International Journal of Dermatology最新文献

{"title":"Inflammatory Nail Disorders in Skin of Color: A Systematic Review of Clinical and Onychoscopic Manifestations.","authors":"Lea Tordjman, Jason Thomas, Antonella Tosti, Brian W Morrison","doi":"10.1111/ijd.17680","DOIUrl":"https://doi.org/10.1111/ijd.17680","url":null,"abstract":"<p><p>Despite increasing attention regarding skin diseases in individuals with skin of color (SoC), there remains a significant gap in understanding and identifying inflammatory nail disorders in this population. This systematic review aims to synthesize the clinical and onychoscopic features of inflammatory nail disorders in patients with SoC, thereby enhancing diagnostic accuracy and patient outcomes. Our systematic PubMed and Medline (Web of Science) search followed PRISMA guidelines. Studies documenting clinical and onychoscopic features of inflammatory nail disorders in Fitzpatrick skin types IV-VI were included. Data extraction focused on study design, patient demographics, diagnostic methods, and nail findings. Of the 608 articles identified, 60 met the inclusion criteria, encompassing 16 inflammatory nail disorders and 12,743 patient cases. Key disorders included nail psoriasis, nail lichen planus, alopecia areata-associated nail changes, and others. Significant variability was noted in reporting skin type, with only a minority explicitly documenting SoC representation. This review underscores the paucity of literature on inflammatory nail disorders in SoC, highlighting gaps in clinical documentation and diagnostic approaches. Improved awareness and inclusion of SoC in dermatologic research are critical to addressing these disparities and enhancing health equity. Recognition of diverse clinical presentations in SoC patients is essential for accurate and timely diagnosis of inflammatory nail disorders. PROSPERO number: CRD42024568649.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Successful Use of Higher Dose Dupilumab in the Treatment of Pemphigoid Nodularis Combined With Parkinson's Disease.","authors":"Zhou Gao, Qichang Liang, Sijia Chen, Jiali Ruan, Kejian Zhu, Hao Cheng","doi":"10.1111/ijd.17685","DOIUrl":"https://doi.org/10.1111/ijd.17685","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Refractory Cutaneous Dermatomyositis With Anifrolumab.","authors":"Matthew F Helm, Natella Maglakelidze, Norhan Shamloul, Galen Foulke","doi":"10.1111/ijd.17675","DOIUrl":"https://doi.org/10.1111/ijd.17675","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Side Effects of PD-1 Inhibitors: A Single-Center Retrospective Study.","authors":"Melánia Pozsgai, Udoh Frieda-Rex Sebastian, Péter Oláh, Viktória Németh, Rolland Gyulai, Zsuzsanna Lengyel","doi":"10.1111/ijd.17683","DOIUrl":"https://doi.org/10.1111/ijd.17683","url":null,"abstract":"<p><strong>Background: </strong>The introduction of immune checkpoint inhibitors (ICIs) opened a new era in cancer immunotherapy. In particular, PD-1 inhibitors have shown remarkable efficacy in various cancers, most notably melanoma. However, the widespread use of immune checkpoint inhibitors comes with the challenge of immune-related adverse events (irAEs), with cutaneous toxicities being the most prevalent.</p><p><strong>Methods: </strong>A retrospective, single-center study was carried out to investigate the cutaneous side effects in patients diagnosed with melanoma and treated with PD-1 inhibitors (pembrolizumab or nivolumab) at the Department of Dermatology, Venereology, and Oncodermatology, University of Pécs, Hungary. The study included patients with stage III or IV melanoma who received PD-1 inhibitor monotherapy, either for metastatic or adjuvant purposes, from August 2015 to May 2022.</p><p><strong>Results: </strong>A cohort of 174 patients was examined, with 29% experiencing cutaneous adverse events (cAEs). The most prevalent cutaneous toxicities were vitiligo (n = 18; 27%), maculopapular rash (n = 14; 21%), pruritus (n = 14; 21%), xerostomia (n = 8; 12%), and lichenoid dermatitis (n = 4; 6%). Treatment primarily involved topical corticosteroids and emollients, with a few cases requiring systemic therapy. Notably, the occurrence of dermatologic adverse events was associated with improved progression-free survival (PFS) (p = 0.007) and overall survival (OS) (p = 0.026) compared to those without any skin toxicity (p < 0.0001), emphasizing their potential prognostic significance. Our data were not influenced by any well-known prognostic factors of melanoma.</p><p><strong>Conclusion: </strong>Our study contributes to the growing body of evidence supporting the prognostic value of cutaneous adverse events in patients treated with PD-1 inhibitors. Optimizing treatment strategies while maintaining oncologic therapy is essential, highlighting the role of dermatologists in multidisciplinary cancer care.