{"title":"Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Delicate Balance of Infection Control, Wound Management, and Multisystem Complications","authors":"Pelin Ertop Doğan, Emel Hazinedar","doi":"10.1111/ijd.17717","DOIUrl":"10.1111/ijd.17717","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 5","pages":"789-790"},"PeriodicalIF":3.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editor's Highlights—April 2025","authors":"Lajos Kemény","doi":"10.1111/ijd.17713","DOIUrl":"10.1111/ijd.17713","url":null,"abstract":"<div>\u0000 \u0000 <p>Skin diseases vary significantly across racial and ethnic groups, influenced by genetic, environmental, and socioeconomic factors. However, patients with skin of color (SOC) have historically been underrepresented in research, resulting in disparities in diagnosis, treatment, and access to care. In the April issue of the Journal, we dedicate attention to these key disparities. We focus on the differences in clinical symptoms and treatment challenges related to inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa in SOC patients.</p>\u0000 </div>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 4","pages":"631-632"},"PeriodicalIF":3.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaycee Nguyen, Mojahed Mohammad K Shalabi, Sloan Long, Marcus Zaayman, Benjamin Kelley, Stanislav N Tolkachjov
{"title":"Surgical Treatment of Digital Papillary Adenocarcinoma: A Systematic Review.","authors":"Kaycee Nguyen, Mojahed Mohammad K Shalabi, Sloan Long, Marcus Zaayman, Benjamin Kelley, Stanislav N Tolkachjov","doi":"10.1111/ijd.17697","DOIUrl":"https://doi.org/10.1111/ijd.17697","url":null,"abstract":"<p><p>Digital papillary adenocarcinoma (DPA) is a rare malignant tumor of eccrine sweat glands, primarily affecting fingers or toes. Currently, there is no established consensus on optimal treatment. Our study compares recurrence rates following various surgical treatments for DPA, including excision, digit amputation, and Mohs micrographic surgery (MMS). A systematic review conducted in June 2024 examined PubMed, Embase, Web of Science, and Scopus databases. The primary search terms included \"DPA\" and \"aggressive digital papillary adenocarcinoma\". Included studies required a histologically confirmed diagnosis of DPA, detailed surgical treatment, and follow-up recurrence or metastasis data. Studies lacking follow-up or involving concurrent treatments were excluded. A total of 43 articles encompassing 122 patients and 123 surgeries were analyzed. Our study demonstrates that MMS is associated with favorable outcomes, reporting zero recurrences in the five cases treated, compared to a 34.1% recurrence rate with surgical excision and a 20% recurrence rate with digit amputation. Understanding optimal surgical management is important for improving outcomes for patients with DPA. The primary limitations of this study include the small sample size for MMS, variability in follow-up durations, and potential reporting bias from case reports. While MMS reports on DPA treatment are limited, MMS should be considered among the surgical options for the treatment of DPA, given its excellent results, which demonstrate no recurrences or metastases in the literature. Additional comparative studies or series with more MMS would help choose between surgical options for DPA.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does Skin Color Matter in Psoriasis?","authors":"Adam Reich","doi":"10.1111/ijd.17714","DOIUrl":"10.1111/ijd.17714","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 4","pages":"635-636"},"PeriodicalIF":3.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natália Czurkó, Katalin Martyin, Mehdi Boostani, Tünde Kerner, András Bánvölgyi, Enikő Kuroli, Márta Medvecz, Eszter Ostorházi, Norbert Kiss
{"title":"Tinea Incognita Unmasked: Diagnostic Challenge in a Male Patient With a 3-Year History of Topical Steroid Use.","authors":"Natália Czurkó, Katalin Martyin, Mehdi Boostani, Tünde Kerner, András Bánvölgyi, Enikő Kuroli, Márta Medvecz, Eszter Ostorházi, Norbert Kiss","doi":"10.1111/ijd.17720","DOIUrl":"https://doi.org/10.1111/ijd.17720","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nessr Abu Rached, Marina Skrygan, Lennart Ocker, Yannik Haven, Daniel Myszkowski, Eggert Stockfleth, Falk G Bechara
{"title":"Haptoglobin Genotypes in Hidradenitis Suppurativa: Haptoglobin 2-2 Genotype Is Associated With Familial Hidradenitis Suppurativa and More Flares.","authors":"Nessr Abu Rached, Marina Skrygan, Lennart Ocker, Yannik Haven, Daniel Myszkowski, Eggert Stockfleth, Falk G Bechara","doi":"10.1111/ijd.17705","DOIUrl":"https://doi.org/10.1111/ijd.17705","url":null,"abstract":"<p><strong>Background: </strong>Haptoglobin (Hp) is an acute-phase protein and an independent marker for hidradenitis suppurativa (HS) severity. The different Hp genotypes (Hp 1-1, Hp 1-2, and Hp 2-2) differ in their antioxidant and anti-inflammatory functions. Hp genotypes have never been investigated in HS patients.</p><p><strong>Objective: </strong>Our aim was to characterize and determine the frequency of Hp genotypes in HS patients. Additionally, the characteristics of the different Hp genotypes are analyzed for differences in personal, disease-specific, and laboratory parameters.