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International Journal of Dermatology最新文献

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Eruptive Disseminated Porokeratosis Induced by PEB Chemotherapy: A Case Report. PEB化疗致爆发性弥散性角化症1例。
IF 3.5 4区 医学
International Journal of Dermatology Pub Date : 2025-06-18 DOI: 10.1111/ijd.17933
Sara H Yang, Andreas Recke, Nils Gilbert
{"title":"Eruptive Disseminated Porokeratosis Induced by PEB Chemotherapy: A Case Report.","authors":"Sara H Yang, Andreas Recke, Nils Gilbert","doi":"10.1111/ijd.17933","DOIUrl":"https://doi.org/10.1111/ijd.17933","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosomes in Dermatology: A Comprehensive Review of Current Applications, Clinical Evidence, and Future Directions. 皮肤病学外泌体：当前应用、临床证据和未来方向的综合综述。
IF 3.5 4区 医学
International Journal of Dermatology Pub Date : 2025-06-18 DOI: 10.1111/ijd.17903
William J Nahm, Christos Nikas, Mohamad Goldust, Nadine Horneck, Juan Antonio Cervantes, Joshua Burshtein, Maria Tsoukas
{"title":"Exosomes in Dermatology: A Comprehensive Review of Current Applications, Clinical Evidence, and Future Directions.","authors":"William J Nahm, Christos Nikas, Mohamad Goldust, Nadine Horneck, Juan Antonio Cervantes, Joshua Burshtein, Maria Tsoukas","doi":"10.1111/ijd.17903","DOIUrl":"https://doi.org/10.1111/ijd.17903","url":null,"abstract":"<p><p>Recent advances have highlighted exosomes as promising therapeutic, prognostic, and diagnostic agents in dermatology and aesthetic medicine, suggesting their expanding role in various skin conditions. This comprehensive review examines the current applications and future directions of exosomes in dermatological practice. The analysis of available literature reveals a growing market of exosome-based products internationally and within the United States, with diverse formulations primarily derived from human stem cells. Clinical studies of exosomes have demonstrated clinical efficacy in addressing skin aging, scarring, hair restoration, and melasma. Additionally, exosomes show potential as therapeutic agents for inflammatory skin conditions like atopic dermatitis and as prognostic and diagnostic biomarkers for various dermatological disorders including psoriasis, vitiligo, and melanoma. Despite promising results, challenges remain in the standardization of isolation protocols, optimization of delivery systems, and establishment of regulatory frameworks. Proper characterization of exosome cargo is necessary to ensure safety and efficacy. Future applications may include engineered exosomes with enhanced targeting capabilities, plant-derived formulations with improved penetration, and combination therapies integrating exosomes with established dermatological procedures for improved outcomes across cosmetic, wound healing, and oncological applications. Exosome-based therapies may represent a paradigm shift in dermatological treatment, yet their transition from promising research to mainstream clinical practice hinges on overcoming key technical and regulatory obstacles.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Standardization of Electronic Medical Record Documentation Improves Hospitalist Communication in Drug Reaction With Eosinophilia and Systemic Symptoms. 电子病历文件的标准化提高了医院医生对嗜酸性粒细胞增多和全身症状的药物反应的沟通。
IF 3.5 4区 医学
International Journal of Dermatology Pub Date : 2025-06-18 DOI: 10.1111/ijd.17917
Kelsey B Nusbaum, Michelle M Huynh, Lauren H Han, Beau Sitton, Catherine Chung, Kristopher Fisher, Rachel M Kirven, Benjamin H Kaffenberger, Abraham M Korman
{"title":"Standardization of Electronic Medical Record Documentation Improves Hospitalist Communication in Drug Reaction With Eosinophilia and Systemic Symptoms.","authors":"Kelsey B Nusbaum, Michelle M Huynh, Lauren H Han, Beau Sitton, Catherine Chung, Kristopher Fisher, Rachel M Kirven, Benjamin H Kaffenberger, Abraham M Korman","doi":"10.1111/ijd.17917","DOIUrl":"https://doi.org/10.1111/ijd.17917","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Staphylococcus aureus Nasal Carriage in Uremic Pruritus and Infection in Hemodialysis Patients. 金黄色葡萄球菌鼻腔携带在血液透析患者尿毒症性瘙痒和感染中的作用。
IF 3.5 4区 医学
International Journal of Dermatology Pub Date : 2025-06-17 DOI: 10.1111/ijd.17904
