International Journal of Dermatology最新文献

{"title":"Lymphocyte Transformation Tests and Patch Tests to Identify Drugs Potentially Associated With Bullous Pemphigoid Development.","authors":"Belen de Nicolas-Ruanes, Carlos Fernandez-Lozano, Patricia Gutierrez-Canales, Asuncion Ballester-Martinez, Natalia Rodriguez-Otero, Javier Martinez-Botas, Belén de la Hoz Caballer, Ana Andres-Martin, Emilio Solano-Solares, Maria Esther Gomez-Salazar Lopez-Silanes, Laura Gisella Diaz-Montalvo, Diana M Arrebola, Vivian Lizeth Stewart-Delcid, Emilio Garcia-Mouronte, Carlos Azcarraga-Llobet, Emilio Berna-Rico, Sonia Ortega-Sanchez, Montserrat Fernandez-Guarino","doi":"10.1111/ijd.17849","DOIUrl":"https://doi.org/10.1111/ijd.17849","url":null,"abstract":"<p><strong>Background: </strong>Bullous pemphigoid (BP) is the most common autoimmune blistering disease, with a rising incidence in the elderly. BP is associated with multiple triggering factors, including drug exposure. However, evidence in this respect is limited, and the underlying immune mechanisms remain unknown. Our study aims to identify the role of specific drugs in BP pathogenesis using in vitro lymphocyte transformation tests (LTT) and in vivo patch testing, aiding in the differentiation between truly associated drugs and coincidental associations.</p><p><strong>Methods: </strong>Thirty-three patients with suspected BP and no ongoing systemic treatment were enrolled. LTT and patch tests were conducted 3 months after diagnosis. BP disease activity was assessed using the Bullous Pemphigoid Disease Activity Index (BPDAI) at diagnosis and at follow-up visits at 3 and 6 months.</p><p><strong>Results: </strong>LTT results were positive in 60% of patients for dipeptidyl peptidase 4 inhibitors, loop diuretics, hydrochlorothiazide, levetiracetam, nivolumab, enalapril, and amlodipine. Patients showed a reduction in BPDAI over the study period, regardless of LTT results. Although limited by the low sample size, positive LTT patients showed a trend toward clinical improvement when the implicated drug was discontinued. Patch testing was positive in one patient, who also had a corresponding positive LTT.</p><p><strong>Conclusions: </strong>Our findings demonstrate the existence of a potential role for certain drugs in BP pathogenesis, suggesting that these drugs may trigger the disease in genetically predisposed individuals. Although further studies are needed, LTT may serve as a useful and available tool in the management of BP patients in the future.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab for the Treatment of Cutaneous Immune-Related Adverse Events: A Systematic Review.","authors":"Ioannis-Alexios Koumprentziotis, Aikaterini Niforou, Antonios Tsimpidakis, Christos Nikolaou, Alexander Stratigos, Vasiliki Nikolaou","doi":"10.1111/ijd.17850","DOIUrl":"https://doi.org/10.1111/ijd.17850","url":null,"abstract":"<p><p>The emergence of immune checkpoint inhibitors has revolutionized the landscape of cancer treatment in the modern era. However, cutaneous immune-related adverse events (cirAEs) are common, significantly affecting patients' quality of life and often leading to treatment discontinuation, which may compromise oncological outcomes. Dupilumab, an immunoglobulin G4 (IgG4) human monoclonal antibody targeting interleukin (IL)-4 and IL-13 receptors, is widely used for dermatologic conditions but remains unapproved for cirAEs due to the limited and scattered supporting evidence. This review aimed to summarize the available evidence regarding the use of dupilumab for the management of cirAEs. A systematic review was conducted using MEDLINE/PubMed, Scopus, and Web of Science in adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In total, 25 publications met the eligibility criteria and were included, reporting 136 patients who were diagnosed with 140 cirAEs and were treated with dupilumab. The most frequently treated cirAEs were eczematous rashes, bullous pemphigoid, and maculopapular/morbilliform rashes. Dupilumab was found to be highly effective, with most patients achieving complete or partial responses, even when affected by two concomitant cirAEs. An acceptable safety profile was demonstrated regarding both adverse events and oncological safety, with no additional concerns to be raised. The findings may be encouraging but are limited by the relatively small number of patients treated and the nature of the included studies, with most of them being case reports and case series. More research is warranted, along with more clinical studies, prospective in design, focused on relevant clinical outcomes of this dupilumab-treated subset of patients.