International Journal of Laboratory Hematology最新文献

{"title":"Evaluation of HemoCue 201 Performance for Hemoglobin Measurement and Anemia Detection in EDTA, Heparinized, and Capillary Blood Samples","authors":"Orakan Limpornpugdee,&nbsp;Sithee Sodmanee,&nbsp;Panatda Sohab,&nbsp;Chitnuphong Saengnil,&nbsp;Narisorn Kongruttanachok","doi":"10.1111/ijlh.14495","DOIUrl":"10.1111/ijlh.14495","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>This study aimed to evaluate the analytical and diagnostic performance of the HemoCue 201 device by comparing venous EDTA, venous heparinized, and capillary blood samples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The HemoCue 201 device was compared with an automated analyzer. Hemoglobin levels were measured from EDTA, heparinized, and capillary blood samples. Analytical performance was assessed using mean ± SD, paired <i>t</i>-test, intraclass correlation coefficient (ICC), and Bland–Altman plots. The CLIA 2025 criteria for acceptable error were applied to determine agreement. Diagnostic performance was determined via sensitivity, specificity, diagnostic effectiveness, positive predictive value (PPV), negative predictive value (NPV), and likelihood ratios.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed excellent reliability with ICC values of 1.00 for both EDTA and heparinized, and 0.97 for capillary blood. Bland–Altman plots indicated small biases for EDTA (0.08 [−0.27 to 0.42]) and heparin (0.09 [−0.40 to 0.57]), but larger negative biases for capillary blood (−0.12 [−1.21 to 0.97]). According to CLIA 2025 criteria, 98% of EDTA and 95% of heparin samples were within the ±4% cut-off, whereas only 68% of capillary samples met this criterion. Diagnostic performance demonstrated strong potential as a rapid and reliable anemia screening tool due to its high sensitivity (100%) and NPV (100%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The HemoCue 201 device reliably measured hemoglobin and detected anemia in all sample types. Heparinized blood, commonly used in point-of-care blood gas tests, can effectively support hemoglobin testing, reducing the need for additional blood draws. However, capillary samples exhibited greater bias, with variability influenced by pre-analytical factors. Standardized protocol and manufacturer guidelines helped minimize analytical variation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 5","pages":"817-825"},"PeriodicalIF":2.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of In Vitro Acidification on APTT Measured With Two Different Reagents on Two Different Analyzers","authors":"Debora Olioso,&nbsp;Elia Ponchini,&nbsp;Simone Denitto,&nbsp;Nicola Baratto,&nbsp;Alessandro Lorenzetto,&nbsp;Davide Demonte,&nbsp;Giuseppe Lippi","doi":"10.1111/ijlh.14491","DOIUrl":"10.1111/ijlh.14491","url":null,"abstract":"","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":"767-769"},"PeriodicalIF":2.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric Reference Intervals and Curves for Haemoglobin Estimated Using Direct Methods: A Systematic Review and Meta-Analysis","authors":"Vid Bijelić,&nbsp;Marijana Bijelić,&nbsp;Josh Larock,&nbsp;Michael Pham,&nbsp;Franco Momoli,&nbsp;Mira Liebman,&nbsp;Beth K. Potter,&nbsp;Patricia C. Parkin,&nbsp;Jemila S. Hamid","doi":"10.1111/ijlh.14489","DOIUrl":"10.1111/ijlh.14489","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Haemoglobin is a commonly ordered laboratory test, used to assess both individual and population-level health. To interpret test results, laboratories provide reference intervals (RIs) with lower (2.5th%) and upper (97.5th%) limits according to age and sex. Reference curves (RCs) treat age as a continuous variable. The objectives were to synthesise evidence on Paediatric haemoglobin RIs/RCs and investigate possible sources of heterogeneity. We placed our findings in the context of the age- and sex-based haemoglobin thresholds to define anaemia, recommended for international use by WHO.