"Katri Sääksjärvi, Hanna M Elonheimo, Jonna Ikonen, Lara Lehtoranta, Suvi Parikka, Tommi Härkänen, Terhi Vihervaara, Päivi Sainio, Tuija Jääskeläinen, Anna Liisa Suominen, Ulla Harjunmaa, Pia Mäkelä, Jouni Lahti, Niina E Kaartinen, Seppo Koskinen, Annamari Lundqvist","doi":"10.1093/ije/dyae166","DOIUrl":"10.1093/ije/dyae166","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erroneous epidemiological findings on vitamins: coming full circle after two decades of Mendelian randomization?","authors":"George Davey Smith, Shah Ebrahim","doi":"10.1093/ije/dyae179","DOIUrl":"https://doi.org/10.1093/ije/dyae179","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile: The Northern Sweden Health and Disease Study (NSHDS).","authors":"Florentin Späth, Patrik Wennberg, Robert Johansson, Lars Weinehall, Margareta Norberg, Anna Rosén, Gerd Johansson, Anna Nordström, Ingegerd Johansson, Lena Maria Nilsson, Sture Eriksson, Anna Winkvist, Maria Wennberg, Sophia Harlid, Sara Rebbling, Beatrice Melin, Olov Rolandsson, Malin Sund, Ingvar A Bergdahl, Stefan Söderberg, Göran Hallmans, Bethany Van Guelpen","doi":"10.1093/ije/dyaf004","DOIUrl":"10.1093/ije/dyaf004","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Many thanks to our reviewers for 2023.","authors":"","doi":"10.1093/ije/dyae082","DOIUrl":"https://doi.org/10.1093/ije/dyae082","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator.","authors":"Matthew A Lee, Charlie A Hatcher, Emma Hazelwood, Lucy J Goudswaard, Konstantinos K Tsilidis, Emma E Vincent, Richard M Martin, Karl Smith-Byrne, Hermann Brenner, Iona Cheng, Sun-Seog Kweon, Loic Le Marchand, Polly A Newcomb, Robert E Schoen, Ulrike Peters, Marc J Gunter, Bethany Van Guelpen, Neil Murphy","doi":"10.1093/ije/dyae175","DOIUrl":"10.1093/ije/dyae175","url":null,"abstract":"<p><strong>Background: </strong>Adiposity is an established risk factor for colorectal cancer (CRC). The pathways underlying this relationship, and specifically the role of circulating proteins, are unclear.</p><p><strong>Methods: </strong>Utilizing two-sample univariable Mendelian randomization (UVMR), multivariable Mendelian randomization (MVMR), and colocalization, based on summary data from large sex-combined and sex-specific genetic studies, we estimated the univariable associations between: (i) body mass index (BMI) and waist-hip ratio (WHR) and overall and site-specific (colon, proximal colon, distal colon, and rectal) CRC risk, (ii) BMI and WHR and circulating proteins, and (iii) adiposity-associated circulating proteins and CRC risk. We used MVMR to investigate the potential mediating role of adiposity- and CRC-related circulating proteins in the adiposity-CRC association.</p><p><strong>Results: </strong>BMI and WHR were positively associated with CRC risk, with similar associations by anatomical tumor site. In total, 6591 adiposity-protein (2628 unique circulating proteins) and 33 protein-CRC (7 unique circulating proteins) associations were identified using UVMR and colocalization. One circulating protein, GREM1, was associated with BMI (only) and CRC outcomes in a manner that was consistent with a potential mediating role in sex-combined and female-specific analyses. In MVMR, adjusting the BMI-CRC association for GREM1, effect estimates were attenuated-suggestive of a potential mediating role-most strongly for the BMI-overall CRC association in women.</p><p><strong>Conclusion: </strong>Results highlight the impact of adiposity on the plasma proteome and of adiposity-associated circulating proteins on the risk of CRC. Supported by evidence from UVMR and colocalization analyses using cis-single-nucleotide polymorphisms, GREM1 was identified as a potential mediator of the BMI-CRC association, particularly in women.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile Update: The Danish Nurse Cohort.","authors":"Mette Kildevæld Simonsen, Berit Lilienthal Heitmann, Dorthe Boe Danbjærg, Christoffer Johansen, Maria Kristiansen, Ola Ekholm","doi":"10.1093/ije/dyae168","DOIUrl":"https://doi.org/10.1093/ije/dyae168","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased risk of subsequent antiphospholipid syndrome in patients with endometriosis.","authors":"Zhiyong Chen, Ran Cui, Shiow-Ing Wang, Hua Zhang, Miao Chen, Qian Wang, Qiang Tong, James Cheng-Chung Wei, Sheng-Ming Dai","doi":"10.1093/ije/dyae167","DOIUrl":"10.1093/ije/dyae167","url":null,"abstract":"<p><strong>Background: </strong>Although autoimmune abnormalities are common in patients with endometriosis, it is unknown whether patients with endometriosis have a higher risk of developing antiphospholipid syndrome (APS).