International Journal of Dermatology最新文献

{"title":"Effectiveness and Safety of Upadacitinib in Adults Older Than 50 Years With Moderate-To-Severe Atopic Dermatitis: A Multicenter Study.","authors":"Francisco Javier Melgosa Ramos, Lorena Vila Cobreros, Marta Galarreta Pascual, Santiago Guillén-Climent, María Matellanes-Palacios, Juncal Roca Ginés, Javier Sabater-Abad, Eduardo Bernia-Petit, Andres Casanova Esquembre, Andrea Estébanez Corrales, Carlos Abril-Pérez, Victor González Delgado","doi":"10.1111/ijd.17797","DOIUrl":"https://doi.org/10.1111/ijd.17797","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Clinical Improvement With Tyrosine Kinase 2 Inhibitor Deucravacitinib in Overlapping Psoriasis and Atopic Dermatitis.","authors":"Jun Ting Tang, Ming Yuan Xu, Nan Hui Wu, Fei Wu, Ye Qiang Liu","doi":"10.1111/ijd.17742","DOIUrl":"https://doi.org/10.1111/ijd.17742","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Eczematous Reactions Secondary to Biologic Use in Psoriasis Patients: A Retrospective Study.","authors":"Shivkar Amara, Nilesh Kodali, Miyahra Lopez, Kelly Hawkins, Scott Stratman, Emma Guttman-Yassky, Mark Lebwohl","doi":"10.1111/ijd.17727","DOIUrl":"https://doi.org/10.1111/ijd.17727","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Dark Side of Calcium Channel Blockers: Increased Risk of Stasis Dermatitis.","authors":"Racha Cherradi, Iman Bouchelkia, Safiya Haque, Jennifer Ezuruike, Omar Pacha","doi":"10.1111/ijd.17738","DOIUrl":"https://doi.org/10.1111/ijd.17738","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Immune-Related Toxicities: Secukinumab-Induced Bullous Pemphigoid Following ICI-Associated Psoriasis in a Cancer Patient.","authors":"Ioanna A Paschou, Vasiliki I Drantaki, Maria Gerochristou, Irene Stefanaki, Antonina Lingria, Alexander J Stratigos, Vasiliki Nikolaou","doi":"10.1111/ijd.17778","DOIUrl":"https://doi.org/10.1111/ijd.17778","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring Skin Hydration and Barrier Function: Mechanistic Insights Into Basic Emollients for Xerosis Cutis.","authors":"Joachim W Fluhr, Valérie Muguet, Stéphanie Christen-Zaech","doi":"10.1111/ijd.17790","DOIUrl":"https://doi.org/10.1111/ijd.17790","url":null,"abstract":"<p><p>Healthy skin is structured to maintain water balance by maximizing water retention and minimizing evaporative loss. The water-holding and barrier functions of the skin can be impaired by several factors that lead to xerosis cutis (dry skin); however, they can also be restored by basic emollients that act through the physicochemical properties of their constituents. This article aims to give a narrative review of the physiology of normal skin hydration, the key pathophysiological mechanisms implicated in dry skin, and the functional effects of basic emollients for managing xerosis cutis. Skin hydration is primarily mediated by the stratum corneum (SC), the outermost layer of the epidermis. Hygroscopic compounds in the SC maintain the skin's water-binding capacity, while the intercellular lipid bilayer and outer hydrolipid film prevent evaporative water loss. Xerosis cutis is characterized by a reduction in natural moisturizing factors or hydrolipids in the SC; it may be caused by exogenous triggers (e.g., cold weather, lifestyle, pollution), endogenous factors (e.g., aging, medication use) or genetic predisposition (as seen in atopic dermatitis, psoriasis, ichthyosis), or it may present as a symptom of a systemic disease (e.g., diabetes mellitus, hypothyroidism). Regardless of the underlying cause, basic emollients are recommended for the treatment of xerosis cutis and are typically formulated with humectants to improve skin hydration and water-holding capacity (e.g., glycerol, urea, lactic acid) and occludents to restore the epidermal barrier (e.g., petrolatum, liquid paraffin). Basic emollients remain the standard of care for the long-term management of xerosis cutis and diseases associated with dry skin.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Current Management and Innovative Therapies.","authors":"Jose Dario Martinez Villarreal, Jesus Alberto Cardenas-de la Garza, Marius-Anton Ionescu, Alin Laurentiu Tatu, Camelia Busila, Mourad Mokni, Luis Manuel Saenz Medina, Sergio Maximo Delgado Jasso, Eduardo David Poletti, Kenneth J Tomecki","doi":"10.1111/ijd.17768","DOIUrl":"https://doi.org/10.1111/ijd.17768","url":null,"abstract":"<p><p>There is no consensus regarding the treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Supportive care remains the preferred approach internationally, while the efficacy of topical/systemic therapies is subject to controversy. We reviewed published guidelines and recommendations on SJS/TEN management and assessed supportive care involving topical and systemic therapies in a series of SJS patients. We included