International journal of epidemiology最新文献

{"title":"Time for evidence-based methodology in epidemiology.","authors":"Robert Goulden","doi":"10.1093/ije/dyaf052","DOIUrl":"https://doi.org/10.1093/ije/dyaf052","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 3","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile Update: The Northern Ireland Longitudinal Study (NILS).","authors":"Estelle Lowry, Ian Shuttleworth, Peter Wilgar, Catherine McLoughlin, Emma Connell","doi":"10.1093/ije/dyaf054","DOIUrl":"10.1093/ije/dyaf054","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 3","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood household dysfunction and psychiatric, criminal, and social outcomes in emerging adulthood. A cousin comparison study.","authors":"Joonas Pitkänen, Amir Sariaslan, Lauren Bishop, Pekka Martikainen","doi":"10.1093/ije/dyaf074","DOIUrl":"https://doi.org/10.1093/ije/dyaf074","url":null,"abstract":"<p><strong>Background: </strong>Childhood household dysfunction is a well-known risk factor for adverse medical and social outcomes. However, less is known about the extent to which such associations are affected by unmeasured familial confounding.</p><p><strong>Methods: </strong>This cohort study is based on Finnish register data on birth cohorts 1987-2000 (n = 835 987). We considered parental hospital-presenting substance use and psychiatric disorders, prison sentences, death, means-tested social assistance, and union dissolution at ages 0-14 as indicators of childhood household dysfunction. The study participants were followed from age 15 until the end of 2020 for hospital-presenting psychiatric disorders and substance use, psychotropic medication purchases, violent and property crime arrests, and not being in education, employment, or training. The associations were estimated using Cox regression, and cousin comparisons were used to account for unmeasured confounders shared within extended families (n = 87 500).</p><p><strong>Results: </strong>All the exposures were associated with the outcomes in the population-level models, with hazard ratios ranging from 1.3 (95% confidence interval 1.3-1.4) to 2.5 (2.4-2.6). The associations attenuated in the cousin comparisons, on average 12% but with a wide range from -2% to 39% [hazard ratios ranging from 1.2 (1.1-1.4) to 1.9 (1.6-2.3)]. A dose-response relationship between the exposures and the outcomes was observed in the population-level models and the cousin comparisons, with attenuated associations in the latter.</p><p><strong>Conclusion: </strong>Our findings show systematic associations between childhood household dysfunction and subsequent outcomes. Unobserved confounding likely creates upward bias in these associations, but the extent of this confounding depends on the specific exposure-outcome pairs.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 3","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The COVID-19 syndemic: a perfect storm for the life expectancy of the most disadvantaged Americans.","authors":"Charlotte Probst, Sophie Bright, Yachen Zhu, Carolin Kilian, Charlotte Buckley, Yu Ye, Nina Mulia, William C Kerr, Jürgen Rehm","doi":"10.1093/ije/dyaf069","DOIUrl":"10.1093/ije/dyaf069","url":null,"abstract":"<p><strong>Background: </strong>To explore the syndemic nature of the COVID-19 pandemic by identifying which subpopulations in the United States (US) suffered the greatest losses in life expectancy (LE) in 2020 and 2021, and to which extent these losses can be attributed to COVID-19 and 'other' causes of death.</p><p><strong>Methods: </strong>We analysed individual death records for 2018-2021 from the National Vital Statistics System and population counts from the American Community Survey. Life table and continuous change decomposition analyses were used to quantify cause-/.specific contributions to changes in LE over time in population subgroups defined by sex, educational attainment, and race/ethnicity.</p><p><strong>Results: </strong>From 2019 to 2020, educational differences in LE (high minus low education) increased substantially by 5.0 and 2.6 years in Hispanic men and women, respectively, with increases of one to two years among Black and White adults. Nearly all losses in LE among high-education Hispanic and White groups were due to COVID-19, while among low-education White and Black groups, COVID-19 accounted for 40%-47% of the total losses in LE. Changes in LE were much smaller during 2020-2021.</p><p><strong>Conclusions: </strong>COVID-19 widened preexisting inequalities in LE in the US, both via direct mortality and through syndemic interactions with other diseases and health conditions. The underlying social, political, economic, and environmental factors driving the clustering and interaction of diseases among the most disadvantaged Americans need to be addressed.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 3","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness and cardiovascular disease incidence: two cohorts of older adults in the USA and South Korea.","authors":"Harold H Lee, Ruijia Chen, Sakurako S Okuzono, Laura D Kubzansky","doi":"10.1093/ije/dyaf050","DOIUrl":"https://doi.org/10.1093/ije/dyaf050","url":null,"abstract":"<p><strong>Background: </strong>We investigated the relationship between loneliness and cardiovascular disease (CVD) in older adults from the USA and South Korea. We conducted counterfactual mediation analyses to explore the potential mediation of this relationship by health behaviors.