</p><p><strong>Methods: </strong>We conducted a retrospective cohort study by using the multi-institutional research network TriNetX from 1 January 2012 to 31 December 2021. A total of 13 131 782 women aged 20-60 years from networks within the USA were included. The risks of APS were compared between an endometriosis cohort and a non-endometriosis cohort in subgroup analyses by age, obesity and systemic lupus erythematosus (SLE), and the sensitivity analysis was stratified by the presence or absence of a history of surgery of the uterus.</p><p><strong>Results: </strong>After 1:1 propensity score matching, the endometriosis and non-endometriosis cohorts each included 50 078 participants. Compared to individuals without endometriosis, patients with endometriosis had a higher risk of incident APS (log-rank test, P < 0.001). The hazard ratios (HRs) ranged from 1.82 [APS within 30 days to 1 year after the index date, 95% confidence intervals (CIs) 1.40-2.53] to 2.44 (APS within 30 days to any time after the index date, 95% CI 1.65-3.61). In the subgroup analyses, an increased risk of APS was observed in all ages, White race, and subgroups without smoking, obesity, asthma, inflammatory bowel disease and SLE (HR range 1.85-2.84). Sensitivity analyses revealed that the risk of APS increased in patients without surgery history of the uterus.</p><p><strong>Conclusions: </strong>Patients with endometriosis had a higher risk (2.84-fold) of developing APS. Future large-scale prospective studies are warranted to confirm our results.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile: Africa Wits-INDEPTH partnership for Genomic studies (AWI-Gen) in four sub-Saharan African countries.","authors":"Furahini Tluway, Godfred Agongo, Vukosi Baloyi, Palwende Romuald Boua, Isaac Kisiangani, Moussa Lingani, Reneilwe Given Mashaba, Shukri F Mohamed, Engelbert A Nonterah, Cairo Bruce Ntimana, Toussaint Rouamba, Theophilous Mathema, Siyanda Madala, Dylan G Maghini, Ananyo Choudhury, Nigel J Crowther, Scott Hazelhurst, Dhriti Sengupta, Patrick Ansah, Solomon Simon Rampai Choma, Cornelius Debpuur, F Xavier Gómez-Olivé, Kathleen Kahn, Lisa K Micklesfield, Shane A Norris, Abraham R Oduro, Hermann Sorgho, Paulina Tindana, Halidou Tinto, Stephen Tollman, Alisha Wade, Michèle Ramsay","doi":"10.1093/ije/dyae173","DOIUrl":"10.1093/ije/dyae173","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute coronary syndrome rates by age and sex before and during the COVID-19 pandemic in Israel: nationwide study","authors":"Alexander Kagan, Donna R Zwas, Ziona Haklai, Hagai Levine","doi":"10.1093/ije/dyae164","DOIUrl":"https://doi.org/10.1093/ije/dyae164","url":null,"abstract":"Background There have been reports of sharp declines in acute coronary syndrome (ACS) during the COVID-19 pandemic. The study aims to assess nationwide ACS emergency department (ED) visit rates across age and sex subgroups and the general population, with a comparison before and throughout the pandemic’s various phases. Methods A multiple interrupted time series analysis was used to assess 61 349 ACS nationwide hospital visits from January 2018 to December 2021 at monthly intervals. The study period was divided into three periods: January 2018–February 2020 (pre-pandemic period); March 2020–January 2021 (early-pandemic period); February 2021–December 2021 (late-pandemic period). Segmented regression with a seasonally adjusted autoregressive moving average structure was used to build predictive models with an estimated reference trendline (counterfactual). Results Over 11 months of the early-pandemic period (lockdowns), the largest decrease in visits was seen in women aged 65 and above, of 18.4% [incidence rate ratio (IRR) 0.82; 95% confidence interval (CI) 0.77–0.86]. The lowest decrease was observed in men aged 25–64, of 7.2% (IRR 0.93; 0.91–0.94). During the late-pandemic period, which included high vaccination coverage and no lockdowns, the largest further decrease was in women aged 25–64 of 20.1% (IRR 0.80; 0.75–0.84) on average. Conclusions The pandemic influenced ACS ED visits variably, with substantial declines during phases of high COVID-19 morbidity and mortality. Older individuals, particularly women, demonstrated the largest decrease in ACS ED visits, highlighting the need for tailored public health strategies to maintain public confidence in access to critical care during future health emergencies.","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"30 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}