International journal of hygiene and environmental health最新文献

{"title":"Association between mixed exposure to per- and polyfluoroalkyl substances and metabolic syndrome in Korean adults: Data from the Korean National environmental health survey cycle 4","authors":"Seung Min Chung ,&nbsp;Kyun Hoo Kim ,&nbsp;Jun Sung Moon ,&nbsp;Kyu Chang Won","doi":"10.1016/j.ijheh.2024.114427","DOIUrl":"10.1016/j.ijheh.2024.114427","url":null,"abstract":"<div><h3>Aim</h3><p>To explore the effect of mixed exposure to per- and polyfluoroalkyl substances (PFAS) on metabolic syndrome (MetS).</p></div><div><h3>Methods</h3><p>This cross-sectional study used data from the Korean National Environmental Health Survey Cycle 4 (2018–2020). The serum concentrations of five PFAS (perfluorooctanoic acid [PFOA], perfluorooctanesulfonic acid [PFOS], perfluorohexanesulfonic acid, perfluorononanoic acid [PFNA], and perfluorodecanoic acid [PFDeA]) were measured, and the relative potency factor approach was employed for the mixture of PFAS (Cmix) assessment. MetS was diagnosed if the patient satisfied three of five criteria: central obesity, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure (BP), and elevated glycated hemoglobin (HbA1c). Age, sex, smoking, drinking, and exercise status were considered as covariates. The risk of MetS for single and mixed exposure to PFAS was analyzed using binomial regression and Bayesian kernel machine regression (BKMR).</p></div><div><h3>Results</h3><p>A total of 2984 (male:female = 1:1.3; age range, 19–80 years) adults were enrolled. The prevalence of MetS was 45.6%. Each PFAS and Cmix levels were higher in participants with MetS than in those without MetS. Cmix increased the risk of elevated BP and HbA1c, and eventually MetS (odds ratio [OR] = 2.00, 95% confidence interval [CI] 1.11–3.60 per log₁₀Cmix; OR = 1.57, 95% CI 1.07–2.31 in the highest quartile of Cmix [Q4] vs. the lowest [Q1]). Sex-specific analyses revealed that the impact of Cmix was valid in females but not in males (Cmix Q4 vs. Q1: OR = 1.01, 95% CI 0.57–1.8 in males; OR = 2.30, 95% CI 1.38–3.84 in females). In the BKMR analysis, mixed exposure to PFAS dose-dependently increased the risk of MetS, particularly in females. Among single exposures, PFNA contributed significantly to the cumulative effect.</p></div><div><h3>Conclusion</h3><p>Mixed exposure to PFAS was associated with a higher risk of MetS in females. Further studies on potential health concerns associated with PFAS mixtures are warranted.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114427"},"PeriodicalIF":4.5,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141729506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual and joint effects of organophosphate esters and hypertension or diabetes on renal injury among Chinese adults","authors":"Sijie Yang ,&nbsp;Yaping Li ,&nbsp;Mingye Zhang ,&nbsp;Qitong Xu ,&nbsp;Chang Xie ,&nbsp;Zhengce Wan ,&nbsp;Lulu Song ,&nbsp;Yongman Lv ,&nbsp;Youjie Wang ,&nbsp;Hui Chen ,&nbsp;Surong Mei","doi":"10.1016/j.ijheh.2024.114424","DOIUrl":"10.1016/j.ijheh.2024.114424","url":null,"abstract":"<div><p>Exposure to environmental contaminants and the development of hypertension and diabetes represent crucial risk factors for chronic kidney disease (CKD). Toxicological studies have revealed that organophosphate esters (OPEs) impair kidney function. However, the joint effects of OPE exposure on kidney injury and the interactions of OPE exposure with hypertension or diabetes on kidney injury remain unclear. Our study aimed to investigate the individual and joint effects of OPE exposure on renal injury, as well as the potential interaction between OPE exposure and hypertension or diabetes on kidney injury. The study enrolled 1938 participants from Wuhan, China. To explore the relationship between OPE exposure and renal injury, we conducted multivariate linear and logistic regression analysis. The results indicated that each