International Journal of Dermatology最新文献

{"title":"Topical Finasteride 0.25% Solution for Female Pattern Hair Loss (FPHL) in Postmenopausal Women: A 52-Week Retrospective Observational Study.","authors":"Bianca Maria Piraccini, Aditya K Gupta, Stephano Cedirian, Luca Rapparini, Federico Quadrelli, Shannon A H Compton, Mesbah Talukder, Michela Starace","doi":"10.1111/ijd.70730","DOIUrl":"https://doi.org/10.1111/ijd.70730","url":null,"abstract":"<p><strong>Background: </strong>Female pattern hair loss (FPHL), characterized by progressive follicular miniaturization, is the most common cause of hair thinning in women and increases in prevalence after menopause. While topical minoxidil is approved for FPHL, clinical response is variable. Oral finasteride is used off label in postmenopausal women but raises concerns regarding systemic adverse effects. Topical finasteride may represent an alternative with reduced systemic exposure.</p><p><strong>Methods: </strong>A retrospective observational study was conducted in 26 postmenopausal women with FPHL who were treated with topical finasteride 0.25% monotherapy for 52 weeks. Clinical and trichoscopic images obtained at baseline and Week 52 were used to assess changes in hair density, hair thickness, and the terminal-to-vellus hair ratio in predefined target areas in frontal or vertex regions. Patient-reported tolerability and compliance, as well as patient- and clinician-reported effectiveness, were assessed using 3-point ordinal scales.</p><p><strong>Results: </strong>Mean hair density increased from 149.48 ± 34.32 to 172.84 ± 35.29 hairs/cm² (p < 0.001). Hair thickness increased from 40.42 ± 7.15 μm to 51.04 ± 9.28 μm (p < 0.001), and terminal-to-vellus hair ratio increased from 1.04 ± 0.61 to 1.56 ± 0.64 (p < 0.001). Subjective patient and clinician assessments indicated good-to-excellent effectiveness. No adverse events were recorded; tolerability and compliance were rated highly by patients.</p><p><strong>Conclusions: </strong>Topical finasteride 0.25% monotherapy was associated with significant improvements in hair density and thickness, alongside favorable reported tolerability and compliance. These findings provide preliminary real-world observational data regarding topical finasteride use in the underserved population of postmenopausal women with FPHL.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Dermoscopy Is Not Enough: RCM and LC-OCT in Basal Cell Carcinoma Diagnosis.","authors":"Stefania Guida, Camila Scharf","doi":"10.1111/ijd.70735","DOIUrl":"https://doi.org/10.1111/ijd.70735","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Wound Care in Mohs Micrographic Surgery: Tradition, Variation, and the Evidence.","authors":"Meredith Hengy, George M Jeha, Umer Nadir, Stanislav N Tolkachjov","doi":"10.1111/ijd.70728","DOIUrl":"https://doi.org/10.1111/ijd.70728","url":null,"abstract":"<p><p>Postoperative wound care following Mohs micrographic surgery (MMS) has high variability and surprisingly limited real-world evidence. Despite over one million MMS procedures performed annually in the United States, recommendations for topical agents, pressure dressings, wound cleansing, dressing change frequency, activity restrictions, and wound check intervals vary substantially across practices and are frequently based on training tradition rather than clinical data. This narrative review critically evaluates 15 common post-Mohs wound care practices, characterizing the evidence quality for each. Six practices are supported by at least Level III evidence, most notably plain petrolatum over topical antibiotics and over multi-ingredient ointments such as Aquaphor, gentle soap-and-water cleansing, the safety of early showering, targeted acetic acid soaks for hypergranulation tissue, and virtual wound checks. Evidence discourages cytotoxic antiseptics such as hydrogen peroxide and Dakin's solution. Most other common postoperative practices, including pressure dressings, activity restrictions, and dressing change frequency, remain understudied in MMS. Standardizing established practices while transparently acknowledging areas of uncertainty may reduce patient confusion, improve outcomes, and highlight priorities for future prospective research in dermatologic surgery.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Highlights-December 2026.","authors":"Lajos Kemény","doi":"10.1111/ijd.70739","DOIUrl":"https://doi.org/10.1111/ijd.70739","url":null,"abstract":"<p><p>The effects of climate change, unequal access to biologic therapies, and the limited representation of Indigenous communities and diverse skin tones in educational materials underscore an important point: dermatology does not operate independently of social and environmental factors. The five papers in this issue not only identify these gaps but also call for specific measures to strengthen climate-resilient preparedness, expand safety-net services, and promote truly inclusive education. Equitable care is no longer a nice-to-have option; it is a fundamental standard of clinical quality.