International Journal of Endocrinology最新文献

{"title":"Association Between Lipid Accumulation Product and Visceral Adiposity Index, as Markers of Visceral Adiposity and Metabolic Dysfunction, and Stroke: NHANES 1999-2018.","authors":"Qian Zhou, Zhongchen Zhang","doi":"10.1155/ije/6820633","DOIUrl":"10.1155/ije/6820633","url":null,"abstract":"<p><strong>Aims: </strong>Lipid accumulation product (LAP) and visceral adiposity index (VAI) are surrogate markers of visceral adiposity-related endocrine and metabolic dysfunction, including insulin resistance, rather than simple obesity indices. This study aimed to evaluate their associations with stroke prevalence using nationally representative data.</p><p><strong>Materials and methods: </strong>This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. Stroke status was determined through standardized questionnaires. LAP and VAI were calculated using established gender-specific formulas. Analyses used the fasting subsample weights with strata and primary sampling units, and missing covariates were multiply imputed. Weighted logistic regression, restricted cubic spline (RCS), subgroup and incremental discrimination analyses were performed.</p><p><strong>Results: </strong>Among 21,146 participants, 721 reported a prior stroke (weighted prevalence 2.64%). Both indices were higher in stroke cases (median LAP 54 vs 42; VAI 1.72 vs 1.46, both <i>p</i> < 0.001). In the primary model (Model 3), each 1-SD increment was associated with higher stroke odds for LAP (OR = 1.115, 95% CI 1.061-1.171, <i>p</i> < 0.001) and VAI (OR = 1.073, 95% CI 1.020-1.129, <i>p</i> = 0.007), and the highest quartile exceeded the lowest (LAP: OR = 1.557, 95% CI 1.117-2.170; VAI: OR = 1.381, 95% CI 1.026-1.858). Both were attenuated after additional adjustment for metabolic mediators (HbA1c, systolic blood pressure, eGFR and medication use), consistent with partial mediation. RCS analyses showed significant overall associations (LAP <i>p</i> < 0.001; VAI <i>p</i> = 0.041) without significant nonlinearity (<i>p</i> = 0.177 and 0.143). Only race/ethnicity modified the LAP-stroke association (<i>p</i> for interaction = 0.009; non-Hispanic Black OR = 1.427, 95% CI 1.231-1.654). Adding either index did not materially improve discrimination.</p><p><strong>Conclusions: </strong>Higher LAP and VAI values are associated with a greater prevalence of stroke after adjustment for demographic, socioeconomic, and lifestyle factors, and their attenuation after adjustment for metabolic variables is consistent with partial mediation through insulin resistance and its hemodynamic consequences. Both indices are inexpensive endocrine-metabolic markers of visceral adipose tissue dysfunction and insulin resistance that warrant prospective evaluation.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"6820633"},"PeriodicalIF":2.5,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverse Association of the Life's Crucial 9 Score With MAFLD: An Exploratory Mediation Analysis of the C-Reactive Protein-Albumin-Lymphocyte (CALLY) Index.","authors":"Hanlu Li, Tianju Li","doi":"10.1155/ije/1340865","DOIUrl":"10.1155/ije/1340865","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Metabolic dysfunction-associated fatty liver disease (MAFLD) is strongly associated with cardiovascular disease. Life's Crucial 9 (LC9), an expanded cardiovascular health metric incorporating psychological health, may provide a multidimensional measure of cardiometabolic health. The CALLY index integrates inflammatory, immune, and nutritional information and has been associated with MAFLD. However, whether ln(CALLY) statistically accounts for part of the association between LC9 and MAFLD remains unclear. This study aimed to examine the association between LC9 and MAFLD and to explore the statistical indirect association through ln(CALLY).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Data were obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2016. Weighted logistic regression, restricted cubic spline (RCS) modeling, subgroup analysis, and weighted quantile sum (WQS) regression were used to assess the relationship between LC9 and MAFLD. Exploratory mediation analysis was performed to evaluate the statistical indirect association through ln(CALLY). Sensitivity and supplementary analyses were conducted to assess the robustness of the findings with respect to missing data, alternative disease definitions, definitional overlap, alternative cardiovascular health metrics, individual LC9 components, and mediator