International Journal of Dermatology最新文献

{"title":"Sustained response to anti-TNF therapy in ASIA syndrome triggered by vaccination and filler.","authors":"Daniel Martín-Torregrosa, Miguel Mansilla-Polo, Carlos Abril-Pérez, Vicent Martínez-Cózar, Mercedes Rodríguez-Serna","doi":"10.1111/ijd.17650","DOIUrl":"https://doi.org/10.1111/ijd.17650","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Non-Response: Prognosis and Strategies in Chronic Spontaneous Urticaria Management","authors":"Emek Kocatürk, Torsten Zuberbier","doi":"10.1111/ijd.17653","DOIUrl":"10.1111/ijd.17653","url":null,"abstract":"<p>The study by Watanabe et al. [<span>1</span>], published in the February issue of the <i>International Journal of Dermatology</i>, on the prognosis of chronic spontaneous urticaria (CSU) patients who exhibit an inadequate response to omalizumab (OMA) is a significant contribution to understanding this challenging patient subgroup. The authors' findings offer valuable insights into prognostic determinants and therapeutic strategies, potentially aiding clinicians in optimizing the management of refractory CSU.</p><p>A pivotal observation from this study is that 58.3% of patients with an initial inadequate response to OMA achieved a favorable prognosis at 12 months. At first glance, this good prognosis could be attributed to the usage of higher doses of omalizumab since the international urticaria guidelines suggest increasing the dose or narrowing the intervals of omalizumab treatment when there is inadequate response to treatment with 300 mg/month [<span>2</span>]. However, the authors did not find an association between continuing omalizumab treatment and good prognosis in the multivariate analysis. This is most probably due to the fact that updosing omalizumab was not possible in Japan. Nevertheless, in clinical trials, more than half of the patients who had not responded to omalizumab 300 mg/month by Week 12 responded between Weeks 13 and 24 [<span>3</span>]. Therefore, a proportion of the patients who continued the same dose of omalizumab might have responded to treatment during follow-up. The authors reported a positive association with good prognosis and the implementation of immunosuppressants and a negative association with systemic corticosteroids. This aligns with existing guidelines that advocate for minimizing corticosteroid use due to its long-term adverse effects and exploring other options like cyclosporine-A (cs-A) for refractory cases.</p><p>The identified good prognostic factors were shorter CSU duration, concomitant angioedema (AE), low serum IgE (≤ 100 IU/mL) prior to OMA, elevated eosinophil counts (≥ 100/mm<sup>3</sup>) post-OMA, and higher urticaria control test (UCT) scores pre- and post-OMA (Figure 1).</p><p>Interestingly, the study highlights that AE, less frequently observed in Japanese patients than in Western patients, emerged as a good prognostic factor. This finding contrasts with previous reports where AE was often associated with poor outcomes [<span>4</span>]. The lower frequency of AE in Japanese CSU patients might reflect genetic or environmental differences, and its association with favorable prognosis in this cohort provides a novel perspective.</p><p>Moreover, the study underscores the importance of patient-reported outcome measures like the urticaria control test (UCT) in evaluating disease control and tailoring management strategies [<span>5</span>]. UCT scores, which reflect the patient's perspective on disease control, emerged as a critical predictor of prognosis in this study. These tools should be ro","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 2","pages":"227-228"},"PeriodicalIF":3.5,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity and dermatology through the lens of generative artificial intelligence portrayals: a demographic analysis of race and gender representation.","authors":"Natalie Braun, Nari Lee, Mary Morcos, Jason Young","doi":"10.1111/ijd.17648","DOIUrl":"https://doi.org/10.1111/ijd.17648","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deadly mucor at an unusual site: A case report of isolated genital mucormycosis.","authors":"Carol Lobo, Shubha Bhagavan, Anuradha Ananthamurthy","doi":"10.1111/ijd.17647","DOIUrl":"https://doi.org/10.1111/ijd.17647","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of a defect of the medial upper cutaneous and vermilion lip.","authors":"Kelly Griffith-Bauer, Ashley O Riddle, Stanislav N Tolkachjov","doi":"10.1111/ijd.17639","DOIUrl":"https://doi.org/10.1111/ijd.17639","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated cutaneous mucormycosis resembling multiple panniculitis.","authors":"Tianwei Liang, Xingye Meng, Xiao Liu, G Sybren de Hoog, Yinggai Song, Ruoyu Li","doi":"10.1111/ijd.17643","DOIUrl":"https://doi.org/10.1111/ijd.17643","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline trichoscopic values for afro-textured hair in indigenous South Africans show lower density and unique features.","authors":"Ncoza Cordelia Dlova, Nkechi Anne Enechukwu, Mohamed Hoosen Suleman, J Z Maseko, Lidia Rudnicka","doi":"10.1111/ijd.17633","DOIUrl":"https://doi.org/10.1111/ijd.17633","url":null,"abstract":"<p><strong>Background: </strong>Afro-textured hair exhibits distinct physicochemical properties with possible variations in measurable hair parameters. Standardized documentation of trichoscopic norms of afro-textured hair in indigenous Africans is notably lacking.