International Journal of Endocrinology最新文献

{"title":"Beyond Drugs and Surgery: Superselective Adrenal Artery Embolization Redefines Primary Aldosteronism Management-A Systematic Review and Meta-Analysis.","authors":"Kimia Darmiani, Mehrad Zare, Alisa Mohebbi, Mohammad Mirza-Aghazadeh-Attari, Mohammad Ghasemi Rad, Afshin Mohammadi","doi":"10.1155/ije/7534774","DOIUrl":"10.1155/ije/7534774","url":null,"abstract":"<p><strong>Background: </strong>Primary aldosteronism (PA) is a leading cause of secondary hypertension associated with increased cardiovascular and cerebrovascular risk. Superselective adrenal artery embolization (SAAE) has emerged as a minimally invasive alternative to adrenalectomy and mineralocorticoid receptor antagonists (MRAs). This systematic review and meta-analysis evaluates the efficacy and safety of SAAE in PA management.</p><p><strong>Methods: </strong>We searched PubMed, Web of Science, Embase, and Cochrane Library through June 2026 for studies enrolling patients with PA treated by SAAE. Outcomes of interest were changes in blood pressure (BP), biochemical markers (serum potassium, aldosterone, renin activity, and aldosterone-to-renin ratio), clinical and biochemical response rates, daily defined dose change, and adverse events. Data were pooled using a random-effects model.</p><p><strong>Results: </strong>Nineteen studies comprising 1242 patients undergoing SAAE met inclusion criteria. SAAE achieved substantial BP reductions: office systolic BP -19.71 mmHg (<i>p</i> < 0.001), office diastolic BP -10.91 mmHg (<i>p</i> < 0.001), home systolic BP -18.58 mmHg (<i>p</i> < 0.001), and 24-h ambulatory systolic BP -14.57 mmHg (<i>p</i> < 0.001). Serum potassium increased +0.34 mmol/L (<i>p</i> < 0.001), aldosterone declined -46.72 ng/dL (<i>p</i> < 0.001), and ARR decreased -32.64 (<i>p</i> < 0.001). Complete clinical response occurred in 27% and partial response in 43%; complete biochemical success was achieved in 48% with partial success in 16%. Antihypertensive burden decreased (-0.52 daily defined dose; <i>p</i> < 0.001). Adverse events were predominantly minor (postprocedural pain 37.17%, low-grade fever 8.55%); serious complications were uncommon (< 1%).</p><p><strong>Conclusions: </strong>SAAE is an effective and somewhat safe treatment for PA that achieves meaningful BP control, biochemical normalization, and reduced medication burden. It represents a valuable option for patients ineligible for or intolerant of surgery or MRAs.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"7534774"},"PeriodicalIF":2.5,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13389810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148561766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Associations of Heparin-Binding Growth and Differentiation Factors With Thyroid Cancer: A Two-Sample Mendelian Randomization Study.","authors":"Xiwei Zhang, Dongqiang Yang, Yan Liu, Yanzhao Wu, Ping Shi","doi":"10.1155/ije/6165618","DOIUrl":"10.1155/ije/6165618","url":null,"abstract":"<p><strong>Background: </strong>Heparin-binding growth and differentiation factors (GDFs) play roles in various cellular processes and are potential contributors to thyroid cancer. Although population-based studies have documented associations between heparin-binding GDFs and thyroid cancer, their causal relationships remain unclear.</p><p><strong>Methods: </strong>A two-sample Mendelian randomization (MR) analysis was conducted using published genome-wide association studies (GWASs) data. The primary method for estimating causal effects was the inverse-variance weighted (IVW) approach, supplemented by multiple sensitivity analyses including weighted median, MR-Egger, and MR-PRESSO. Heterogeneity and outlier effects were systematically evaluated. Additionally, key MR findings were validated at the transcriptomic level using differential expression analysis of data from the Cancer Genome Atlas (TCGA).</p><p><strong>Results: </strong>The IVW method revealed significant causal relationships between midkine levels (OR = 1.2099, 95% CI: 1.013-1.445, <i>p</i> = 0.0355) and IGF2 (OR = 0.7496, 95% CI: 0.6056-0.9279, <i>p</i> = 0.0081) with thyroid cancer and between heparin-binding EGF-like growth factor and malignant thyroid neoplasms (OR = 0.8821, 95% CI: 0.7873-0.9882, <i>p</i> = 0.0304). Heterogeneity was identified in the association between FGF1 and malignant thyroid neoplasms (<i>Q</i> = 20.725, <i>p</i> = 0.036). Neither MR-Egger analysis nor the MR-PRESSO global test found evidence of horizontal pleiotropy in the association between heparin-binding GDFs and thyroid cancer. The robustness of these findings was supported by sensitivity analyses, and transcriptomic analysis of TCGA data further revealed that midkine (<i>MDK</i> was significantly upregulated in thyroid tumor tissues.