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Dapsone for Recalcitrant Erosive Pustular Dermatosis of the Scalp in a Patient Unsuitable for Systemic Dapsone.","authors":"Lorenzo Luotti, Camilla Brunello, Marco Zanette, Raffaele Dante Caposiena Caro, Iris Zalaudek","doi":"10.1111/ijd.70731","DOIUrl":"https://doi.org/10.1111/ijd.70731","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newly Recorded Cardiometabolic Diagnoses in Adolescents With Hidradenitis Suppurativa.","authors":"Rahib K Islam, Kazi N Islam, Nicholas Culotta, Christopher Haas","doi":"10.1111/ijd.70714","DOIUrl":"https://doi.org/10.1111/ijd.70714","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Dose Tumescent Triamcinolone-Clindamycin Mixture for Hidradenitis Suppurativa: A Case Series.","authors":"Krisztian Nemeth, Mollye Goldberg","doi":"10.1111/ijd.70724","DOIUrl":"https://doi.org/10.1111/ijd.70724","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequent TP53 Mutations and Associated p53 Dysfunction Suggestive of Tumor Suppression Role in Complex Basal Cell Carcinomas.","authors":"Sophia Gandarillas, Sydney Wolfe, Darius Mehregan, Jason Lee, Bahar Dasgeb","doi":"10.1111/ijd.70711","DOIUrl":"https://doi.org/10.1111/ijd.70711","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrochlorothiazide Exposure and Skin Cancer Hazards Versus ACE Inhibitors Among Adults Aged 65 Years or Older: A TriNetX-Based Cohort Study.","authors":"Rahib K Islam, Kazi N Islam, Lacey M Falgout, Nicholas Culotta, Shari R Lipner, Christopher Haas","doi":"10.1111/ijd.70707","DOIUrl":"https://doi.org/10.1111/ijd.70707","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Intralesional Bleomycin and Triamcinolone Acetonide in the Treatment of Keloids: A Prospective, Randomized, Open-Label, Comparative Study","authors":"Divya Ravali Bandaru,&nbsp;Nirupama Bhagya Lakshmi Tatavarthi,&nbsp;Dasika Subba Rao,&nbsp;Ramala Amala","doi":"10.1111/ijd.70554","DOIUrl":"10.1111/ijd.70554","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Keloids are benign fibroproliferative scars resulting from dysregulated wound healing and excessive collagen deposition. Despite the availability of multiple therapeutic options, an optimal treatment strategy remains uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective, randomized, open-label comparative study enrolled 136 patients with clinically diagnosed keloids, who were assigned to receive either intralesional bleomycin (Group A, <i>n</i> = 68) or intralesional triamcinolone acetonide (Group B, <i>n</i> = 68). Treatments were administered at 4-week intervals for four sessions, with follow-up conducted 2 months after the final session. Outcomes were assessed using the Vancouver Scar Scale (VSS), and responder rates were defined as ≥ 50%, ≥ 75%, and ≥ 90% reductions in VSS. Secondary outcomes included changes in scar height, surface area, and treatment-related adverse effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Bleomycin resulted in a significantly greater mean percentage reduction in VSS than triamcinolone (72.02% vs. 58.10%; <i>p</i> &lt; 0.00001). A higher proportion of patients treated with bleomycin achieved ≥ 75% improvement (36.8%, <i>n</i> = 25/68) than those treated with triamcinolone (14.7%, <i>n</i> = 10/68; <i>p</i> = 0.0027). Improvements in vascularity, pliability, and scar height were also significantly greater in the bleomycin group, with a mean scar height reduced to 0.8 versus 1.9 mm in the triamcinolone group (<i>p</i> = 0.003). The reduction in surface area was comparable between the groups (<i>p</i> = 0.850). Pain (<i>n</i> = 50, 74%) and hyperpigmentation (<i>n</i> = 18, 26%) were more frequently observed with bleomycin, whereas skin atrophy (<i>n</i> = 16, 24%) and telangiectasia (<i>n</i> = 15, 22%) were more common with triamcinolone.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Both therapies were associated with significant clinical improvement; however, bleomycin demonstrated superior efficacy in reducing scar severity and achieving higher response rates. Larger, multicenter, blinded studies with longer follow-up periods are warranted to confirm these findings and evaluate long-term outcomes, including recurrence rates.</p>\u0000 \u0000 <div>\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"65 11","pages":"2334-2342"},"PeriodicalIF":4.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}