</p><p><strong>Methods: </strong>We used the Health and Retirement Study (HRS; n = 13 073) from the USA and the Korean Longitudinal Study of Aging (KLoSA; n = 8311) from South Korea. In both cohorts, baseline loneliness was assessed using one item from the Center for Epidemiologic Studies Depression Scale. Incident CVD was defined as reporting new-onset CVD on the biennial questionnaire or CVD death reported by proxies. Within each cohort, we estimated adjusted hazard ratios (aHRs) of incident CVD according to loneliness (yes/no) over 12-14 years of follow-up, adjusting for baseline covariates: social isolation, sociodemographic factors, health conditions, and health behaviors.</p><p><strong>Results: </strong>Feeling lonely was associated with an increased likelihood of developing CVD in the USA (aHR: 1.15, 95% CI: 1.04, 1.27) and South Korea (aHR: 1.16, 95% CI: 1.00, 1.34). Several behaviors accounted for a proportion of the association: physical activity (14.3%, P = 0.03 in HRS; 1.3%, P = 0.04 in KLoSA) and alcohol (3.9%, P < 0.001 in HRS; 1.3%, P < 0.001 in KLoSA) in both countries, smoking only in HRS (4.7%, P < 0.001).</p><p><strong>Conclusion: </strong>The magnitude of the impact of loneliness on CVD was similar in both countries, but behavioral pathways differed. Loneliness may be a risk factor for CVD regardless of culture; however, different prevention strategies in clinical settings may be required.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 3","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile: Kunshan Aging Research with E-health (KARE).","authors":"Tian Xie, Ying Pan, Ke Lu, Yinlin Wei, Fei Chen, Zijian Tian, Peng Wu, Qian Li, Benrui Wu, Yiying Liu, Jingnan Xue, Jie Bai, Wanqing Dong, Yang Liu, Jian Shao, Ying Chen, Xiaozhou Zhou, Yuxuan Du, Ziqing Liu, Shiteng Gao, Yao Cheng, Rong Huang, Zhiqin Zhang, Yushan Yue, Shao Zhong, Zhiyong Deng, Kaiyun Zhou, Jian Jin, Chong Li, Tao Xu, Kaixin Zhou","doi":"10.1093/ije/dyaf041","DOIUrl":"https://doi.org/10.1093/ije/dyaf041","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 3","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A heartfelt thanks to our reviewers for 2024.","authors":"","doi":"10.1093/ije/dyaf056","DOIUrl":"https://doi.org/10.1093/ije/dyaf056","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 3","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newborn blood DNA methylation and childhood asthma: findings from the ECHO program.","authors":"Yijun Li, Krystin Jones, Carole Ober, Anne P Starling, William A Gower, Leonard B Bacharier, Aruna Chandran, Dana M Dabelea, Rebecca C Fry, Diane R Gold, Kasper D Hansen, Julie B Herbstman, Marie-France Hivert, Corinne Keet, Rachel L Miller, Lisa P Jacobson, Christine Ladd-Acosta","doi":"10.1093/ije/dyaf067","DOIUrl":"https://doi.org/10.1093/ije/dyaf067","url":null,"abstract":"<p><strong>Background: </strong>DNA methylation (DNAm) at birth has been linked to childhood asthma in epigenome-wide association studies (EWASs). However, existing EWASs have limited representation of non-European and extremely preterm participants and have not explored sex-specific DNAm differences. This study examined the association between DNAm in newborn blood and subsequent childhood asthma risk in a diverse population.</p><p><strong>Methods: </strong>Data from the Environmental influences on Child Health Outcomes (ECHO) Program were used for EWAS meta-analyses in United States (US) cohorts of children born before and after 28 weeks of gestation. DNAm was measured in newborn blood using Illumina arrays. Childhood asthma was defined as provider-diagnosed asthma with persistent symptoms beyond age 5. Linear regression was used to identify differentially methylated positions (DMPs), and \"comb-p\" was used to identify differentially methylated regions (DMRs). Sex-stratified analyses were performed.</p><p><strong>Results: </strong>The meta-analysis included 942 children (369 asthma cases) born after 28 weeks of gestation. We identified a novel DMP (cg24749470 in CADM1, P = 9.31 × 10-8) and 18 DMRs (Šidák P-value <.001) associated with asthma, with four DMRs in the human leukocyte antigen region. At these four DMRs, the association between DNAm and asthma differed by sex. In the extremely preterm cohort (n = 271, 106 asthma cases), we identified 20 DMRs, with two novel asthma-associated DMPs (cg03237868 in SPATA18, P = 2.71 × 10-8; cg20681219 in IRF2, P = 5.18 × 10-8) identified in males.</p><p><strong>Conclusion: </strong>In US children born before and after 28 weeks of gestation, we discovered novel genomic loci linking newborn blood DNAm to childhood asthma, suggesting DNAm involvement in early asthma development.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 3","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile: Shanghai Municipal Dynamic Cohort of Student Common Diseases (SMDCSCD).","authors":"Liting Chu, Fengyun Zhang, Wenjuan Qi, Yanting Yang, Yuting Huang, Shuangxiao Qu, Shenglei Huang, Keyang Zheng, Dongling Yang, Chunyan Luo","doi":"10.1093/ije/dyaf048","DOIUrl":"https://doi.org/10.1093/ije/dyaf048","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 3","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile: The Children's Health in London and Luton (CHILL) cohort.","authors":"Helen E Wood, Rosamund E Dove, Jasmine Chavda, Grainne Colligan, Louise Cross, Harpal Kalsi, James Scales, Ivelina Tsocheva, Sean Beevers, Bill Day, Monica Fletcher, W James Gauderman, Jonathan Grigg, Hajar Hajmohammadi, Frank J Kelly, Borislava Mihaylova, Chris Newby, Gurch Randhawa, Aziz Sheikh, Veronica Toffolutti, Florian Tomini, Esther van Sluijs, Ian S Mudway, Chris J Griffiths","doi":"10.1093/ije/dyaf055","DOIUrl":"https://doi.org/10.1093/ije/dyaf055","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 3","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}