International Journal of Laboratory Hematology最新文献

{"title":"Correction to “Improving Platelet Function Following Prophylactic Platelet Transfusion in Patients With Hematological Malignancies”","authors":"","doi":"10.1111/ijlh.14481","DOIUrl":"10.1111/ijlh.14481","url":null,"abstract":"<p>Y. F. Wu, C. L. Shen, W. H. Huang, et al., “Improving Platelet Function Following Prophylactic Platelet Transfusion in Patients With Hematological Malignancies,” <i>International Journal of Laboratory Hematology</i> 46, no. 4 (2024): 722–730, https://doi.org/10.1111/ijlh.14283.</p><p>In the published article, on page 1 of the “Funding Information,” the text “Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Grant/Award Number: TCRD108-73” was incorrect. This should be corrected to: “Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Grant/Award Number: TCRD108-73, and Buddhist Tzu Chi Medical Foundation, Grant/Award Number: TCMMP112-01-03.”</p><p>On page 8 of the “ACKNOWLEDGEMENTS,” the text “This study was supported by a grant (TCRD108-73) from the Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.” was incorrect. This should be corrected to: “This study was supported by grants TCRD108-73 from the Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, and TCMMP112-01-03 from the Buddhist Tzu Chi Medical Foundation, Hualien Tzu Chi Hospital, Hualien, Taiwan.”</p><p>The authors apologize for the error.</p>","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijlh.14481","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic ctDNA Monitoring: A Primary Tool Predictive of Response in a Patient on CAR-T Cell Therapy","authors":"Bhargava Rahul,&nbsp;Nathany Shrinidhi,&nbsp;Sen Ishita,&nbsp;M. Kumar Nikhil,&nbsp;Yadav Chitresh,&nbsp;Swaminathan Anusha,&nbsp;Thakrani Darshan,&nbsp;Verma Kanika,&nbsp;Saini Manish,&nbsp;Dua Vikas","doi":"10.1111/ijlh.14503","DOIUrl":"10.1111/ijlh.14503","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Dynamic monitoring of circulating tumor DNA (ctDNA) offers a non-invasive method to track treatment response in malignancies. While well-established in solid tumors, its role in lymphomas, especially in predicting response to CAR-T cell therapy, remains underexplored—more so in the Indian context. This case highlights ctDNA as a potential predictive biomarker in relapsed/refractory DLBCL undergoing CAR-T therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Report</h3>\u0000 \u0000 <p>A 48-year-old male with transformed follicular lymphoma to DLBCL, refractory to R-CHOP and BR, was treated with anti-CD19 CAR-T cell therapy. Baseline ctDNA profiling from plasma revealed a TP53 p.E286K mutation at 1.3% VAF. Serial monitoring showed a decline to 0.4% at four weeks and complete clearance at eight weeks post-infusion, correlating with metabolic complete response on PET-CT. No co-occurring mutations were observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>This case illustrates how dynamic ctDNA profiling can reflect early molecular response, preceding radiological confirmation. Existing literature suggests that early ctDNA negativity post-CAR-T correlates with improved outcomes. This is the first reported Indian case employing a validated, homebrew NGS-based ctDNA assay to longitudinally track CAR-T response. Incorporating ctDNA-guided surveillance may refine response assessment and reduce unnecessary imaging, optimizing outcomes in resource-constrained settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":"773-776"},"PeriodicalIF":2.2,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Council for Standardization in Haematology (ICSH) Guidance on the Validation of Laboratory Developed Tests in Haemostasis","authors":"Chris Gardiner,&nbsp;Akbar Dorgalaleh,&nbsp;Marión Echenagucia,&nbsp;Robert C. Gosselin,&nbsp;Teruto Hashiguchi,&nbsp;Mingting Peng,&nbsp;Alan Neal,&nbsp;Steve Kitchen","doi":"10.1111/ijlh.14502","DOIUrl":"10.1111/ijlh.14502","url":null,"abstract":"<p>Laboratory developed tests (LDTs) are widely used in clinical hemostasis laboratories. An LDT may be defined as an in vitro diagnostic (IVD) test that is designed, manufactured, and used within a single laboratory. As with all other clinical laboratory tests, LDTs must be validated to ensure fitness for purpose. This may include the assessment of accuracy/comparability, precision, analytical sensitivity, and specificity, reportable range, reference intervals, linearity, and carryover. Not all validation elements will be applicable to all situations, and this will be dictated by the type of assay, the intended use, and the laboratory setting, for example a minor modification of an assay with regulatory approval will require fewer validation procedures than a wholly new test using reagents developed within the laboratory. Many LDTs in the hemostasis laboratory cannot be assessed in the usual fashion, so alternative approaches must be developed.