choice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;This study included 3841 participants. Higher LC9 scores were significantly associated with lower odds of prevalent MAFLD. Specifically, every 10-point increase in the LC9 score was associated with lower odds of MAFLD (OR = 0.51, 95% CI: 0.47-0.56, &lt;i&gt;p&lt;/i&gt; &lt; 0.001). Participants in the highest tertile of the LC9 score had lower odds of MAFLD (OR = 0.16, 95% CI: 0.12-0.22, &lt;i&gt;p&lt;/i&gt; &lt; 0.001) compared with those in the lowest tertile. Similarly, ln(CALLY) was inversely associated with MAFLD (OR = 0.57, 95% CI: 0.52-0.64, &lt;i&gt;p&lt;/i&gt; &lt; 0.001). Exploratory mediation analysis indicated that ln(CALLY) statistically accounted for approximately 17.7% of the LC9-MAFLD association (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Sensitivity and supplementary analyses showed that the association was attenuated but remained statistically significant after exclusion of overlapping metabolic components from LC9 (OR per 10-point increase in modified LC9 = 0.891, 95% CI: 0.832-0.955, &lt;i&gt;p&lt;/i&gt; = 0.002) and remained materially consistent when MASLD was used as an alternative outcome (OR = 0.545, 95% CI: 0.494-0.602, &lt;i&gt;p&lt;/i&gt; &lt; 0.001). No significant indirect association was observed using PNI as an alternative mediator (&lt;i&gt;p&lt;/i&gt; = 0.988). WQS analysis assigned relatively larger weights to BMI, blood glucose, and psychological health.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Higher LC9 scores were associated with lower odds of prevalent MAFLD. Exploratory mediation analysis suggested a statistical indirect association through ln(CALLY), although causal or temporal mediation cannot be inferred","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"1340865"},"PeriodicalIF":2.5,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Insulin Resistance Surrogate Indices With Component-Defined Metabolically Unhealthy Phenotype Among Women With Overweight or Obesity: A Cross-Sectional Analysis of CHNS and NHANES.","authors":"Xiaoye Zhu, Jinghui Zou, Hong Zhu, Honghong Wang, Yisheng Zhang, Yanfei Jin","doi":"10.1155/ije/5660424","DOIUrl":"https://doi.org/10.1155/ije/5660424","url":null,"abstract":"<p><strong>Background: </strong>Women with overweight or obesity are metabolically heterogeneous, and body mass index (BMI) alone does not fully characterise their endocrine and metabolic health. We examined associations between five insulin resistance surrogate indices and a component-defined metabolically unhealthy phenotype (MUP) to characterise insulin resistance-related metabolic variation in this population.</p><p><strong>Methods: </strong>This cross-sectional analysis used the China Health and Nutrition Survey (CHNS) 2009 for discovery and the National Health and Nutrition Examination Survey (NHANES) 2011-2018 for independent replication. Final samples comprised 1751 CHNS and 2953 NHANES participants. The indices were homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride-glucose index (TyG), triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C), triglyceride-glucose body mass index (TyG-BMI) and metabolic score for insulin resistance (METS-IR). MUP was defined as at least two abnormal metabolic components. Modified Poisson regression estimated prevalence ratios (PRs) per 1-standard-deviation increment and across quartiles. Fully adjusted models included 1721 CHNS and 2799 NHANES participants. Receiver operating characteristic curves and areas under the curve (AUCs) provided a descriptive, exploratory assessment of internal discrimination.</p><p><strong>Results: </strong>All five indices were positively associated with MUP in both datasets. Fully adjusted PRs per 1-standard-deviation increment ranged from 1.027 (95% confidence interval 1.011-1.043) for HOMA-IR to 1.133 (1.110-1.157) for TyG in CHNS and from 1.058 (1.024-1.094) for TG/HDL-C to 1.168 (1.144-1.192) for TyG in NHANES. Positive quartile gradients were observed for all indices (<i>p</i> for trend < 0.001). Exploratory internal discrimination for MUP showed different patterns across the two datasets.</p><p><strong>Conclusions: </strong>Higher values of all five indices were associated with MUP among women with overweight or obesity in both datasets. These findings highlight the co-occurrence of insulin resistance-related glucose and lipid disturbances with clustered metabolic abnormalities. They support considering metabolic function alongside adiposity when characterising endocrine-metabolic heterogeneity among women with overweight or obesity.