International Journal of Dermatology最新文献

Association Between Androgenetic Alopecia and Glucagon-Like Peptide-1 Receptor Treatment in Type 2 Diabetes Mellitus Patients: A Retrospective Cohort Study. 2型糖尿病患者雄激素性脱发与胰高血糖素样肽-1受体治疗的相关性：一项回顾性队列研究

IF 3.5 4区医学

International Journal of Dermatology Pub Date : 2025-07-15 DOI: 10.1111/ijd.17971

Amit Singal, Michael M Ong, Zachary Neubauer, Shari R Lipner

引用次数: 0

Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System. 非那雄胺的安全性与其给药途径相关：局部还是口服？基于美国食品和药物管理局不良事件报告系统数据的药物警戒研究。

IF 3.5 4区医学

International Journal of Dermatology Pub Date : 2025-07-15 DOI: 10.1111/ijd.17957

Aditya K Gupta, Mesbah Talukder, Sharon A Keene, Mary A Bamimore

{"title":"Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System.","authors":"Aditya K Gupta, Mesbah Talukder, Sharon A Keene, Mary A Bamimore","doi":"10.1111/ijd.17957","DOIUrl":"https://doi.org/10.1111/ijd.17957","url":null,"abstract":"Background: The United States Food and Drug Administration (FDA) approved oral finasteride for androgenetic alopecia. In 2022, approximately 2.6 million U.S. men used it for hair loss and prostate conditions. Post-finasteride syndrome (PFS), proposed in 2012, involves persistent sexual and neuropsychiatric adverse events (AEs) after cessation. These AEs are controversial and often lack assessment of contributing risk factors. We analyzed FDA Adverse Event Reporting System (FAERS) data to explore finasteride's administration route and PFS-like AEs.Methods: Using the information component (IC) method for disproportionality analyses, we assessed signals for 13 PFS-related AEs with topical and oral finasteride and dutasteride across two periods: 2006-2011 (pre-PFS reporting) and 2019-2024 (post-PFS reporting). These periods reflect times before and after formal PFS reporting in 2012. Eight analyses per AE were conducted based on agent, route, and era.Results: Fewer signals for PFS-like AEs were detected with topical finasteride compared to oral finasteride in both eras. No signals were found for topical dutasteride, possibly because its use is very limited. Many reported AEs, such as erectile dysfunction and depression, may be influenced by age, stress, or comorbidities.Conclusions: Signals for PFS-like AEs were detected with topical finasteride, but were less frequent than with oral finasteride. The high prevalence of these AEs in the general population and the influence of confounding factors, such as psychological stress or nocebo effects, combined with the lack of genotyping, hormonal assessments, or family history data in most reports, suggest caution in attributing causality to finasteride. Topical finasteride may pose a lower risk, but robust evidence is needed to clarify its safety profile.","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can't Judge a Book by Its Cover: An Unusual Case of Orbital Swelling. 不能以貌取人：一个不寻常的眼眶肿胀案例。

IF 3.5 4区医学

International Journal of Dermatology Pub Date : 2025-07-14 DOI: 10.1111/ijd.17960

Cristina Sarda, Luca Mastorino, Paolo Dapavo, Luca Conti, Alberto Sciarrillo, Sara Silvestri, Pietro Quaglino, Simone Ribero

引用次数: 0

Hair Transplant: Patient Candidacy, Medical Optimization, and Surgical Considerations. 头发移植：患者候选资格，医疗优化和手术考虑。

IF 3.5 4区医学

International Journal of Dermatology Pub Date : 2025-07-14 DOI: 10.1111/ijd.17961

Anna L Brinks, Carli D Needle, Caitlin A Kearney, Meena Singh, Néstor Carreño, Achiamah Osei-Tutu, Reba Suri, David Saceda Corralo, Nicole Rogers, Sergio Vañó-Galván, Kenneth Washenik, Jerry Shapiro, Kristen I Lo Sicco

{"title":"Hair Transplant: Patient Candidacy, Medical Optimization, and Surgical Considerations.","authors":"Anna L Brinks, Carli D Needle, Caitlin A Kearney, Meena Singh, Néstor Carreño, Achiamah Osei-Tutu, Reba Suri, David Saceda Corralo, Nicole Rogers, Sergio Vañó-Galván, Kenneth Washenik, Jerry Shapiro, Kristen I Lo Sicco","doi":"10.1111/ijd.17961","DOIUrl":"https://doi.org/10.1111/ijd.17961","url":null,"abstract":"Alopecia is a medical condition that impact many people worldwide and has diverse causes, ranging from autoimmune to genetic factors. Hair transplantation represents a key therapeutic option for patients with progressive hair loss who are seeking improvement beyond the capacity of medications or less invasive procedures. While hair transplantation is most commonly utilized for androgenetic alopecia, individuals with other alopecia diagnoses may also benefit. The two main techniques for hair transplantation include follicular unit transplantation and follicular unit excision. Hair transplantation is particularly important given the profound psychosocial implications and cosmetic disfigurement associated with alopecia. Chronic hair loss patients may experience reduced self-esteem, increased depression and anxiety, and poorer quality of life. Despite the significance of hair transplantation, comprehensive guidelines informing the clinical and surgical management of transplant candidates remain limited. Therefore, this review aims to explore patient candidacy criteria, pretransplant medical therapy optimization, intraoperative considerations, and postoperative complications and medical management.","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Perspectives in Aesthetic Dermatology: Focusing on Epigenetics. 美学皮肤病学的新观点：关注表观遗传学。

