Device-measured stationary behaviour and cardiovascular and orthostatic circulatory disease incidence.

IF 6.4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Matthew N Ahmadi,Pieter Coenen,Leon Straker,Emmanuel Stamatakis
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引用次数: 0

Abstract

BACKGROUND Previous studies have indicated that standing may be beneficially associated with surrogate metabolic markers, whereas more time spent sitting has an adverse association. Studies assessing the dose-response associations of standing, sitting and composite stationary behaviour time with cardiovascular disease (CVD) and orthostatic circulatory disease are scarce and show an unclear picture. OBJECTIVE To examine associations of daily sitting, standing and stationary time with CVD and orthostatic circulatory disease incidence. METHODS We used accelerometer data from 83 013 adults (mean age ± standard deviation = 61.3 ± 7.8; female = 55.6%) from the UK Biobank to assess daily time spent sitting and standing. Major CVD was defined as coronary heart disease, heart failure and stroke. Orthostatic circulatory disease was defined as orthostatic hypotension, varicose vein, chronic venous insufficiency and venous ulcers. To estimate the dose-response hazard ratios (HR) we used Cox proportional hazards regression models and restricted cubic splines. The Fine-Gray subdistribution method was used to account for competing risks. RESULTS During 6.9 (±0.9) years of follow-up, 6829 CVD and 2042 orthostatic circulatory disease events occurred. When stationary time exceeded 12 h/day, orthostatic circulatory disease risk was higher by an average HR (95% confidence interval) of 0.22 (0.16, 0.29) per hour. Every additional hour above 10 h/day of sitting was associated with a 0.26 (0.18, 0.36) higher risk. Standing more than 2 h/day was associated with an 0.11 (0.05, 0.18) higher risk for every additional 30 min/day. For major CVD, when stationary time exceeded 12 h/day, risk was higher by an average of 0.13 (0.10, 0.16) per hour. Sitting time was associated with a 0.15 (0.11, 0.19) higher risk per extra hour. Time spent standing was not associated with major CVD risk. CONCLUSIONS Time spent standing was not associated with CVD risk but was associated with higher orthostatic circulatory disease risk. Time spent sitting above 10 h/day was associated with both higher orthostatic circulatory disease and major CVD risk. The deleterious associations of overall stationary time were primarily driven by sitting. Collectively, our findings indicate increasing standing time as a prescription may not lower major CVD risk and may lead to higher orthostatic circulatory disease risk.
设备测量的静止行为与心血管和正压循环系统疾病的发病率。
背景以前的研究表明,站立可能对代用代谢指标有益,而坐着的时间越长越不利。我们使用英国生物库中 83 013 名成年人(平均年龄 ± 标准差 = 61.3 ± 7.8;女性 = 55.6%)的加速度计数据来评估每天坐着和站着的时间。主要心血管疾病定义为冠心病、心力衰竭和中风。直立性循环系统疾病是指直立性低血压、静脉曲张、慢性静脉功能不全和静脉溃疡。为了估算剂量反应危险比(HR),我们使用了 Cox 比例危险回归模型和限制性三次样条。结果在 6.9 (±0.9) 年的随访期间,共发生了 6829 起心血管疾病和 2042 起静态循环疾病事件。当静止时间超过 12 小时/天时,正静态循环系统疾病风险较高,平均 HR(95% 置信区间)为每小时 0.22(0.16,0.29)。每天坐着的时间超过 10 小时,每增加一小时,风险就增加 0.26(0.18,0.36)。每天站立超过 2 小时,每增加 30 分钟,风险就会增加 0.11(0.05,0.18)。就主要心血管疾病而言,当静止时间超过 12 小时/天时,风险平均每小时增加 0.13(0.10,0.16)。坐着的时间每增加一小时,风险就会增加0.15(0.11,0.19)。结论:站立时间与心血管疾病风险无关,但与较高的正压循环系统疾病风险有关。坐的时间超过 10 小时/天与较高的正压循环系统疾病和主要心血管疾病风险有关。整体静止时间的有害关联主要是由久坐引起的。总之,我们的研究结果表明,作为一种处方,增加站立时间可能不会降低主要心血管疾病风险,反而会导致更高的正压性循环系统疾病风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International journal of epidemiology
International journal of epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
13.60
自引率
2.60%
发文量
226
审稿时长
3 months
期刊介绍: The International Journal of Epidemiology is a vital resource for individuals seeking to stay updated on the latest advancements and emerging trends in the field of epidemiology worldwide. The journal fosters communication among researchers, educators, and practitioners involved in the study, teaching, and application of epidemiology pertaining to both communicable and non-communicable diseases. It also includes research on health services and medical care. Furthermore, the journal presents new methodologies in epidemiology and statistics, catering to professionals working in social and preventive medicine. Published six times a year, the International Journal of Epidemiology provides a comprehensive platform for the analysis of data. Overall, this journal is an indispensable tool for staying informed and connected within the dynamic realm of epidemiology.
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