</p><p><strong>Conclusions: </strong>Genetically predicted midkine levels and IGF2 were associated with thyroid cancer, and heparin-binding EGF-like growth factor was associated with malignant thyroid neoplasms. Future studies are needed to validate these findings.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"6165618"},"PeriodicalIF":2.5,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13373531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148470317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically Predicted Causal Relationship Between Polycystic Ovary Syndrome and Preeclampsia.","authors":"Guige Xue, Xuegui Zhou, Huan Zhang, Jinfang Wang, Xiaohua Song","doi":"10.1155/ije/5536687","DOIUrl":"10.1155/ije/5536687","url":null,"abstract":"<p><strong>Background: </strong>Clarifying the causal relationship between polycystic ovary syndrome (PCOS) and its characteristic markers with preeclampsia (PE) is of utmost importance in preventing the development of PE. Observational studies have investigated the relationship, but the conclusions have been inconsistent.</p><p><strong>Methods: </strong>Utilizing publicly accessible genomewide association study (GWAS) data, we performed a two-sample Mendelian randomization analysis to investigate causal relationships between PCOS, its characteristic biomarkers, and PE. The inverse variance weighting (IVW) method served as the primary analytical approach. To ensure methodological rigor, we assessed potential pleiotropy using the MR-Egger intercept and evaluated heterogeneity through Cochran's Q test with associated <i>p</i> values.</p><p><strong>Results: </strong>The study's results showed a causal relationship between PCOS and PE (IVW OR = 1.172, 95% CI: 1.003-1.371, <i>p</i> = 0.046). Using the IVW method, we also discovered that characteristic indicators of PCOS, including decreased high-density lipoprotein (HDL) levels, increased body mass index (BMI), and elevated fasting insulin levels, pose a risk for PE. At the same time, there is no clear causal relationship between low-density lipoprotein (LDL), total cholesterol (TC), triglycerides (TGs), testosterone (T), fasting blood glucose (FBG), and circulating sex hormone-binding globulin (SHBG) and PE.</p><p><strong>Conclusion: </strong>Our research results provide new evidence at the genetic prediction level for PCOS as a risk factor for PE. Furthermore, analysis of PCOS characteristics suggests that HDL levels, BMI, and fasting insulin levels may be causally associated with PE. These findings provide a novel theoretical basis and practical strategies for the clinical management of women with PCOS, aimed at predicting and preventing PE.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"5536687"},"PeriodicalIF":2.5,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13366495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148446170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Metabolites Mediate the Effects of Gut Microbiota on Diabetic Nephropathy: A Mendelian Randomization Study.","authors":"Weiwei Zhang, Yun Zhang, Huijuan Yuan","doi":"10.1155/ije/6642332","DOIUrl":"10.1155/ije/6642332","url":null,"abstract":"<p><strong>Background: </strong>The gut microbiota (GM) might be related to diabetic nephropathy (DN). The role of blood metabolites, immune cells, and plasma lipidomes in mediating the impact of GM on DN remains unexplored.</p><p><strong>Methods: </strong>412 GM, 1400 blood metabolites, 731 immune cells, 179 plasma lipidomes, and DN were identified through genome-wide association study (GWAS) datasets. We employed Mendelian randomization (MR) to investigate the relationship among GM, blood metabolomes, immune cells, plasma lipidomes, and DN. Furthermore, we conducted mediation analyses to ascertain if the blood metabolomes, immune cells, and plasma lipidomes function as mediators.