Mei-Ju Ko, Jenny Chiang, Chun-Hsing Liao, Wan-Chuan Tsai, Ping-Hsiu Tsai, Le-Yin Hsu, Fang-Yeh Chu, Yen-Ling Chiu, Hon-Yen Wu
{"title":"Role of Staphylococcus aureus Nasal Carriage in Uremic Pruritus and Infection in Hemodialysis Patients.","authors":"Mei-Ju Ko, Jenny Chiang, Chun-Hsing Liao, Wan-Chuan Tsai, Ping-Hsiu Tsai, Le-Yin Hsu, Fang-Yeh Chu, Yen-Ling Chiu, Hon-Yen Wu","doi":"10.1111/ijd.17904","DOIUrl":"https://doi.org/10.1111/ijd.17904","url":null,"abstract":"<p><strong>Background: </strong>While Staphylococcus aureus (S. aureus) is a well-recognized concern in hemodialysis (HD) patients, its role in uremic pruritus remains unknown. This study investigated the impact of S. aureus nasal carriage on the prevalence and severity of uremic pruritus and its association with subsequent infection in HD patients.</p><p><strong>Methods: </strong>We conducted a prospective cohort study from April 2019 to January 2020, enrolling 100 HD patients in Taiwan. Nasal swab cultures determined S. aureus colonization status. Odds ratios (ORs) for uremic pruritus, effect estimates for pruritus intensity, and hazard ratios (HRs) for subsequent S. aureus infections were assessed.</p><p><strong>Results: </strong>S. aureus nasal carriage was detected in 24% of HD patients and was more prevalent among those with uremic pruritus (32.7% vs. 13.3%, p = 0.02). S. aureus nasal carriage was associated with a significantly increased risk of uremic pruritus (OR: 4.21; 95% confidence interval [CI], 1.34-13.24, p < 0.01) and correlated with higher pruritus intensity (effect estimate: 1.18; 95% CI, 0.05-2.30; p = 0.04). During a median follow-up of 8.97 months, five patients developed S. aureus infections. While S. aureus nasal carriage showed a trend toward an increased risk of subsequent infection, the finding did not reach statistical significance (HR: 50.93; 95% CI, 0.62-4181.02; p = 0.08).</p><p><strong>Conclusions: </strong>S. aureus nasal carriage is significantly associated with the prevalence and severity of uremic pruritus in HD patients. Larger studies are needed to confirm its role in infection risk and to explore decolonization as a potential therapeutic strategy.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Microbiome in Hidradenitis Suppurativa Tunnels: A Systematic Review. 化脓性汗腺炎隧道微生物组：系统综述。
IF 3.5 4区 医学
International Journal of Dermatology Pub Date : 2025-06-17 DOI: 10.1111/ijd.17892
Alberto Soto-Moreno, Sofía Haselgruber-de Francisco, Javier León-Pérez, Carmen García-Moronta, Carlos Cuenca Barrales, Salvador Arias-Santiago, Alejandro Molina Leyva
{"title":"The Microbiome in Hidradenitis Suppurativa Tunnels: A Systematic Review.","authors":"Alberto Soto-Moreno, Sofía Haselgruber-de Francisco, Javier León-Pérez, Carmen García-Moronta, Carlos Cuenca Barrales, Salvador Arias-Santiago, Alejandro Molina Leyva","doi":"10.1111/ijd.17892","DOIUrl":"https://doi.org/10.1111/ijd.17892","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) is a chronic inflammatory disease that affects the pilosebaceous units, particularly in large skin folds. The pathophysiology of HS is multifactorial, with evidence suggesting that the microbiome plays a crucial role in perpetuating inflammation. The persistent nature of HS tunnels, coupled with potential dysbiosis in these lesions, may help explain the recurrent episodes of HS, even with systemic treatment. To explore this further, a literature search was conducted on June 20, 2024. A total of eight studies, involving 418 patients, 632 HS lesions, 360 HS tunnels, and 300 controls, were included. The findings from these studies suggested that HS tunnels are characterized by a polymicrobial microbiome, predominantly dominated by anaerobic bacteria such as Porphyromonas, Parvimonas, Fusobacterium, and Prevotella. In contrast, HS tunnels exhibit a notable reduction in saprophytic species like Cutibacterium acnes and Staphylococcus epidermidis, which are commonly found in healthy skin. Disease stage, as classified by the Hurley system, is the most significant factor influencing the microbiome composition of HS tunnels, with advanced lesions showing a greater presence of dysbiotic and pathogenic flora. Interestingly, no significant differences in bacterial colonization were observed based on variables such as sex, age, smoking status, body mass index (BMI), or anatomical location. Larger biofilms with active bacteria were found in tunnels and anaerobic regions of hair follicles. Overall, these results highlight the distinct polymicrobial, predominantly anaerobic bacterial flora of HS tunnels and the significant reduction in commensal bacteria typically found in healthy skin. This specific microbiome may help explain both the pathogenic characteristics and therapeutic challenges associated with HS tunnels.