</p>","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":"600-612"},"PeriodicalIF":2.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijlh.14502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Dr. Sorigue's Letter Regarding Our Article: “A New Diagnostic Approach for Myelodysplastic Neoplasms Using a Combination of Scores Based on Flow Cytometry and Automated Hematology Sysmex XN Analyzers”","authors":"Ludovic Firrera,&nbsp;Benjamin Podvin,&nbsp;Julien Herlem,&nbsp;Marion Magierowicz,&nbsp;Alexandre Willaume,&nbsp;Vincent Thibaud,&nbsp;Agnès Charpentier","doi":"10.1111/ijlh.14496","DOIUrl":"10.1111/ijlh.14496","url":null,"abstract":"","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":"777-778"},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of In Vitro Acidification on APTT Measured With Two Different Reagents on Two Different Analyzers","authors":"Debora Olioso,&nbsp;Elia Ponchini,&nbsp;Simone Denitto,&nbsp;Nicola Baratto,&nbsp;Alessandro Lorenzetto,&nbsp;Davide Demonte,&nbsp;Giuseppe Lippi","doi":"10.1111/ijlh.14491","DOIUrl":"10.1111/ijlh.14491","url":null,"abstract":"","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":"767-769"},"PeriodicalIF":2.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric Reference Intervals and Curves for Haemoglobin Estimated Using Direct Methods: A Systematic Review and Meta-Analysis","authors":"Vid Bijelić,&nbsp;Marijana Bijelić,&nbsp;Josh Larock,&nbsp;Michael Pham,&nbsp;Franco Momoli,&nbsp;Mira Liebman,&nbsp;Beth K. Potter,&nbsp;Patricia C. Parkin,&nbsp;Jemila S. Hamid","doi":"10.1111/ijlh.14489","DOIUrl":"10.1111/ijlh.14489","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Introduction&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Haemoglobin is a commonly ordered laboratory test, used to assess both individual and population-level health. To interpret test results, laboratories provide reference intervals (RIs) with lower (2.5th%) and upper (97.5th%) limits according to age and sex. Reference curves (RCs) treat age as a continuous variable. The objectives were to synthesise evidence on Paediatric haemoglobin RIs/RCs and investigate possible sources of heterogeneity. We placed our findings in the context of the age- and sex-based haemoglobin thresholds to define anaemia, recommended for international use by WHO.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We conducted a systematic review of studies publishing Paediatric haemoglobin RIs/RCs (PROSPERO: CRD42023399802). EMBASE, MEDLINE, SCOPUS and The Cochrane electronic libraries were searched from inception to July 31, 2023. Studies involving unhealthy children, lacking males and females RIs/RCs, or limited to cord-blood RIs/RCs were excluded. Studies adhering to guidelines for RIs development from the Clinical Laboratory Standards Institute (CLSI) and RCs studies reporting confidence intervals (CIs) were included in the meta-analysis. Lower and upper males and females RI limits were pooled for age groups with heterogeneity &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; &lt; 75%. All studies meeting eligibility criteria were included in the narrative synthesis. Sources of heterogeneity were analyzed using heatmaps, forest plots and Shiny app.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Of 9123 studies screened, 177 were retained for full-text review. We identified 48 eligible studies (63 529 male and 59 969 female participants) from 25 countries (4 continents) published 1938–2023. There was inconsistency in age partitioning and length of age intervals. Meta-analysis was conducted on 13 studies reporting RIs and 2 studies reporting RCs. Pooled estimates for the 0–3 months age group could not be generated for males or females due to paucity of data. For children aged 3 months or older, both lower and upper RI limits generally increased with age, from approximately 100 to 130 g/L and from approximately 130 to 150 g/L, respectively. For visualisation of our narrative synthesis of all 48 studies, we created a novel web-based computational tool using Shiny-app. Sources of heterogeneity included child age, sex, analyser type and country. For many studies, the lower RIs were substantially different from WHO anaemia thresholds. Study limitations include a small sample size for younger age groups, potentially impacting heterogeneity estimates, reliance on CLSI guidelines due to the lack of a suitable quality assessm","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":"588-599"},"PeriodicalIF":2.2,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijlh.14489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Tranexamic Acid Therapy Corrects the Impaired Epinephrine Aggregation Responses of Quebec Platelet Disorder","authors":"Natalie Mathews,&nbsp;Subia Tasneem,&nbsp;Georges E. Rivard,&nbsp;Catherine P. M. Hayward","doi":"10.1111/ijlh.14492","DOIUrl":"10.1111/ijlh.14492","url":null,"abstract":"","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":"770-772"},"PeriodicalIF":2.