International Journal of Dermatology最新文献

{"title":"JAK Family Expression and Therapeutic Implications in Primary Cicatricial Alopecias.","authors":"Juan Ruano","doi":"10.1111/ijd.70094","DOIUrl":"https://doi.org/10.1111/ijd.70094","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Risk of Dermatoses Following Sulfur Mustard Exposure: A Retrospective Cohort Study.","authors":"Parviz Toossi, SeyedHasan Etemadzadeh, Mohammadreza Sedighimoghadam, Fahimeh Abdollahimajd, Mohammad Roustanezhad Arabani, Aliakbar Babaei, Marziye Asgari, Shahram Ariaeenejad, Nima Sarrafi-Rad, Batool Mousavi","doi":"10.1111/ijd.70080","DOIUrl":"https://doi.org/10.1111/ijd.70080","url":null,"abstract":"<p><strong>Background: </strong>Sulfur mustard (SM) was extensively used during the Iraq-Iran War (1983-1988). The study assessed the prevalence of dermatoses in exposed survivors compared to the general population.</p><p><strong>Methods: </strong>Using a retrospective cohort study, we visited and compared the prevalence of skin complaints and active dermatoses in 1538 SM-exposed survivors and 1425 unexposed controls. All participants underwent clinical evaluations by dermatologists across multiple centers.</p><p><strong>Results: </strong>The exposed group demonstrated a higher prevalence of chronic diseases (odds ratio [OR]: 4.57, 95% confidence interval [CI]: 3.92-5.34), history of dermatoses (OR: 2.32, 95% CI: 1.97-2.73), need for dermatologic care (OR: 5.91, 95% CI: 4.67-7.50), and corticosteroid use (OR: 10.98, 95% CI: 8.77-13.74) with concurrent use of multiple corticosteroid forms. Dermatologist examinations revealed a higher rate of skin complaints (92.1% vs. 23.4%; OR: 36.47, 95% CI: 29.24-44.5) and dermatoses (86.7% vs. 32.1%; OR: 13.81, 95% CI: 11.48-16.61) in the exposed group. The most prevalent symptom among the exposed group was itching (84.7% vs. 14.5%; OR: 32.46, 95% CI: 26.52-39.74), followed by burning sensation (38% vs. 3.6%; OR: 16.54, 95% CI: 12.28-22.28) and dry skin (36.2% vs. 5.6%; OR: 9.52, 95% CI: 7.43-12.20). Dermatologist visits indicated the highest odds in the exposed group compared to the control group for: blistering disorders (OR: 40.4, 95% CI: 2.4-667.4); persistent warts (OR: 17.7, 95% CI: 1.0-304.5); pruritus (OR: 17.1, 95% CI: 9.5-30.77); xerosis (OR: 11.98, 95% CI: 9.36-15.34); neurodermatitis (OR: 10.28, 95% CI: 5.79-18.56); lichen simplex chronicus (OR: 9.02, 95% CI: 6.13-13.28); and excoriated dermatitis (OR: 7.75, 95% CI: 5.88-10.23). There was no significant rise in the risk of vitiligo, psoriasis, keloids, drug-induced acne, basal cell carcinoma (BCC), morphea, discoid lupus erythematosus (DLE), systemic lupus erythematosus (SLE), squamous cell carcinoma (SCC), or melanoma in the exposed group compared to the control group.</p><p><strong>Conclusions: </strong>Single-dose SM exposure-regardless of its amount or duration-leads to significantly more long-lasting skin conditions compared to the controls.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regression of Eruptive Syringomas Following Immune Modulation in an Elderly Male With Psoriasis.","authors":"Andriani Tsiakou, Melpomeni Theofili, Alexios Zarras, Emmanouil Karampinis, Vasiliki Chasapi","doi":"10.1111/ijd.70093","DOIUrl":"https://doi.org/10.1111/ijd.70093","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinguishing Nevi Suspected for Malignancy With 3D High-Frequency Ultrasound Imaging.","authors":"Julian Henke, Kuo Zhang, Ella Castellano, Jiwoong Jason Jeong, Xiaofeng Yang, Mohammad Khan","doi":"10.1111/ijd.70089","DOIUrl":"https://doi.org/10.1111/ijd.70089","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Model for End-Stage Liver Disease Is a Novel Potential Predictor of 30-Day Mortality in Patients With Necrotizing Fasciitis.","authors":"Thilo Gambichler, Nesrien Abou Rasched, Laura Susok, Alexander Kreuter, Nessr Abu Rached","doi":"10.1111/ijd.70044","DOIUrl":"https://doi.org/10.1111/ijd.70044","url":null,"abstract":"<p><strong>Background: </strong>Necrotizing fasciitis (NF) is a rapidly progressive soft-tissue infection with high morbidity and mortality. Early identification of patients at risk for ICU admission and 30-day mortality is critical.</p><p><strong>Methods: </strong>In this multicenter cohort study, 88 NF patients were compared with age- and gender-matched erysipelas controls. We studied systemic immune-inflammation biomarkers (e.g., SII, NLR), the model for end-stage liver disease (MELD; calculated from serum bilirubin, creatinine, and INR), kidney markers, and the LRINEC score at presentation. Logistic regression identified ICU admission predictors; Cox regression assessed 30-day mortality.</p><p><strong>Results: </strong>Compared with erysipelas controls, NF patients had higher white-cell counts, liver enzymes, creatinine, CRP, and procalcitonin; only MELD differed among composite indices (p < 0.01). Of 88 NF cases, 58 (65.9%) required ICU care and 21 (23.9%) died within 30 days. Univariable analysis linked ICU admission to CRP > 295.3 mg/L, sepsis, trunk involvement, no upper-extremity infection, and higher LRINEC (all p < 0.01). Thirty-day mortality correlated with younger age, dementia, severe liver disease, eosinopenia, and elevated MELD, INR, and creatinine (all p < 0.05). Multivariable models showed CRP > 295.3 mg/L (OR 42.5; 95% CI 4.3-424.4) and sepsis (OR 13.5; 95% CI 3.3-32.8) as independent ICU admission predictors, and MELD score alone predicted 30-day mortality (HR 1.61 per point; 95% CI 1.13-2.30).