</p><p><strong>Results: </strong>Our research identified suggestive causal linkages among 15 GM, 27 immune cells, 27 plasma lipidomes, and 55 blood metabolites associated with DN. Mediation analysis showed that advanced glycation end products (AGEs) pyrraline may mediate the causal relationship between s_Bacteroides_eggerthii and DN, with a mediation percentage of 39.96% (<i>p</i> = 0.015). Furthermore, immune cells and plasma lipidomes do not appear to play a mediating role.</p><p><strong>Conclusion: </strong>Gut microbiota, blood metabolomes, immune cells, and plasma lipidomes were causally linked to DN. The blood metabolite pyrraline may act as a potential mediator by which s_Bacteroides_eggerthii influences the risk of developing DN.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"6642332"},"PeriodicalIF":2.5,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13369588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148455763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: PDE5A Suppresses Proteasome Activity Leading to Insulin Resistance in C2C12 Myotubes.","authors":"International Journal Of Endocrinology","doi":"10.1155/ije/9851367","DOIUrl":"10.1155/ije/9851367","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.1155/2019/3054820.].</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"9851367"},"PeriodicalIF":2.5,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13369002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148455810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Exercise Regimens on Childhood Obesity Through Gut Microbiota Regulation: A Systematic Review.","authors":"Si Zhang, Fei Han, Bo Wang, Zilin Chen, Jing Lyu, Fei Fan","doi":"10.1155/ije/9999960","DOIUrl":"10.1155/ije/9999960","url":null,"abstract":"<p><p>Childhood obesity represents a global concern, adversely affecting the physical and mental health of children. This condition results from a complex interplay of genetic and environmental factors, among which the gut microbiota plays a significant role. Exercise, a crucial lifestyle factor, impacts obesity, with the gut microbiota potentially serving as a mediating link between the two. Numerous clinical studies have demonstrated that physical activity can modify microbial imbalances and the metabolic networks of the gut microbiota, thereby effectively addressing childhood obesity. However, the precise molecular mechanisms involved remain inadequately understood. This review aims to investigate the impact of exercise on the gut microbiota and the microbial metabolites it produces. In addition, we provide a summary of several clinical trials from the past two decades that have examined how exercise influences the gut microbiota and affects the progression of childhood obesity. This study offers both theoretical and practical insights for comprehensive interventions targeting childhood obesity.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"9999960"},"PeriodicalIF":2.5,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13359112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Thyroid Function Parameters and Aldosterone-Renin Ratio in Patients With Primary Aldosteronism and Their Association With Target Organ Damage.","authors":"Changjiang Deng, Yixin Xu, Ying Pan, Tingting Wu, Zhihui Jiang, Mingming Lv, Yingying Zheng, Xiang Xie","doi":"10.1155/ije/7275578","DOIUrl":"10.1155/ije/7275578","url":null,"abstract":"<p><strong>Background: </strong>Primary aldosteronism (PA) is one of the most common causes of secondary hypertension. The relationship between thyroid function parameters and the aldosterone-renin ratio (ARR) in PA patients, as well as their combined impact on target organ damage, remains incompletely understood.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 317 patients with suspected or confirmed PA who underwent comprehensive endocrine evaluation, including thyroid function testing, plasma aldosterone concentration, plasma renin activity (PRA), ARR, and assessment of target organ damage. Biomarker correlation and regression analyses were performed in the whole cohort, while thyroid function subgroup comparisons were restricted to patients with confirmed PA. Suppressed renin activity was predefined as PRA < 1.0 ng/mL/h, with profound suppression defined as PRA < 0.5 ng/mL/h.