侵袭性/难治性生长激素分泌型垂体神经内分泌肿瘤的诊断和治疗。

IF 2.3 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

International Journal of Endocrinology Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI:10.1155/2024/5085905

Xiaojuan Zhang, Yu Chen, Yerong Yu, Jianwei Li

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引用次数: 0

摘要

大多数肢端肥大症和巨人症是由分泌生长激素的垂体神经内分泌肿瘤（PitNET）引起的。大多数病例可以通过手术、药物治疗和/或放射治疗治愈或控制病情。然而，少数肿瘤对传统疗法有抵抗力，预后总是不佳。侵袭性/难治性这一称谓用于将它们与垂体癌区分开来。迄今为止，如何诊断侵袭性/难治性分泌生长激素的垂体网状细胞瘤尚无定论，这可能会延缓探索新治疗策略的进程。我们总结了描述该疾病诊断和治疗的文献。其中还包括潜在的疾病标志物和前瞻性疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Diagnosis and Management of Aggressive/Refractory Growth Hormone-Secreting Pituitary Neuroendocrine Tumors.

The majority of acromegaly and gigantism are caused by growth hormone-secreting pituitary neuroendocrine tumors (PitNETs). Most cases can be cured or controlled by surgery, medical therapy, and/or radiotherapy. However, a few of these tumors are resistant to traditional therapy and always have a poor prognosis. The title aggressive/refractory is used to differentiate them from pituitary carcinomas. To date, there is no definitive conclusion on how to diagnose aggressive/refractory growth hormone-secreting PitNETs, which may have slowed the process of exploring new therapeutical strategies. We summarized the literature described diagnosis and treatment of the disease. Potential disease markers and prospective therapies were also included.

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来源期刊

International Journal of Endocrinology ENDOCRINOLOGY & METABOLISM-

CiteScore

5.20

自引率

0.00%

发文量

147

审稿时长

1 months

期刊介绍： International Journal of Endocrinology is a peer-reviewed, Open Access journal that provides a forum for scientists and clinicians working in basic and translational research. The journal publishes original research articles, review articles, and clinical studies that provide insights into the endocrine system and its associated diseases at a genomic, molecular, biochemical and cellular level.