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Stromal Tumor Environment in Advancing Skin Cancer Diagnosis and Treatment.","authors":"Frank Jing, Ani Pazhava, Catherine Shachaf, Alexander Meves","doi":"10.1111/ijd.17827","DOIUrl":"https://doi.org/10.1111/ijd.17827","url":null,"abstract":"<p><p>The stromal tumor environment (STE) plays a vital yet often underrecognized role in cancer progression, shaping tumor development. It influences complex interactions among stromal cells, immune cells, extracellular matrix (ECM) components, and signaling molecules. Stromal cells regulate integrin signaling and are involved in remodeling the tumor microenvironment, driving critical processes such as cell migration, survival, angiogenesis, and proliferation. Advances in understanding the STE are creating new opportunities for early cancer detection and treatment. Innovations in molecular imaging, particularly for melanoma, are transforming cancer diagnostics by providing deeper insights into tumor biology, cellular interactions, and angiogenesis, paving the way for more personalized and timely therapeutic interventions. Among these advancements, in vivo skin fluorescent imaging (SFI) stands out as a powerful tool, offering real-time molecular insights at the point of care with the ability to improve patient management.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Dermatofibrosarcoma Protuberans of the Hallux Treated With Mohs Micrographic Surgery.","authors":"Deepika Narayanan, Kyle C Lauck, Jorge Roman, Stanislav N Tolkachjov","doi":"10.1111/ijd.17852","DOIUrl":"https://doi.org/10.1111/ijd.17852","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intralesional Clindamycin and Triamcinolone for Hidradenitis Suppurativa: A Targeted Therapeutic Approach for Rapid Inflammation Control-A Prospective Case Series.","authors":"Caterina Mariarosaria Giorgio, Gaetano Licata, Elisabetta Fulgione, Giuseppe Argenziano, Eugenia Veronica Di Brizzi","doi":"10.1111/ijd.17858","DOIUrl":"https://doi.org/10.1111/ijd.17858","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spectrum of Epidermolysis Bullosa in KwaZulu-Natal, South Africa.","authors":"Antoinette Chateau, Thirona Naicker, Cassandra Bruce-Brand, Johann Schneider, Colleen Aldous, Ncoza Dlova, Hui-Ching Cheng, Pei-Chi Lin, Hsin-Yu Huang, Chao-Kai Hsu, John A McGrath","doi":"10.1111/ijd.17843","DOIUrl":"https://doi.org/10.1111/ijd.17843","url":null,"abstract":"<p><strong>Background: </strong>Epidermolysis bullosa (EB) is a rare, heterogeneous genodermatosis characterized by skin fragility due to inherited defects in genes encoding proteins that maintain epidermal-dermal integrity. The severity and complications of EB vary by subtype, and no cure currently exists. The epidemiology is unknown in South Africa.</p><p><strong>Methods: </strong>This prospective observational study in KwaZulu-Natal correlated African Zulu EB patients' phenotypic features with genotypic and histological findings. Whole-exome sequencing, electron microscopy, and immunofluorescence mapping were used to identify EB subtypes.</p><p><strong>Results: </strong>Fourteen of the 15 patients recruited initially were confirmed to have EB, while one was excluded due to poor clinicopathological-genetic correlation. Junctional EB (JEB) was identified in 11 patients, with 10 cases linked to a recurrent homozygous pathogenic variant in LAMB3, causing severe JEB, and one to ITGA3 with an unusual variant of interstitial lung disease, nephrotic syndrome, and EB (ILNEB). Two patients had autosomal dominant EB simplex, both with heterozygous KRT14 variants, and one had dominant dystrophic EB associated with a heterozygous COL7A1 variant. Eleven patients presented during the neonatal period, with a mean survival of four weeks, highlighting a high mortality rate, especially in the severe JEB cases. The cohort exhibited a balanced sex distribution, with no clear cases of consanguinity observed.