unit increase in 4-hydroxyphenyl diphenyl phosphate (4-HO-DPHP), bis(2-butoxyethyl) phosphate (BBOEP), and tris(2-chloroethyl) phosphate (TCEP) (1 μg/L-ln transformed) was associated with a decreased 0.57 mL/min/1.73 m² (95%CI: -1.05, −0.09), 0.85 mL/min/1.73 m² (95%CI: -1.52, −0.19) and 1.24 mL/min/1.73 m² (95%CI: -2.26, −0.23) of estimated glomerular filtration rate (eGFR), while each unit increase in 4-HO-DPHP and BBOEP (1 μg/L-ln transformed) was associated with 14% and 20% elevation of incident impaired renal function (IRF) risk. Notably the highest tertile of BCIPHIPP was positively associated with eGFR, although the p for trend ＞ 0.05. We employed Bayesian kernel machine regression (BKMR) and quartile-based g-computation (qgcomp) models to explore the joint effects of OPE mixtures on eGFR and IRF. Both the results of BKMR and qgcomp model consistently demonstrated negative associations between OPE mixtures and eGFR, and TCEP and 4-HO-DPHP were major contributors. Furthermore, we observed multiplicative interactions of diphenyl phosphate (DPHP), BBOEP, di-ocresyl phosphate (DoCP) &amp; di-p-cresyl phosphate (DpCP), 1-hydroxy-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP) and hypertension or diabetes on kidney injury (all <em>P</em>＜0.05). Those with diabetes or hypertension and higher OPE metabolite concentrations had increased risk of kidney function impairment compared to those who did not have diabetes or hypertension. These findings suggest that specific OPE exposure may elevate the risk of renal injury, particularly among hypertensive and diabetic populations.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114424"},"PeriodicalIF":4.5,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phthalate exposure during pregnancy and its association with thyroid hormones: A prospective cohort study","authors":"Iman Al-Saleh ,&nbsp;Rola Elkhatib ,&nbsp;Reem Alghamdi ,&nbsp;Nujud Alrushud ,&nbsp;Hissah Alnuwaysir ,&nbsp;Maha Alnemer ,&nbsp;Hesham Aldhalaan ,&nbsp;Mohamed Shoukri","doi":"10.1016/j.ijheh.2024.114421","DOIUrl":"10.1016/j.ijheh.2024.114421","url":null,"abstract":"&lt;div&gt;&lt;p&gt;Phthalate esters (PAEs) possess endocrine-disrupting properties. Studies in humans have indicated that &lt;em&gt;in utero&lt;/em&gt; phthalate exposure affects maternal thyroid hormones, which are essential for fetal growth and development. However, these studies also reported inconsistent results on the relationship between phthalates and thyroid hormones. This prospective cohort study aimed to assess phthalate exposure across the three trimesters of pregnancy and its association with thyroid hormone levels. From 2019 to 2022, we recruited 672 pregnant women, and two urine samples and one blood sample were collected from each participant during the pregnancy. We examined the urine samples from 663, 335, and 294 women in the first, second, and third trimester, respectively, for the following seven phthalate metabolites: monoethyl phthalate (MEP) from diethyl phthalate (DEP); mono-n-butyl phthalate (M&lt;em&gt;n&lt;/em&gt;BP) and mono-iso-butyl phthalate (M&lt;em&gt;i&lt;/em&gt;BP) from dibutyl phthalate (DBP); monobenzyl phthalate (MB&lt;em&gt;z&lt;/em&gt;P) from butyl benzyl phthalate; and three di(2-ethylhexyl) phthalate (DEHP) metabolites, mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP). Additionally, we examined the levels of free thyroxine (FT4), thyroid-stimulating hormone (TSH), and total triiodothyronine (TT3) in the serum samples of the following participants: 596, 627, and 576 in the first trimester; 292, 293, and 282 in the second trimester; and 250, 250, and 248 in the third trimester, respectively. Other than MBzP, which was detected in 25%–33% of the samples, other metabolites were detectable in &gt;86% of urine samples, indicating widespread exposure to DEP, DBP, and DEHP. The detected phthalate exposure levels in our cohort were significantly higher than those