</p><p><strong>Methods: </strong>A cross-sectional study involving 122 South Africans of both genders of African ancestry (mean age 20.9 ± 3.3 years) with natural afro-textured hair was performed to establish trichoscopic norms. Standard images, one overview, and five microimages (one 20× and four 50× magnifications) were captured with the FotoFinder Medicam1000V2 videodermoscope. Hair density (HD; N/cm²); hair shaft thickness (HST; μm); the proportion of thin, mid, and thick hairs (%); cumulative hair thickness (mm/cm²); and follicular units (FU; N/cm²) were assessed.</p><p><strong>Results: </strong>The average HD was 139.1 ± 33.88 hairs/cm² with significant variations across different scalp areas. The average hair thickness was 62.59 ± 8.45 μm with the frontal scalp showing the greatest HST, the proportion of thick hairs, cumulative hair thickness, and FU densities; the temporal had the greatest proportion of thin hairs, whereas the occipital showed the highest proportion of triple hair FU. Male participants exhibited significantly greater average hair thickness, more thick hairs, and more double and triple FU, whereas females had higher cumulative hair thickness density, more thin and intermediate hairs, and more single follicular units.</p><p><strong>Conclusion: </strong>Baseline trichoscopic values for natural afro-textured hair in indigenous South Africans reveal lower hair densities, variations in shaft diameters, and follicular unit patterns compared to other racial groups. Significant gender-based differences are evident in some of the measured parameters. Tailored reference values are essential for accurate clinical evaluations and hair transplant planning.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trachyonychia secondary to pediatric alopecia areata responding to oral tofacitinib therapy: a case report and review of literature.","authors":"Parul Bansal, Akash Agarwal, Maitreyee Panda","doi":"10.1111/ijd.17640","DOIUrl":"https://doi.org/10.1111/ijd.17640","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amitriptyline for the treatment of vulvodynia in patients with vulvar lichen sclerosus: a case series of 20 patients.","authors":"Gaetano Licata, Eugenia Veronica Di Brizzi, Vittorio Tancredi, Mariachiara Arisi, Cesare Ariasi, Caterina Mariarosaria Giorgio","doi":"10.1111/ijd.17634","DOIUrl":"https://doi.org/10.1111/ijd.17634","url":null,"abstract":"<p><p>Vulvar Lichen Sclerosus (VLS) is a chronic autoimmune disease that often leads to vulvodynia, a debilitating chronic pain condition in the vulvar region. Treating vulvodynia in the context of VLS presents a significant therapeutic challenge due to the lack of standardized protocols. This article presents a case series of 20 women treated with amitriptyline for vulvodynia secondary to VLS, accompanied by an extended review of the literature. The results suggest that amitriptyline may offer significant pain relief and improvements in the patients' quality of life, although adverse effects need to be carefully managed. Further studies are needed to validate these findings in larger controlled trials.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of BCG vaccination against multibacillary disease, reactions, and disabilities in childhood leprosy: Insights from a retrospective observational study from a tertiary care center in India.","authors":"Tarun Narang, Apoorva Sharma, Ishita Kaushal, Debajyoti Chatterjee, Sunil Dogra","doi":"10.1111/ijd.17636","DOIUrl":"https://doi.org/10.1111/ijd.17636","url":null,"abstract":"<p><strong>Background and methods: </strong>While leprosy primarily affects adults, childhood leprosy poses unique challenges because of its potential to cause lifelong disabilities and stigma. This is a retrospective record review of all patients aged 15 or below, diagnosed with leprosy, who were registered at the leprosy clinic of our tertiary care center from June 2014 to December 2023.</p><p><strong>Results: </strong>As per hospital records, 1083 leprosy cases were registered at our center during the study period. Of these, 50 (4.6%) were children below 15 years of age. Persistent skin lesions (PSL) were seen in 11 (22%) cases, and the most common spectrum in which PSL were seen was the bordeline tuberculoid spectrum (BT) (7/11; 63.6%). Among these cases, a Bacillus Calmette-Guerin (BCG) scar was present in only four (36.4%) patients. Overall, a BCG scar was noted in 39/50 cases (78%). The relationship between having no BCG scar and multibacillary disease, lepromatous leprosy (LL), or the borderline lepromatous (BL) spectrum was statistically significant (P = 0.021). Of the six reaction cases, only one patient had a BCG scar (2%). A statistically significant association was found between the absence of a BCG scar and having a reaction (P < 0.01). Of the 11 grade 2 disability cases, nine cases (all within the BL or LL spectrum) had no BCG scar, which was also statistically significant (P < 0.01).</p><p><strong>Conclusions: </strong>Further research is warranted to strengthen the evidence of the impact of vaccination [BCG/Mycobacterium indicus pranii (MIP)] on the patterns of childhood leprosy, its effect on PSL, and its role in the prevention of reactions and disabilities. Such research would also help in optimizing strategies for the vaccine's universal application.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}