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We conducted a systematic review of studies publishing Paediatric haemoglobin RIs/RCs (PROSPERO: CRD42023399802). EMBASE, MEDLINE, SCOPUS and The Cochrane electronic libraries were searched from inception to July 31, 2023. Studies involving unhealthy children, lacking males and females RIs/RCs, or limited to cord-blood RIs/RCs were excluded. Studies adhering to guidelines for RIs development from the Clinical Laboratory Standards Institute (CLSI) and RCs studies reporting confidence intervals (CIs) were included in the meta-analysis. Lower and upper males and females RI limits were pooled for age groups with heterogeneity &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; &lt; 75%. All studies meeting eligibility criteria were included in the narrative synthesis. Sources of heterogeneity were analyzed using heatmaps, forest plots and Shiny app.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Of 9123 studies screened, 177 were retained for full-text review. We identified 48 eligible studies (63 529 male and 59 969 female participants) from 25 countries (4 continents) published 1938–2023. There was inconsistency in age partitioning and length of age intervals. Meta-analysis was conducted on 13 studies reporting RIs and 2 studies reporting RCs. Pooled estimates for the 0–3 months age group could not be generated for males or females due to paucity of data. For children aged 3 months or older, both lower and upper RI limits generally increased with age, from approximately 100 to 130 g/L and from approximately 130 to 150 g/L, respectively. For visualisation of our narrative synthesis of all 48 studies, we created a novel web-based computational tool using Shiny-app. Sources of heterogeneity included child age, sex, analyser type and country. For many studies, the lower RIs were substantially different from WHO anaemia thresholds. Study limitations include a small sample size for younger age groups, potentially impacting heterogeneity estimates, reliance on CLSI guidelines due to the lack of a suitable quality assessm","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":"588-599"},"PeriodicalIF":2.2,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijlh.14489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Tranexamic Acid Therapy Corrects the Impaired Epinephrine Aggregation Responses of Quebec Platelet Disorder","authors":"Natalie Mathews,&nbsp;Subia Tasneem,&nbsp;Georges E. Rivard,&nbsp;Catherine P. M. Hayward","doi":"10.1111/ijlh.14492","DOIUrl":"10.1111/ijlh.14492","url":null,"abstract":"","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":"770-772"},"PeriodicalIF":2.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Lymphoma Aggressiveness Using Machine Learning Algorithms","authors":"Julien Cabo,&nbsp;Benoît Bihin,&nbsp;Nicolas Debortoli,&nbsp;Virginie Lepage,&nbsp;Reza Soleimani,&nbsp;Rhita Bennis,&nbsp;Julien Favresse,&nbsp;Thierry Vander Borght,&nbsp;Carlos Graux,&nbsp;Caroline Fervaille,&nbsp;Jonathan Degosserie,&nbsp;Marie Pouplard,&nbsp;François Mullier","doi":"10.1111/ijlh.14474","DOIUrl":"10.1111/ijlh.14474","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Lymph nodes are essential to diagnose lymphoid neoplasms, metastases, and infections. Some lymphomas, particularly aggressive non-Hodgkin lymphomas (NHL), need urgent diagnosis. Combining lymph node cytology (LNC) and flow cytometry (FC) with other rapidly available parameters through multivariable predictive models could offer valuable diagnostic information while waiting for anatomopathological results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Results of 196 lymph node specimens were retrospectively analyzed for parameters like age, sex, LNC, FC, positron emission tomography scan, lymphocytosis, leukocytosis, lactate dehydrogenase (LDH) levels, and hemoglobin. We constructed five multivariable models predicting the aggressive nature of lymphoma as defined by the anatomopathological diagnostic. The first three were logistic regression models based on two (model 1), four (model 2), and up to 16 independent variables (model 3). The last two models were based on ensemble learning algorithms, bagging (model 4) and boosting (model 5), respectively. The performance of these five models was compared after 10-fold cross-validation, evaluating metrics such as sensitivity, specificity, and the area under the receiver operating characteristic curve (AUC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to individual variables associated with the aggressive nature of the lymphoma (AUCs from 0.69 to 0.87), the multivariable models achieved better AUCs, ranging from 0.88 to 0.94. The best model (model 5) achieved a sensitivity and a specificity of 77% and 94%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>LNC, FC, and other rapidly available parameters are associated with the aggressive nature of the lymphomas. It is possible to combine them in multivariable models to obtain a valuable diagnostic information and to initiate a prompt treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 5","pages":"859-868"},"PeriodicalIF":2.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability of Argatroban Effects on the Multiple APTT Reagents in High and Low Coagulation Activity Samples","authors":"Osamu Kumano,&nbsp;Masahiro Ieko,&nbsp;Teruto Hashiguchi,&nbsp;Takashi Ito,&nbsp;Satoshi Yamazaki,&nbsp;Sumiyoshi Naito,&nbsp;Masako Yamazaki","doi":"10.1111/ijlh.14488","DOIUrl":"10.1111/ijlh.14488","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Argatroban is routinely monitored using activated partial thromboplastin time (APTT), with a recommended target range of 1.5–3.0 times. Although this range was established based on clinical trial data, including several APTT reagents, the differences in reactivity among APTT reagents remain unclear. This study compared the reactivity of six commercial APTT reagents to argatroban in normal and abnormal plasma samples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Normal samples were spiked with argatroban and five abnormal samples: low coagulation factor activity, high factor VIII, high factor VIIa, low fibrinogen, and high fibrinogen. Drug concentrations were adjusted to 0, 0.5, 1.0, 1.5, and 2.0 μg/mL in each plasma. Six APTT reagents, including silica or ellagic acid activator and phospholipids derived from synthetic or natural sources, were tested.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The APTT ratio range among the six reagents was 2.4–3.2 in normal plasma at a concentration of 2.0 μg/mL. The sample showing the most expanded range was low coagulation activity (3.3–5.2), and the range in the sample with high factor VIII activity decreased (1.5–2.2).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A reactivity difference was observed in argatroban-spiked samples, which increased in abnormal plasma samples. APTT may not reflect the anticoagulant activity of argatroban in patients with abnormal coagulation activity. The reactivity of APTT should be confirmed in each laboratory, and patient background coagulation status should be assessed before monitoring is conducted using the APTT ratio.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 5","pages":"923-930"},"PeriodicalIF":2.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijlh.14488","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Clauss Fibrinogen Assay Clot Waveform Analysis for the Detection of Dysfibrinogenemia on Sysmex CN-6000","authors":"Kevin Horner,&nbsp;Steve Kitchen","doi":"10.1111/ijlh.14484","DOIUrl":"10.1111/ijlh.14484","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Dysfibrinogenemia is associated with thrombosis and bleeding. Identification is important as it correlates with adverse clinical outcomes. Clot waveform analysis (CWA) measures optical changes during clot formation to generate a clot waveform curve. Mathematical interpretation allows for the determination of velocity through the first derivative (Min1). Clauss Fibrinogen (CF) Min1 correlates with fibrinogen antigen (FbAg) levels. After calibration, estimated fibrinogen antigen (eAg) can be calculated. Studies have established a ratio of functional fibrinogen activity (FbAc) to eAg (FbAc/eAg) threshold of 0.7 effective for identifying dysfibrinogenemia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Samples were analysed by CN-6000 (Sysmex) for PT-derived fibrinogen, Thrombin and Reptilase Times, CF (Dade Innovin, Thromboclotin, Baxotrobin and Dade Thrombin respectively, Siemens) and FbAg (Liaphen Fibrinogen, Hyphen), along with CF-CWA. The effectiveness of eAg for quantifying fibrinogen was compared to traditional FbAg measurements, along with the efficacy of FbAc/eAg in identifying dysfibrinogenemia relative to the classical FbAc/Ag ratio.