International Journal of Endocrinology最新文献

{"title":"Thyroid Hormone Resistance Indices and Their Correlations With Insulin Resistance in Chinese Euthyroid Subjects.","authors":"Ruixiang Cui, GuiHua Li, Ying Wei, Jia Liu, Ying Wang, Song Leng, Guang Wang","doi":"10.1155/ije/5397686","DOIUrl":"10.1155/ije/5397686","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to analyze the relationship between sensitivity to thyroid hormones and insulin resistance (IR) in people with different levels of body mass index (BMI). <b>Methods:</b> We included 32,478 euthyroid participants, and they were divided into three groups according to body mass index (BMI): normal weight (<i>n</i> = 20,200), overweight (<i>n</i> = 10,178), and obesity (<i>n</i> = 2100). We used the Thyroid Feedback Quantile-based Index (TFQI), the TSH index (TSHI), and the Thyrotroph T4 Resistance Index (TT4RI) to represent thyroid hormones sensitivity and used Triglyceride-Glucose (TyG) Index, the Atherogenic Index of Plasma (AIP), and The Metabolic Score for Insulin Resistance (METS-IR) to represent IR. <b>Results:</b> In the BMI < 25 kg/m² group, linear regression showed that TFQI, TSHI, and TT4RI were all positively correlated with TyG (<i>β</i> = 0.096, 0.089, and 0.089, respectively, all <i>p</i> < 0.001). Logistic regression showed that the odds ratios (ORs) for having high TyG in the highest quartiles of the TFQI, TSHI, and TT4RI were 1.430, 1.537, and 1.518, respectively (all <i>p</i> < 0.001), compared with the lowest quartiles of the TFQI, TSHI, and TT4RI. In the 25 ≤ BMI < 29.9 kg/m² group, TFQI, TSHI, and TT4RI were positively associated with TyG (<i>β</i> = 0.071, 0.067, and 0.066, respectively, all <i>p</i> < 0.001) according to linear regression. The ORs for having high TyG in the highest quartiles of the TFQI, TSHI, and TT4RI were 1.269, 1.363, and 1.353, respectively (all <i>p</i> < 0.001) by logistic regression. In the BMI ≥ 30 kg/m² group, positive correlations were found between the three thyroid indices and TyG (<i>β</i> _TFQI = 0.097, <i>β</i> _TSHI = 0.084, <i>β</i> _TT4RI = 0.083, all <i>p</i> < 0.01) by linear regression. The ORs for having high TyG in the highest quartiles of the TFQI, TSHI, and TT4RI were 1.298 (<i>p</i>=0.101), 1.454 (<i>p</i>=0.05), and 1.455 (<i>p</i>=0.05), respectively. <b>Conclusions:</b> Reduced sensitivity to thyroid hormones was associated with high levels of IR in euthyroid adults of normal weight and overweight. In obese patients, no significant correlation was found between sensitivity to thyroid hormones and IR.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2025 ","pages":"5397686"},"PeriodicalIF":2.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression Profile of Urinary Exosomal miRNAs in Patients With Diabetic Kidney Disease and Their Association With Kidney Damage.","authors":"Juan Li, Lulu Han, Ting Wang, Lin Yang, Hong Zhou","doi":"10.1155/ije/9927320","DOIUrl":"10.1155/ije/9927320","url":null,"abstract":"<p><p><b>Purpose:</b> Diabetic kidney disease (DKD) is the primary cause of end-stage renal disease. The aim of this study is to identify noninvasive biomarkers for early-stage DKD or targets for DKD treatment through the analysis of urinary exosomal miRNA expression profiles in DKD patients. <b>Methods:</b> The urinary exosomes were isolated from type 2 diabetes (T2DM) patients with DKD confirmed by renal biopsy (DKD-Exo). The urinary exosomal miRNAs expression profiles were detected using miRNA sequencing, and differentially expressed miRNAs were verified by real-time quantitative PCR. Target genes of these miRNAs and relevant pathways in DKD were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. Human podocytes and renal tubular epithelial cells (TECs) were treated with DKD-Exo to investigate the effects of DKD-Exo on podocyte apoptosis and the epithelial-mesenchymal transition (EMT) of TECs. <b>Results:</b> A total of 40 miRNAs were found to be differentially downregulated, 17 of which were named and 23 were untitled; miR-371a-3p, miR-371a-5p, miR-1260b, miR-222-3p, miR-1224-5p, and miR-1253 were reported in DKD for the first time. GO and KEGG pathway analyses suggest that these target genes are related to cellular apoptosis and renal fibrosis in DKD, and are involved in 135 pathways. <i>In vitro</i>, DKD-Exo induced the apoptosis of podocytes and collagen synthesis in TECs. <b>Conclusion:</b> Our study implies that the urinary DKD-Exo could deliver biological information to podocytes or TECs, which play an important role in pathogenesis of DKD.