</p><p><strong>Results: </strong>Among 317 patients (54.9% male, 45.1% female), 229 (72.24%) were diagnosed with PA. Hypertension was present in 248 patients (78.23%), of whom 239 (75.39%) were classified as Grade 3 hypertension with very high cardiovascular risk. Thyroid dysfunction was observed in a subset of patients, with elevated TSH levels present among individuals with hypothyroid status. The mean TSH was 3.86 ± 2.41 μIU/mL, and the mean ARR was 48.058 ± 3.161. Significant correlations were found between TSH and ARR (<i>r</i> = 0.35, <i>p</i> < 0.01). Patients with higher ARR values showed a higher prevalence of target organ damage, including coronary artery atherosclerosis (24.92%), carotid artery atherosclerosis (21.45%), and lacunar cerebral infarction (31.86%). Multiple regression analysis revealed that thyroid function abnormalities and elevated ARR were associated with an increased risk of target organ damage after adjustment for conventional risk factors.</p><p><strong>Conclusion: </strong>Thyroid function parameters, particularly TSH and FT4, are significantly associated with ARR in patients with suspected or confirmed PA. Thyroid dysfunction and elevated ARR are associated with target organ damage, and their combined assessment may improve endocrine and cardiovascular risk stratification in PA-related hypertension.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"7275578"},"PeriodicalIF":2.5,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13334131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Ethanol Ablation of Parathyroid Adenoma and Parathyroidectomy Are Comparable.","authors":"Iraj Heydari, Sara Golmohammadi, Mohammad Reza Babaei, Hamed Iraji, Hossein Akhondi","doi":"10.1155/ije/4939126","DOIUrl":"10.1155/ije/4939126","url":null,"abstract":"<p><strong>Aim: </strong>To compare ethanol injection of parathyroid adenoma with surgical parathyroidectomy (PTX).</p><p><strong>Methods: </strong>A prospective, partially randomized preference clinical trial of two groups assigned to surgical PTX (20 patients) or ethanol injection (PEA) (10 patients). The inequality was due to patient preferences and limitations caused by the coronavirus pandemic.</p><p><strong>Results: </strong>Both PEA and PTX resulted in 80% or more of patients having normalized calcium levels after one month. These were sustained through 6 months. A significant proportion of patients after both PEA and PTX had normalized PTH levels after one month (55% and 70%, respectively), which remained unchanged at the 3- and 6-month measurements. After 12 months, calcium and parathyroid hormone levels were lower in the PTX group, while phosphorus levels were higher; however, the differences were not statistically significant. Complications were more common in the PTX group, although the difference was not statistically significant.</p><p><strong>Conclusion: </strong>Overall, PEA and PTX have similar outcomes. Although not statistically significant, the PEA of parathyroid adenoma causes a less pronounced effect on calcium and parathyroid hormone levels and has fewer side effects.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"4939126"},"PeriodicalIF":2.5,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13333659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148436482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Association Between Thyroid Function and Myeloproliferative Disease: A Two-Sample Mendelian Randomization Study.","authors":"Jingjing Xiang, Jun Yan, Jianping Shen, Mengke Mao, Zhiyin Zheng, Shu Deng","doi":"10.1155/ije/6688740","DOIUrl":"10.1155/ije/6688740","url":null,"abstract":"<p><strong>Background: </strong>Thyroid dysfunction has been linked to hematologic abnormalities, but whether thyroid function has a causal role in myeloproliferative diseases (MDs), including chronic myeloproliferative disease (CMD), remains unclear. We used Mendelian randomization (MR) to assess the potential causal effects of thyroid-related traits on MD risk.</p><p><strong>Methods: </strong>A two-sample MR analysis was performed using genome-wide association study (GWAS) summary statistics. Outcome data for CMD and MD, excluding chronic myelogenous leukemia (CML), were obtained from the Finnish R12 cohort (European ancestry). Genetic instruments for thyroid traits-including thyrotropin (TSH), free thyroxine (FT4), free/total triiodothyronine (FT3/TT3), FT3/FT4 and TT3/FT4 ratios, high/low TSH, and genetic liability to hyperthyroidism and hypothyroidism-were selected at genome-wide significance (<i>p</i> < 5 × 10^-8), clumped for linkage disequilibrium (<i>R</i> ² < 0.001, 10,000 kb), and required F-statistics > 10. Primary causal estimates were obtained using inverse-variance weighted (IVW) MR, with sensitivity analyses using MR-Egger, weighted median, weighted mode, MR-PRESSO, heterogeneity tests, and leave-one-out analyses. Steiger tests were applied to assess directionality, and false discovery rate (FDR) correction was used for multiple comparisons.