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Use of Tralokinumab in Patients With Atopic Dermatitis: A Real-World Multicentric Case Series. 特应性皮炎患者长期使用曲洛单抗：真实世界多中心病例系列
IF 3.5 4区 医学
International Journal of Dermatology Pub Date : 2025-06-17 DOI: 10.1111/ijd.17913
Christine Bangert, Barbara Ebner, Barbara Gruber, Damian Meyersburg, Judith Traxler
{"title":"Long-Term Use of Tralokinumab in Patients With Atopic Dermatitis: A Real-World Multicentric Case Series.","authors":"Christine Bangert, Barbara Ebner, Barbara Gruber, Damian Meyersburg, Judith Traxler","doi":"10.1111/ijd.17913","DOIUrl":"https://doi.org/10.1111/ijd.17913","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypersensitivity Reaction to Vancomycin in Bone Cement in the Knee. 膝关节骨水泥对万古霉素的过敏反应。
IF 3.5 4区 医学
International Journal of Dermatology Pub Date : 2025-06-16 DOI: 10.1111/ijd.17915
Yurie Shizukawa, Yuji Kan, Toshiya Handa, Kazuki Furudate, Marina Hamada, Takahiko Abe, Chika Fujie, Hisashi Uhara
{"title":"Hypersensitivity Reaction to Vancomycin in Bone Cement in the Knee.","authors":"Yurie Shizukawa, Yuji Kan, Toshiya Handa, Kazuki Furudate, Marina Hamada, Takahiko Abe, Chika Fujie, Hisashi Uhara","doi":"10.1111/ijd.17915","DOIUrl":"https://doi.org/10.1111/ijd.17915","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimodal Non-Invasive Imaging in Erythema Elevatum Diutinum: Insights From Dermoscopy and Reflective Confocal Microscopy. 从皮肤镜和反射共聚焦显微镜观察叠层隆起红斑的多模态无创成像。
IF 3.5 4区 医学
International Journal of Dermatology Pub Date : 2025-06-16 DOI: 10.1111/ijd.17912
Zhe Gao, Xin Zhang, Weifei Gao, Riqu Cao, Tianhong Xu
{"title":"Multimodal Non-Invasive Imaging in Erythema Elevatum Diutinum: Insights From Dermoscopy and Reflective Confocal Microscopy.","authors":"Zhe Gao, Xin Zhang, Weifei Gao, Riqu Cao, Tianhong Xu","doi":"10.1111/ijd.17912","DOIUrl":"https://doi.org/10.1111/ijd.17912","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Growing Pink Periorbital Papule in a Middle-Aged Man: A Clinicopathological Challenge. 中年男性眼眶周围长出粉红色丘疹：临床病理挑战。
IF 3.5 4区 医学
International Journal of Dermatology Pub Date : 2025-06-16 DOI: 10.1111/ijd.17921
Lydia A Luu, Linglei Ma, Mark Russell
{"title":"A Growing Pink Periorbital Papule in a Middle-Aged Man: A Clinicopathological Challenge.","authors":"Lydia A Luu, Linglei Ma, Mark Russell","doi":"10.1111/ijd.17921","DOIUrl":"https://doi.org/10.1111/ijd.17921","url":null,"abstract":"<p><p>This report describes a case of a 48-year-old man who presented with a slowly enlarging lesion on the right lower eyelid that had been present for 8-9 years. The skin biopsy revealed an apocrine carcinoma of the eyelid. We discuss the clinical and histopathological differential diagnosis of apocrine carcinoma, along with treatment recommendations for these tumors.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beneficial Therapeutic Effect of Endothelin-Receptor Antagonist in Generalized Morphea: A Report of Two Cases. 内皮素受体拮抗剂治疗广泛性睡眠的有益疗效：附2例报告。
IF 3.5 4区 医学
International Journal of Dermatology Pub Date : 2025-06-13 DOI: 10.1111/ijd.17900
Leticia Szadai, Nóra Belső, Daniella Hulló, Erika Varga, Irma Korom, Zsuzsanna Bata-Csörgö
{"title":"Beneficial Therapeutic Effect of Endothelin-Receptor Antagonist in Generalized Morphea: A Report of Two Cases.","authors":"Leticia Szadai, Nóra Belső, Daniella Hulló, Erika Varga, Irma Korom, Zsuzsanna Bata-Csörgö","doi":"10.1111/ijd.17900","DOIUrl":"https://doi.org/10.1111/ijd.17900","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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