</p><p><strong>Methods: </strong>Genomic DNA was extracted from peripheral blood leukocytes using the Maxwell RSC Blood DNA Kit. Polymerase chain reaction (PCR) products were separated and analyzed using 0.7% agarose gels for genotyping. The chi-square test, Kruskal-Wallis test, and/or post hoc analysis with the Dunn-Bonferroni test were used to determine differences between the different genotypes and HS characteristics. We compared the genotype distribution in HS with 69 randomly selected, unmatched, and healthy control patients.</p><p><strong>Results: </strong>A total of 72 patients with HS were included in this study, including 29 women (40.3%) and 43 men (59.7%). A positive family history of HS was reported by 29.2% of patients (n = 21). Hp genotype 1-1 was present in 20.8%, Hp 1-2 in 33.3%, and Hp 2-2 in 45.8% of HS patients. The control group had a similar Hp distribution with 18.8%, 37.7%, and 43.5%, respectively. A positive family history of HS was significantly more frequent in Hp 2-2 (42.4%) compared to Hp 1-1 (6.7%) and Hp 1-2 (25%) (p = 0.035). The number of HS flares in the last 4 weeks was significantly higher in Hp 2-2 patients compared to Hp 1-2 patients (p = 0.006).</p><p><strong>Conclusion: </strong>Hp genotype 2-2 and the Hp2 allele were significantly more associated with familial HS than the other genotypes. In addition, HS patients with genotypes 2-2 had more frequent flare-ups than those with the different genotypes.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erythromelalgia and the Association With Paraproteinemias: A Retrospective Case Series.","authors":"Clayton P Burruss, Jeffrey P Callen","doi":"10.1111/ijd.17721","DOIUrl":"https://doi.org/10.1111/ijd.17721","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reducing Medical Waste","authors":"George M. Jeha, Stanislav N. Tolkachjov","doi":"10.1111/ijd.17715","DOIUrl":"10.1111/ijd.17715","url":null,"abstract":"<p>In this issue of the <i>International Journal of Dermatology</i>, Silva and colleagues [<span>1</span>] provide a timely examination of regulated medical waste (RMW) management, addressing a pressing issue as climate change and healthcare sustainability become increasingly prominent in public discourse. While environmental discussions are often politicized, inefficient medical waste management significantly increases costs for all, making waste reduction not just ethically but also financially important for clinics and healthcare systems [<span>2, 3</span>]. The authors' study presents an opportunity to reassess how medical waste is generated, why inefficiencies persist, and what steps can be taken to improve sustainability.</p><p>While medical waste discussions often focus on RMW, other types of waste in clinics and supply chains come to mind. Excessive packaging, with small items shipped in oversized boxes, creates unnecessary cardboard waste (Figure 1). One potential solution may be a cooperative purchasing model, where practices place bulk orders and share supplies to reduce waste, costs, and shipping inefficiencies [<span>4</span>]. Pharmaceutical waste is another significant issue in certain practices where strict institutional policies often treat multi-use vials of medications, like local anesthetics, as single-use, resulting in avoidable waste. Similarly, single-use suture removal kits create waste by including gauze and other packaged items already stocked in patient rooms. Additionally, the relatively dull disposable instruments included in these kits are often discarded in favor of sharper surgical tools. A more efficient alternative may involve using a disposable No. 11 or 15 blade with autoclaved reusable forceps, reducing reliance on disposable kits while maintaining sterility. In the Veterans Affairs system, outpatient surgery clinics often use disposable instruments instead of sterilizing and reusing them. Finally, laboratory-generated waste from stains, solvents, and reagents also contributes to a practice's environmental impact. Minimizing spills, reducing excess use, and raising awareness of proper handling can help limit waste (Figure 1). Addressing these sources of non-RMW waste alongside RMW-reducing strategies can reduce a practice's overall waste footprint, promoting sustainability and cost efficiency.</p><p>Silva and colleagues highlight the kick bucket as a key source of procedural waste, particularly in surgical settings where workflow efficiency influences disposal behaviors. In many dermatologic procedures, the amount of biohazardous waste per case is insufficient to fill a kick bucket, yet a red biohazard bag is changed between every case. This results in unnecessary waste of both bags and some improperly placed materials. The issue is compounded by suboptimal waste bin placement in procedural areas. Under pressure, assistants may dispose of nonbiohazardous waste in red bags simply because they are more accessibl","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":"64 5","pages":"791-793"},"PeriodicalIF":3.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijd.17715","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}