{"title":"The Differential That Never Gets Generated.","authors":"Apurv Khandelwal","doi":"10.1111/ijd.70743","DOIUrl":"https://doi.org/10.1111/ijd.70743","url":null,"abstract":"<p><p>Residents increasingly ask large language models to name a lesion before diagnosing it themselves. The practice contributes a specific harm: never-skilling, a phenomenon in which reasoning is never acquired, and is distinct from 'deskilling' or 'model error'. Forming a differential first is necessary but insufficient. Departments should require documented differentials, supervise disagreement, and examine unassisted reasoning.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristián Cádiz-Bosch, Fernando Lohse, Sofía Maldonado, Nelson Lobos
{"title":"Reconstruction of a Large Anterior Auricular Defect Following Mohs Surgery Preserving Auricular Projection.","authors":"Cristián Cádiz-Bosch, Fernando Lohse, Sofía Maldonado, Nelson Lobos","doi":"10.1111/ijd.70749","DOIUrl":"https://doi.org/10.1111/ijd.70749","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyed Mohammad Vahabi, Sama Heidari, Farzad Esmaeili, William J Crisler, Joe K Tung, Elena Netchiporouk, Mohamad Goldust, Elnaz Pourgholi
{"title":"Emerging Role of Janus Kinase Inhibitors in Primary Cutaneous Amyloidosis: A Systematic Review of 61 Reported Patients.","authors":"Seyed Mohammad Vahabi, Sama Heidari, Farzad Esmaeili, William J Crisler, Joe K Tung, Elena Netchiporouk, Mohamad Goldust, Elnaz Pourgholi","doi":"10.1111/ijd.70745","DOIUrl":"https://doi.org/10.1111/ijd.70745","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sophie H Kelly, Sara Lowe, Stephen L Walker, Sarah Bernays, L Claire Fuller, Nicola Willis, Vimbai Karimatsenga, Sinéad M Langan, Rashida A Ferrand
{"title":"Addressing the Geographic Reporting Bias in HIV-Associated Acquired Epidermodysplasia Verruciformis.","authors":"Sophie H Kelly, Sara Lowe, Stephen L Walker, Sarah Bernays, L Claire Fuller, Nicola Willis, Vimbai Karimatsenga, Sinéad M Langan, Rashida A Ferrand","doi":"10.1111/ijd.70741","DOIUrl":"https://doi.org/10.1111/ijd.70741","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Malak Husseinali, Ayisat Adegbindin, Dina Zamil, Oyetewa Asempa
{"title":"Hair Loss and Scalp Symptoms in Hijab-Wearing Women: Reported Frequency, Psychosocial Impact, and Barriers to Dermatologic Care.","authors":"Malak Husseinali, Ayisat Adegbindin, Dina Zamil, Oyetewa Asempa","doi":"10.1111/ijd.70746","DOIUrl":"https://doi.org/10.1111/ijd.70746","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rowena Lee Ying Kwan, Joyce Siong See Lee, Choon Guan Chua, Manish Mahadeorao Bundele, Jiun Yit Pan
{"title":"IgG4-Related Disease Presenting as Inflammatory Midline Pseudotumor of the Face and Neck.","authors":"Rowena Lee Ying Kwan, Joyce Siong See Lee, Choon Guan Chua, Manish Mahadeorao Bundele, Jiun Yit Pan","doi":"10.1111/ijd.70700","DOIUrl":"https://doi.org/10.1111/ijd.70700","url":null,"abstract":"<p><p>A 78-year-old Chinese woman presented with a one-year history of a progressively enlarging purpuric rash over the central face and nasal dorsum, with subsequent development of a firm midline neck mass. Histopathology revealed dense lymphoplasmacytic infiltrate with fibrosis and obliterative phlebitis. Immunohistochemistry showed over 200 IgG4-positive plasma cells per high-power field with an IgG4-IgG ratio exceeding 40%, and serum IgG4 was markedly elevated at 3648.0 mg/L, confirming IgG4-related disease (IgG4-RD) with a head-and-neck limited phenotype. She responded well to prednisolone. This case illustrates a rare cutaneous presentation of IgG4-RD, which should be considered in differential diagnoses of head and neck lesions.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jakub Żółkiewicz, Marco Spadafora, Claudio Conforti, Silvana Ciardo, Roman J Nowicki, Giovanni Pellacani, Caterina Longo
{"title":"Combining Dermoscopy and Reflectance Confocal Microscopy to Improve External Ear Melanoma Diagnosis: A Multicenter Retrospective Study.","authors":"Jakub Żółkiewicz, Marco Spadafora, Claudio Conforti, Silvana Ciardo, Roman J Nowicki, Giovanni Pellacani, Caterina Longo","doi":"10.1111/ijd.70734","DOIUrl":"https://doi.org/10.1111/ijd.70734","url":null,"abstract":"<p><strong>Background: </strong>External ear melanoma remains poorly characterized by non-invasive imaging. We characterized dermoscopic and reflectance confocal microscopy (RCM) features of auricular melanocytic lesions and evaluated whether combining both modalities improves diagnosis.</p><p><strong>Methods: </strong>This multicenter retrospective study included 77 auricular lesions evaluated at three tertiary centers. Blinded readers assessed predefined dermoscopic and RCM criteria. Firth-penalized logistic regression was used to develop dermoscopy-only, RCM-only, and combined models. Model development and discrimination were internally validated with 2000 bootstrap replications.</p><p><strong>Results: </strong>Thirty melanomas, one melanocytic tumor of uncertain malignant potential, one intraepidermal atypical melanocytic proliferation of uncertain significance, and 45 nevi were analyzed. Lentigo maligna/lentigo maligna melanoma-like imaging features were observed among melanomas of several histopathological subtypes. The combined model included blue-white veil (odds ratio [OR] 10.79, 95% confidence interval [CI]: 1.72-67.72), regression structures (OR 30.16, 95% CI: 3.53-257.97), dendritic pagetoid cells (OR 5.12, 95% CI: 1.25-21.08), and medusa head-like structures (OR 10.50, 95% CI: 2.11-52.18). It outperformed the dermoscopy-only model (apparent area under the curve [AUC] 0.931 vs. 0.852, DeLong p = 0.047, Holm-adjusted p = 0.047). Selection-aware optimism-corrected AUCs were 0.899 and 0.831, respectively. Excluding the two lesions of uncertain malignant potential produced comparable results (AUC 0.952 vs. 0.863, Holm-adjusted p = 0.040).</p><p><strong>Conclusions: </strong>Auricular melanocytic lesions warrant site-specific and sublocation-aware evaluation. Combining dermoscopy with RCM improved diagnostic discrimination over dermoscopy alone in this cohort, although prospective external validation is required.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Has the Desmoglein Compensation Hypothesis Reached Its Limits?","authors":"Yulu Wang, Sabrina Schundler, Kyle T Amber","doi":"10.1111/ijd.70729","DOIUrl":"https://doi.org/10.1111/ijd.70729","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}