reported in other countries. Metabolite levels varied across the trimesters, implying changes in exposure and metabolism throughout pregnancy. The observed variability in urinary concentrations of phthalate metabolites, which ranged from poor to moderate, underscores the importance of taking multiple measurements during pregnancy for precise exposure assessment. Using a linear mixed model, we analyzed the effects of repeated phthalate exposure on thyroid hormone levels while adjusting for potential confounders. We observed significant linear trends in FT4, TSH, and, to a lesser extent, TT3 across quartiles of specific phthalate metabolites. Comparing the highest to the lowest quartiles, we found a significant increase in FT4 levels, ranging from 2 to 3.7%, associated with MEP; MECPP; MEHHP; and the sum of seven metabolites (∑&lt;sub&gt;7&lt;/sub&gt;PAE), three DEHP metabolites (∑&lt;sub&gt;3&lt;/sub&gt;DEHP), two DBP metabolites (∑DBP), and both low molecular weight (∑LMW) and high molecular weight metabolites. Increased TSH levels (5%–16%) were observed for all phthalate metabolites (except MEHHP) and their molar sums, including ∑&lt;sub&gt;7&lt;/s","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114421"},"PeriodicalIF":4.5,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924001020/pdfft?md5=c4e404d1559741baa0d58ea05bfb9af3&pid=1-s2.0-S1438463924001020-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of antenatal exposure to a mixture of persistent organic pollutants on intellectual development","authors":"Christophe Barrea ,&nbsp;Patrice Dufour ,&nbsp;Pirard Catherine ,&nbsp;Corinne Charlier ,&nbsp;Fanny Brevers ,&nbsp;Laurence Rousselle ,&nbsp;Anne-Simone Parent","doi":"10.1016/j.ijheh.2024.114422","DOIUrl":"10.1016/j.ijheh.2024.114422","url":null,"abstract":"<div><h3>Objective</h3><p>Strong experimental evidence exists that several endocrine disrupting chemicals (EDCs) have neurobehavioral toxicity. However, evidence of associations between prenatal exposure and child's cognitive development is inconsistent. Moreover, toxicants are generally analyzed one by one without considering aggregate effects. We examined here the impact of a prenatal exposure to a mixture of persistent organic pollutants (POPs) on intellectual abilities in preschool children, and compared their effects to those described in the literature.</p></div><div><h3>Methods</h3><p>Sixty-two children were included in a longitudinal cohort. Four organochlorine pesticides, four polychlorinated biphenyls (PCBs) and seven perfluorinated compounds (PFCs) were measured in cord blood. Intellectual abilities were assessed at 6 years of age using the Wechsler Preschool and Primary Scale of Intelligence 4th ed. (WPPSI-IV). We examined the associations between a mixture of POPs and cognitive performances using principal components approach (PCA) and weighted quantile sum (WQS) regression taking sex difference into account.</p></div><div><h3>Results</h3><p>No negative correlation was found when analyses were performed on boys and girls together. In sex-stratified analyses, lower scores in full scale intelligence quotient (FSIQ) and fluid reasoning index (FRI) were observed in boys most exposed to a mixture of POPs. Increase of the WQS index was also associated with lower verbal comprehension index (VCI) scores in girls only. No other negative correlation was found using both WQS and PCA models.</p></div><div><h3>Conclusion</h3><p>Our study suggests deleterious associations between antenatal exposure to a mixture of POPs and sex-specific cognitive level, clarifying some trends described in the literature.