International Journal of Dermatology最新文献

{"title":"Infrared Thermography for Detection of Neural Impairment in Leprosy: A Cross-Sectional Study.","authors":"Narayanan Baskaran, Tarun Narang, Manoj Goyal, Simone Cazzaniga, Luca Borradori, Keshavamurthy Vinay, Sunil Dogra","doi":"10.1111/ijd.70099","DOIUrl":"https://doi.org/10.1111/ijd.70099","url":null,"abstract":"<p><strong>Background: </strong>Leprosy, caused by Mycobacterium leprae, leads to peripheral neuropathy and significant functional disability if its diagnosis is delayed. Infrared thermography may offer a non-invasive method for the detection of neurological complications.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 100 leprosy patients and 20 healthy controls. Participants were assessed for cutaneous temperature using infrared thermography at defined areas corresponding to peripheral nerve innervation points (hands, feet, and face). Sensory neuropathy was analyzed using the Semmes-Weinstein (SW) monofilament test, while autonomic nerve dysfunction was evaluated through the sympathetic skin response (SSR). Data were analyzed with the aim of verifying whether changes in skin temperature clinically correlated with sensory loss, autonomic nerve dysfunction, and distinct forms of the leprosy spectrum.</p><p><strong>Results: </strong>Leprosy patients had significantly lower skin temperature compared to controls, with a mean temperature of 32.5°C ± 2.3°C vs. 35.2°C ± 0.4°C for hands (p < 0.001) and 24.1°C ± 2.8°C vs. 34.8°C ± 0.5°C for feet (p < 0.001). Temperature differences were most pronounced in body areas showing sensory neuropathy (e.g., 30.1°C ± 2.2°C for hands with absent sensation vs. 34.1°C ± 1.6°C with normal sensation, p < 0.001). Strong linear correlations were found between cutaneous temperature and sensory loss assessed using SW filaments (p < 0.001) and between cutaneous temperature and SSR (p < 0.001). Disability grade also correlated with lower temperatures, with hands at 34.3°C for no disability, 31.3°C for Grade 1, and 31.5°C for Grade 2 disability.</p><p><strong>Conclusion: </strong>Infrared thermography is a promising, non-invasive tool for the detection of peripheral sensory impairment in leprosy. The results obtained by infrared thermography show a strong correlation with those obtained using standard tests for sensory loss and autonomic nerve dysfunction.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic Switch From Atopic Dermatitis to Psoriasis During Dupilumab Therapy: A Real-Life Experience From a Tertiary Referral Center.","authors":"Alessandra Chiei Gallo, Gianluca Tavoletti, Davide Termini, Gianluca Avallone, Francesca Barei, Paolo Calzari, Roberto Pinto, Angelo V Marzano, Silvia M Ferrucci","doi":"10.1111/ijd.70105","DOIUrl":"https://doi.org/10.1111/ijd.70105","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Code Rust: A Protocol-Based Approach for Managing Suture Needle Breakage.","authors":"Isabella Ribaudo, Shifa Akhtar, Diana Keron, Gowri Kabbur, Jennifer Lucas","doi":"10.1111/ijd.70108","DOIUrl":"https://doi.org/10.1111/ijd.70108","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Risks of Psychiatric Comorbidities in Melasma Patients Treated With Tranexamic Acid: A Multicenter Cohort Study.","authors":"Kritin K Verma, Kevin T Nguyen, Sabrina C Camacho, Sahil Kapur, Kermanjot Sidhu, Michelle B Tarbox, Seemal R Desai","doi":"10.1111/ijd.70106","DOIUrl":"https://doi.org/10.1111/ijd.70106","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Variations in Onychomycosis Across Fitzpatrick Phototypes: A Retrospective Cohort Study.","authors":"Michael M Ong, Rachel C Hill, Brieann Sobieski, Bilal Shaikh, Shari