IF 3.5 4区医学

International Journal of Dermatology Pub Date : 2025-07-14 DOI: 10.1111/ijd.17952

Renáta Bozó, Laura Kiss

引用次数: 0

Regulatory T Cell Dysregulation in Vitiligo: A Meta-Analysis and Systematic Review of Immune Mechanisms and Therapeutic Perspectives. 白癜风调节性T细胞失调：免疫机制和治疗前景的荟萃分析和系统综述。

IF 3.5 4区医学

International Journal of Dermatology Pub Date : 2025-07-14 DOI: 10.1111/ijd.17959

Gabriela Lerner, Maria Nikolaou, Corinne Stoffel, Eloi Schmauch, Thomas Kündig, Thierry Passeron, Julien Seneschal, Nanja van Geel, Ulrike Held, Antonios G A Kolios

{"title":"Regulatory T Cell Dysregulation in Vitiligo: A Meta-Analysis and Systematic Review of Immune Mechanisms and Therapeutic Perspectives.","authors":"Gabriela Lerner, Maria Nikolaou, Corinne Stoffel, Eloi Schmauch, Thomas Kündig, Thierry Passeron, Julien Seneschal, Nanja van Geel, Ulrike Held, Antonios G A Kolios","doi":"10.1111/ijd.17959","DOIUrl":"https://doi.org/10.1111/ijd.17959","url":null,"abstract":"Vitiligo is an autoimmune disorder marked by the progressive loss of skin melanocytes, increasingly linked to immune dysregulation as a key driver of disease onset and progression. Regulatory T (Treg) cells are essential for maintaining immune homeostasis by suppressing autoreactive immune responses. Mounting evidence implicates functional and numerical alterations in Treg cells in the pathogenesis of vitiligo. This study reviews findings on lesional and circulating Treg cells in vitiligo patients compared to healthy controls (HCs), examining Treg cell frequency, their ability to suppress CD4+ and CD8+ T cell activity, levels of the immunoregulatory cytokines interleukin-10 (IL-10) and transforming growth factor-β (TGF-β), expression of the key suppressive marker FOXP3, as well as levels of the pro-inflammatory cytokines interleukin-17 (IL-17) and interleukin-22 (IL-22). A comprehensive systematic search was performed across Embase, MEDLINE/PubMed, and Scopus databases to identify eligible studies. A total of 21 studies comprising 1016 vitiligo patients and 846 HCs were included in the review. The analysis revealed a significant reduction in peripheral Treg cell counts (p = 0.01), impaired overall suppressive capacity of CD4+ and CD8+ T cells (p = 0.01), reduced levels of IL-10 (p = 0.02), increased levels of IL-17 (p ≤ 0.01) and IL-22 (p ≤ 0.01) in the blood of vitiligo patients compared to HCs. No statistically significant difference was observed in circulating TGF-β levels (p = 0.1). Most studies reported reduced FOXP3 expression in both skin and blood of vitiligo patients. Current evidence suggests vitiligo involves both reduced numbers and impaired function of Treg cells, supporting further study of Treg pathways as targets for immunomodulatory therapy.","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the Gap: Enhancing Patch Test Interpretation Across Fitzpatrick Skin Types. 弥合差距：加强对菲茨帕特里克皮肤类型的斑贴测试解释。

IF 3.5 4区医学

International Journal of Dermatology Pub Date : 2025-07-13 DOI: 10.1111/ijd.17965

Sanjana Likki, T Austin Black, Rajani Katta, Megan N Rogge

引用次数: 0

Development of Multiple Flat Warts During Treatment With Ruxolitinib 1.5% Cream for Non-Segmental Vitiligo: A Case Report. 1.5% Ruxolitinib乳膏治疗非节段性白癜风期间多发扁平疣的发展：1例报告。

IF 3.5 4区医学

International Journal of Dermatology Pub Date : 2025-07-13 DOI: 10.1111/ijd.17963

Veronica Lestani, Irene D'Odorico, Alba Guglielmo, Enzo Errichetti, Giuseppe Stinco