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"5660424"},"PeriodicalIF":2.5,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Link Between the Cardiometabolic Index and Stroke Risk Across Different Glucose Metabolic Status in Chinese Middle-Aged and Older Adults: A Longitudinal Cohort Study.","authors":"Meng Li, Yongbo Yu, Xuan Chen, Yonglai Zhang, Wei Lu","doi":"10.1155/ije/6169486","DOIUrl":"https://doi.org/10.1155/ije/6169486","url":null,"abstract":"<p><strong>Background: </strong>The cardiometabolic index (CMI) encompasses central obesity and atherogenic dyslipidemia, two metabolic abnormalities that are closely associated with insulin resistance and issues in glucose metabolism. However, whether the association between CMI and incident stroke differs across glucose metabolic states remains unclear.</p><p><strong>Methods: </strong>Utilizing data from the China Health and Retirement Longitudinal Study (CHARLS), we carried out a cohort study with 7980 individuals aged 45 years and above who were free of stroke. We explored the associations between the initial CMI and stroke incidents across various glucose metabolism status through Cox proportional hazards models, restricted cubic spline analyses, Kaplan-Meier survival analysis, subgroup and sensitivity analyses, and receiver operating characteristic analysis.</p><p><strong>Results: </strong>Incident stroke risk was independently associated with both log (CMI) and CMI quartiles, increasing with higher values and quartiles. The fully adjusted model showed that each 1-unit rise in log (CMI) was associated with an increased risk of stroke (HR = 1.13, 95% CI 1.00-1.28; <i>p</i> = 0.044). Compared to Q1, Q4 had a higher risk of stroke (HR = 1.52; 95% CI 1.11-2.08; <i>p</i> = 0.008). Moreover, for individuals with diabetes mellitus (DM), a higher CMI was associated with a greater likelihood of stroke, with Q4 presenting an increased risk (HR = 1.49, 95% CI: 1.02-2.31, <i>p</i> = 0.019) when compared to Q1. By contrast, no significant association was observed among individuals with prediabetes or normal glucose regulation. The findings' robustness was further corroborated by conducting subgroup and sensitivity analyses. In those with DM, the CMI had a moderate level of accuracy in predicting new stroke cases, with an area under the receiver operating characteristic curve of 0.675.</p><p><strong>Conclusions: </strong>A higher baseline CMI was associated with an increased risk of incident stroke, with a more apparent association among individuals with DM. These findings suggest that the vascular relevance of the CMI may vary according to the underlying glucose metabolic status and support its potential role as a marker of cardiometabolic dysfunction. Further research is essential to shed light on the metabolic pathways involved in these associations and to establish the clinical value of CMI.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"6169486"},"PeriodicalIF":2.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the Platelet-to-Neutrophil Ratio With Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis in U.S. Adults: NHANES 2017-March 2020.","authors":"Yuguan Zhang, Huaibin Zhang, Shanshan Li, Baoyong Zhou, Zhongjun Wu, Hang Yang","doi":"10.1155/ije/5591067","DOIUrl":"https://doi.org/10.1155/ije/5591067","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic liver disease that is not related to alcohol and is characterized by excessive accumulation of fat within liver cells. As one of the most common chronic liver diseases worldwide, MASLD affects about a quarter of the world's population and is expected to become a leading indication for liver transplantation by 2030. The disease not only increases the risk of cirrhosis and hepatocellular carcinoma, but also is closely associated with a variety of extra-hepatic complications such as type 2 diabetes and cardiovascular disease. Although many biomarkers such as N-terminal type III collagen propeptide (PRO-C3), enhanced liver fibrosis (ELF), and Fibrosis-4 Score (FIB-4) have been used to identify and predict MASLD and metabolic dysfunction-associated steatohepatitis (MASH), their clinical utility remains limited. Recent studies have shown that neutrophils and platelets play a crucial role in the progression of MASLD. The platelet-to-neutrophil ratio (PNR), a novel biomarker, has shown predictive value in ovarian cancer and myocardial infarction. However, PNR has not been fully studied in MASLD. The aim of this study was to investigate the association between PNR and MASLD and to