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114422"},"PeriodicalIF":4.5,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation as a pathway for heavy metal-induced liver damage—Insights from a repeated-measures study in residents exposed to metals and bioinformatics analysis","authors":"Shuanzheng Zhao ,&nbsp;Guohuan Yin ,&nbsp;Meiduo Zhao ,&nbsp;Jingtao Wu ,&nbsp;Xiaolin Liu ,&nbsp;Lanping Wei ,&nbsp;Qun Xu ,&nbsp;Jing Xu","doi":"10.1016/j.ijheh.2024.114417","DOIUrl":"10.1016/j.ijheh.2024.114417","url":null,"abstract":"<div><h3>Background</h3><p>Epidemiological studies on heavy metal exposure and liver injury are predominantly cross-sectional, lacking longitudinal data and exploration of potential mechanisms.</p></div><div><h3>Method</h3><p>We conducted a repeated-measures study in Northeast China from 2016 to 2019, involving 322 participants. Linear mixed models (LMM) and Bayesian kernel machine regression (BKMR) were employed to explore the associations between individual and mixed blood metal concentrations [chromium (Cr), cadmium (Cd), vanadium (V), manganese (Mn), lead (Pb)] and liver function biomarkers [alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB), globulin (GLB), total protein (TP)]. Mediation and enrichment analyses were used to determine whether the inflammatory response is a critical pathway for heavy metal-induced liver damage.</p></div><div><h3>Result</h3><p>We obtained a total of 958 observations. The results from LMM and BKMR indicated significant associations between individual and mixed heavy metals and liver function biomarkers. Longitudinal analysis revealed associations between Cd and the annual increase rate of ALT (<em>β</em> = 2.61; 95% CI: 0.97, 4.26), the annual decrease rate of ALB (<em>β</em> = −0.21; 95% CI: −0.39, −0.03), Mn and the annual increase rate of GLB (<em>β</em> = 0.38; 95% CI: 0.05, 0.72), and V and the annual decrease rate of ALB/GLB (<em>β</em> = −1.15; 95% CI: −2.00, −0.31). Mediation analysis showed that high-sensitivity C-reactive protein (hsCRP) mediated the associations between Cd and AST, TP, with mediation effects of 27.7% and 13.4%, respectively. Additionally, results from Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses supported the role of inflammatory response pathways.</p></div><div><h3>Conclusion</h3><p>Our findings indicate that heavy metal exposure leads to liver damage, with the inflammatory response potentially serving as a crucial pathway in this process. This study offers a novel perspective on understanding heavy metal-induced liver injury and provides insights for preventive measures against the health damage caused by heavy metals.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114417"},"PeriodicalIF":4.5,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal exposure to polycyclic aromatic hydrocarbons and phthalate acid esters and gestational diabetes mellitus: A prospective cohort study","authors":"Minghao Guo ,&nbsp;Yiwei Fang ,&nbsp;Meilin Peng ,&nbsp;Chao He ,&nbsp;Jin Chen ,&nbsp;Borui Sun ,&nbsp;Chunyan Liu ,&nbsp;Yuanzhong Zhou ,&nbsp;Huiping Zhang ,&nbsp;Kai Zhao","doi":"10.1016/j.ijheh.2024.114419","DOIUrl":"10.1016/j.ijheh.2024.114419","url":null,"abstract":"<div><h3>Background</h3><p>Polycyclic aromatic hydrocarbons and phthalate acid esters (PAHs &amp; PAEs), known as endocrine disrupting chemicals (EDCs), widely exist in daily life and industrial production. Previous studies have suggested that PAHs &amp; PAEs may modify the intrauterine homeostasis and have adverse effects on fetal development. However, epidemiological evidence on the associations between PAHs &amp; PAEs and gestational diabetes mellitus (GDM) is still limited.</p></div><div><h3>Objective</h3><p>To investigate the effects of prenatal PAHs &amp;PAEs exposure on the risk of GDM and hyperglycemia in pregnant women.</p></div><div><h3>Methods</h3><p>The study population was a total of 725 pregnant women from a prospective birth cohort study conducted from December 2019 to December 2021. Blood glucose levels were collected by the hospital information system. Urinary PAHs &amp; PAEs concentrations were determined by gas chromatography tandem mass spectrometry. The Poisson regression in a generalized linear model (GLM), multiple linear regression, quantile-based g-computation method (qgcomp), and Bayesian kernel machine regression (BKMR) were applied to explore and verify the individual and overall effects of PAHs &amp; PAEs on glucose homeostasis. Potential confounders were adjusted in all statistical models.