Breaking Free From MCHC Interferences? French-Speaking Cellular Haematology Group (GFHC) Review of Causes, Rising Trends and Practical Solutions

IF 2.3 4区 医学 Q3 HEMATOLOGY
Sandrine Girard, Yaël Berda-Haddad, Chantal Brouzes, Bouchra Badaoui, Agathe Boussaroque, Alexandre Janel, Bernard Chatelain, Véronique Baccini
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引用次数: 0

Abstract

Mean corpuscular haemoglobin concentration (MCHC) is determined by the ratio of haemoglobin concentration to haematocrit. Managing increased MCHC presents significant challenges, mainly due to variations in analytical methods and pathophysiological conditions. Depending on the haematological analyser (HA), MCHC can be measured directly or calculated. It is important that all people involved in hematocytometry must identify and correct artefacts to ensure accurate erythrocyte parameters. In order to harmonise and standardise haematology practices in all laboratories, the French-speaking Cellular Haematology Group (GFHC) has reviewed the interferences and pathophysiological situations that could increase MCHC, and the advice on how to manage cases of elevated MCHC. We will review current techniques, such as impedance and optical methods, for accurate determination of MCHC. We will also examine the interferences that can artificially increase MCHC; and the pathophysiological conditions responsible for such increases. Finally, we will present guidelines for the management of elevated MCHC, including strategies to bypass interferences and determine which erythrocyte parameters can be reliably reported, as well as the acceptable MCHC values for various pathophysiological variations.

Abstract Image

摆脱母婴健康中心的干扰?法语细胞血液病小组(GFHC)的原因,上升趋势和实际解决方案的审查。
红细胞平均血红蛋白浓度(MCHC)由血红蛋白浓度与红细胞压积的比值决定。管理增加的MCHC提出了重大挑战,主要是由于分析方法和病理生理条件的变化。根据血液学分析仪(HA), MCHC可以直接测量或计算。重要的是,所有参与血细胞测定的人必须识别和纠正伪影,以确保准确的红细胞参数。为了协调和标准化所有实验室的血液学操作,法语细胞血液学小组(GFHC)审查了可能增加母婴健康的干扰和病理生理情况,以及如何管理母婴健康升高病例的建议。我们将回顾当前的技术,如阻抗和光学方法,以准确测定MCHC。我们还将研究人为增加MCHC的干扰;以及导致这种增加的病理生理条件。最后,我们将提出MCHC升高的管理指南,包括绕过干扰的策略,确定哪些红细胞参数可以可靠地报告,以及各种病理生理变化的可接受的MCHC值。
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来源期刊
CiteScore
4.50
自引率
6.70%
发文量
211
审稿时长
6-12 weeks
期刊介绍: The International Journal of Laboratory Hematology provides a forum for the communication of new developments, research topics and the practice of laboratory haematology. The journal publishes invited reviews, full length original articles, and correspondence. The International Journal of Laboratory Hematology is the official journal of the International Society for Laboratory Hematology, which addresses the following sub-disciplines: cellular analysis, flow cytometry, haemostasis and thrombosis, molecular diagnostics, haematology informatics, haemoglobinopathies, point of care testing, standards and guidelines. The journal was launched in 2006 as the successor to Clinical and Laboratory Hematology, which was first published in 1979. An active and positive editorial policy ensures that work of a high scientific standard is reported, in order to bridge the gap between practical and academic aspects of laboratory haematology.
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