explore its relationship with hepatic steatosis and fibrosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This cross-sectional study included participants from the National Health and Nutrition Examination Survey (NHANES) 2017-March 2020 pre-pandemic dataset. Hepatic steatosis was defined as a controlled attenuation parameter (CAP) ≥ 274 dB/m, and MASLD was defined as hepatic steatosis plus at least one cardiometabolic criterion according to the 2023 multisociety steatotic liver disease (SLD) nomenclature. Advanced liver fibrosis was defined as a liver stiffness measurement (LSM) ≥ 8.2 kPa. PNR was calculated as the platelet count divided by the neutrophil count and log2-transformed (log2-PNR). Missing covariates were handled by multiple imputation (&lt;i&gt;m&lt;/i&gt; = 20). Survey-weighted logistic regression, natural-spline smoothing, threshold effect analysis, and subgroup analyses were used to evaluate the association between log2-PNR and MASLD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 3437 adults aged 18 years and older were included (mean age 47.5 ± 17.5 years; 48.1% male). In the fully adjusted model, higher log2-PNR was inversely associated with MASLD (OR 0.75 per doubling of PNR, 95% CI 0.63-0.90), and with hepatic steatosis; participants in the highest PNR quartile had lower odds of MASLD than those in the lowest quartile. Threshold effect analysis identified a breakpoint at PNR approximately 38 for MASLD, with a significant nonlinear pattern. Higher log2-PNR was also inversely associated with advanced fibrosis (OR 0.43, 95% CI 0.33-0.57), with no significant nonlinearity. Subgroup analyses showed that the inverse association was more pronounced in males and non-Hispanic White par","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"5591067"},"PeriodicalIF":2.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Genetic Variants of <i>ABCC8</i> Gene With Type 2 Diabetes Mellitus in the Mongolian Population.","authors":"Nyamjav Byambasuren, Erkhembayar Shinebaatar, Solongo Enkhjargal, Purevdulam Erdenetsog, Munkhtsetseg Janlav, Buyankhuu Tuvshintur","doi":"10.1155/ije/5514592","DOIUrl":"10.1155/ije/5514592","url":null,"abstract":"<p><strong>Introduction: </strong>Type 2 diabetes constitutes 90 percent of all diabetes cases, and some polymorphism in the <i>ABCC8</i> gene, which encodes the ATP-sensitive potassium channel Sur1 protein involved in pancreatic beta cell insulin release, are associated with Type 2 diabetes. Sulfonylurea is used to treat diabetes caused by this metabolic disorder. Recent studies indicate that the rs1799854 and rs1801261 polymorphisms of the <i>ABCC8</i> gene may be associated with the development of Type 2 diabetes.</p><p><strong>Materials and methods: </strong>This study was designed as a case-control study. Group 89 included individuals with Type 2 diabetes mellitus (T2DM), while the control group included 89 individuals determined healthy based on specific criteria. DNA was extracted from the blood, and the rs1799854 and rs1802161 polymorphisms of the <i>ABCC8</i> gene were analyzed using the RELP-PCR method.</p><p><strong>Results: </strong>Our study's results showed significant differences in BMI, glucose, and glycated hemoglobin levels between the case and control groups. Individuals with Type 2 diabetes showed higher frequencies of the TT genotype and the <i>T</i> allele of the rs1799854 polymorphism in the <i>ABCC8</i> gene (<i>p</i> < 0.05). The high frequency of the mutant <i>T</i> allele and TT genotype in the case group suggests that individuals carrying these genetic variations may have an increased susceptibility to Type 2 diabetes. Individuals with and without T2DM exhibited similar frequencies of the <i>T</i> allele and TT genotype of the rs1801261 polymorphism in the <i>ABCC8</i> gene (<i>p</i> > 0.05). Moreover, no statistically significant differences were detected between the case and control groups in those carrying risk alleles versus those not (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>The rs1801261 polymorphisms of the <i>ABCC8</i> gene were not associated with Type 2 diabetes. However, findings indicated that the <i>ABCC8</i> 1,799,854 polymorphism may affect susceptibility to T2DM in this study.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"5514592"},"PeriodicalIF":2.