</p></div><div><h3>Results</h3><p>A total of 179 (24.69%) women were diagnosed with GDM. The Poisson regression suggested that a ln-unit increment of 4-OHPHE (4-hydroxyphenanthrene) (adjusted Risk Ratio (aRR) = 1.13; 1.02–1.26) was associated with the increased GDM risk. Mixed-exposure models showed similar results. We additionally found that MBZP (mono-benzyl phthalate) (aRR = 1.19; 1.02–1.39) was positively related to GDM risk in qgcomp model. Although neither model demonstrated that 2-OHNAP (2-hydroxynaphthalene) and 9-OHFLU (9-hydroxyfluorene) increased the risk of GDM, 2-OHNAP and 9-OHFLU exposure significantly increased blood glucose levels. BKMR model further confirmed that overall effects of PAHs &amp; PAEs were significantly associated with the gestational hyperglycemia and GDM risk.</p></div><div><h3>Conclusions</h3><p>Our study presents that environmental exposure to PAHs &amp; PAEs was positively associated with gestational glucose levels and the risks of developing GDM. In particular, 2-OHNAP, 9-OHFLU, 4-OHPHE and MBZP may serve as important surveillance markers to prevent the development of GDM.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114419"},"PeriodicalIF":4.5,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts","authors":"Carmen Freire ,&nbsp;Francesca Castiello ,&nbsp;Izaro Babarro ,&nbsp;Augusto Anguita-Ruiz ,&nbsp;Maribel Casas ,&nbsp;Martine Vrijheid ,&nbsp;Blanca Sarzo ,&nbsp;Andrea Beneito ,&nbsp;Manik Kadawathagedara ,&nbsp;Claire Philippat ,&nbsp;Cathrine Thomsen ,&nbsp;Amrit Kaur Sakhi ,&nbsp;Maria-Jose Lopez-Espinosa","doi":"10.1016/j.ijheh.2024.114418","DOIUrl":"10.1016/j.ijheh.2024.114418","url":null,"abstract":"<div><h3>Background</h3><p>There is limited epidemiological evidence on the association of prenatal exposure to phthalates and synthetic phenols with altered pubertal timing.</p></div><div><h3>Objective</h3><p>To examine the association of prenatal exposure to phthalates, bisphenol A (BPA), parabens, benzophenone 3 (BP-3), and triclosan (TCS) with pubertal development in girls and boys from three European cohorts.</p></div><div><h3>Methods</h3><p>Urinary metabolites of six different phthalate diesters (DEP, DiBP, DnBP, BBzP, DEHP, and DiNP), BPA, methyl- (MePB), ethyl- (EtPB), propyl- (PrPB), and butyl-paraben (BuPB), BP-3, and TCS were quantified in one or two (1st and 3rd trimester) urine samples collected during pregnancy (1999–2008) from mothers in three birth cohorts: INMA (Spain), EDEN (France), and MoBa (Norway). Pubertal development of their children was assessed at a single visit at age 7–12 years (579 girls, 644 boys) using the parent-reported Pubertal Development Scale (PDS). Mixed-effect Poisson and g-computation and Bayesian Kernel Machine Regression (BKMR) were employed to examine associations of individual and combined prenatal chemical exposure, respectively, with the probability of overall pubertal onset, adrenarche, and gonadarche (stage 2+) in girls and boys. Effect modification by child body mass index (BMI) was also assessed.</p></div><div><h3>Results</h3><p>Maternal concentrations of the molar sum of DEHP and of DiNP metabolites were associated with a slightly higher probability of having started puberty in boys (relative risk, RR [95% CI] = 1.13 [0.98–1.30] and 1.20 [1.06–1.34], respectively, for a two-fold increase in concentrations), with a stronger association for DiNP in boys with overweight or obesity. In contrast, BPA, BuPB, EtPB, and PrPB were associated with a lower probability of pubertal onset, adrenarche, and/or gonadarche in all boys (<em>e.g.