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2025 ","pages":"9927320"},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Disorders and Serum Selenium Levels in a Southwestern Nigerian Population.","authors":"Olufunmilayo Olubusola Adeleye, Olayinka Olabode Ogunleye, Oluwajimi Olanrewaju Sodipo, Ayotunde Oladunni Ale, Ibironke Jadesola Akinola","doi":"10.1155/ije/6915227","DOIUrl":"10.1155/ije/6915227","url":null,"abstract":"<p><p><b>Background/Objective:</b> Thyroid hormones are central to the regulation of energy expenditure and homoeostasis. An important microelement required for the optimal function of the thyroid gland is selenium. The question of whether Nigerian patients with thyroid disorders are deficient in selenium is what this study aims to answer. <b>Methods:</b> This was a comparative cross-sectional study carried out at a tertiary hospital in Southwest Nigeria. Fifty individuals with various thyroid disorders who gave consent were consecutively recruited and compared with one hundred apparently healthy age and sex-matched controls. Blood samples were collected for free thyroxine, free triiodothyronine, thyroid-stimulating hormone and selenium levels. The thyroid hormones were assayed with enzyme-linked immunoassay. Selenium was measured using inductively coupled plasma optical emission spectroscopy. Data were analysed with SPSS Version 26. <b>Results:</b> The mean age of the subjects and control was 40.3 ± 10.6 and 38.0 ± 9.1 years, respectively (<i>p</i>=0.157). The subjects and controls were predominantly females, 80% and 72%, respectively. Thyroid disorders were most prevalent in the 41-50 years age category. The male:female ratio was 1:4. The majority of the cases (60%) had biochemical evidence of hyperthyroidism, 28% were euthyroid and 12% were hypothyroid. Selenium levels were significantly lower among the cases than healthy controls (mean selenium level: 24.9 ± 15.7 and 59.0 ± 35.9 μg/L, respectively, <i>p</i> < 0.001). With normal selenium levels of 80 μg/L, all the participants were deficient in selenium. There was no significant difference in selenium levels across the spectrum of thyroid disorders although the mean selenium levels were lowest for the hypothyroid subjects. <b>Conclusion:</b> There is significant selenium deficiency in all subjects with thyroid disorders; apparently, healthy Nigerians are generally deficient. Selenium supplementation is recommended for Nigerian patients with thyroid disease and may be required for the general population.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2025 ","pages":"6915227"},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of 25-Hydroxyvitamin D With Metabolic Dysfunction-Associated Fatty Liver Disease: Results From NHANES 2017-2018.","authors":"Xiaojuan Rao, Xinxin Zhang, Shuo Li, Bo Huang, Junhe Wang, Jingqiu Cui, Ming Liu, Tiekun Yan","doi":"10.1155/ije/1368301","DOIUrl":"10.1155/ije/1368301","url":null,"abstract":"<p><p><b>Background:</b> The association of vitamin D with metabolic dysfunction-associated fatty liver disease (MAFLD) remained unclear. This study aimed to examine the relationships of total 25-hydroxyvitamin D [25(OH)D, the sum of 25(OH)D₂ and 25(OH)D₃], 25(OH)D₃, and epi-25(OH)D₃ with MAFLD. <b>Methods:</b> We used the National Health and Nutrition Examination Survey of the 2017-2018 cycle for our present analysis. Binary logistic regression analyses were conducted to explore the associations of total 25(OH)D, 25(OH)D₃, and epi-25(OH)D₃ with MAFLD after adjusting for confounders. Interaction tests were conducted to compare the association between 25(OH)D and MAFLD in subgroups. <b>Results:</b> The final analysis included 4605 subjects. After adjustment for confounders, the odds of MAFLD decreased with increasing concentrations of total 25(OH)D (odds ratio [OR], 0.45; 95% confidence interval [CI], 0.29-0.68; <i>p</i> for trend < 0.001). Serum 25(OH)D₃ showed a strong inverse association with MAFLD (OR, 0.39; 95% CI, 0.25-0.59; <i>p</i> for trend < 0.001). In addition, participants with lower epi-25(OH)D₃ levels had a higher likelihood of MAFLD, as demonstrated in both quartile and continuous models (OR, 0.77; 95% CI, 0.60-0.99; <i>p</i>=0.041). After stratification by lipid status, inverse associations of total 25(OH)D and 25(OH)D₃ with MAFLD were found only in dyslipidemic participants (<i>p</i> for interaction < 0.001). A sex-specific interaction was also noted for 25(OH)D₃, showing stronger effects in women than in men (<i>p</i>=0.036). <b>Conclusions:</b> Low serum total 25(OH)D, 25(OH)D₃, and epi-25(OH)D₃ were significantly associated with a higher prevalence of MAFLD. These associations showed nonlinear patterns and were particularly evident among participants with dyslipidemia, with 25(OH)D₃ demonstrating stronger protective effects in women than in men. Given the cross-sectional design, causality cannot be inferred, and further prospective studies are required to confirm these findings.