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Role of Janus Kinase Inhibitors in Treating Granuloma Annulare: A Clinical, Narrative Review of Efficacy and Safety.","authors":"Sama Heidari, Reza Omid, Hanie Babaie, Zeinab Aryanian","doi":"10.1111/ijd.17684","DOIUrl":"https://doi.org/10.1111/ijd.17684","url":null,"abstract":"<p><p>Granuloma annulare (GA) is a non-infectious, granulomatous skin disease with an unknown pathoetiology whose treatment remains challenging. In recent decades, the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway have been implicated in the pathogenesis of various skin diseases, including GA. This pathway involves T-helpers and macrophages, launching a cytokine cascade that plays a crucial role in the disease pathology. Janus kinase (JAK) inhibitors can prevent cytokine involvement. To date, limited clinical data has been reported about the effectiveness of JAK inhibitors on granulomatous diseases. This review aims to examine studies that have reported off-label use of different JAK inhibitors in treating GA, focusing on their effectiveness and safety. Since there is no definitive treatment for GA, evaluating the role of JAK inhibitors could help establish a consensus on their future use in this type of medication.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Educational Intervention to Reduce Regulated Medical Waste: The Inpatient Medicine and Outpatient Dermatology Settings","authors":"Genevieve S. Silva,&nbsp;Jeromy W. Gotschall,&nbsp;Fengling Hu,&nbsp;Elizabeth Whidden,&nbsp;Phoebe Cunningham,&nbsp;Jacob Niculcea,&nbsp;Cody Chapman,&nbsp;Prateek V. Sharma,&nbsp;Greg Evans,&nbsp;Farah Hussain,&nbsp;Zelma C. Chiesa Fuxench,&nbsp;Kirstin Knox,&nbsp;Misha Rosenbach","doi":"10.1111/ijd.17682","DOIUrl":"10.1111/ijd.17682","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Improving regulated medical waste (RMW) management is crucial for enhancing planetary health and cost savings. We sought to assess an educational intervention on clinical staff understanding and behavior regarding RMW management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This two-month (2023–2024) controlled, prospective educational intervention at the University of Pennsylvania Health System surveyed healthcare workers, including physicians, nurses, and medical assistants, from four inpatient medicine floors and two dermatology clinics. Half of the medicine and dermatology settings were controls. The intervention included in-person staff training sessions and printed materials (posters, bin stickers) describing waste segregation and RMW's environmental, health, and cost impacts. A deidentified online survey pre- and post-intervention measured RMW knowledge and behaviors. The primary outcome was a change in performance on survey questions on proper RMW disposal and RMW's negative externalities. Secondary outcomes were self-reported changes in environmental beliefs and waste stewardship motivators and behaviors, qualitative responses around stewardship barriers, and the impact of clinical role on intervention efficacy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Average baseline inpatient knowledge scores were 6.17 of 9 versus 7.51 for outpatient. The inpatient intervention increased the odds of answering each question correctly by 3-fold (odds ratio: 3.71, 95% CI: 2.218–6.401, <i>p</i> &lt; 0.001). The outpatient clinical role was associated with receptivity to the intervention: the intervention effect was 12.7 times stronger for nursing staff than for physicians (95% CI: 1.86, 263.29, <i>p</i> = 0.024). The intervention improved the overall understanding of RMW's negative environmental impact.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>An educational intervention can improve understanding of RMW's proper disposal and environmental impact, particularly among nursing staff, and inform future interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 5","pages":"901-908"},"PeriodicalIF":3.5,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijd.17682","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in the Exploration and Treatment of Itch/Pruritus.","authors":"Jacek C Szepietowski, Mohamad Goldust","doi":"10.1111/ijd.17678","DOIUrl":"https://doi.org/10.1111/ijd.17678","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Facial Skin Artificial Intelligence (AI) to Capture Atopic Dermatitis Patients' Response to Therapy: A Single-Center Prospective Study.","authors":"Shirley P Parraga, Jessica Q Duong, Morgan L Agner, Sujeeth K Shanmugam, Sarah L Taylor, Steven R Feldman","doi":"10.1111/ijd.17688","DOIUrl":"https://doi.org/10.1111/ijd.17688","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No Significant Skin Cancer Risk From UV/LED Nail Lamp Radiation Exposure","authors":"Brian L. Diffey","doi":"10.1111/ijd.17686","DOIUrl":"10.1111/ijd.17686","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 4","pages":"633-634"},"PeriodicalIF":3.5,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Lichen Planopilaris With Abrocitinib.","authors":"Giuseppe Gallo, Simone Ribero, Michela Ortoncelli, Luca Valtellini, Angelo V Marzano, Pietro Quaglino, Gianluca Avallone","doi":"10.1111/ijd.17681","DOIUrl":"https://doi.org/10.1111/ijd.17681","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}