</em> overall puberty, BPA: RR [95% CI] = 0.93 [0.85–1.01] and BuPB: 0.95 [0.90–1.00], respectively), and the association with BPA was stronger in boys with underweight/normal weight. In girls, MEHP and BPA were associated with delayed gonadarche in those with underweight/normal weight (RR [95% CI] = 0.86 [0.77–0.95] and 0.90 [0.84–0.97], respectively). Most of these associations were trimester specific. However, the chemical mixture was not associated with any pubertal outcome in boys or girls.</p></div><div><h3>Conclusions</h3><p>Prenatal exposure to certain phthalates and synthetic phenols such as BPA may impact the pubertal development of boys, and weight status may modify this effect. BPA may also alter the pubertal development of girls.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114418"},"PeriodicalIF":4.5,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924000993/pdfft?md5=ac171343a92a8e90deda08695602e71b&pid=1-s2.0-S1438463924000993-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer incidence in Swedish oil refinery workers exposed to benzene","authors":"E.M. Andersson ,&nbsp;L. Barregard ,&nbsp;M. Akerstrom ,&nbsp;G. Sallsten ,&nbsp;B. Järvholm ,&nbsp;R.I. Nilsson","doi":"10.1016/j.ijheh.2024.114420","DOIUrl":"10.1016/j.ijheh.2024.114420","url":null,"abstract":"<div><h3>Background</h3><p>Oil refinery workers are exposed to benzene, which is a well-known cause of leukaemia, but results on leukaemia in oil refinery workers have been mixed, and the data on workers’ exposure is limited. Oil refinery workers are also exposed to asbestos and several studies have shown increased risk of mesothelioma.</p></div><div><h3>Aim</h3><p>The objective was to investigate cancer incidence, especially leukaemia, at low to moderate exposure to benzene in an update of a previous study of employees at three Swedish oil refineries.</p></div><div><h3>Methods</h3><p>Cancer incidence was followed up in 2264 men (1548 refinery operators) employed at three oil refineries in Sweden for at least one year. Job types and employment times were collected from complete company files. A retrospective assessment of the benzene exposure was performed by occupational hygienists in collaboration with the refineries using historic measurements as well as detailed information on changes in the industrial hygiene and technological developments. Cases of cancer were retrieved by a linkage with the Swedish Cancer Register through 35–47 years of follow-up and standardized incidence ratios (SIR) with 95% confidence intervals (CI) were calculated.</p></div><div><h3>Results</h3><p>In total, 258 tumors had occurred versus 240 expected (SIR 1.07; 95% CI 0.95–1.21). There were 10 cases of leukaemia, all in refinery operators (SIR 2.4; 95% CI 1.18–4.51). There were three cases of pleural mesothelioma, two of which in refinery operators. The mean estimated cumulative benzene exposure for the cases of leukaemia was 7.9 ppm-years (median 4.9, range 0.1–31.1).</p></div><div><h3>Discussion</h3><p>The study suggests that low to moderate average cumulative benzene exposure increases the risk of leukaemia. Limitations include the modest number of cases and potential misclassification of exposure.</p></div><div><h3>Conclusion</h3><p>The present study indicated an increased risk of leukaemia in male oil refinery workers with low to moderate exposure to benzene.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114420"},"PeriodicalIF":4.5,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924001019/pdfft?md5=d38eff61ad991bfd1b0aafb2a4b78489&pid=1-s2.0-S1438463924001019-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outbreak of cholera due to contaminated pond water utilisation in a rural area of West Bengal, India, 2021","authors":"Dhiraj Roy ,&nbsp;Tanima Roy Mondal ,&nbsp;Pallavi Indwar","doi":"10.1016/j.ijheh.2024.114409","DOIUrl":"10.1016/j.ijheh.2024.114409","url":null,"abstract":"<div><h3>Background</h3><p>On March 31, 2021, an outbreak of diarrhoeal disease was reported in Dangapara village of Purba Bardhaman district, West Bengal, India. The outbreak was investigated to estimate the magnitude, identify aetiological agents and source of infection, and guide prevention control measures.