</p><p><strong>Conclusion: </strong>JEB, with a recurrent pathogenic variant in LAMB3, emerged as the predominant subtype among African Zulu patients, underscoring the critical need for early diagnosis and tailored management strategies in resource-limited settings. Integrating clinicopathological and genetic data is essential for accurate diagnosis and prognosis, emphasizing the importance of advanced diagnostic tools in improving outcomes for EB patients in South Africa.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Collagenous Vasculopathy With Unilateral Facial Involvement: A Rare Variant.","authors":"Qi Zhang, Xiaopo Wang","doi":"10.1111/ijd.17856","DOIUrl":"https://doi.org/10.1111/ijd.17856","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geospatial Analysis of Cutaneous Malignant Melanoma Epidemiology in Europe From 2017 to 2021.","authors":"Rocío C Bueno-Molina, Mercedes Sendín-Martín, Juan-Carlos Hernández-Rodríguez, Lucía Cayuela, Aurelio Cayuela, José-Juan Pereyra-Rodríguez","doi":"10.1111/ijd.17851","DOIUrl":"https://doi.org/10.1111/ijd.17851","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous melanoma is the most aggressive form of skin cancer. Although some studies have explored the epidemiology of melanoma in Europe, there is limited data on its spatial distribution.</p><p><strong>Materials and methods: </strong>A longitudinal ecological study was conducted to analyze melanoma incidence and mortality from 2017 to 2021 using data from the Global Burden of Disease database. Cases were identified using the International Classification of Diseases (ICD)-9 and ICD-10 codes for both sexes across four European geographical regions, excluding Russia. Age-standardized incidence and mortality rates were calculated. A distance-based spatial weights matrix was generated using GeoDa software to define neighborhood structure. Hotspot analysis of spatial clusters was conducted using the Getis-Ord Gi* statistic. Additionally, the mortality-to-incidence ratio was calculated.</p><p><strong>Results: </strong>Between 2017 and 2021, a total of 606,448 new melanoma cases were diagnosed in Europe. Both sexes exhibited higher incidence and mortality rates in Northern Europe. All rates were consistently lower in women. For both sexes, incidence hotspots were identified in Sweden, Denmark, the Netherlands, and the United Kingdom. In contrast, mortality hotspots are primarily observed in the Nordic countries, as well as in Eastern Europe. Incidence coldspots are predominantly found in southeastern Europe, whereas mortality coldspots are primarily concentrated in Spain and Portugal. The overall mortality-to-incidence ratio in Europe remained stable during the period, with an evident east-west gradient and higher mortality relative to incidence observed in Eastern Europe.</p><p><strong>Conclusion: </strong>This analysis reveals distinct geographical patterns, characterized by a north-south gradient in incidence and mortality. In contrast, the mortality-to-incidence ratio follows an east-west gradient, highlighting significant disparities in healthcare access.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rowell Syndrome: A Controversial Entity.","authors":"Carmen Cánovas Seva, Ana Batalla, Jose Ramón Maneiro Fernández, Jose Manuel Suárez Peñaranda, Maria Montserrat López Franco, Noelia Moreiras Arias","doi":"10.1111/ijd.17857","DOIUrl":"https://doi.org/10.1111/ijd.17857","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reticulate Hyperpigmentation Secondary to Chemotherapy Combining Gemcitabine and Cisplatin.","authors":"Amor Fourat, Rouatbi Jacem, Afly Donia, Ben Abdelkader Atef, Denguezli Mohamed","doi":"10.1111/ijd.17855","DOIUrl":"https://doi.org/10.1111/ijd.17855","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}