引用次数: 0

Alopecia Treatments in Breastfeeding: Safety and Clinical Considerations. 母乳喂养中脱发治疗：安全性和临床考虑。

IF 3.5 4区医学

International Journal of Dermatology Pub Date : 2025-07-08 DOI: 10.1111/ijd.17940

Carli D Needle, Anna L Brinks, Caitlin A Kearney, Grace Rachko, Amy K Bieber, Jerry Shapiro, Margaret Nachtigall, Kristen I Lo Sicco, Daniela Majerson

{"title":"Alopecia Treatments in Breastfeeding: Safety and Clinical Considerations.","authors":"Carli D Needle, Anna L Brinks, Caitlin A Kearney, Grace Rachko, Amy K Bieber, Jerry Shapiro, Margaret Nachtigall, Kristen I Lo Sicco, Daniela Majerson","doi":"10.1111/ijd.17940","DOIUrl":"https://doi.org/10.1111/ijd.17940","url":null,"abstract":"Despite the wide variety of treatment options for alopecia areata (AA), androgenetic alopecia (AGA), and primary cicatricial alopecias, these options become more limited for women who are breastfeeding, given concerns surrounding potential transfer into breast milk and subsequent adverse effects (AEs) on the newborn infant. Alopecia is associated with significant psychological distress, poorer quality of life (QOL), and negative impacts on self-esteem and body image, which may be exacerbated by undergoing the physical, hormonal, and emotional changes of pregnancy and breastfeeding. Furthermore, many of these medications must be taken continuously to maintain their benefits, reinforcing the importance of understanding which therapies are compatible with breastfeeding. This review aimed to help guide clinicians in choosing safe and appropriate hair loss therapies for women during lactation, including a detailed discussion of medication transfer to breast milk and infant blood serum levels, potential neonatal AEs, and further clinical considerations specific to each treatment option.","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil-to-Lymphocyte Ratio Associated With Worse Melanoma Specific-Survival and Distant Metastasis Free Survival in Localized (Stage I and II) Cutaneous Melanoma: An Observational Retrospective Study on 988 Patients. 中性粒细胞与淋巴细胞比率与局部（I期和II期）皮肤黑色素瘤更差的黑色素瘤特异性生存和无远处转移生存相关：一项988例患者的观察性回顾性研究

IF 3.5 4区医学

International Journal of Dermatology Pub Date : 2025-07-08 DOI: 10.1111/ijd.17920

Irina Ciobotariu, Luis Acacio Ortega-Berbel, Andrea Calderón-Mollinedo, Maider Aguerralde-Martin, Celia Requena, Ruggero Moro, Esperanza Manrique-Silva, Victor Traves, Eduardo Nagore

{"title":"Neutrophil-to-Lymphocyte Ratio Associated With Worse Melanoma Specific-Survival and Distant Metastasis Free Survival in Localized (Stage I and II) Cutaneous Melanoma: An Observational Retrospective Study on 988 Patients.","authors":"Irina Ciobotariu, Luis Acacio Ortega-Berbel, Andrea Calderón-Mollinedo, Maider Aguerralde-Martin, Celia Requena, Ruggero Moro, Esperanza Manrique-Silva, Victor Traves, Eduardo Nagore","doi":"10.1111/ijd.17920","DOIUrl":"https://doi.org/10.1111/ijd.17920","url":null,"abstract":"Introduction: The neutrophil-to-lymphocyte ratio (NLR) is a critical biomarker of the immune system that plays an important role in predicting the outcome of various malignant tumors, including skin cancer. This study aimed to evaluate an NLR cutoff that could help better predict the prognosis of patients with localized melanoma.Materials and methods: We designed a retrospective, longitudinal, observational study of 988 patients with localized melanoma for whom NLR levels were collected at baseline. To evaluate the prognostic value of NLR, the patients were divided into two groups: > 4.8 vs. ≤ 4.8. We analyzed the association between increased NLR levels and clinical and pathological variables using Pearson's chi-squared test and Fisher's exact test. Univariate and multivariate Cox proportional hazards models were built using stepwise backward selection to evaluate the association between NLR values and melanoma-specific survival (MSS); NLR values and distant metastasis-free survival (DMFS). Kaplan-Meier survival curves were used to illustrate the difference in survival outcomes between the two groups.Results: An NLR level of > 4.8 was associated with male sex, melanoma located on the head or neck, a mitotic index of > 5 mitoses/mm2, ulceration, worse MSS (hazard ratio [HR] 3.2, 95% confidence interval [CI] 1.8-5.9; p < 0.001) and a higher probability of developing distant metastasis (HR 2.0, 95% CI 1.1-3.7; p = 0.034).Conclusions: We identified an NLR level of 4.8 as the best cutoff to distinguish patients with localized melanoma (stages I and II) who are at an increased risk of death due to melanoma (MSS) and of developing distant metastasis (DMFS).","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0