</p><p><strong>Results: </strong>Most thyroid function measures (TSH, FT4, FT3, TT3, hormone ratios, and hypothyroidism) showed no evidence of a causal association with CMD or MD excluding CML (IVW <i>p</i> > 0.05 <i>p</i> > 0.05 <i>p</i> > 0.05). A nominal association was observed between self-reported hyperthyroidism/thyrotoxicosis and CMD, but the effect estimate was implausibly extreme (IVW OR = 5.53 × 10^-14, 95% CI: 7.78 × 10^-27-0.3935, <i>p</i> = 0.0432) and did not remain significant after FDR correction. After outlier removal, genetically predicted hyperthyroidism was nominally associated with MD excluding CML (OR = 0.8806, 95% CI: 0.7954-0.9750; <i>p</i> = 0.0144), but this also did not survive FDR correction (FDR = 0.2015). Sensitivity analyses and pleiotropy tests did not indicate strong directional pleiotropy for the nominal signals, and Steiger tests supported the hypothesized exposure-to-outcome direction.</p><p><strong>Conclusions: </strong>In this MR study, we found no robust evidence for a causal association between most genetically predicted thyroid function traits and MD after multiple-testing correction. The nominal signals observed for hyperthyroidism were phenotype-dependent and statistically unstable, particularly for self-reported CMD. These results emphasize that previously observed associations may be driven by nongenetic factors or clinical confounding.Jingjing Xiang and Jun Yan were co-first authors.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"6688740"},"PeriodicalIF":2.5,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13309939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Sarcopenia Screening Score Based on Thyroid Function Parameters in Euthyroid Middle-Aged and Elderly Chinese Adults.","authors":"Fei Ding, Jirong Yue, Yong He","doi":"10.1155/ije/1577695","DOIUrl":"10.1155/ije/1577695","url":null,"abstract":"<p><strong>Background: </strong>This research aims to develop an alternative sarcopenia screening score based on thyroid hormone function parameters, intended for screening and validating the probability of having sarcopenia among middle-aged and elderly participants with normal thyroid function tests in China.</p><p><strong>Methods: </strong>This multicenter, cross-sectional study assessed the prevalence of sarcopenia among 3,858 thyroid-healthy Chinese adults across hospitals in western China hospitals. Participants were randomized to exploratory and validation cohorts. After applying Lasso to select variables, multivariate logistic regression analysis was conducted. We developed a novel sarcopenia screening score from exploratory data, subsequently validating it internally across both cohorts.</p><p><strong>Results: </strong>The new sarcopenia screening score comprises five variables: age, body mass index (BMI), calf circumference (CC), aspartate aminotransferase/alanine aminotransferase ratio (AST/ALT), and free T4 (FT4), with a scoring range of 0-14. The area under the receiver operating characteristic (ROC) curve for screening for sarcopenia was 0.845 (95% CI: 0.831-0.859) in the exploratory group and 0.854 (95% CI: 0.831-0.874) in the validation group. At the optimal cutoff of 3, the sensitivity and specificity were 78.3% and 75.1%, respectively, in the exploratory cohort; in the validation cohort, with a cutoff of 4, sensitivity and specificity were 68.4% and 87.0%. The Brier score was 0.092 in the exploratory cohort and 0.068 in the validation cohort, confirming satisfactory calibration.</p><p><strong>Conclusion: </strong>The newly developed sarcopenia screening score shows promise as a practical tool for identifying sarcopenia in middle-aged and elderly participants with normal thyroid function tests in China.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"1577695"},"PeriodicalIF":2.5,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13291889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148329248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}