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin in Elderly Patients With Type 2 Diabetes and Muscle Strength, Muscle Mass, and Physical Function: Positive or Negative Correlation?","authors":"Chuanli Wei, Jieyuzhen Qiu, Mengjuan Xue, Bin Lu, Cuiping Jiang, Xiaoming Tao","doi":"10.1155/ije/6423817","DOIUrl":"https://doi.org/10.1155/ije/6423817","url":null,"abstract":"<p><p>This study aimed to explore the association between long-term use of metformin and muscle strength, muscle mass, and physical function, providing a basis for rational use of glucose-lowering drugs in elderly patients with Type 2 diabetes. A total of 290 elderly patients were enrolled. Patients were screened using propensity score matching, resulting in 132 matched individuals, 66 in the metformin group (Group A) and 66 in the nonmetformin group (Group B). Group comparisons assessed the correlation between metformin and muscle strength, muscle mass, and physical function, with further stratification by glycated hemoglobin (HbA1c). Statistical methods included <i>t</i>-tests, nonparametric tests, chi-square tests, and logistic regression analyses. Results obtained are as follows: (1) The difference in the proportion of low grip strength between Groups A and B was statistically significant (48.5% vs. 19.7%, <i>p</i> < 0.001). (2) In HbA1c-stratified analysis, when 7.8% ≤ HbA1c < 9.4%, Groups A and B showed statistically significant differences in skeletal muscle mass (17.2 ± 3.0 vs. 19.9 ± 4.5 kg, <i>p</i> = 0.049), relative skeletal muscle mass (6.5 ± 0.8 vs. 7.2 ± 1.1 kg/m², <i>p</i> = 0.03), proportion of low grip strength (57.1% vs. 13.6%, <i>p</i> = 0.013), and proportion of low gait speed (71.4% vs. 40.9%, <i>p</i> = 0.039); when HbA1c ≥ 9.4%, significant difference in proportion of low grip strength (41.2% vs. 5.9%, <i>p</i> = 0.033) was observed between groups. This study found that long-term metformin use in elderly patients with Type 2 diabetes is positively associated with a higher proportion of low grip strength. Particularly in patients with poor glycemic control, metformin constitutes an unfavorable factor for sarcopenia. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT07788378.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"6423817"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13629291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Monitoring Value of 2D Shear Wave Elastography in Subacute Thyroiditis: A Prospective Case-Control Study.","authors":"Ioana Golu, Melania Balas, Mervat Matei, Toma Andreea-Daniela, Ana Corlan, Daniel Luches, Dana Amzar, Natalia Milos, Ioan Sporea, Alina Popescu, Mihaela Vlad","doi":"10.1155/ije/4035441","DOIUrl":"10.1155/ije/4035441","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze the applicability of different shear wave elastography (SWE) methods in the diagnosis, differentiation, and monitoring of subacute thyroiditis (SAT).</p><p><strong>Methods: </strong>This prospective study included 26 patients diagnosed with SAT and 40 healthy controls. All participants underwent conventional B-mode ultrasonography followed by two-dimensional shear wave elastography (2D-SWE), using a 4-15 MHz linear transducer (Aixplorer, Supersonic Imagine, France). Thyroid stiffness was assessed in kilopascals (kPa) and evaluated at diagnosis, 4 weeks, and 8 weeks. Statistical analysis included <i>t</i>-tests, repeated-measures ANOVA, receiver operating characteristic curve analysis, and Youden Index calculation to determine optimal diagnostic cut-off values.</p><p><strong>Results: </strong>Baseline thyroid stiffness in SAT patients was significantly higher than in controls (127.25 ± 54.06 kPa vs. 19.5 ± 7.1 kPa; <i>p</i> < 0.001). Stiffness values decreased over time, reaching 117 ± 44.67 kPa at 4 weeks and 57.17 ± 22.89 kPa at 8 weeks. An exploratory cutoff value of 37.2 kPa showed complete separation between groups within this specific cohort. Beyond baseline group differences, the most relevant finding was the longitudinal change in thyroid stiffness during clinical recovery, supporting the role of SWE as a quantitative imaging biomarker of inflammatory activity.</p><p><strong>Conclusions: </strong>2D-SWE showed promising performance as a quantitative imaging biomarker for evaluating and monitoring SAT in this exploratory cohort. It provides valuable quantitative data on tissue stiffness, complementing conventional ultrasound and aiding clinical decision-making during follow-up.