Haptoglobin Genotypes in Hidradenitis Suppurativa: Haptoglobin 2-2 Genotype Is Associated With Familial Hidradenitis Suppurativa and More Flares.

IF 3.5 4区医学 Q1 DERMATOLOGY

International Journal of Dermatology Pub Date : 2025-02-28 DOI:10.1111/ijd.17705

Nessr Abu Rached, Marina Skrygan, Lennart Ocker, Yannik Haven, Daniel Myszkowski, Eggert Stockfleth, Falk G Bechara

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引用次数: 0

Abstract

Background: Haptoglobin (Hp) is an acute-phase protein and an independent marker for hidradenitis suppurativa (HS) severity. The different Hp genotypes (Hp 1-1, Hp 1-2, and Hp 2-2) differ in their antioxidant and anti-inflammatory functions. Hp genotypes have never been investigated in HS patients.

Objective: Our aim was to characterize and determine the frequency of Hp genotypes in HS patients. Additionally, the characteristics of the different Hp genotypes are analyzed for differences in personal, disease-specific, and laboratory parameters.

Methods: Genomic DNA was extracted from peripheral blood leukocytes using the Maxwell RSC Blood DNA Kit. Polymerase chain reaction (PCR) products were separated and analyzed using 0.7% agarose gels for genotyping. The chi-square test, Kruskal-Wallis test, and/or post hoc analysis with the Dunn-Bonferroni test were used to determine differences between the different genotypes and HS characteristics. We compared the genotype distribution in HS with 69 randomly selected, unmatched, and healthy control patients.

Results: A total of 72 patients with HS were included in this study, including 29 women (40.3%) and 43 men (59.7%). A positive family history of HS was reported by 29.2% of patients (n = 21). Hp genotype 1-1 was present in 20.8%, Hp 1-2 in 33.3%, and Hp 2-2 in 45.8% of HS patients. The control group had a similar Hp distribution with 18.8%, 37.7%, and 43.5%, respectively. A positive family history of HS was significantly more frequent in Hp 2-2 (42.4%) compared to Hp 1-1 (6.7%) and Hp 1-2 (25%) (p = 0.035). The number of HS flares in the last 4 weeks was significantly higher in Hp 2-2 patients compared to Hp 1-2 patients (p = 0.006).

Conclusion: Hp genotype 2-2 and the Hp2 allele were significantly more associated with familial HS than the other genotypes. In addition, HS patients with genotypes 2-2 had more frequent flare-ups than those with the different genotypes.

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化脓性汗腺炎中的珠蛋白基因型：珠蛋白2-2基因型与家族性化脓性汗腺炎和更多的发作有关。

背景：触珠蛋白（Hp）是一种急性期蛋白，是化脓性汗腺炎（HS）严重程度的独立标志物。不同的Hp基因型（Hp 1-1、Hp 1-2和Hp 2-2）在抗氧化和抗炎功能上存在差异。从未在HS患者中调查过Hp基因型。目的：我们的目的是表征和确定HS患者Hp基因型的频率。此外，还分析了不同Hp基因型在个人、疾病特异性和实验室参数方面的差异。方法：采用麦克斯韦RSC血液DNA试剂盒提取外周血白细胞基因组DNA。聚合酶链反应（PCR）产物分离，用0.7%琼脂糖凝胶进行基因分型分析。采用卡方检验、Kruskal-Wallis检验和/或Dunn-Bonferroni检验的事后分析来确定不同基因型和HS特征之间的差异。我们将HS患者的基因型分布与随机选择的69例未匹配的健康对照患者进行比较。结果：本研究共纳入72例HS患者，其中女性29例（40.3%），男性43例（59.7%）。29.2%的患者有HS家族史（n = 21）。Hp基因型1-1占20.8%，Hp基因型1-2占33.3%，Hp基因型2-2占45.8%。对照组Hp分布相似，分别为18.8%、37.7%和43.5%。Hp 2-2组HS家族史阳性率（42.4%）明显高于Hp 1-1组（6.7%）和Hp 1-2组（25%）（p = 0.035）。Hp 2-2患者在最后4周内HS发作次数明显高于Hp 1-2患者（p = 0.006）。结论：Hp基因2-2型和Hp2等位基因与家族性HS的相关性显著高于其他基因型。此外，基因型2-2的HS患者比不同基因型的患者更频繁发作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Dermatology 医学-皮肤病学

CiteScore

4.70

自引率

2.80%

发文量

476

审稿时长

3 months

期刊介绍： Published monthly, the International Journal of Dermatology is specifically designed to provide dermatologists around the world with a regular, up-to-date source of information on all aspects of the diagnosis and management of skin diseases. Accepted articles regularly cover clinical trials; education; morphology; pharmacology and therapeutics; case reports, and reviews. Additional features include tropical medical reports, news, correspondence, proceedings and transactions, and education. The International Journal of Dermatology is guided by a distinguished, international editorial board and emphasizes a global approach to continuing medical education for physicians and other providers of health care with a specific interest in problems relating to the skin.