International Journal of Dermatology最新文献

{"title":"Clinical and Dermoscopic Manifestations of Ungual Scabies in an Infant.","authors":"Al-Muriesh Maher, Al-Ghaithi Suaad","doi":"10.1111/ijd.17656","DOIUrl":"10.1111/ijd.17656","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":"1677-1679"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing Treatment-Resistant Tumid Lupus Erythematosus: A Comparative Cohort Analysis of Refractory Versus Responsive Cases.","authors":"Lily Kaufman, Judith Lin, Matthew D Viveiros, Rachel M Kirven, Catherine G Chung, Brittany Dulmage, Jessica Kaffenberger, Abraham M Korman","doi":"10.1111/ijd.17674","DOIUrl":"10.1111/ijd.17674","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":"1672-1674"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Twenty-Nail Dystrophy With Upatacitinib.","authors":"Mingjie Tu, Yali Guo, Jiaxuan Wang, Jingyue Ma, Huiping Wang","doi":"10.1111/ijd.17702","DOIUrl":"10.1111/ijd.17702","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":"1659-1660"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double Trouble: A Case Series on Dual Morphology Cutaneous Immune-Related Adverse Events in Cancer Patients Treated With Immune Checkpoint Inhibitors.","authors":"Joseph Ebriani, Mike Westmeijer, Bethany Brumbaugh, Allison Holt, Baraa Hijaz, Kevin Sheng-Kai Ma, Kerry L Reynolds, Yevgeniy R Semenov, Steven T Chen","doi":"10.1111/ijd.17737","DOIUrl":"10.1111/ijd.17737","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":"1735-1740"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic Dermatitis in Indonesian Children: Association of Toilet Seat Dermatitis With Moderate-Severe Manifestation and Low Prevalence of Loss-of-Function Filaggrin Gene Variants.","authors":"Raden Mohamad Rendy Ariezal Effendi, Luba M Pardo, Reiva Farah Dwiyana, Oki Suwarsa, Michel van Geel, Yunia Sribudiani, Tamar E C Nijsten, Hok Bing Thio","doi":"10.1111/ijd.17733","DOIUrl":"10.1111/ijd.17733","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":"1711-1714"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paws to Patients: Canine Pyoderma Gangrenosum as a Reflective Model of Human Pyoderma Gangrenosum.","authors":"Kateryna Karpoff, Lori Sun, Christine L Cain, Becky Valentine, Andrew Simpson, Alex G Ortega-Loayza","doi":"10.1111/ijd.17863","DOIUrl":"10.1111/ijd.17863","url":null,"abstract":"<p><p>Human pyoderma gangrenosum (hPG) is a rare, non-infectious neutrophilic dermatosis characterized by painful, necrotic ulcers with violaceous borders. Research on hPG is limited by minimal existing animal models, the sole being a pharmacologically induced murine model. Few cases of canine pyoderma gangrenosum (cPG) have been published, and dogs are genetically closer to humans than are mice, making them a potentially valuable model of hPG. We aimed to characterize all published cPG cases and compare their presentation to that of hPG. A Google Scholar, PubMed, and Embase search of \"canine AND pyoderma gangrenosum\" was conducted in August 2024, with seven case reports, two case series, and two veterinarian-sourced cases ultimately reviewed. Of the 31 analyzed cPG cases, 30 presented with skin ulcers at multiple sites, the most common being the trunk (64.5%), paws (41.9%), and limbs (32.3%), mirroring the typical localization of hPG on the lower extremities, back, and abdomen. The average age of cPG presentation was 7.8 +/- 3.7 years (range: 0.25-14.5 years). Dogs reflected hPG comorbidities, with 16.1% presenting with gastrointestinal pathologies, 6.5% with arthritis, and 6.5% with hematologic disorders. Dogs were responsive to medications frequently employed in hPG-prednisone/prednisolone (80.6%) as initial therapy, and cyclosporine (77.4%) as maintenance therapy. Overall, cPG resembles hPG in affected anatomic sites, comorbidities, and therapeutic response. It offers a representative, spontaneously occurring hPG animal model alternative to the existing murine model. Future studies are necessary to reproduce cPG to further investigate disease pathophysiology.