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"4035441"},"PeriodicalIF":2.5,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Dorema Aucheri</i> Extract Modulates Unfolded Protein Response Pathways in Streptozotocin-Induced Diabetic Rats: A Protective Role Against Hepatic Damage.","authors":"Alireza Raeisi, Farhad Koohpeyma, Roozbeh Kiani, Somayeh Igder, Amir Maleksabet, Nima Rahimikashkooli, Narges Rezaei, Mesbah Shams, Sanaz Dastghaib","doi":"10.1155/ije/5570446","DOIUrl":"10.1155/ije/5570446","url":null,"abstract":"<p><strong>Purpose: </strong>Endoplasmic reticulum stress (ERS) plays a pivotal role in the development of diabetes-induced liver damage. Under elevated ERS, the unfolded protein response (UPR) balances cellular survival and death. There may be a preventive effect of herbal extracts against problems associated with diabetes. In this study, the effects of a hydroalcoholic extract from <i>Dorema aucheri</i> on liver damage, ERS, and UPR in diabetic rats were assessed.</p><p><strong>Methods: </strong>There were five groups of rats, each including six rats. A 60 mg/kg intraperitoneal injection of streptozotocin (STZ) was used to cause diabetes. Every day, 1 mL of normal saline was given to the control groups, who were normal and diabetic. For 28 days, three diabetic groups were given oral gavage doses of 250/500 mg/kg of <i>D. aucheri</i> extract and 500 mg/kg of metformin daily. Serum and liver samples were used to assess blood glucose, liver enzymes, oxidative stress, inflammatory markers, and antioxidant levels after treatment. Furthermore, liver tissue pathology, stereology, and gene expression were examined.</p><p><strong>Results: </strong>Compared to the diabetic groups, the treated groups exhibited a significant decrease in oxidative stress, inflammatory markers, liver enzymes, blood glucose, and increased antioxidant capacity. They significantly reduced mRNA levels of proapoptotic markers (<i>CHOP</i>, <i>caspase-9</i>, and <i>NF-κB</i>) and increased <i>GRP78</i>, <i>XBP1s</i>, and <i>BCL2</i> expression, suggesting attenuation of apoptosis and modulation of UPR-related gene expression.</p><p><strong>Conclusion: </strong><i>D. aucheri</i> extract may modulate UPR- and apoptosis-related pathways, alleviate ERS, and potentially reduce diabetes-associated complications in STZ-induced diabetic rats. However, further mechanistic and translational studies are required to confirm these findings and evaluate their clinical relevance.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"5570446"},"PeriodicalIF":2.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TyG-HDL Outperforms TyG Combined With Obesity Indicators in Predicting Chronic Kidney Disease Associated With High Fasting Blood Glucose Levels in the Chinese Elderly Population: A Two-Stage Study Based on GBD 2023 and CHARLS Data.","authors":"Letai Li, Li Long, Tingting Chen, Xinhong Tian, Can Huang, Yutong Chen, Shiying Ye, Meng Ye, Jiajie Leng, Zhenrui Cao, Yingjiu Jiang, Mengjun Bie","doi":"10.1155/ije/8245427","DOIUrl":"10.1155/ije/8245427","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a major public health issue in China, especially among older adults, with rising prevalence linked to metabolic disorders such as hyperglycemia. This study aimed to assess the burden of CKD attributable to elevated fasting blood glucose (FBG) in elderly Chinese, focusing on the predictive value of composite metabolic indices derived from the triglyceride-glucose (TyG) index.</p><p><strong>Method: </strong>The study included two phases: (1) analysis of the 2023 Global Burden of Disease (GBD) database to assess the CKD burden due to hyperglycemia among adults aged ≥ 60 years in China from 1990 to 2023 and (2) evaluation using the China Health and Retirement Longitudinal Study (CHARLS) cohort, analyzing associations between 15 blood glucose-related indices and CKD in older adults.</p><p><strong>Results: </strong>The GBD analysis revealed a significant burden of CKD due to hyperglycemia in China, with increasing mortality and disability-adjusted life years (DALYs) projections. In the CHARLS cohort, four indices-TyG-HDL, TCBI, FBG-HDL, and CTI-were significantly associated with CKD. Elevated levels of these indices, particularly TyG-HDL, demonstrated strong associations with CKD risk, with nonlinear, threshold-dependent effects observed in restricted cubic spline analyses.</p><p><strong>Conclusion: </strong>Blood glucose-related indices, especially TyG-HDL, offer strong predictive value for CKD risk in older Chinese adults. These findings suggest that integrating these indices into screening programs could enhance early CKD detection and management strategies, helping mitigate the growing disease burden in aging populations.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2026 ","pages":"8245427"},"PeriodicalIF":2.5,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}