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Strong correlations between FbAg and eAg were evident in normal (<i>R</i>\u0000 ² 0.9559) and hypofibrinogenemic (<i>R</i>\u0000 ² 0.9119) cohorts; however, a weak correlation was observed in dysfibrinogenemic cohorts (<i>R</i>\u0000 ² 0.3987). In the dysfibrinogenemic cohort, modification of the test dilution for calculating eAg was assessed; however, these changes did not enhance correlation. eAg values by both dilutions did not impair the ability of the FbAc/eAg ratio to distinguish dysfibrinogenemia from normal and hypofibrinogenemia cohorts, proving as effective as the FbAc/Ag ratio.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results endorse the reliability of the FbAc/eAg ratio as a cost-effective parameter for identifying dysfibrinogenemia, despite eAg quantification limitations in dysfibrinogenemia cases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 5","pages":"915-922"},"PeriodicalIF":2.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapsed Acute Promyelocytic Leukemia With PML: RARA Fusion With Vacuolated Morphology Suggestive of Acute Monocytic/Monoblastic Leukemia","authors":"Fang Long,&nbsp;Ting Li,&nbsp;Yingdong Xu,&nbsp;Fang Chen","doi":"10.1111/ijlh.14485","DOIUrl":"10.1111/ijlh.14485","url":null,"abstract":"","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 5","pages":"788-790"},"PeriodicalIF":2.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Speed Centrifugation Fails to Mitigate Severe Lipemic Interference in D-dimer Measurement","authors":"Xiaoping Xu,&nbsp;Shuqian Cai,&nbsp;Junchi Xue,&nbsp;Junqi Wu","doi":"10.1111/ijlh.14479","DOIUrl":"10.1111/ijlh.14479","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the impact of varying lipid turbidity (LT) levels on D-dimer measurements after routine centrifugation (RC) and high-speed centrifugation (HC) in lipemic samples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Lipemic samples (triglyceride &gt; 1.7 mmol/L) were classified into four LT grades via HIL testing and visual inspection. Coagulation parameters (APTT, TT, FIB, PT-INR, and D-dimer) were compared between RC (2600 × <i>g</i>/10 min) and HC (10 000 × <i>g</i>/10 min) in 104 lipemic and 30 non-lipemic control samples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant differences (<i>p</i> &lt; 0.05) were observed in all coagulation indices between RC and HC for lipemic samples. LT level was positively correlated with TG and total cholesterol (TC). Deviation rates for APTT, TT, FIB, and PT-INR were below 15%, while D-dimer deviation rates exceeded 50% in severe LT (grades 3–4). D-dimer levels in the lipid layer were significantly higher than those in the plasma layer (<i>p</i> &lt; 0.05). HC failed to resolve interference in severely turbid samples, where D-dimer adhered to chylomicron-rich lipid fractions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Contrary to CLSI recommendations, high-speed centrifugation (HC) significantly reduced D-dimer concentrations in the lower plasma layer of severely turbid specimens (e.g., type II hyperlipidemia), failing to mitigate turbidity interference. This discrepancy may lead to misdiagnosis of high-risk thrombotic conditions, such as pancreatitis. The upper lipid layer, predominantly composed of chylomicrons, exhibits a strong binding affinity with D-dimer, further complicating accurate measurement. Direct dilution, however, may resolve measurement failures in severe LT samples by maintaining analyte integrity while eliminating lipid interference.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 5","pages":"906-914"},"PeriodicalIF":2.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knizocytes in an Infant With Hemoglobin CE","authors":"Amr Elgehiny,&nbsp;Sara E. Amin,&nbsp;Ahmed H. Hussein,&nbsp;Nghia D. Nguyen,&nbsp;Lakshmi V. Srivaths","doi":"10.1111/ijlh.14482","DOIUrl":"10.1111/ijlh.14482","url":null,"abstract":"","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 5","pages":"786-787"},"PeriodicalIF":2.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}