</p><p><strong>Conclusions: </strong>High CRP levels confirm their value in predicting ICU admission; however, the most novel finding is the independent prognostic power of MELD for 30-day mortality. Incorporating MELD alongside CRP into clinical pathways could markedly improve early risk stratification.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical Characterization of JAK Family Expression in the Primary Inflammatory Infiltrate of Lichen Planopilaris and Folliculitis Decalvans, With an Exploratory Clinical Assessment of Oral JAK Inhibitors.","authors":"Miguel Antonio Lasheras-Pérez, María Concepción Garrido-Ruiz, Alejandro Lobato-Berezo, Rodolfo David Palacios-Diaz, Irene Albert-Cobo, Giuseppe Gallo, Virginia Velasco-Tamariz, Ricardo Ruiz-Villaverde, Rocío Gil-Redondo, Conrad Pujol-Marco, Rosa María García-Martín, María Del Mar Blanes-Martínez, Begoña Escutia-Muñoz, Jorge Magdaleno-Tapial, Mercedes Rodríguez-Serna, Antonio Sahuquillo-Torralba, Simone Ribero, Federica Gelato, Margarita Llavador-Ros, Vicent Martínez-Cózar, Nicolay S Pantoja Borja, Kristen I Lo Sicco, Jerry Shapiro, José Luis Rodríguez-Peralto, Rafael Botella-Estrada","doi":"10.1111/ijd.70084","DOIUrl":"https://doi.org/10.1111/ijd.70084","url":null,"abstract":"<p><strong>Background: </strong>Lichen planopilaris (LPP) and folliculitis decalvans (FD) are two of the most common types of primary scarring alopecia. Several Janus kinase inhibitors (JAKis) have been used effectively in their treatment. We conducted an immunohistochemical (IHC) study to evaluate whether any member of the JAK family was overexpressed in the primary inflammatory infiltrate of FD and LPP. Additionally, we performed an exploratory retrospective study on the efficacy and safety of oral JAKis in LPP.</p><p><strong>Methods: </strong>Pathology scalp samples from seven healthy controls and 28 patients with LPP or FD were selected for staining with anti-JAK1, anti-JAK2, anti-JAK3, and anti-TYK2 antibodies. Cases and controls were compared using the H-score of the inflammatory cells. On the other hand, an exploratory retrospective clinical study was conducted in which patients with LPP who were treated with JAKis for at least three months were included. Clinical characteristics, severity scores, and the presence of adverse events were collected.</p><p><strong>Results: </strong>The IHC study determined that JAK1 and JAK2 exhibited similar expression patterns in cases and controls. However, JAK3 and TYK2 were expressed solely in cases of primary scarring alopecia and were negative in the controls. In the exploratory clinical study, 19 patients with LPP were treated with JAKis. Severity scores improved in follow-up visits, with adverse events generally being mild.</p><p><strong>Conclusions: </strong>JAK3 and TYK2 were overexpressed in LPP and FD samples compared to healthy controls, supporting JAKs as potential pharmacological targets of interest. JAKis could be an effective and safe treatment for LPP patients.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopy of Atypical Granular Cell Tumor: Sometimes Yellow Is More Than Expected.","authors":"Martina Lambertini, Emi Dika, Marco Morante, Beatrice Raone, Biagio Scotti, Costantino Ricci","doi":"10.1111/ijd.70088","DOIUrl":"https://doi.org/10.1111/ijd.70088","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Effectiveness and Safety of Dupilumab for the Treatment of Prurigo Nodularis.","authors":"Elena Ippoliti, Niccolò Gori, Giulia Guadagno, Lucia Di Nardo, Cristina Guerriero, Ketty Peris","doi":"10.1111/ijd.70091","DOIUrl":"https://doi.org/10.1111/ijd.70091","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Highlights—November 2025","authors":"Lajos Kemény","doi":"10.1111/ijd.70090","DOIUrl":"10.1111/ijd.70090","url":null,"abstract":"<div>\u0000 \u0000 <p>Skin cancer represents a significant public health burden due to its high incidence, potential for morbidity, and, in the case of melanoma, substantial mortality. In the November issue of the Journal, we highlight the different aspects of skin cancer prevention and equity. A European melanoma analysis shows north–south and east–west gradients, reflecting genetic risk and unequal access to care. Research on nevus counts confirms their value as dynamic risk markers shaped by age, sex, and height. A global review of skin cancer in albinism reveals a huge disease burden in Africa due to a lack of photoprotection and care. Chemoprevention studies expose gaps between prescriptions and patient adherence. Although sunscreens play a significant role in skin cancer prevention, the chemicals in the sunblocks may also pose a risk to human health and the environment. Together, these insights call for integrated and sustainable prevention strategies.</p>\u0000 </div>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 11","pages":"1975-1976"},"PeriodicalIF":3.2,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Marketing Safety of Bimekizumab in Psoriasis Patients: Pharmacovigilance Data From FDA Adverse Event Reporting System.","authors":"Tung S Tran, Duc V Le, Jena C Jacobs, Trang M Nguyen, David A Wetter, Giang H Nguyen","doi":"10.1111/ijd.70082","DOIUrl":"https://doi.org/10.1111/ijd.70082","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}