</p></div><div><h3>Methods</h3><p>We did an active search for case patients at Dangapara village. We excluded children under five years of age from the epidemiological analysis. We described the outbreak by time, place, and person. We conducted a case control study with 133 controls and 65 cases. Water samples from different sources and rectal swabs from case patients were collected and sent for laboratory investigations.</p></div><div><h3>Results</h3><p>We identified 95 case patients among 330 residents of Dangapara village (attack rate 29 %). Three stool samples were positive for <em>Vibrio cholerae</em>, and two pond water samples were contaminated with coliform organisms. Washing utensils [adjusted odds ratio (AOR): 69.8, (95% confidence interval (CI) 6.5–749.5)] and taking a bath in pond water [AOR: 3.4, (95% CI 1.2–9)] were associated with increased risk of illness. About 97% of cases were attributed to washing utensils in pond water. Washing hands before taking food was associated with a lower risk of developing disease with AOR: 0.1 (95% CI 0.03–0.33).</p></div><div><h3>Conclusion</h3><p>A cholera outbreak occurred among residents of Dangapara village due to theuse of contaminated pond water for washing utensils and bathing. Prompt management of cases and immediate discontinuation of pond water use stopped the outbreak.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114409"},"PeriodicalIF":4.5,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of metals with early postnatal gut microbiota among infants admitted to the neonatal intensive care unit","authors":"Shi-ting Xiang ,&nbsp;Changci Zhou ,&nbsp;Kunyan Zhao ,&nbsp;Ye Ma ,&nbsp;Ruiwen Huang ,&nbsp;Yunlong Peng ,&nbsp;Yan Tang ,&nbsp;Fei Yang ,&nbsp;Jun Qiu","doi":"10.1016/j.ijheh.2024.114410","DOIUrl":"10.1016/j.ijheh.2024.114410","url":null,"abstract":"<div><p>The gut microbiota is closely related to infant health. However, the impact of environmental factors on the gut microbiota has not been widely investigated, particularly in vulnerable populations such as infants admitted to the neonatal intensive care unit (NICU). This study investigated the association between exposure to 12 metals and the composition of the gut microbiota in infants admitted to the NICU. Metal concentrations were determined in serum samples obtained from 107 infants admitted to the NICU at Hunan Children's hospital, China. Gut microbiota data were derived from 16S rRNA sequencing using stool samples. Generalized linear regression (GLR) models and Bayesian kernel machine regression (BKMR) analyses were used to estimate the associations between metals and both alpha-diversity indices and bacterial taxa. The GLR models showed that tin correlated negatively with the Shannon index (β = −0.55, 95% conficence interval [CI]: −0.79, −0.30, <em>P</em>_FDR&lt; 0.001) and positively with the Simpson index (β = 0.26, 95% CI: 0.13, 0.39, <em>P</em>_FDR&lt; 0.001). The BKMR analysis yielded similar results, showing that tin had the largest posterior inclusion probability for both the Shannon (0.986) and the Simpson (0.796) indices. Tin, cadmium, mercury, lead, and thallium were associated with changes in one or more taxa at the genus level. The BKMR analysis also revealed a negative correlation between metal mixtures and <em>Clostridium_sensu_stricto</em>, and tin contibuted mostly to the negative correlation. Early postnatal exposure to metals were associated with differences in the microbiome among infants admitted to the NICU. However, as the study was cross-sectional, these relationships must be confirmed in further studies.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"261 ","pages":"Article 114410"},"PeriodicalIF":4.5,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}