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Streamlining the Diagnosis of MDS: Navigating Growing Pains Towards Greater Accuracy and Efficiency","authors":"Marc Sorigue","doi":"10.1111/ijlh.14477","DOIUrl":"10.1111/ijlh.14477","url":null,"abstract":"","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":"760-762"},"PeriodicalIF":2.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensive Care Infection Score (ICIS) is an Early Marker for Infection in Time of Admission to Intensive Care Units","authors":"Filip Vrbacký,&nbsp;Martin Blažek,&nbsp;Ilona Fátorová,&nbsp;Karolína Šímová,&nbsp;Pavel Žák","doi":"10.1111/ijlh.14468","DOIUrl":"10.1111/ijlh.14468","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite all the effort, infections remain one of the major causes of morbidity and mortality in clinically ill patients, and novel diagnostic markers detecting infections in early stages are searched for. Intensive Care Infection Score (ICIS) was developed as such a marker.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 102 patients admitted to intensive care units (ICU) in the University Hospital Hradec Kralove, Czech Republic were enrolled in this study. ICIS along with relevant biochemical markers (procalcitonin, C-reactive protein and Interleukin 6) was analyzed on the day of the admission. Individual parameters used to calculate ICIS were analyzed too. Infection was subsequently confirmed in 30 patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ICIS predicted infections with the highest AUC (0.958) of all analyzed markers. The cut-off value (&lt; 4) was selected as the value with the highest Youden index, and it predicted sepsis with high specificity (84.2%) and sensitivity (93.3%). Negative predictive value was very high too (96.8%). Positive predictive value was 71.8%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ICIS is a reliable, cheap, fast, and simply interpretable score for the early identification of infection in patients admitted to ICUs. ICIS ≥ 4 predicts infection with high sensitivity, specificity, and negative predictive value.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":"707-712"},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of a Drug-Specific Calibration Curve for Monitoring Treatment With Albutrepenonacog Alfa: A Multicenter Study in Argentina","authors":"Pablo Martínez,&nbsp;María Verónica Arrieta,&nbsp;Germán Alejandro Detarsio,&nbsp;Mariana Paula Raviola","doi":"10.1111/ijlh.14469","DOIUrl":"10.1111/ijlh.14469","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Laboratory testing is important for ensuring treatment effectiveness of hemophilia B. The most widely used laboratory test to measure factor IX (FIX) activity is the modified activated partial thromboplastin time (aPTT, one-stage clotting assay [OSA]). Concerns emerged about albutrepenonacog alfa (Idelvion) impact on laboratory measurement. We aimed to evaluate a product-specific calibration curve for determining the activity of Idelvion in Argentina.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In our nationwide, prospective, noninterventional study, a product-specific calibration standard (PCS) was prepared from a reconstituted vial. Commercial FIX-deficient plasma (FIXdp) spiked with Idelvion was used as a normal control (NC:0.7 IU/mL) and low control (LC:0.1 IU/mL). A drug-specific OSA calibration curve was constructed starting from 1.0 IU/mL, followed by serial dilutions. Thirteen different aPTT reagents were used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thiry-six results from 27 Care Centers were retrieved. Median (interquartile range [IQR]) NC local standard human plasma (LSH) and NC PCSs were 0.48 IU/mL (0.38–0.92) and 0.72 IU/mL (0.58–0.82), respectively. Coefficients of variation (CVs) for NC LSH and PCS were 44.6% and 24.8%, respectively; recovery rates (± 20%) were 22% and 83%. Median LC LSH and PCS were 0.09 IU/mL (0.07–0.13) and 0.10 IU/mL (0.07–0.13), respectively; CVs for LC LSH and PCS were 104.8% and 24.7%. Recovery rates (±30%) were 58% and 89%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Idelvion-specific calibration curve showed better performance and lower CV rates independently of the aPTT reagent or the platform used. Calibration using this specific standard might allow more laboratories to obtain acceptable FIX values when processing NC and LC levels and patients' plasmas.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"47 4","pages":"713-719"},"PeriodicalIF":2.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}