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":"1584-1591"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichoscopic Features of Scalp Psoriasis: Their Association With Disease Severity and Quality of Life in a Hispanic Population.","authors":"Mayra A Reyes Soto, Daniela López-Quintero, Andrés Noyola-Perez, Minerva Gómez-Flores, Sonia S Ocampo-Garza, Jorge Ocampo-Candiani","doi":"10.1111/ijd.70038","DOIUrl":"https://doi.org/10.1111/ijd.70038","url":null,"abstract":"<p><strong>Background: </strong>Scalp psoriasis is a common condition that impairs quality of life (QoL). Trichoscopy is a valuable tool for diagnosis, but its correlation with disease severity or patient-reported outcomes, especially in Hispanic populations, remains unclear due to limited data. This study aimed to characterize the trichoscopic findings of scalp psoriasis in a Hispanic cohort and to evaluate their association with clinical severity and QoL measures.</p><p><strong>Methods: </strong>We conducted a cross-sectional study in Hispanic adults with scalp psoriasis. Participants underwent a comprehensive clinical assessment, involving the Psoriasis Scalp Severity Index (PSSI), the Dermatology Life Quality Index (DLQI), and the Scalp-Specific Dermatology Life Quality Index (SCALPDEX). Standardized trichoscopic images were captured from five scalp regions and analyzed for characteristic vascular patterns. Multiple linear regression analyses were used to identify associations between trichoscopic findings and clinical outcomes.</p><p><strong>Results: </strong>Among the 81 participants (mean age 40 ± 13.65 years, 50.6% female), twisted red loops were the most frequent vascular pattern (64-84% across regions), which significantly correlated with elevated PSSI, Videodermoscopy Scalp Psoriasis Severity Index (VSCAPSI), and DLQI scores (p < 0.05). Hemorrhagic dots in the parietal regions were associated with higher QoL impairment (DLQI: +5 points; SCALPDEX: +17.1 points, p < 0.01). Females reported greater scalp-specific symptom burden despite lower objective severity scores.</p><p><strong>Conclusion: </strong>In this cohort, specific trichoscopic findings were associated with increased clinical severity and impaired QoL. These preliminary findings suggest that trichoscopy can serve as a complementary tool for a more holistic assessment. Longitudinal studies are needed to validate trichoscopic features as biomarkers of disease activity and treatment response.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocyte Transformation Tests and Patch Tests to Identify Drugs Potentially Associated With Bullous Pemphigoid Development.","authors":"Belen de Nicolas-Ruanes, Carlos Fernandez-Lozano, Patricia Gutierrez-Canales, Asuncion Ballester-Martinez, Natalia Rodriguez-Otero, Javier Martinez-Botas, Belén de la Hoz Caballer, Ana Andres-Martin, Emilio Solano-Solares, Maria Esther Gomez-Salazar Lopez-Silanes, Laura Gisella Diaz-Montalvo, Diana M Arrebola, Vivian Lizeth Stewart-Delcid, Emilio Garcia-Mouronte, Carlos Azcarraga-Llobet, Emilio Berna-Rico, Sonia Ortega-Sanchez, Montserrat Fernandez-Guarino","doi":"10.1111/ijd.17849","DOIUrl":"10.1111/ijd.17849","url":null,"abstract":"<p><strong>Background: </strong>Bullous pemphigoid (BP) is the most common autoimmune blistering disease, with a rising incidence in the elderly. BP is associated with multiple triggering factors, including drug exposure. However, evidence in this respect is limited, and the underlying immune mechanisms remain unknown. Our study aims to identify the role of specific drugs in BP pathogenesis using in vitro lymphocyte transformation tests (LTT) and in vivo patch testing, aiding in the differentiation between truly associated drugs and coincidental associations.