International journal of epidemiology最新文献

{"title":"Cohort Profile Update: The National Prostate Cancer Register of Sweden and PCBase.","authors":"Marcus Westerberg, Lennart Holm, Hans Garmo, Pär Stattin, Rolf Gedeborg","doi":"10.1093/ije/dyaf172","DOIUrl":"10.1093/ije/dyaf172","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12516312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges with Mendelian randomization and its application to the study of vitamins.","authors":"Elina Hyppönen","doi":"10.1093/ije/dyaf165","DOIUrl":"https://doi.org/10.1093/ije/dyaf165","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile Update: The Intergenerational Childhood Adversity and Lifetime Morbidity (I-CALM) study, an extension of the Mater-University of Queensland Study of Pregnancy (MUSP).","authors":"Claudia Bull, Mike Trott, Jake Najman, Natasha Reid, Lakshmi Neelakantan, Rebecca Moran, Anne Edwards, Steve Kisely","doi":"10.1093/ije/dyaf151","DOIUrl":"10.1093/ije/dyaf151","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohort Profile Update: The Norwegian Mother, Father and Child Cohort (MoBa).","authors":"Ragnhild E Brandlistuen,Dana Kristjansson,Elin Alsaker,Ragnhild Valen,Even Birkeland,Ellen C Røyrvik,Christian M Page,Maria Aamelfot,Sille Vangbæk,Helga Ask,Alexandra Havdahl,Anne Lise Brantsæter,Guri Rortveit,Siri E Håberg,Per Magnus","doi":"10.1093/ije/dyaf139","DOIUrl":"https://doi.org/10.1093/ije/dyaf139","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"27 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When will causal structure learning become practical?","authors":"Johannes Textor","doi":"10.1093/ije/dyaf145","DOIUrl":"https://doi.org/10.1093/ije/dyaf145","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education and cardiovascular disease: a within-family Mendelian randomization analysis.","authors":"Paul R Jones, Laxmi Bhatta, Laurence J Howe, María Fernanda Vinueza-Veloz, Neil M Davies, George Davey Smith, Øyvind E Næss, Ben M Brumpton","doi":"10.1093/ije/dyaf144","DOIUrl":"https://doi.org/10.1093/ije/dyaf144","url":null,"abstract":"<p><strong>Background: </strong>Observational studies have consistently found educational inequalities in cardiovascular disease (CVD) risk. Mendelian randomization (MR) analyses have suggested a direct causal effect of education; however, estimates may be biased by demography or dynastic effects. This study aimed to estimate the effects of educational attainment on CVD risk and serum lipid concentrations before and after accounting for family structure.</p><p><strong>Methods: </strong>This study included 26 961 siblings from the Trøndelag Health Study (HUNT) and 23 640 siblings from UK Biobank, and used data on >120 000 individuals, predominantly of European ancestry, from a recent international within-sibship genome-wide association study. The exposure was educational attainment. The outcomes were CVD risk and serum concentrations of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. Standard and within-sibship MR analyses were used.</p><p><strong>Results: </strong>In the summary data analysis, there was a 6% lower risk of CVD [odds ratio (OR) 0.94, 95% confidence interval (CI) 0.92 to 0.96] for each additional standard deviation of liability to educational attainment. This was consistent having accounted for family structure (OR 0.96, 95% CI 0.91 to 1.01). Educational attainment was also beneficially associated with each serum lipid concentration both before and after accounting for family structure. Results were broadly similar in the individual participant analysis.</p><p><strong>Conclusion: </strong>There is a protective effect of educational attainment on CVD risk and a beneficial effect on serum lipid concentrations not due to familial factors shared by siblings, suggesting that increasing education may be beneficial for cardiovascular health.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forty years of investigations of childhood leukaemia 'clusters' near nuclear installations.","authors":"Richard Wakeford","doi":"10.1093/ije/dyaf174","DOIUrl":"https://doi.org/10.1093/ije/dyaf174","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A reanalysis of the bidirectional association between vitamin D and C-reactive protein using the doubly-ranked non-linear Mendelian randomization approach.","authors":"Ang Zhou, Elina Hyppönen","doi":"10.1093/ije/dyaf166","DOIUrl":"https://doi.org/10.1093/ije/dyaf166","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria amidst the COVID-19 pandemic in Gabon: an application of autoregressive integrated moving average (ARIMA) models within an interrupted time series (ITS) framework to hospital-based data.","authors":"Friederike Roeder, Olouyomi Scherif Adegnika, Yabo Josiane Honkpehedji, Manuel Huth, Bertrand Lell, Ayôla Akim Adegnika, Iris Lopes-Rafegas, Elisa Sicuri","doi":"10.1093/ije/dyaf140","DOIUrl":"10.1093/ije/dyaf140","url":null,"abstract":"<p><strong>Background: </strong>Coinciding with the SARS-CoV-2 pandemic, malaria cases and malaria-related deaths increased globally between 2020 and 2022. However, evidence linking the pandemic to increased malaria burden remains ambiguous. We assessed the extent to which an observed malaria resurgence in Lambaréné, Gabon, can be associated with pandemic-related disruptions in malaria control programmes.</p><p><strong>Methods: </strong>Using observational data from two tertiary referral hospitals, spanning 2018 to early 2023, we applied autoregressive integrated moving average (ARIMA) models in an interrupted time series (ITS) framework to test for changes in trends and levels following the onset of the pandemic. The primary outcome is the monthly malaria diagnosis rate (per 1000 all-cause hospital diagnoses). As a sub-analysis, we focused on monthly maternal malaria incidence.</p><p><strong>Results: </strong>Following an initial drop (-47.32, P = 0.031), potentially due to risk-averse behaviours, the malaria diagnosis rate gradually and concavely increased (linear term: 7.32, P = 0.001; squared term: -0.19, P = 0.001) to a peak above pre-pandemic levels. Additional analyses suggest that this resurgence was likely driven by disruptions to malaria control activities and a waning efficacy of malaria control tools administered pre-pandemic. Conversely, a resurgence in maternal malaria incidence was not estimated.</p><p><strong>Conclusion: </strong>Findings align with several national and global descriptive reports, but add a more detailed understanding of underlying dynamics, therefore reinforcing the importance of maintaining malaria control in the general population. The absence of a meaningful increase in maternal malaria provides some reassurance that malaria in pregnancy-specific control remained unchanged during the SARS-CoV-2 pandemic. However, observed peaks in post-pandemic maternal malaria incidence should raise concerns given the risks that malaria poses to this group.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No evidence for the validity of ICE FALCON.","authors":"Arvid Sjölander, Thomas Frisell","doi":"10.1093/ije/dyaf159","DOIUrl":"https://doi.org/10.1093/ije/dyaf159","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"54 5","pages":""},"PeriodicalIF":5.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}