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2025 ","pages":"1368301"},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavin-Containing Monooxygenase 3 Genetic Variants and Possible Susceptibility to Coronary Heart Disease Among Han Chinese With Type 2 Diabetes.","authors":"Yuanmin Mao, Nan Gu, Xiaowei Ma, Yuxin Wang, Na Yu, Difei Lu, Linchao Tong, Xiaohui Guo, Junqing Zhang, Ying Gao, Dahong Yu, Jianping Li","doi":"10.1155/ije/1020054","DOIUrl":"10.1155/ije/1020054","url":null,"abstract":"<p><p><b>Purpose:</b> To explore the flavin-containing monooxygenase 3 (FMO3) single-nucleotide polymorphisms (SNPs) and their connection to coronary heart disease (CHD) among Han Chinese with type 2 diabetes (T2D). <b>Methods:</b> The case-control research involved 781 individuals with T2D: 506 CHD cases and 275 controls. The tag-SNPs rs2266780, rs1736557, rs1800822, and rs909530 were selected according to the e!Ensembl database. The genotypes of all the research populations were analyzed via mass spectrometry. SPSS 25.0 software was used to analyze the associations between the selected SNPs and the risk of developing CHD. <b>Results:</b> The rs1800822 T allele frequency was lower in the CHD group than in the non-CHD group (<i>p</i> = 0.049), as was the rs909530 T allele frequency (<i>p</i> = 0.029). The carriers of rs909530 CX genotype had a greater risk of developing CHD than did the TT genotype carriers in the non-premature CHD group (<i>p</i> < 0.001). <b>Conclusion:</b> Our study revealed that rs1800822 and rs909530 in the FMO3 gene may be related to CHD risk among Han Chinese with T2D. We observed a significant gene-by-age interaction at rs909530 on CHD risk, indicating that aging modulates the effect of this locus. Young patients with T2D and the CX genotype may require more stringent management of cardiovascular risk factors.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2025 ","pages":"1020054"},"PeriodicalIF":2.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Stratification of Thyroid Nodules 10 mm in Diameter or Less: Strength and Pitfalls of the Ultrasonographic Assessment From a Cross-Sectional Study.","authors":"Giuseppe Lisco, Anna De Tullio, Vito Angelo Giagulli, Giuseppina Renzulli, Vincenzo Triggiani","doi":"10.1155/ije/4063672","DOIUrl":"10.1155/ije/4063672","url":null,"abstract":"<p><p><b>Background:</b> The selection of thyroid nodules ≤ 10 mm requiring characterization and treatment should be improved, as extensive detection, cytological assessment, and surgery of small and well-differentiated thyroid carcinoma are not cost-effective. <b>Aim:</b> To assess the accuracy of algorithms and ultrasonographic characteristics in selecting actual high-risk thyroid nodules ≤ 10 mm. <b>Methods:</b> A cross-sectional study was conducted on 38 of 112 outpatients who attended the University of Bari and underwent echo-assisted FNA for cytological characterization of thyroid nodules ≤ 10 mm (65 out of 118) and thyroid surgery from January 01 to December 31, 2016. <b>Results:</b> The median age of patients was 49.5 years [16; 69]. Thyroid cytology (SIAPeC-IAP 2014) was classified as TIR1 (one nodule), TIR2 (15), TIR3A (7), TIR3B (10), TIR4 (8), and TIR5 (24). Thirty-nine thyroid nodules were diagnosed as well-differentiated thyroid microcarcinoma. The clinical performance of 4 algorithms widely employed in clinical practice was low (AACE/ACE/AME, 38%; ACR-TIRADS, 45%; K-TIRADS, 60%; EU-TIRADS, 66%). Ultrasonographic features indicating high-risk nodules were hypoechogenicity (<i>p</i>=0.0047), irregular margins (<i>p</i>=0.004), and microcalcifications (<i>p</i>=0.0019). Multivariable analyses indicated that hypoechogenicity was the main ultrasonographic characteristic associated with high-risk nodules (OR = 5.48, <i>p</i>=0.0484). <b>Discussion:</b> Validated algorithms fail to select thyroid nodules ≤ 10 mm for which cytological characterization is needed. Our results are expected to improve the reliability of current algorithms by improving the weight of variables associated with a more consistent risk of thyroid malignancy in nodules ≤ 10 mm.