several specialty departments from different countries to determine the consensus in the management of SJS/TEN. We also included SJS patients and provided supportive care including silver nitrate at 0.5% sprayed on denuded areas, in conjunction with a single dose of subcutaneous etanercept. Based on our literature review and experience, we propose a management algorithm for SJS/TEN. Our review confirmed the importance of supportive care, including specific topical and systemic treatments, for SJS/TEN. Systemic corticotherapy, cyclosporine A, intravenous immunoglobulin, tumor necrosis factor-alpha (TNF-α) blockers, or combinations are subject to controversies. In our pilot series of seven adult patients with SJS, we obtained good clinical results within 1 week, with mucosal and skin clearance at Week 2, along with a good safety profile. This was achieved by spraying topical silver nitrate at a concentration of 0.5% on denuded areas, following a single dose of etanercept. This consensus led to the recommendation of a combination of supportive care along with several possible topical and systemic therapies for SJS/TEN. Corticosteroids, immunoglobulins, cyclosporine A, and TNF-alpha blockers were used in our centers alone or in combination, with good results associated with 0.5% topical silver nitrate. In our series of SJS patients, silver nitrate at 0.5% associated with etanercept showed a good response.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Periorbital Edema Linked to Artificial Nails: A Case of Allergic Contact Dermatitis.","authors":"Rebekka Søgaard, Jakob Ferløv Baselius Schwensen, Maria Booth Nielsen, Jesper Elberling","doi":"10.1111/ijd.17787","DOIUrl":"https://doi.org/10.1111/ijd.17787","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delphi Consensus on the Distinct Clinical and Histopathological Features of Lichen Planopilaris and Frontal Fibrosing Alopecia: Insights From the Hair Diseases EADV Task Force.","authors":"Michela Valeria Rita Starace, Francesca Pampaloni, Matilde Iorizzo, Zoe Apalla, Leila Asfour, Azael Freites-Martinez, Dimitrios Ioannides, Awatef Kelati, Bianca Maria Piraccini, Adriana Rakowska, Lidia Rudnicka, Andrea Sechi, Seyed Morteza Seyed Jafari, Anita Takwale, Anastasia Therianou, Anna Waśkiel-Burnat, Alexander Katoulis","doi":"10.1111/ijd.17780","DOIUrl":"https://doi.org/10.1111/ijd.17780","url":null,"abstract":"<p><strong>Background: </strong>Frontal fibrosing alopecia (FFA) has been defined as a lichen planopilaris (LPP) variant, and both are characterized by lymphocytic scarring alopecia. Despite histopathological similarities, they differ clinically, suggesting potentially different pathogenetic factors. This Delphi study aimed to collect expert opinions to clarify the relationship between FFA and LPP.</p><p><strong>Methods: </strong>The Delphi method was employed via an anonymous survey among experts in hair disorders from the Hair Diseases Task Force of the European Academy of Dermatology and Venereology (EADV), ensuring broad international representation. Two rounds of online questionnaires assessed the definition, clinical presentation, diagnosis, and management of LPP and FFA. The statements, developed based on an extensive literature review, were validated by the core expert panel. A 5-point Likert scale was utilized to quantify agreement levels, with strong consensus defined as ≥ 75% agreement or disagreement. Statements lacking strong consensus in the first round were revised and merged for inclusion in the second round.</p><p><strong>Results: </strong>Seventeen experts from seven countries joined the Delphi consensus process. In the first round, 65 statements underwent qualitative content analysis, yielding strong consensus in 30.7% of cases. Participants provided written justifications for their assessments. In the second round, an increased consensus rate (53.7%) was reached after the expert panel statement's revision.</p><p><strong>Conclusions: </strong>This study confirms that FFA and LPP are clinical variants within the same lichenoid spectrum. While moderate consensus supports FFA as a variant of LPP, uncertainties remain regarding its demographic distribution, the presence of vellus hairs, and blue-gray dots. The study refines diagnostic and management approaches but is limited by the absence of dermatopathologists and basic researchers.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Use of 5% Cyclosporine in Pentravan for Managing Erosive Pustulosis of the Scalp: A Case Series.","authors":"Caterina Mariarosaria Giorgio, Vittorio Tancredi, Gaetano Licata, Elvira Moscarella, Graziella Babino, Elisabetta Fulgione, Giuseppe Argenziano, Eugenia Veronica Di Brizzi","doi":"10.1111/ijd.17785","DOIUrl":"https://doi.org/10.1111/ijd.17785","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}