R Lipner","doi":"10.1111/ijd.70104","DOIUrl":"https://doi.org/10.1111/ijd.70104","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tofacitinib for Urticarial Vasculitis: A Retrospective Study of 13 Patients.","authors":"Yu-Ting Gan, Shi Yan, Yi Liu, Feng-Lin Chen","doi":"10.1111/ijd.70098","DOIUrl":"https://doi.org/10.1111/ijd.70098","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement in Patient-Reported Emotional Symptoms and Activity Limitations due to Hair Loss in Patients With Alopecia Areata Treated With Ritlecitinib: Additional Analyses From ALLEGRO-2b/3.","authors":"Ernest H Law, Bintu Sherif, Arash Mostaghimi, Brett King, Rodney Sinclair, Natasha Mesinkovska, Kent A Hanson, Dane Korver, Costel Chirila","doi":"10.1111/ijd.70035","DOIUrl":"https://doi.org/10.1111/ijd.70035","url":null,"abstract":"<p><strong>Background: </strong>Patients with alopecia areata (AA) in ALLEGRO-2b/3 (NCT03732807) had clinically significant hair regrowth and patient-reported improvements with ritlecitinib versus placebo, but patient-reported improvements in AA Patient Priority Outcomes (AAPPO) emotional symptoms (ES) or activity limitations (AL) were not observed during the 24-week placebo-controlled phase. This study compared AAPPO scores between the 50-mg ritlecitinib maintenance dose (+/- 200-mg 4-week loading dose) and subtherapeutic 10-mg ritlecitinib through Week 48 of ALLEGRO-2b/3.</p><p><strong>Methods: </strong>Least squares mean (LSM) changes from baseline (CFBs) in domain scores were estimated for the full analysis population and for participants with baseline domain scores ≥ 1. Item-level responses (scores < 2) were evaluated for participants with baseline item scores ≥ 2, since lower baseline item scores (measured on 5-point response scales; range, 0-4) indicated less frequent/severe impacts from hair loss.</p><p><strong>Results: </strong>There were 325 participants (200/50-mg [n = 132] and 50-mg [n = 130], combined and as subgroups; 10-mg [n = 63]). LSM CFBs in ES and AL domain scores generally improved through Week 48 for all 50-mg groups, with significant differences versus 10-mg starting at Week 34 for ES and Week 40 for AL. The proportion of responders for all ES and AL items generally increased through Week 48 for all 50-mg groups. The largest improvements versus 10-mg were for ES items 5 and 6 (self-consciousness and embarrassment) and AL item 11 (interactions with others).</p><p><strong>Conclusions: </strong>ALLEGRO-2b/3 participants reported greater improvements in ES and AL due to hair loss by Week 48 with the 50-mg ritlecitinib maintenance dose (+/- 200-mg loading dose) versus subtherapeutic 10-mg ritlecitinib.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating Japanese Spotted Fever Risk: Numerical Differences Between Field-Dwelling and Human-Biting Tick Species.","authors":"Makoto Kondo, Koji Habe, Keiichi Yamanaka","doi":"10.1111/ijd.70102","DOIUrl":"https://doi.org/10.1111/ijd.70102","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medial Cutaneous Nerve Abscess: An Uncommon Manifestation of Borderline Tuberculoid Leprosy.","authors":"Priya Yadav, Shreya K Gowda, Surabhi Jain, Sudheer Arava, Ankur Goyal, Rajat Choudhary","doi":"10.1111/ijd.70096","DOIUrl":"https://doi.org/10.1111/ijd.70096","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Favorable Clinical Response to Nivolumab and Radiotherapy in Advanced Metastatic Porocarcinoma: A Case Report.","authors":"Hiroaki Ishida, Teruhiko Makino, Shohei Kitayama, Ko Kagoyama, Megumi Mizawa, Tadamichi Shimizu","doi":"10.1111/ijd.70095","DOIUrl":"https://doi.org/10.1111/ijd.70095","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}