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2025 ","pages":"4063672"},"PeriodicalIF":2.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Lipidome and Metabolome Alterations in Obese Patients Undergoing Targeted Diet and Exercise Interventions: A Marker of Thyroid Function Recovery?","authors":"Changxu Zhou, Heng Wang, Qingtao Yu, Jingxin Xin, Huiqi Chen, Ran Zhang, Qingbo Guan, Shanshan Shao","doi":"10.1155/ije/6065721","DOIUrl":"10.1155/ije/6065721","url":null,"abstract":"<p><p><b>Purpose:</b> Dietary and exercise interventions have the potential to modify thyroid hormone levels in individuals with obesity. This study investigates the specific mechanisms through which these interventions influence thyroid function, employing a multiomics approach. <b>Methods:</b> 16 volunteers with obesity participated in a two-week regimen of aerobic exercise combined with dietary control. Fasting blood samples and anthropometric measurements were taken before and after the intervention. Serum untargeted lipidomics and metabolomics analyses were performed, alongside evaluations of serum thyroid hormone levels. Additionally, an RNA sequencing dataset was obtained which included gene expression data for skeletal muscle and subcutaneous fat both prior to and following weight loss. <b>Results:</b> Following the intervention, significant alterations were observed in serum levels of thyroid hormones, lipid molecules, and metabolites among participants. Notably, there was a substantial reduction in the levels of tyrosine and phenylalanine (<i>p</i> < 0.001). Furthermore, this intervention had a pronounced effect on the activity of thyroid hormone signaling pathways. <b>Conclusion:</b> Dietary modifications along with exercise facilitate the restoration of thyroid function by enhancing the consumption of tyrosine and phenylalanine while concurrently altering the activity within thyroid hormone signaling pathways. These findings provide valuable insights into potential treatments for obesity-related thyroid dysfunction. <b>Trial Registration:</b> Chinese Registry of Clinical Trials: ChiCTR2000040981.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2025 ","pages":"6065721"},"PeriodicalIF":2.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes Control and the Occurrence of Postoperative Hyperglycemia Among Adults With Type 1 and Type 2 Diabetes in a Tertiary Care Center.","authors":"Hanan Aljedani, Jomanah Mazi, Arwa Almutairi, Halah Namnkani, Reffal Aldainiy, Suhaib Radi, Alaa Althubaiti","doi":"10.1155/ije/8829049","DOIUrl":"10.1155/ije/8829049","url":null,"abstract":"<p><p><b>Background:</b> Diabetes mellitus (DM) is a growing concern globally. DM control is indicated by hemoglobin A1c, measuring glucose levels within two to 3 months. Patients with DM who have surgery may experience postoperative hyperglycemia (POHG) which is associated with many complications. This study aimed to investigate POHG incidence among patients with DM based on their level of glycemic control. <b>Methods:</b> This was a retrospective cohort study of patients with DM ≥ 18 years who had orthopedic, intra-abdominal, cardiothoracic, or vascular surgery at King Abdulaziz Medical City, Jeddah, between October 2016 and October 2023. Patients with DM were considered controlled if the hemoglobin A1c was < 7%. <b>Results:</b> The study included 306 patients, and the majority (69.28%) experienced POHG. There was a significant association between POHG and the level of glycemic control. POHG was experienced by 32.55% of patients with controlled DM vs 67.45% of patients with uncontrolled DM. Furthermore, patients with preoperative random glucose readings (RBG) of ≥ 9.2 mmol/L had a significantly higher risk of developing POHG. Moreover, older age and male sex were associated with higher POHG risk. <b>Conclusion:</b> Our data indicate that the incidence of POHG was significantly greater among patients with uncontrolled DM. Patients with DM with a preoperative RBG of ≥ 9.2 mmol/L had a higher likelihood of developing POHG. Future research should include a larger sample and investigate associations between POHG, other complications, and the influence of varying levels of DM control.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2025 ","pages":"8829049"},"PeriodicalIF":2.