</p><p><strong>Methods: </strong>Thirty-three patients with suspected BP and no ongoing systemic treatment were enrolled. LTT and patch tests were conducted 3 months after diagnosis. BP disease activity was assessed using the Bullous Pemphigoid Disease Activity Index (BPDAI) at diagnosis and at follow-up visits at 3 and 6 months.</p><p><strong>Results: </strong>LTT results were positive in 60% of patients for dipeptidyl peptidase 4 inhibitors, loop diuretics, hydrochlorothiazide, levetiracetam, nivolumab, enalapril, and amlodipine. Patients showed a reduction in BPDAI over the study period, regardless of LTT results. Although limited by the low sample size, positive LTT patients showed a trend toward clinical improvement when the implicated drug was discontinued. Patch testing was positive in one patient, who also had a corresponding positive LTT.</p><p><strong>Conclusions: </strong>Our findings demonstrate the existence of a potential role for certain drugs in BP pathogenesis, suggesting that these drugs may trigger the disease in genetically predisposed individuals. Although further studies are needed, LTT may serve as a useful and available tool in the management of BP patients in the future.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":"1636-1643"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum C-Reactive Protein as a Potential Indicator for Screening Fecal Calprotectin in Patients With Moderate-to-Severe Hidradenitis Suppurativa: A Cross-Sectional Cohort Study.","authors":"Neslihan Demirel Öğüt, Rahşan Ilıkçı Sağkan, Rabia Arıcı, Ece Gökyayla, Simge Ünal, Sema Koç Yıldırım, Ece Erbağcı, Ayris Öztürk","doi":"10.1111/ijd.17868","DOIUrl":"10.1111/ijd.17868","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder frequently associated with immune-mediated comorbidities, including inflammatory bowel disease (IBD). Given the potential risk of IBD, particularly before initiating therapies such as interleukin (IL)-17 inhibitors, screening through a fecal calprotectin (FC) test may be warranted. While FC is a reliable, non-invasive biomarker for ruling out IBD, its cost and limited availability in dermatology settings present challenges. Therefore, this study aims to investigate the potential association between FC and serum C-reactive protein (CRP) levels in patients with moderate-to-severe HS, which may provide a more accessible screening approach.</p><p><strong>Method: </strong>This cross-sectional cohort study was conducted at the Department of Dermatology and Venereology of Uşak University between April 2, 2024, and December 31, 2024, including 18-65-year-old patients with moderate-to-severe HS. Serum CRP and FC levels were analyzed using an enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>Stool samples from 61 patients with moderate-to-severe HS were included. The median FC and serum CRP levels were 28.2 μg/g and 5.3 mg/L, respectively, with a significant correlation between them (rho = 0.289, p = 0.026). While FC levels did not significantly differ between moderate and severe HS, CRP levels were significantly higher in patients with severe disease (p = 0.009). Receiver operating characteristic (ROC) analysis identified a CRP cut-off of 5.35 mg/L for predicting FC ≥ 50 μg/g (AUC = 0.660, p = 0.045), with 70% sensitivity and 61.5% specificity.</p><p><strong>Conclusion: </strong>Patients with moderate-to-severe HS and serum CRP levels above 5.35 mg/L may benefit from FC screening, and those with FC levels exceeding 50 μg/g may be considered for further endoscopic evaluation to assess IBD.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":"1615-1622"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brodalumab for Darier Disease: A Case Series Highlighting IL-17 Inhibition as a Potential Treatment.","authors":"Caterina Mariarosaria Giorgio, Eugenia Veronica Di Brizzi, Gaetano Licata, Carmine Fiorentino, Giuseppe Argenziano, Anna Balato","doi":"10.1111/ijd.17751","DOIUrl":"10.1111/ijd.17751","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":"1720-1722"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}