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Successful Parathyroid Adenoma Localisation in Sestamibi Study-Can Change in Serum Calcium Be a Useful Indicator?","authors":"Peter Jarvis, Jennifer Downs, Tony Skene, Abigail Evans, Tristan Richardson, Amit Parekh","doi":"10.1155/ije/3922886","DOIUrl":"10.1155/ije/3922886","url":null,"abstract":"<p><p><b>Objective:</b> Primary hyperparathyroidism can be cured by the successful removal of the culpable parathyroid adenoma. Successful localisation allows the specialist surgeon to perform safer and more cost-effective focused excisions rather than exploratory surgery. This study aims to identify possible factors that predict successful adenoma localisation using technetium99m-sestamibi. <b>Design, Patients and Measurements:</b> Retrospective analysis of 159 patients undergoing parathyroid localisation with technetium99m-sestamibi SPECT/CT. Patients were classified as successful or unsuccessful localisation when compared to the surgical site of a proven adenoma following successful parathyroidectomy. Preoperative and postoperative serum parathyroid hormone (PTH), calcium and 25-hydroxyvitamin D levels and pathological size of the parathyroid adenoma were recorded. <b>Results:</b> Larger specimen volume, weight and higher preoperative PTHs were strongly associated with successful localisation. The percentage change in serum calcium (calculated as the difference between pre- and post-op calcium) was also strongly associated with successful localisation. Higher preoperative serum calcium (> 2.85 mmol/L) was also associated with successful localisation although with a reduced statistical significance. Seventy percent of patients in our cohort underwent parathyroidectomy with a serum calcium < 2.85 mmol/L, of which 92% had pathologically confirmed adenomas and 67% had successful localisation with sestamibi. <b>Conclusion:</b> The serum PTH and change in serum calcium were most strongly associated with successful localisation. The degree of hypercalcaemia was also associated with successful localisation but without as strong an association when compared to the change in calcium. Several factors influence the degree of hypercalcaemia in patients with primary hyperparathyroidism including parathyroid adenoma size, 25-hydroxyvitamin D status and the individual's baseline calcium set point. Historic information (if available) on the patient's individual baseline set point prior to developing primary hyperparathyroidism, and subsequent elevation when primary hyperparathyroidism has developed, could aid decision-making for clinicians when deciding on parathyroidectomy.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2025 ","pages":"3922886"},"PeriodicalIF":2.3,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Value of the Random Urine Potassium‒Creatinine Ratio to the Synchronous Serum Potassium Concentration Squared for Renal Potassium Loss in Hypokalemia Patients.","authors":"Xinyi Wang, Fei Ding, Xinyi Huang, Yong He, Guixing Li","doi":"10.1155/ije/9911400","DOIUrl":"10.1155/ije/9911400","url":null,"abstract":"<p><p><b>Background:</b> Few parameters are available for diagnosing renal potassium loss in emergency patients or patients receiving treatment. This study aimed to investigate the ratio of random urine potassium‒creatinine to the synchronous serum potassium concentration squared ([UK/UCr]/SK²) and compare it with other parameters in the diagnostic ability of renal potassium loss. <b>Methods:</b> This single-center study enrolled 380 subjects, including 218 hypokalemia patients (91 with nonrenal potassium loss and 127 with renal potassium loss) and 162 normal potassium controls. The values of serum and urine were based on laboratory data. Groups were compared in pairs, and the ROC curve analysis was used to evaluate the predictive ability of parameters related to renal potassium loss. <b>Results:</b> (UK/UCr)/SK² was significantly elevated in potassium loss patients, especially in females. Moreover, a greater (UK/UCr)/SK² ratio was observed in those with nonrenal potassium loss, which demonstrated a trend toward increases in the normal potassium, nonrenal potassium loss, and renal potassium loss groups among males and females. Ultimately, the AUC of (UK/UCr)/SK² was the highest at 0.880 (95% CI: 0.822-0.938) in males and 0.878 (95% CI: 0.831-0.924) in females for potassium loss diagnosis. <b>Conclusion:</b> Random (UK/UCr)/SK² has good diagnostic value for renal potassium loss in patients with hypokalemia. Given that these serum and random urine parameters are easily obtainable from patients during treatment, regularly observing (UK/UCr)/SK² may prove to be an effective indicator.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2025 ","pages":"9911400"},"PeriodicalIF":2.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}